Explanipedia

OP0261 THE NATURAL SEQUENCE IN WHICH SUBCLINICALLY INFLAMED JOINT TISSUES PROGRESS TO CLINICAL ARTHRITIS OR SUBSIDE; A STUDY ON SERIAL MRIS IN THE PLACEBO-ARM OF THE TREAT EARLIER TRIAL Open

Doortje I Krijbolder, X. Matthijssen, Quirine A Dumoulin, B. Van Dijk, H.W. van Steenbergen , et al. · 2023

POS0976 HAND FUNCTION IS ALREADY REDUCED BEFORE RA-DEVELOPMENT AND REFLECTS SUBCLINICAL TENOSYNOVITIS Open

Doortje I Krijbolder, Sarah J H Khidir, X. Matthijssen, Robin Ten Brinck, Jill van Aken , et al. · 2023

Background Clinically suspect arthralgia (CSA) is characterized by arthralgia of small joints and considered a risk stage for development of rheumatoid arthritis (RA). However, it remains unknown if the function of the hands is already aff…

Country-level socioeconomic status relates geographical latitude to the onset of RA: a worldwide cross-sectional analysis in the METEOR registry Open

Sytske Anne Bergstra, Alexandre Sepriano, Arvind Chopra, Lai-Ling Winchow, David Vega‐Morales , et al. · 2023

The Natural Sequence in Which Subclinical Inflamed Joint Tissues Subside or Progress to Rheumatoid Arthritis: A Study of Serial <span>MRIs</span> in the <span>TREAT EARLIER</span> Trial Open

Doortje I Krijbolder, X. Matthijssen, Bastiaan T van Dijk, H.W. van Steenbergen, Debbie M. Boeters , et al. · 2023

Objective The natural trajectory of clinical arthritis progression at the tissue level remains elusive. We hypothesized that subclinical inflammation in different joint tissues (synovitis, tenosynovitis, osteitis) increases in a distinct t…

Hand function is already reduced before RA development and reflects subclinical tenosynovitis Open

Doortje I Krijbolder, Sarah J H Khidir, X. Matthijssen, Robin M. ten Brinck, Jill van Aken , et al. · 2023

Background Clinically suspect arthralgia (CSA) is characterised by arthralgia of small joints and considered a risk stage for development of rheumatoid arthritis (RA). However, it remains unknown if the function of the hands is already aff…

Frequency of joint inflammation is associated with local joint damage progression in rheumatoid arthritis despite long-term targeted treatment Open

Sascha L Heckert, Sytske Anne Bergstra, Yvonne P M Goekoop-Ruiterman, Melek Güler-Yüksel, Willem F. Lems , et al. · 2023

Objectives To investigate whether in rheumatoid arthritis (RA) frequency of local joint inflammation is associated with radiographic joint damage progression in that joint. Methods Data from 473 patients with RA and available radiographs f…

OP0035 WHAT EXPLAINS THE WORLDWIDE GRADIENT OF AGE AT ONSET OF RHEUMATOID ARTHRITIS ALONG LATITUDE? A MULTILEVEL ANALYSIS IN THE METEOR REGISTRY Open

Sytske Anne Bergstra, A. Sepriano, A. Chopra, L. L. Winchow, David Vega‐Morales , et al. · 2022

ACPA-negative and ACPA-positive RA patients achieving disease resolution demonstrate distinct patterns of MRI-detected joint-inflammation Open

Marloes Verstappen, X. Matthijssen, Seán Connolly, Michael A. Maldonado, T. Huizinga , et al. · 2022

Objectives Although sustained DMARD-free remission (SDFR; sustained absence of clinical-synovitis after DMARD-discontinuation) is increasingly achievable in RA, prevalence differs between ACPA-negative (40%) and ACPA-positive RA (5–10%). A…

Undifferentiated arthritis: a changing population who did not benefit from enhanced disease-modifying anti-rheumatic drug strategies—results from a 25 year longitudinal inception cohort Open

Marloes Verstappen, X. Matthijssen, Annette H M van der Helm–van Mil · 2021

Objectives International guidelines stress timely DMARD initiation in early arthritis as well as when classification criteria are not yet fulfilled. Consequently, undifferentiated arthritis (UA) patients may be increasingly treated with DM…

Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis Open

Fenne Wouters, M. Maurits, Laurette van Boheemen, Marloes Verstappen, Kulveer Mankia , et al. · 2021

Correspondence on ‘Role of joint damage, malalignment and inflammation in articular tenderness in rheumatoid arthritis, psoriatic arthritis and osteoarthritis‘ Open

Quirine A Dumoulin, X. Matthijssen, Fenne Wouters, Doortje I Krijbolder, Ellis Niemantsverdriet , et al. · 2021

Value of imaging detected joint inflammation in explaining fatigue in RA at diagnosis and during the disease course: a large MRI study Open

X. Matthijssen, Fenne Wouters, Navkiran Sidhu, Annette H M van der Helm–van Mil · 2021

Objective Fatigue in rheumatoid arthritis (RA) is hypothesised to be caused by inflammation. Still ~50% of the variance of fatigue in RA cannot be explained by the Disease Activity Score (DAS), nor by background or psychological factors. S…

OP0217 IS METACARPOPHALANGEAL-JOINT PAIN AS AN EARLY SYMPTOM OF PATIENTS AT RISK FOR PROGRESSION TO INFLAMMATORY ARTHRITIS EXPLAINED BY MRI-DETECTED SUBCLINICAL INFLAMMATION? – A LARGE OBSERVATIONAL STUDY Open

Quirine A Dumoulin, X. Matthijssen, Fenne Wouters, A. Van der Helm – van Mil, Ellis Niemantsverdriet · 2021

Intermetatarsal Bursitis, a Novel Feature of Juxtaarticular Inflammation in Early Rheumatoid Arthritis Related to Clinical Signs: Results of a Longitudinal Magnetic Resonance Imaging Study Open

Bastiaan T van Dijk, Yousra J. Dakkak, X. Matthijssen, Ellis Niemantsverdriet, M. Reijnierse , et al. · 2021

Objective Intermetatarsal bursae in the forefeet possess a synovial lining similar to joints and tendon sheaths. Inflammation of these bursae (intermetatarsal bursitis [IMB]) was recently identified as specific for early rheumatoid arthrit…

Tenosynovitis has a high sensitivity for early ACPA-positive and ACPA-negative RA: a large cross-sectional MRI study Open

X. Matthijssen, Fenne Wouters, Navkiran Sidhu, Ellis Niemantsverdriet, Annette H M van der Helm–van Mil · 2021

Early DAS response after DMARD-start increases probability of achieving sustained DMARD-free remission in rheumatoid arthritis Open

Marloes Verstappen, Ellis Niemantsverdriet, X. Matthijssen, Saskia le Cessie, Annette H M van der Helm–van Mil · 2020

Background Sustained DMARD-free remission (SDFR) is increasingly achievable. The pathogenesis underlying SDFR development is unknown and patient characteristics at diagnosis poorly explain whether SDFR will be achieved. To increase the und…

Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands Open

X. Matthijssen, Ellis Niemantsverdriet, T. Huizinga, Annette H M van der Helm–van Mil · 2020

Although disease activity has improved in both autoantibody-positive and autoantibody-negative RA in recent decades, the response in long-term outcomes differed. We propose that it is time to subdivide RA into autoantibody-positive RA (typ…

Differing time-orders of inflammation decrease between ACPA subsets in RA patients suggest differences in underlying inflammatory pathways Open

X. Matthijssen, Ellis Niemantsverdriet, Saskia le Cessie, Annette H M van der Helm–van Mil · 2020

Objectives Advanced imaging modalities have shown that not only joints but also bones and tendon sheaths can be inflamed at diagnosis of RA. We aimed to better understand the time-order in which the inflamed tissues respond to DMARD treatm…

Walking Disabilities in Association With Tenosynovitis at the Metatarsophalangeal Joints: A Longitudinal Magnetic Resonance Imaging Study in Early Arthritis Open

Yousra J. Dakkak, Fenne Wouters, X. Matthijssen, M. Reijnierse, Annette H M van der Helm–van Mil · 2020

Objective The relationship between functional disability and magnetic resonance imaging (MRI) inflammation has been studied for the hands, but has not been well established for the feet, even though walking difficulties are common. Therefo…

OP0176 CHRONOLOGICAL ORDER OF DECREASE OF SYNOVITIS, OSTEITIS AND TENOSYNOVITIS IN ARTHRITIS PATIENTS RECEIVING FIRST DMARD-TREATMENT Open

X. Matthijssen, Ellis Niemantsverdriet, Saskia le Cessie, A. van der Helm-van Mil · 2020

FRI0542 OBTAINING HIGH POSITIVE PREDICTIVE VALUES FOR THE DEVELOPMENT OF CLINICALLY APPARENT ARTHRITIS IN PATIENTS PRESENTING WITH CLINICALLY SUSPECT ARTHRALGIA; IS IT FEASIBLE? Open

X. Matthijssen, B. Van Dijk, Fenne Wouters, Ellis Niemantsverdriet, A. van der Helm-van Mil · 2020

Increasing incidence of autoantibody-negative RA is replicated and is partly explained by an aging population Open

X. Matthijssen, T. Huizinga, Annette H M van der Helm–van Mil · 2020

The value of MRI examination on bilateral hands including proximal interphalangeal joints for disease assessment in patients with early rheumatoid arthritis: a cross-sectional cohort study Open

Ying‐Qian Mo, Zehong Yang, Wang Jun-wei, Qianhua Li, X.-Y. Du , et al. · 2019

Background Bilateral hands including proximal interphalangeal joints (PIPJs) are recommended on physical, X-ray radiographic, or ultrasonographic examination by clinical guidelines of rheumatoid arthritis (RA), but MRI still tends to exami…

A search to the target tissue in which RA-specific inflammation starts: a detailed MRI study to improve identification of RA-specific features in the phase of clinically suspect arthralgia Open

X. Matthijssen, Fenne Wouters, Debbie M. Boeters, Aleid C. Boer, Yousra J. Dakkak , et al. · 2019

Reliability of Magnetic Resonance Imaging (MRI) Scoring of the Metatarsophalangeal Joints of the Foot according to the Rheumatoid Arthritis MRI Score Open

Yousra J. Dakkak, X. Matthijssen, Désirée van der Heijde, M. Reijnierse, Annette H M van der Helm–van Mil · 2019

Objective. The Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) is validated for hand MRI. Its reliability applied to metatarsophalangeal (MTP 1–5) joints is unknown and was studied in early arthritis and clinically suspect a…

Early intensive treatment normalises excess mortality in ACPA-negative RA but not in ACPA-positive RA Open

X. Matthijssen, T. Huizinga, Ellis Niemantsverdriet, Annette H M van der Helm–van Mil · 2019

OP0023 ACPA-POSITIVE RHEUMATOID ARTHRITIS PATIENTS BENEFITED MORE FROM ADVANCED TREATMENT STRATEGIES THAN ACPA-NEGATIVE RHEUMATOID ARTHRITISPATIENTS: 25-YEAR RESULTS OF A LONGITUDINAL COHORT STUDY Open

X. Matthijssen, Ellis Niemantsverdriet, T. Huizinga, A. Van der Helm – van Mil · 2019

FRI0626 DIFFICULTIES WITH MAKING A FIST IN PATIENTS WITH CLINICALLY SUSPECT ARTHRALGIA; AN EARLY PHENOMENON PREDICTIVE FOR RA THAT IS RELATED TO MRI-DETECTED TENOSYNOVITIS Open

Fenne Wouters, Florus van der Giesen, X. Matthijssen, Ellis Niemantsverdriet · 2019

THU0674 CLINICAL PRESENTATION AND MANAGEMENT OF MONO- AND BILATERAL KNEE ARTHRITIS: RESULTS FROM THE LEIDEN EARLY ARTHRITIS CLINIC COHORT Open

Johanna Maria Maassen, X. Matthijssen, Sytske Anne Bergstra, Cornelia F Allaart · 2019

FRI0653 IMPROVING AND VALIDATING THE PREDICTIVE ACCURACY OF MRI DETECTED SUBCLINICAL INFLAMMATION FOR RHEUMATOID ARTHRITIS DEVELOPMENT IN CLINICALLY SUSPECT ARTHRALGIA Open

X. Matthijssen, Fenne Wouters, Debbie M. Boeters, Aleid C. Boer, Yousra J. Dakkak , et al. · 2019

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