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View article: Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline
Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline Open
View article: Epigenome-Wide Association Study in Asian Cohort Identifies Novel DNA Methylation Markers for Carotid Intima-Media Thickness
Epigenome-Wide Association Study in Asian Cohort Identifies Novel DNA Methylation Markers for Carotid Intima-Media Thickness Open
2. ABSTRACT Background Carotid-intima media-thickness predicts cardiovascular events and informs mechanistic research on cardiovascular diseases (CVD). However, CVD research remains Eurocentric despite etiological differences across ancest…
View article: High-throughput plasma proteomic platforms: Insights from a multi-ethnic Asian cohort
High-throughput plasma proteomic platforms: Insights from a multi-ethnic Asian cohort Open
We compared three leading affinity-based and mass-spectrometry-based proteomic platforms (SomaScan11K, Olink Explore HT, Orbitrap Astral with Seer Proteograph [MS-Seer]) in a multi-ethnic Asian cohort, to inform biomarker discovery and fun…
View article: Effects of Cognitive States on Momentary Response Biases in an Ecological Momentary Assessment Study (Preprint)
Effects of Cognitive States on Momentary Response Biases in an Ecological Momentary Assessment Study (Preprint) Open
BACKGROUND Ecological momentary assessments (EMAs) are a widely used method in health and psychological research to assess people’s thoughts, emotions, and behaviours in daily life. However, EMAs are affected by several response biases in…
View article: Development and Validation of Polygenic Scores for Retinal Vessel Calibers
Development and Validation of Polygenic Scores for Retinal Vessel Calibers Open
PGSs for CRAE and CRVE are associated with measured retinal microvascular phenotypes. These findings illustrate the genetic contribution to retinal vessel calibers and provide insights into mechanisms of microvascular and macrovascular hea…
View article: Factors affecting disease progression in early-stage chronic kidney disease in a multi-ethnic, southeast Asian primary care population
Factors affecting disease progression in early-stage chronic kidney disease in a multi-ethnic, southeast Asian primary care population Open
Background While effective risk factor control and medication optimization in early-stage CKD can significantly slow disease progression, a paucity of studies hinders comprehensive understanding. This study aims to identify factors associa…
View article: An empirical dietary inflammatory pattern increases the incidence of the metabolic syndrome in a multi-ethnic Asian population
An empirical dietary inflammatory pattern increases the incidence of the metabolic syndrome in a multi-ethnic Asian population Open
View article: The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort
The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort Open
View article: Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues
Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues Open
Weight loss through exercise and diet reduces the risk of type 2 diabetes, but the genetic regulation of gene expression and splicing in response to weight loss remains unclear in humans. We collected clinical data and skeletal muscle biop…
View article: Vision transformer-based stratification of pre/diabetic and pre/hypertensive patients from retinal photographs for 3PM applications
Vision transformer-based stratification of pre/diabetic and pre/hypertensive patients from retinal photographs for 3PM applications Open
View article: Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits
Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits Open
View article: Author Correction: Identification of genetic effects underlying type 2 diabetes in South Asian and European populations
Author Correction: Identification of genetic effects underlying type 2 diabetes in South Asian and European populations Open
View article: Identification of genetic effects underlying type 2 diabetes in South Asian and European populations
Identification of genetic effects underlying type 2 diabetes in South Asian and European populations Open
View article: Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits
Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits Open
View article: National Scale Genomic Engine for Precision Medicine: Singapore PRECISE-SG100K Experience
National Scale Genomic Engine for Precision Medicine: Singapore PRECISE-SG100K Experience Open
Precision medicine (PM) research in recent years has witnessed a remarkable surge in large-scale population genomics programs. In 2017, Singapore initiated the National Precision Medicine (NPM) program, a three-phase national strategy driv…
View article: Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations
Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations Open
To identify biomarkers and pathways to Type-2 diabetes (T2D), a major global disease, we completed array-based epigenome-wide association in whole blood in 5,709 Asian people. We found 323 Sentinel CpGs (from 314 genetic loci) that predict…
View article: Are Traditional Deep Learning Model Approaches as Effective as a Retinal-Specific Foundation Model for Ocular and Systemic Disease Detection?
Are Traditional Deep Learning Model Approaches as Effective as a Retinal-Specific Foundation Model for Ocular and Systemic Disease Detection? Open
Background: RETFound, a self-supervised, retina-specific foundation model (FM), showed potential in downstream applications. However, its comparative performance with traditional deep learning (DL) models remains incompletely understood. T…
View article: Attainment of Global Diabetes Targets in 2021: A Pooled Analysis of Individual-Level Data from National Surveys in 100 Low-, Middle-, and High-Income Countries
Attainment of Global Diabetes Targets in 2021: A Pooled Analysis of Individual-Level Data from National Surveys in 100 Low-, Middle-, and High-Income Countries Open
View article: Interethnic analyses of blood pressure loci in populations of East Asian and European descent
Interethnic analyses of blood pressure loci in populations of East Asian and European descent Open
View article: Diet, physical activity, and sleep in relation to postprandial glucose responses under free-living conditions: an intensive longitudinal observational study
Diet, physical activity, and sleep in relation to postprandial glucose responses under free-living conditions: an intensive longitudinal observational study Open
View article: Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population
Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population Open
The biomarkers connecting obesity and cardiometabolic diseases are not fully understood. We aimed to 1) evaluate the associations between BMI, waist circumference (WC), and ∼5,000 plasma proteins (SomaScan V4), 2) identify protein signatur…
View article: Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population
Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population Open
The biomarkers connecting obesity and cardiometabolic diseases are not fully understood. We aimed to (i) evaluate the associations between body mass index (BMI), waist circumference (WC), and ~5,000 plasma proteins (SomaScan v4), (ii) iden…
View article: Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population
Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population Open
The biomarkers connecting obesity and cardiometabolic diseases are not fully understood. We aimed to (i) evaluate the associations between body mass index (BMI), waist circumference (WC), and ~5,000 plasma proteins (SomaScan v4), (ii) iden…
View article: A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes
A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes Open
Structural variants (SVs) are significant contributors to inter-individual genetic variation associated with traits and diseases. Current SV studies using whole-genome sequencing (WGS) have a largely Eurocentric composition, with little kn…
View article: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes Open
View article: Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes Open
View article: Risk prediction of cardiovascular disease in the Asia-Pacific region: the SCORE2 Asia-Pacific model
Risk prediction of cardiovascular disease in the Asia-Pacific region: the SCORE2 Asia-Pacific model Open
Background and Aims To improve upon the estimation of 10-year cardiovascular disease (CVD) event risk for individuals without prior CVD or diabetes mellitus in the Asia-Pacific region by systematic recalibration of the SCORE2 risk algorith…
View article: Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score
Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score Open
Combining information from multiple GWASs for a disease and its risk factors has proven a powerful approach for development of polygenic risk scores (PRSs). This may be particularly useful for type 2 diabetes (T2D), a highly polygenic and …
View article: Substituting Animal Protein Foods With Plant Protein Foods Influences Vitamin B12 and Folate Statuses in a Multiethnic Asian Population
Substituting Animal Protein Foods With Plant Protein Foods Influences Vitamin B12 and Folate Statuses in a Multiethnic Asian Population Open
View article: SMIM1 absence is associated with reduced energy expenditure and excess weight
SMIM1 absence is associated with reduced energy expenditure and excess weight Open