Le Xuan Truong Nguyen
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View article: Loss of endothelial mir-126 drives age-related reduction of hematopoietic activity
Loss of endothelial mir-126 drives age-related reduction of hematopoietic activity Open
Aging hematopoietic stem cells (HSCs) expand but their functional capacity declines. To prioritize the relative contributions of intrinsic versus (vs) extrinsic factors to HSC aging, we transplanted BM HSCs (Fit3−CD150+CD48− LSK) from youn…
View article: Corrigendum to Identification of CD84 as a potent survival factor in acute myeloid leukemia
Corrigendum to Identification of CD84 as a potent survival factor in acute myeloid leukemia Open
View article: Phase I first-in-human dose escalation study of the oral casein kinase 1α and cyclin dependent kinase 7/9 inhibitor BTX A51 in advanced MDS and AML
Phase I first-in-human dose escalation study of the oral casein kinase 1α and cyclin dependent kinase 7/9 inhibitor BTX A51 in advanced MDS and AML Open
NCT04872166.
View article: RNA m6A modification: a key regulator in normal and malignant processes
RNA m6A modification: a key regulator in normal and malignant processes Open
The dedicated control of gene abundance is essential for both biological and pathological processes in mammals. Multiple layers of gene expression regulation, including transcriptional, post-transcriptional, translational, and post-transla…
View article: Overcoming treatment resistance mediated by the bone marrow vascular niche in acute myeloid leukemia
Overcoming treatment resistance mediated by the bone marrow vascular niche in acute myeloid leukemia Open
Acute myeloid leukemia (AML) is a hematologic malignancy originating in the bone marrow, frequently progressing to extramedullary sites. Despite advances in molecularly targeted therapies and hematopoietic stem cell transplantation, clinic…
View article: Correction: Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia
Correction: Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia Open
View article: Correction: AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition
Correction: AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition Open
View article: Identification of CD84 as a potent survival factor in acute myeloid leukemia
Identification of CD84 as a potent survival factor in acute myeloid leukemia Open
Acute myeloid leukemia (AML) is an aggressive and often deadly malignancy associated with proliferative immature myeloid blasts. Here, we identified CD84 as a critical survival regulator in AML. High levels of CD84 expression provided a su…
View article: The role of YTHDF2 in anti-tumor immunity
The role of YTHDF2 in anti-tumor immunity Open
View article: Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells
Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells Open
View article: Targeting RNA modification and mitochondrial metabolism cross talk in leukemic stem cells with CDK7 inhibitor TGN-1062
Targeting RNA modification and mitochondrial metabolism cross talk in leukemic stem cells with CDK7 inhibitor TGN-1062 Open
[Figure: see text]
View article: miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape
miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape Open
We reported that an acquired miR-142 deficit transforms chronic phase (CP) chronic myeloid leukemia (CML) leukemic stem cells (LSCs) into blast crisis (BC) LSCs. Given the role of miR-142 in the development and activity of the immune syste…
View article: AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition
AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition Open
View article: Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity Open
View article: Phase I First-in-Human Dose Escalation Study of the oral Casein Kinase 1α and Cyclin Dependent Kinase 7/9 inhibitor BTX-A51 in advanced MDS and AML
Phase I First-in-Human Dose Escalation Study of the oral Casein Kinase 1α and Cyclin Dependent Kinase 7/9 inhibitor BTX-A51 in advanced MDS and AML Open
View article: IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells
IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells Open
The novel anti-IL1RAP/CD3 TCE, BIF002, eradicates LSCs and significantly prolongs survival of AML xenografts, representing a promising, novel treatment for AML.
View article: Homoharringtonine inhibits the NOTCH/MYC pathway and exhibits antitumor effects in T-cell acute lymphoblastic leukemia
Homoharringtonine inhibits the NOTCH/MYC pathway and exhibits antitumor effects in T-cell acute lymphoblastic leukemia Open
We report on the antileukemic activity of homoharringtonine (HHT) in T-cell acute lymphoblastic leukemia (T-ALL). We showed that HHT inhibited the NOTCH/MYC pathway and induced significantly longer survival in mouse and patient-derived T-A…
View article: 8-Cl-Ado and 8-NH2-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia
8-Cl-Ado and 8-NH2-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia Open
View article: Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity Open
View article: OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia
OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia Open
View article: A phase 1 trial of 8‐chloro‐adenosine in relapsed/refractory acute myeloid leukemia: An evaluation of safety and pharmacokinetics
A phase 1 trial of 8‐chloro‐adenosine in relapsed/refractory acute myeloid leukemia: An evaluation of safety and pharmacokinetics Open
Background This study evaluated the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of 8‐chloro‐adenosine (8‐Cl‐Ado) in patients with relapsed/refractory acute myeloid leukemia (AML). Methods 8‐Cl‐Ado was administered daily for 5 …
View article: Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis
Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis Open
The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of miR-142 in CD34 + CD38 − blasts from BC CML patients than i…
View article: TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal Open
View article: Targeting miR-126 in Ph+ acute lymphoblastic leukemia
Targeting miR-126 in Ph+ acute lymphoblastic leukemia Open
View article: Table of Contents
Table of Contents Open
View article: Supplemental Figure S4 from Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells
Supplemental Figure S4 from Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells Open
Supplemental Figure S4. Effects of Ebp1 overexpression on rRNA synthesis and cell proliferation in MEF Ebp1 -/-cells.
View article: Supplemental Figure S3 from Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells
Supplemental Figure S3 from Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells Open
Supplemental Figure S3. Relative expression of Ebp1 and rRNA synthesis in bone marrow cells from control and MLL-AF9 and MLL-AF10 mice.
View article: Supplemental Figure S5 from Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells
Supplemental Figure S5 from Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells Open
Supplemental Figure S5. Colocalization of Ebp1 p48 and Pol I complex.
View article: Supplemental Figure S3 from Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells
Supplemental Figure S3 from Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells Open
Supplemental Figure S3. Relative expression of Ebp1 and rRNA synthesis in bone marrow cells from control and MLL-AF9 and MLL-AF10 mice.
View article: Supplemental data from Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells
Supplemental data from Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells Open
Supplemental data contains supplemental figure legends, supplemental tables and supplemental materials and methods. Supplemental Table 1. Target sequences of siRNAs Supplemental Table 2. Primer's sequences for RT-qPCR Supplemental Table S3…