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View article: Dietary Serine Restriction Impacts H3K27 and H3K4 Methyl Epigenomes to Impede Head and Neck Cancer Cell Plasticity and Tumor Growth
Dietary Serine Restriction Impacts H3K27 and H3K4 Methyl Epigenomes to Impede Head and Neck Cancer Cell Plasticity and Tumor Growth Open
Head and neck cancer with its major subsite, oral squamous cell carcinoma (OSCC), is a devastating malignancy with limited treatment options. Given that recent advances in nutritional interventions have been recognized as potential strateg…
View article: Age-Dependent Glioma Progression and Functional Decline in a Syngeneic Murine Model: Host Vulnerabilities and Opportunities for Targeted Intervention
Age-Dependent Glioma Progression and Functional Decline in a Syngeneic Murine Model: Host Vulnerabilities and Opportunities for Targeted Intervention Open
Background Glioblastoma (GBM) disproportionately affects older adults, who experience worse survival outcomes and reduced tolerance to aggressive therapies. Despite this, most preclinical GBM studies rely on young animal models, limiting i…
View article: Author Correction: Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells
Author Correction: Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells Open
View article: LSD1 inhibition corrects dysregulated MHC-I and dendritic cells activation through IFNγ-CXCL9-CXCR3 axis to promote antitumor immunity in HNSCC
LSD1 inhibition corrects dysregulated MHC-I and dendritic cells activation through IFNγ-CXCL9-CXCR3 axis to promote antitumor immunity in HNSCC Open
Poor infiltration of CD8+ T cells and dysregulated MHC-I confer resistance to anticancer clinical therapies. This study aimed to elucidate the mechanisms of lysine-specific demethylase 1 (LSD1, encoded by KDM1A gene) in antitumor immunity …
View article: A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer
A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer Open
Head and Neck Squamous Cell Carcinomas (HNSCC) are the seventh most prevalent form of cancer and are associated with human papilloma virus infection (HPV-positive) or with tobacco and alcohol use (HPV-negative). HPV-negative HNSCCs have a …
View article: Protocol for the differentiation of human alveolar epithelial type I cells from pluripotent stem cell-derived type II-like cells
Protocol for the differentiation of human alveolar epithelial type I cells from pluripotent stem cell-derived type II-like cells Open
View article: Reply to Huang <i>et al.</i>: Sowing Tailored Seeds: Gene-edited Basal Cells for Precision Regulation of Airway Phenotypes
Reply to Huang <i>et al.</i>: Sowing Tailored Seeds: Gene-edited Basal Cells for Precision Regulation of Airway Phenotypes Open
View article: LATS1/2 inactivation in the mammary epithelium drives the evolution of a tumor-associated niche
LATS1/2 inactivation in the mammary epithelium drives the evolution of a tumor-associated niche Open
Basal-like breast cancers exhibit distinct cellular heterogeneity that contributes to disease pathology. In this study we used a genetic mouse model of basal-like breast cancer driven by epithelial-specific inactivation of the Hippo pathwa…
View article: Epithelial miR-149-5p up-regulation is associated with immune evasion in progressive bronchial premalignant lesions
Epithelial miR-149-5p up-regulation is associated with immune evasion in progressive bronchial premalignant lesions Open
The molecular drivers bronchial premalignant lesion progression to invasive lung squamous cell carcinoma are not well defined. Prior work profiling longitudinally collected bronchial premalignant lesion biopsies by RNA sequencing defined a…
View article: Additional file 3 of Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer
Additional file 3 of Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer Open
Tabular ranked gene list file (viewable in Excel) pertaining to differential gene expression testing comparing siRNA-mediated knockdown of β-catenin versus scrambled siRNA control in HSC-3 cells used for GSEA. Fields indicate gene symbol a…
View article: Additional file 2 of Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer
Additional file 2 of Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer Open
Tabular spreadsheet file containing both table of differential gene expression results comparing ICG-001 treatment (n = 3) versus DMSO (vehicle) control (n = 3) in HSC-3 and CAL27 OSCC cell lines, as well as the ICG-001 treatment gene expr…
View article: Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming
Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming Open
Repeated antigen exposure leads to T-cell exhaustion, a transcriptionally and epigenetically distinct cellular state marked by loss of effector functions (e.g., cytotoxicity, cytokine production/release), up-regulation of inhibitory recept…
View article: Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia
Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia Open
Congenital diaphragmatic hernia (CDH) is characterized by incomplete closure of the diaphragm. Although the ensuing compression to the fetal lung causes lung hypoplasia, specific cellular phenotypes and developmental signaling defects in t…
View article: Influenza induces lung lymphangiogenesis independent of YAP/TAZ activity in lymphatic endothelial cells
Influenza induces lung lymphangiogenesis independent of YAP/TAZ activity in lymphatic endothelial cells Open
The lymphatic system consists of a vessel network lined by specialized lymphatic endothelial cells (LECs) that are responsible for tissue fluid homeostasis and immune cell trafficking. The mechanisms for organ-specific LEC responses to env…
View article: Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis
Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis Open
Progressive lung fibrosis is associated with poorly understood aging-related endothelial cell dysfunction. To gain insight into endothelial cell alterations in lung fibrosis we performed single cell RNA-sequencing of bleomycin-injured lung…
View article: B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells
B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells Open
Recovery from respiratory pneumococcal infections generates lung-localized protection against heterotypic bacteria, mediated by resident memory lymphocytes. Optimal protection in mice requires re-exposure to pneumococcus within days of ini…
View article: Generation of human alveolar epithelial type I cells from pluripotent stem cells
Generation of human alveolar epithelial type I cells from pluripotent stem cells Open
Alveolar epithelial type I cells (AT1s) line the gas exchange barrier of the distal lung and have been historically challenging to isolate or maintain in cell culture. Here, we engineer a human in vitro AT1 model system via directed differ…
View article: Abstract LB156: Targeting epigenetic activity of beta-catenin/CBP impedes oral cancer progression
Abstract LB156: Targeting epigenetic activity of beta-catenin/CBP impedes oral cancer progression Open
Head and neck cancer is a complex malignancy with its major anatomical subsite, cancer of the oral cavity, ranking among the most deadly and disfiguring cancers. Oral cancer presents primarily as HPV-negative oral squamous cell carcinoma (…
View article: Influenza Induces Lung Lymphangiogenesis Independent of YAP/TAZ Activity in Lymphatic Endothelial Cells
Influenza Induces Lung Lymphangiogenesis Independent of YAP/TAZ Activity in Lymphatic Endothelial Cells Open
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Contents Open
View article: Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells Open
View article: Contents
Contents Open
View article: Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer
Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer Open
View article: β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer Open
View article: Structure learning for gene regulatory networks
Structure learning for gene regulatory networks Open
Inference of biological network structures is often performed on high-dimensional data, yet is hindered by the limited sample size of high throughput “omics” data typically available. To overcome this challenge, often referred to as the “s…
View article: Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression
Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression Open
View article: Airway goblet cells resulting from conditional YAP/TAZ deletion promote distinct pulmonary inflammation
Airway goblet cells resulting from conditional YAP/TAZ deletion promote distinct pulmonary inflammation Open
The aberrant presence of goblet cells, which are epithelial cells of the conducting airways that have specialized roles in secreting mucus, is frequently associated with distinct innate and adaptive immune changes that together are hallmar…
View article: Supplementary Table 2 from A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma
Supplementary Table 2 from A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma Open
Supplementary Table 2. Antibodies used in the study.
View article: Supplementary Table 2 from A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma
Supplementary Table 2 from A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma Open
Supplementary Table 2. Antibodies used in the study.
View article: Supplementary Table from Inhibition of LSD1 Attenuates Oral Cancer Development and Promotes Therapeutic Efficacy of Immune Checkpoint Blockade and YAP/TAZ Inhibition
Supplementary Table from Inhibition of LSD1 Attenuates Oral Cancer Development and Promotes Therapeutic Efficacy of Immune Checkpoint Blockade and YAP/TAZ Inhibition Open
Supplementary Table from Inhibition of LSD1 Attenuates Oral Cancer Development and Promotes Therapeutic Efficacy of Immune Checkpoint Blockade and YAP/TAZ Inhibition