Xianlin Han
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View article: AGPAT2 acts at the crossroads of lipid biosynthesis and DRP1-mediated ER morphogenesis
AGPAT2 acts at the crossroads of lipid biosynthesis and DRP1-mediated ER morphogenesis Open
The morphology of the endoplasmic reticulum (ER), characterized by central sheets and peripheral tubules, is controlled by membrane-shaping proteins. However, the role of lipids in ER morphogenesis remains elusive, despite the ER being the…
View article: Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice
Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice Open
Abnormal lipid metabolism is observed in Alzheimer's disease (AD), but its contribution to disease progression remains unclear. Genetic studies indicate that microglia, the brain's resident immune cells, influence lipid processing during A…
View article: Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease
Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease Open
Disturbances within the cerebrovascular system substantially contribute to the pathogenesis of age-related cognitive impairment and Alzheimer's disease (AD). Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid-β…
View article: Compromised lipid metabolism, mitochondria respiration and neuroprotective effects in iPSC-derived astrocytes from a Smith-Lemli-Opitz syndrome patient
Compromised lipid metabolism, mitochondria respiration and neuroprotective effects in iPSC-derived astrocytes from a Smith-Lemli-Opitz syndrome patient Open
Smith-Lemli-Opitz syndrome (SLOS) is a rare, autosomal recessive disorder characterized by congenital malformations, intellectual disability, and behavioral abnormalities. SLOS results from mutations in the DHCR7 gene, leading to impaired …
View article: Decoding adipose–brain crosstalk: Distinct lipid cargo in human adipose‐derived extracellular vesicles modulates amyloid aggregation in Alzheimer's disease
Decoding adipose–brain crosstalk: Distinct lipid cargo in human adipose‐derived extracellular vesicles modulates amyloid aggregation in Alzheimer's disease Open
INTRODUCTION Obesity is a major modifiable risk factor for Alzheimer's disease (AD), but the mechanistic link between peripheral metabolic dysfunction and AD progression remains unclear. Adipose‐derived extracellular vesicles (EVs) may pen…
View article: A sensory and motor neuropathy caused by a genetic variant of <i>NAMPT</i>
A sensory and motor neuropathy caused by a genetic variant of <i>NAMPT</i> Open
Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway for nicotinamide adenine dinucleotide (NAD + ) biosynthesis in mammalian cells and is essential for survival. Here, we report on a previousl…
View article: A pharmacovigilance study of vortioxetine based on data from the FDA adverse event reporting system
A pharmacovigilance study of vortioxetine based on data from the FDA adverse event reporting system Open
Vortioxetine is an antidepressant approved for the treatment of major depressive disorder (MDD). Given its widespread post-marketing clinical use, it is essential to explore its real-world safety. Reports were extracted from the FDA Advers…
View article: Crosstalk between mitochondrial quality control and novel programmed cell death in pulmonary diseases
Crosstalk between mitochondrial quality control and novel programmed cell death in pulmonary diseases Open
Dysfunctional mitochondrial quality control (MQC) and dysregulated programmed cell death (PCD) are increasingly recognized as key drivers of pulmonary diseases. This review explores the intricate crosstalk between MQC mechanisms, encompass…
View article: Multidisciplinary Treatment of Pancreatic Neuroendocrine Neoplasm with Portal Vein Thrombosis and Multiple Liver Metastases by Minimally Invasive Surgical and Neoadjuvant Therapy: A Case Report
Multidisciplinary Treatment of Pancreatic Neuroendocrine Neoplasm with Portal Vein Thrombosis and Multiple Liver Metastases by Minimally Invasive Surgical and Neoadjuvant Therapy: A Case Report Open
The treatment of patients with pancreatic neuroendocrine neoplasms accompanied by metastasis is complex and highly individualized. This article reports a 43-year-old male patient diagnosed with a neuroendocrine tumor on the pancreatic tail…
View article: Integrated spatial omics of metabolic reprogramming and the tumor microenvironment in pancreatic cancer
Integrated spatial omics of metabolic reprogramming and the tumor microenvironment in pancreatic cancer Open
Metabolic reprogramming is a defining feature of pancreatic cancer, influencing tumor progression and the tumor microenvironment. By integrating single-cell transcriptomics, spatial transcriptomics, and spatial metabolomics, this study vis…
View article: Mitochondrial Cardiolipin-Targeted Tetrapeptide, SS-31, Exerts Neuroprotective Effects Within In Vitro and In Vivo Models of Spinal Cord Injury
Mitochondrial Cardiolipin-Targeted Tetrapeptide, SS-31, Exerts Neuroprotective Effects Within In Vitro and In Vivo Models of Spinal Cord Injury Open
Spinal cord injury (SCI) affects millions globally, leading to severe motor and sensory deficits with no effective clinical treatment. Cardiolipin (CL), a mitochondria-specific phospholipid, plays a critical role in bioenergetics and apopt…
View article: Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease
Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease Open
INTRODUCTION Loss‐of‐function variants of the ABCA7 gene are associated with an increased risk of Alzheimer's disease (AD). How neuronal ABCA7 contributes to AD pathogenesis is unknown. METHODS Using neuron‐specific Abca7 KO mice (n Abca7 …
View article: Comparative study of the inhibitory effects of different antibiotic administration routes on bone healing in a rat tibial infection model
Comparative study of the inhibitory effects of different antibiotic administration routes on bone healing in a rat tibial infection model Open
Objective This study aimed to evaluate the effectiveness of intravenous versus oral antibiotic treatments in managing bone infections, particularly osteomyelitis, using a rat tibial infection model. Methods A tibial bone infection model wa…
View article: Evaluating the surgical and oncological outcomes of hepatic artery variations in minimally invasive pancreaticoduodenectomy: insights from 2023 data at a high-volume pancreatic center
Evaluating the surgical and oncological outcomes of hepatic artery variations in minimally invasive pancreaticoduodenectomy: insights from 2023 data at a high-volume pancreatic center Open
HAV and CR-HAV do not significantly impact overall or progression-free survival in patients undergoing MIPD. While HAV is associated with longer operation times, other perioperative and oncological outcomes remain comparable between HAV/CR…
View article: Microglial cGAS Deletion Preserves Intercellular Communication and Alleviates Amyloid‐β‐Induced Pathogenesis of Alzheimer's Disease
Microglial cGAS Deletion Preserves Intercellular Communication and Alleviates Amyloid‐β‐Induced Pathogenesis of Alzheimer's Disease Open
Innate immune activation plays a crucial role in the pathogenesis of Alzheimer's disease (AD) and related dementias (ADRD). The cytosolic DNA sensing pathway, involving cGAMP synthase (cGAS) and Stimulator of Interferon Genes (STING), has …
View article: Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation
Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation Open
Ketogenesis is a dynamic metabolic conduit supporting hepatic fat oxidation particularly when carbohydrates are in short supply. Ketone bodies may be recycled into anabolic substrates, but a physiological role for this process has not been…
View article: Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications
Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications Open
Alzheimer’s disease (AD) is among the most devastating neurodegenerative disorders with limited treatment options. Emerging evidence points to the involvement of lipid dysregulation in the development of AD. Nevertheless, the precise lipid…
View article: Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer’s disease in humans
Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer’s disease in humans Open
Intervention with a MMKD was able to alter the plasma lipidome in ways that contrast with AD-associated patterns. Given its low risk and cost, MMKD could be a promising approach for prevention or early symptomatic treatment of AD.
View article: Nanotension Relief Agent Enhances Tissue Penetration by Reducing Solid Stress in Pancreatic Ductal Adenocarcinoma via Rho/ROCK Pathway Inhibition
Nanotension Relief Agent Enhances Tissue Penetration by Reducing Solid Stress in Pancreatic Ductal Adenocarcinoma via Rho/ROCK Pathway Inhibition Open
The formidable contractile tension exerted by cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma (PDAC) tissue is crucial for maintaining high tissue solid stress (TSS), which impedes the delivery and penetration of c…
View article: Deep Learning HRNet-FCN for Blood Vessel Identification in Laparoscopic Pancreatic Surgery
Deep Learning HRNet-FCN for Blood Vessel Identification in Laparoscopic Pancreatic Surgery Open
Laparoscopic pancreatic surgery remains highly challenging due to the complexity of the pancreas and surrounding vascular structures, with risk of injuring critical blood vessels such as the Superior Mesenteric Vein (SMV)-Portal Vein (PV) …