Karl Wah Keung Tsim
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View article: Proteomic study of Akkermansia muciniphila and Bifidobacterium species co-culture under different carbon sources
Proteomic study of Akkermansia muciniphila and Bifidobacterium species co-culture under different carbon sources Open
Akkermansia muciniphila and Bifidobacterium spp. are major probiotic strains that have been shown to improve host metabolism and treat metabolic diseases. Previous studies have proposed formulating these probiotics as a therapeutic product…
View article: Profiling Class-Wide Bioactivities of Flavonoids While Minimizing Compound-Specific Effects Using an Equimolar Mixture Strategy
Profiling Class-Wide Bioactivities of Flavonoids While Minimizing Compound-Specific Effects Using an Equimolar Mixture Strategy Open
Flavonoids share a C6-C3-C6 core yet vary in side-chain decorations. Here, we tested whether an equimolar cross-subclass mixture could serve as a "class reference" by capturing class-wide bioactivities and …
View article: The Hepatoprotective Properties of the Revised Formulation of Dahuang Xiaoshi Tang, an Ancient Chinese Herbal Decoction, Are Probed by Integrated Metabolomics and Network Pharmacology
The Hepatoprotective Properties of the Revised Formulation of Dahuang Xiaoshi Tang, an Ancient Chinese Herbal Decoction, Are Probed by Integrated Metabolomics and Network Pharmacology Open
Background: Dahuang Xiaoshi Tang (DXT), an ancient Chinese herbal remedy dating back to 220 AD, as documented initially in “Treatise on Febrile and Miscellaneous Diseases,” is used to treat damp-heat jaundice with interior sthenia syndrome…
View article: The Mechanistic Evaluation of Danggui Buxue Tang, an Ancient Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, by Network Pharmacology
The Mechanistic Evaluation of Danggui Buxue Tang, an Ancient Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, by Network Pharmacology Open
Background/Objectives: Danggui Buxue Tang (DBT), an herbal formula deriving from traditional Chinese medicine (TCM), is widely recognized for its therapeutic effectiveness in clinical practice. To uncover the molecular mechanisms underlyin…
View article: The Identification of Gyrophoric Acid, a Phytochemical Derived from Lichen, as a Potent Inhibitor for Aggregation of Amyloid Beta Peptide: In Silico and Biochemical Evaluation
The Identification of Gyrophoric Acid, a Phytochemical Derived from Lichen, as a Potent Inhibitor for Aggregation of Amyloid Beta Peptide: In Silico and Biochemical Evaluation Open
Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) plaque accumulation and neurodegeneration. This study identified gyrophoric acid, a lichen-derived phenolic metabolite, as a dual-action Aβ42 inhibitor preventing aggregation a…
View article: The Identification of Gyrophoric Acid, a Phytochemical Derived from Lichen, as a Potent Inhibitor for Aggregation of Amyloid Beta Peptide: In Silico and Biochemical Evaluation
The Identification of Gyrophoric Acid, a Phytochemical Derived from Lichen, as a Potent Inhibitor for Aggregation of Amyloid Beta Peptide: In Silico and Biochemical Evaluation Open
Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) plaque accumulation and neurodegeneration. This study identifies gyrophoric acid, a lichen-derived phenolic metabolite, as a dual-action Aβ42 inhibitor preventing aggregation a…
View article: The Tacrine‐Induced Endoplasmic Reticulum Stress in <scp>AChE</scp> ‐Expressed Cells Leads to Improper Assembly and Transport of the Oligomeric Enzyme: Reversal by Trehalose
The Tacrine‐Induced Endoplasmic Reticulum Stress in <span>AChE</span> ‐Expressed Cells Leads to Improper Assembly and Transport of the Oligomeric Enzyme: Reversal by Trehalose Open
Alzheimer's disease (AD) is the most common dementia with progressive loss of cognitive functions. Acetylcholinesterase (AChE) inhibitors have been approved as conventional pharmacotherapies for AD. Tacrine was the first AChE inhibitor int…
View article: Genomic and Metabolomic Analysis of the Endophytic Fungus Alternaria alstroemeriae S6 Isolated from Veronica acinifolia: Identification of Anti-Bacterial Properties and Production of Succinic Acid
Genomic and Metabolomic Analysis of the Endophytic Fungus Alternaria alstroemeriae S6 Isolated from Veronica acinifolia: Identification of Anti-Bacterial Properties and Production of Succinic Acid Open
Background: Endophytic fungi are prolific sources of bioactive metabolites with potential in pharmaceutical and biotechnological applications. Methods: Here, the endophytic fungus, Alternaria alstroemeriae S6, was isolated from Veronica ac…
View article: Pan-cancer analysis of acetylcholinesterase (AChE) expression by a data-driven approach: future directions of AChE in cancer neuroscience
Pan-cancer analysis of acetylcholinesterase (AChE) expression by a data-driven approach: future directions of AChE in cancer neuroscience Open
There is evidence that the expression of acetylcholinesterase (AChE) is associated with the development of certain cancers. However, there are still insufficient studies to reveal the correlation between AChE expression and cancer developm…
View article: Camelia seed and its functional properties promising for dermatological applications
Camelia seed and its functional properties promising for dermatological applications Open
Tea or camelia (Camelia spp.) is considered as the important crop of the world with several health benefits. The leaves are processed and consumed as the popular beverage, as well as in varieties of consumer products. While camellia leaves…
View article: PT109B, a Multikinase Inhibitor, Converts Astrocytes into Dopaminergic Neurons and Alleviates Parkinson's Disease in Mice
PT109B, a Multikinase Inhibitor, Converts Astrocytes into Dopaminergic Neurons and Alleviates Parkinson's Disease in Mice Open
Background Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons (DANs), leading to motor dysfunction, while current treatments fail to restore neuronal loss. Reprogramming astrocytes into induced DANs b…
View article: Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models
Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models Open
Vascular endothelial growth factor (VEGF), also known as VEGF-A, has been linked to various diseases, such as wet age-related macular degeneration (wAMD) and cancer. Even though there are VEGF inhibitors that are currently commercially ava…
View article: Disruption of Copper Redox Balance and Dysfunction under <i>In Vivo</i> and <i>In Vitro</i> Alzheimer’s Disease Models
Disruption of Copper Redox Balance and Dysfunction under <i>In Vivo</i> and <i>In Vitro</i> Alzheimer’s Disease Models Open
Alzheimer's disease (AD) is a neurodegenerative disorder disease mainly caused by extracellular senile plaques (SP) formed by β-amyloid (Aβ1-42) protein deposits. Copper (Cu) is an essential metal involved in neural system, and its homeost…
View article: The activation of inflammatory responses in the brain is potentiated by over‐expressing acetylcholinesterase in myeloid lineage of transgenic mice
The activation of inflammatory responses in the brain is potentiated by over‐expressing acetylcholinesterase in myeloid lineage of transgenic mice Open
Acetylcholinesterase (AChE) has functions in neuroinflammation, beyond its classical role in neurotransmission. Understanding the role of AChE in neuroinflammation is of great significance, as it highlights the potential therapeutic target…
View article: Berberine and palmatine, acting as allosteric potential ligands of α7 <scp>nAChR</scp> , synergistically regulate inflammation and phagocytosis of microglial cells
Berberine and palmatine, acting as allosteric potential ligands of α7 <span>nAChR</span> , synergistically regulate inflammation and phagocytosis of microglial cells Open
Berberine and palmatine are isoquinoline quaternary alkaloids derived from Chinese medicinal herbs. These alkaloids have shown promising synergy in inhibiting acetylcholinesterase (AChE), indicating their potential in treating Alzheimer's …
View article: Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet‐Induced Release of Melanosome in Cultured Melanoma Cells
Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet‐Induced Release of Melanosome in Cultured Melanoma Cells Open
In skin, melanin is synthesized and stored in melanosomes. In epidermal melanocytes, melanosomes are transported to and internalized by the neighboring keratinocytes, subsequently leading to skin pigmentation. Ultraviolet (UV) radiation in…
View article: Plant growth-promoting rhizobacteria enhance active ingredient accumulation in medicinal plants at elevated CO2 and are associated with indigenous microbiome
Plant growth-promoting rhizobacteria enhance active ingredient accumulation in medicinal plants at elevated CO2 and are associated with indigenous microbiome Open
Introduction Plant growth-promoting rhizobacteria (PGPR) and elevated CO 2 (eCO 2 ) have demonstrated their individual potential to enhance plant yield and quality through close interaction with rhizosphere microorganisms and plant growth.…
View article: Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer’s disease
Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer’s disease Open
Background: The development of effective inhibitors that can inhibit amyloid β (A β ) peptides aggregation and promote neurite outgrowth is crucial for the possible treatment of Alzheimer’s disease (AD). Lobaria (Schreb.) Hoffm., a traditi…
View article: Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina
Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina Open
View article: Computational Docking as a Tool in Guiding the Drug Design of Rutaecarpine Derivatives as Potential SARS-CoV-2 Inhibitors
Computational Docking as a Tool in Guiding the Drug Design of Rutaecarpine Derivatives as Potential SARS-CoV-2 Inhibitors Open
COVID-19 continues to spread around the world. This is mainly because new variants of the SARS-CoV-2 virus emerge due to genomic mutations, evade the immune system and result in the effectiveness of current therapeutics being reduced. We p…
View article: Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation
Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation Open
Combination therapy is one of the promising approaches in developing therapeutics to cure complex diseases, such as Alzheimer’s disease (AD). In Thai traditional medicines, the clinical application often comprises multiple botanical drugs …
View article: Acetylcholinesterase is regulated by exposure of ultraviolet B in skin keratinocytes: A potential inducer of cholinergic urticaria
Acetylcholinesterase is regulated by exposure of ultraviolet B in skin keratinocytes: A potential inducer of cholinergic urticaria Open
Cholinergic urticaria is a dermatological disease characterized by the presence of large patches of red skin and transient hives triggered by factors, such as exercise, sweating, and psychological tension. This skin problem is hypothesized…
View article: The Extracts of Evodiae Fructus and Stephaniae Tetrandrae Radix Show Synergy in Blocking the Entry of SARS-CoV-2
The Extracts of Evodiae Fructus and Stephaniae Tetrandrae Radix Show Synergy in Blocking the Entry of SARS-CoV-2 Open
Given the fact that herbal extracts have been effectively used in clinical applications and have well-established safety records, our current findings suggest that these drug combinations might be considered as potential anti-COVID-19 trea…
View article: The muscarinic acetylcholine receptor in dermal papilla cells regulates hair growth
The muscarinic acetylcholine receptor in dermal papilla cells regulates hair growth Open
The role of cholinergic system in hair biology is poorly understood. In M4 muscarinic receptor (mAChR) knockout mice, the hair follicles have a prolonged telogen phase and failed to produce hair shafts. Here, we reported that hair growth w…
View article: Luteolin, a common flavone in vegetables, acts as a hormetin possessing neurotrophic function: signaling mediated by inducing mitochondrial stress
Luteolin, a common flavone in vegetables, acts as a hormetin possessing neurotrophic function: signaling mediated by inducing mitochondrial stress Open
This study aims to uncover the hormetic process of luteolin, a common dietary flavone, in neuronal cells through its role in inducing mitochondrial stress. In rat pheochromocytoma PC12 cells, luteolin at low concentrations caused a mild an…
View article: Xiao Cheng Qi Decoction, an Ancient Chinese Herbal Mixture, Relieves Loperamide-Induced Slow-Transit Constipation in Mice: An Action Mediated by Gut Microbiota
Xiao Cheng Qi Decoction, an Ancient Chinese Herbal Mixture, Relieves Loperamide-Induced Slow-Transit Constipation in Mice: An Action Mediated by Gut Microbiota Open
Xiao Cheng Qi (XCQ) decoction, an ancient Chinese herbal mixture, has been used in treating slow-transit constipation (STC) for years. The underlying action mechanism in relieving the clinical symptoms is unclear. Several lines of evidence…
View article: Acetylcholine Regulates the Melanogenesis of Retinal Pigment Epithelia Cells Via a CAMP-Dependent Pathway: A Non-Neuronal Function of Cholinergic System in Retina
Acetylcholine Regulates the Melanogenesis of Retinal Pigment Epithelia Cells Via a CAMP-Dependent Pathway: A Non-Neuronal Function of Cholinergic System in Retina Open
View article: Review of: "Bisphosphonate-Related Osteonecrosis of the Jaws Treated with Platelet-Rich Plasma: Preliminary Results from a Case Series"
Review of: "Bisphosphonate-Related Osteonecrosis of the Jaws Treated with Platelet-Rich Plasma: Preliminary Results from a Case Series" Open
View article: Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties
Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties Open
Introduction: Pathological angiogenesis, the abnormal or excessive generation of blood vessels, plays an important role in many diseases including cancer, diabetic retinopathy, psoriasis, and arthritis. Additionally, increasing evidence su…
View article: Comparative proteomic analysis of edible bird’s nest from different origins
Comparative proteomic analysis of edible bird’s nest from different origins Open