Xiao Zhang
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View article: ZEB1 and ALKBH5 coregulate CRABP2 and FABP5 and jointly determine the sensitivity of anaplastic thyroid cancers to gemcitabine and retinoic acid
ZEB1 and ALKBH5 coregulate CRABP2 and FABP5 and jointly determine the sensitivity of anaplastic thyroid cancers to gemcitabine and retinoic acid Open
Retinoic acid (RA) signaling through CRABP2 and FABP5 differentially influences therapeutic responses and drug resistance in anaplastic thyroid cancer (ATC), yet regulatory mechanisms remain unclear. Our study reveals low CRABP2 and high F…
View article: Network pharmacology-based approach to research the effects and mechanisms of Salvia Miltiorrhiza injection against idiopathic pulmonary fibrosis
Network pharmacology-based approach to research the effects and mechanisms of Salvia Miltiorrhiza injection against idiopathic pulmonary fibrosis Open
Background Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening lung disease with limited treatment efficacy. Salvia miltiorrhiza (SM), a traditional Chinese medicine (TCM), is widely used in Chinese hospitals due to its …
View article: INSIG1 parallel substitution drives lipid/sterol metabolic plasticity mediating desert adaptation in ungulates
INSIG1 parallel substitution drives lipid/sterol metabolic plasticity mediating desert adaptation in ungulates Open
Desert ungulates, such as Camelus bactrianus and Hippotraginae antelopes, exhibit extraordinary adaptation to extreme environment. Deciphering these genetic adaptations is critical for understanding evolutionary resilience under climate ch…
View article: Numerical Simulation on a Transient High Heat Flux Density Thermal Management System
Numerical Simulation on a Transient High Heat Flux Density Thermal Management System Open
In this work, a one-dimensional simulation model is developed to investigate a transient high heat flux density thermal management system. A specific heat capacity at constant pressure equivalent model is applied to simulate the capacity o…
View article: CUGUV: A Benchmark Dataset for Promoting Large-Scale Urban Village Mapping with Deep Learning Models
CUGUV: A Benchmark Dataset for Promoting Large-Scale Urban Village Mapping with Deep Learning Models Open
Delineating the extent of urban villages (UVs) is crucial for effective urban planning and management, as well as for providing targeted policy and financial support. Unlike field surveys, the interpretation of satellite imagery provides a…
View article: DNA methylation of CA10 regulates the proliferation and metastasis of bladder cancer
DNA methylation of CA10 regulates the proliferation and metastasis of bladder cancer Open
This study investigated the role of CA10 gene DNA methylation in bladder cancer progression, revealing that hypermethylation significantly reduces CA10 expression in tumor tissues compared to adjacent tissues. Utilizing TCGA data analysis …
View article: Activating PIK3CA Mutations of Adipose-derived Stem Cells Drive Mutant-like Phenotypes of Wild-type Cells in Macrodactyly
Activating PIK3CA Mutations of Adipose-derived Stem Cells Drive Mutant-like Phenotypes of Wild-type Cells in Macrodactyly Open
Background Pathological adipose proliferation is one of characteristic manifestations of macrodactyly. Although PIK3CA gain-of-function mutations are known to impact adipose-derived stem cells (ADSCs) in macrodactyly, their effects on adja…
View article: UCFE: A User-Centric Financial Expertise Benchmark for Large Language Models
UCFE: A User-Centric Financial Expertise Benchmark for Large Language Models Open
This paper introduces the UCFE: User-Centric Financial Expertise benchmark, an innovative framework designed to evaluate the ability of large language models (LLMs) to handle complex real-world financial tasks. UCFE benchmark adopts a hybr…
View article: Smart ageing with sway: Opportunities and challenges
Smart ageing with sway: Opportunities and challenges Open
Smart ageing is the process of leveraging accessible socio-ecological opportunities to proactively build the desired lifestyle and preferred quality of life as people age. Different from other ageing models, smart ageing views the ageing p…
View article: Recent progress of exosomal lncRNA/circRNA–miRNA–mRNA axis in lung cancer: implication for clinical application
Recent progress of exosomal lncRNA/circRNA–miRNA–mRNA axis in lung cancer: implication for clinical application Open
Lung cancer is the leading cause of death among malignant tumors in the world. High lung cancer mortality rate is due to most of patients diagnosed at advanced stage. The Liquid biopsy of lung cancer have received recent interest for early…
View article: Senior employment technology: Leveraging opportunities in population ageing
Senior employment technology: Leveraging opportunities in population ageing Open
Rapid population ageing, compounded by declines in the younger workforce that could offer timely caregiving assistance, is undermining society's ability to effectively and sufficiently protect people's health and quality of life as they gr…
View article: M2 Macrophages Guide Periosteal Stromal Cell Recruitment and Initiate Bone Injury Regeneration
M2 Macrophages Guide Periosteal Stromal Cell Recruitment and Initiate Bone Injury Regeneration Open
The periosteum plays a critical role in bone repair and is significantly influenced by the surrounding immune microenvironment. In this study, we employed 10× single-cell RNA sequencing to create a detailed cellular atlas of the swine cran…
View article: SwinCell: a transformer-based framework for dense 3D cellular segmentation
SwinCell: a transformer-based framework for dense 3D cellular segmentation Open
Segmentation of three-dimensional (3D) cellular images is fundamental for studying and understanding cell structure and function. However, 3D cellular segmentation is challenging, particularly for dense cells and tissues. This challenge ar…
View article: Exploring the Mediating Role of Different Aspects of Learning Motivation between Metaverse Learning Experiences and Gamification
Exploring the Mediating Role of Different Aspects of Learning Motivation between Metaverse Learning Experiences and Gamification Open
In recent years, research and applications related to the metaverse have garnered widespread attention in the field of online education. However, enhancing user experiences in metaverse learning remains a challenging issue. This study aims…
View article: The role of FPR2-mediated ferroptosis in formyl peptide-induced acute lung injury against endothelial barrier damage and protective effect of the mitochondria-derived peptide MOTS-c
The role of FPR2-mediated ferroptosis in formyl peptide-induced acute lung injury against endothelial barrier damage and protective effect of the mitochondria-derived peptide MOTS-c Open
Overall, fMLP disrupts the vascular endothelial barrier through FPR2-mediated ferroptosis, leading to the development and progression of ALI. MOTS-c demonstrates potential as a protective treatment against ALI by alleviating the damage ind…
View article: Identification and validation of mutual hub genes in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated usual interstitial pneumonia
Identification and validation of mutual hub genes in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated usual interstitial pneumonia Open
Though IPF and RA-UIP are distinct diseases, they may to some extent have mutual pathogenesis in the development of fibrosis. THBS2, TIMP1, POSTN, and CD19 may be the potential biomarkers of IPF and RA-UIP, and intervention on related path…
View article: FinBen: A Holistic Financial Benchmark for Large Language Models
FinBen: A Holistic Financial Benchmark for Large Language Models Open
LLMs have transformed NLP and shown promise in various fields, yet their potential in finance is underexplored due to a lack of comprehensive evaluation benchmarks, the rapid development of LLMs, and the complexity of financial tasks. In t…
View article: A Deep U-Net-ConvLSTM Framework with Hydrodynamic Model for Basin-Scale Hydrodynamic Prediction
A Deep U-Net-ConvLSTM Framework with Hydrodynamic Model for Basin-Scale Hydrodynamic Prediction Open
Traditional hydrodynamic models face the significant challenge of balancing the demands of long prediction spans and precise boundary conditions, large computational areas, and low computational costs when attempting to rapidly and accurat…
View article: Hypo-osmolality activates Wnt/β-catenin mediated by AQP1 in nucleus pulposuscells degeneration
Hypo-osmolality activates Wnt/β-catenin mediated by AQP1 in nucleus pulposuscells degeneration Open
The goals of this study were to investigate whether Wnt/β-catenin signaling plays a role in hypo-osmolality-related degeneration of nucleus pulposus (NP) cells, and if so, to define the mechanism underlying AQP1 in this effect. Human NP ce…