Explanipedia

Functional unfolding of the integrin αX transmembrane helix Open

Han Vu, Minhyeong Lee, Alan J. Situ, Woojin An, Klaus Ley , et al. · 2025

In biological membranes, proteins face a fundamentally different environment than in water. To avoid untenable lipid contacts with polar backbone atoms, they use the continuous hydrogen bonding achieved by α-helices or β-barrels to travers…

Exploring the Sustainability of Sports OTT Service Open

Yongwon Choi, Woojin An, Jongchul Park · 2025

In South Korea, Generation Z’s influence on the growth of sports over-the-top (OTT) services is significant. For sustainable growth, OTT service providers need to focus on converting existing users into loyal customers. In this context, un…

VprBP regulates osteoclast differentiation via an epigenetic mechanism involving histone H2A phosphorylation Open

Yonghwan Shin, Sungmin Kim, Tae‐Ik Choi, Cheolhee Kim, Woojin An · 2024

Promoter hypermethylation as a novel regulator of ANO1 expression and function in prostate cancer bone metastasis Open

Yonghwan Shin, Sung‐Min Kim, Woojin An · 2024

MMP‐9‐dependent proteolysis of the histone H3 N‐terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis Open

Yonghwan Shin, Sungmin Kim, Gangning Liang, Woojin An · 2024

Matrix metalloproteinase 9 (MMP‐9) is a member of the MMP family and has been recently identified as a nuclear protease capable of clipping histone H3 N‐terminal tails (H3NT). This MMP‐9 ‐dependent H3NT proteolysis is critical for establis…

Non-canonical MLL1 activity regulates centromeric phase separation and genome stability Open

Sha Liang, Zi Yang, Sojin An, Wentao Yang, Sungmin Kim , et al. · 2023

VprBP/DCAF1 Triggers Melanomagenic Gene Silencing through Histone H2A Phosphorylation Open

Yonghwan Shin, Sungmin Kim, Gangning Liang, Tobias S. Ulmer, Woojin An · 2023

Vpr binding protein (VprBP), also known as DDB1- and CUL4-associated factor1 (DCAF1), is a recently identified atypical kinase and plays an important role in downregulating the transcription of tumor suppressor genes as well as increasing …

VprBP/DCAF1 triggers melanomagenic gene silencing through histone H2A phosphorylation Open

Yonghwan Shin, Sungmin Kim, Gangning Liang, Tobias S. Ulmer, Woojin An · 2023

Background Melanoma is the most aggressive form of skin cancer arising from pigment-producing melanocytes and is often associated with dysregulation of epigenetic factors targeting histones. VprBP, also known as DCAF1, is a recently identi…

VprBP/DCAF1 triggers melanomagenic gene silencing through histone H2A phosphorylation Open

Yonghwan Shin, Sungmin Kim, Gangning Liang, Tobias S. Ulmer, Woojin An · 2023

Background Melanoma is the most aggressive form of skin cancer arising from pigment-producing melanocytes and is often associated with dysregulation of epigenetic factors targeting histones. VprBP, also known as DCAF1, is a recently identi…

DCAF1/VprBP triggers melanomagenic gene silencing through histone H2A phosphorylation Open

Yonghwan Shin, Sungmin Kim, Gangning Liang, Tobias S. Ulmer, Woojin An · 2023

Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer Open

Nikhil Baban Ghate, Sungmin Kim, Yonghwan Shin, Jin‐Man Kim, Michael E. Doche , et al. · 2023

Our recent work has shown that DCAF1 (also known as VprBP) is overexpressed in colon cancer and phosphorylates histone H2AT120 to drive epigenetic gene inactivation and oncogenic transformation. We have extended these observations by inves…

VprBP/DCAF1 regulates p53 function and stability through site-specific phosphorylation Open

Nikhil Baban Ghate, Sungmin Kim, Roasa Mehmood, Yonghwan Shin, Kyunghwan Kim , et al. · 2023

VprBP (also known as DCAF1) is a recently identified kinase that is overexpressed in cancer cells and serves as a major determinant for epigenetic gene silencing and tumorigenesis. The role of VprBP in driving target gene inactivation has …

DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma Open

Lian Zhang, Hongtao Li, Rachel Shereda, Qianjin Lu, Daniel J. Weisenberger , et al. · 2022

mAM Facilitates Conversion by ESET of Dimethyl to Trimethyl Lysine 9 of Histone H3 to Cause Transcriptional Repression Open

Hengbin Wang, Woojin An, Ru Cao, Xia Li, Hediye Erdjument‐Bromage , et al. · 2021

Methylation of histone tails plays an important role in chromatin structure and function. Previously, we reported that ESET/SETDB1 is a histone methyltransferase (HMTase). Here, we show that SETDB1 tightly associates with the human homolog…

VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer Open

Nikhil Baban Ghate, Sangnam Kim, Erin Spiller, Sung Min Kim, Yonghwan Shin , et al. · 2021

Histone modification is aberrantly regulated in cancer and generates an unbalanced state of gene transcription. VprBP, a recently identified kinase, phosphorylates histone H2A on threonine 120 (T120) and is involved in oncogenic transcript…

Author response for "VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer" Open

Nikhil Baban Ghate, Sangnam Kim, Erin Spiller, Sung‐Min Kim, Yonghwan Shin , et al. · 2021

Author response for "VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer" Open

Nikhil Baban Ghate, Sangnam Kim, Erin Spiller, Sung Min Kim, Yonghwan Shin , et al. · 2021

MMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation Open

Judd C. Rice, Benjamin H. Weekley, Tomas Kanholm, Zhihui Chen, Sunyoung Lee , et al. · 2021

Insight Into Pathological Integrin αIIbβ3 Activation From Safeguarding The Inactive State Open

Alan J. Situ, Jiyoon Kim, Woojin An, Chungho Kim, Tobias S. Ulmer · 2021

Linker Histone H1.2 Cooperates with Cul4A and PAF1 to Drive H4K31 Ubiquitylation-Mediated Transactivation Open

Kyunghwan Kim, Bomi Lee, Jaehoon Kim, Jongkyu Choi, Jin‐Man Kim , et al. · 2020

Increasing evidence suggests that linker histone H1 can influence distinct cellular processes by acting as a gene-specific regulator. However, the mechanistic basis underlying such H1 specificity and whether H1 acts in concert with other c…

A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes Open

Lei Zhang, Anshun He, Bohan Chen, Jinfang Bi, Jun Chen , et al. · 2020

Temozolomide (TMZ) is a frequently used chemotherapy for glioma; however, chemoresistance is a major problem limiting its effectiveness. Thus, knowledge of mechanisms underlying this outcome could improve patient prognosis. Here, we report…

Epigenetic Modification as a Regulatory Mechanism for Spatiotemporal Dynamics of ANO1 Expression in Salivary Glands Open

Yonghwan Shin, Sang‐Woo Lee, Eun Namkoong, Woojin An, Jong-Ho Lee , et al. · 2019

Anoctamin1 (ANO1), a calcium activated chloride channel, is known to play a critical role in salivary secretion. In the salivary gland, ANO1 is expressed exclusively in the acinar cells, with no expression in the ductal cells. However, the…

p32 is a negative regulator of p53 tetramerization and transactivation Open

Nikhil Baban Ghate, Jin‐Man Kim, Yonghwan Shin, Alan J. Situ, Tobias S. Ulmer , et al. · 2019

p53 is a sequence‐specific transcription factor, and proper regulation of p53 transcriptional activity is critical for orchestrating different tumor‐suppressive mechanisms. p32 is a multifunctional protein which interacts with a large numb…

DNMT and HDAC inhibitors modulate MMP-9-dependent H3 N-terminal tail proteolysis and osteoclastogenesis Open

Yonghwan Shin, Nikhil Baban Ghate, Byoung-San Moon, Kyungpyo Park, Wange Lu , et al. · 2019

Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3 Open

Jin‐Man Kim, Yonghwan Shin, Sunyoung Lee, Miyeong Kim, Vasu Punj , et al. · 2018

MacroH2A1.2 inhibits prostate cancer-induced osteoclastogenesis through cooperation with HP1α and H1.2 Open

Jin‐Man Kim, Yonghwan Shin, Sunyoung Lee, Mi Yeong Kim, Vasu Punj , et al. · 2018

H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis Open

Kyunghwan Kim, Yonghwan Shin, Jin‐Man Kim, Tobias S. Ulmer, Woojin An · 2018

Membrane Anchoring of α-Helical Proteins: Role of Tryptophan Open

Alan J. Situ, So-Min Kang, Benjamin B. Frey, Woojin An, Chungho Kim , et al. · 2018

The function of membrane proteins relies on a defined orientation of protein relative to lipid. In apparent correlation to protein anchoring, tryptophan residues are enriched in the lipid headgroup region. To characterize the thermodynamic…

Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing Open

Zhuo Zhang, Amanda E. Jones, Wei Wu, Jin‐Man Kim, Yue Kang , et al. · 2017

Significance Histone H2AK119 ubiquitination (H2Aub), as mediated by Polycomb repressive complex 1 (PRC1), is a prevalent modification which has been linked to gene silencing. We report that remodeling and spacing factor 1 (RSF1), a subunit…

Correction for Kim et al., “Vpr-Binding Protein Antagonizes p53-Mediated Transcription via Direct Interaction with H3 Tail” Open

Kyung Hwan Kim, Kyu Heo, Jongkyu Choi, Sarah Jackson, Hyun‐Jung Kim , et al. · 2017

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