Xavier Barreau
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View article: FRED-EPI study: Safety and efficacy of FRED/FRED Jr aneurysm treatment in current clinical practice
FRED-EPI study: Safety and efficacy of FRED/FRED Jr aneurysm treatment in current clinical practice Open
FRED-EPI confirms good safety of aneurysm treatment with FRED/FRED Jr in current clinical practice with 4.4% 1-year morbimortality.
View article: Efficacy and safety of the PHIL embolic agent in the treatment of intracranial dural arteriovenous fistulas: results of the PHIL-dAVF study
Efficacy and safety of the PHIL embolic agent in the treatment of intracranial dural arteriovenous fistulas: results of the PHIL-dAVF study Open
Background and Purpose Embolization is the first-line treatment for dural arteriovenous fistulas (dAVF). The precipitating hydrophobic injectable liquid (PHIL) embolic agent is a non-adhesive copolymer with specific features and endovascul…
View article: An Individual-Participant Data Pooled Analysis of the ASTER, ASTER2, and VECTOR Mechanical Thrombectomy Trials
An Individual-Participant Data Pooled Analysis of the ASTER, ASTER2, and VECTOR Mechanical Thrombectomy Trials Open
View article: Predictors and Outcomes of Excellent Recanalization Versus Successful Recanalization After Thrombectomy in Proximal and Distal Medium Vessel Occlusion Strokes: A Multinational Study
Predictors and Outcomes of Excellent Recanalization Versus Successful Recanalization After Thrombectomy in Proximal and Distal Medium Vessel Occlusion Strokes: A Multinational Study Open
Background Acute ischemic stroke arising from medium vessel occlusions (MeVO) poses substantial challenges in treatment and management. This study aims to elucidate the outcomes and factors contributing to achieving excellent recanalizatio…
View article: Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study
Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study Open
Background and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness of intravenous thrombolysis (IVT) plus mechanical thrombectomy…
View article: Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke
Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke Open
Background: Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients with distal medium vessel occl…
View article: Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational study
Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational study Open
Background: Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium vessel occlusion (MeVO) remain less explored. This multicen…
View article: Endovascular Therapy vs. Best Medical Management in Distal Medium Middle Cerebral Artery Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study
Endovascular Therapy vs. Best Medical Management in Distal Medium Middle Cerebral Artery Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study Open
View article: First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study
First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study Open
Introduction: First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is a significant predictor of favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). Howeve…
View article: Safety and effectiveness of the LVIS and LVIS Jr devices for the treatment of intracranial aneurysms: Final results of the LEPI multicenter cohort study
Safety and effectiveness of the LVIS and LVIS Jr devices for the treatment of intracranial aneurysms: Final results of the LEPI multicenter cohort study Open
View article: O12/125 CHOICE, prospective multicenter study of endovascular treatment for cerebral AVMs treated with SQUID: clinical and angiographic results at 1 year
O12/125 CHOICE, prospective multicenter study of endovascular treatment for cerebral AVMs treated with SQUID: clinical and angiographic results at 1 year Open
Introduction Most brain arteriovenous malformations (bAVM) are or become symptomatic over time with a persistent risk of rupture. bAVM treatment remains challenging and standard practices continue to evolve. Aim of Study The purpose of thi…
View article: O02/16 COATING study (the first RCT evaluating a surface-modified flow diverter – p64-MW-HPC): current status
O02/16 COATING study (the first RCT evaluating a surface-modified flow diverter – p64-MW-HPC): current status Open
Introduction Flow diversion (FD) is increasingly used for the treatment of intracranial aneurysms due to its efficacy and performance. Initially limited to large and giant ICA aneurysms, the FD approach has progressively enlarged to distal…
View article: Aspiration Versus Stent‐Retriever as First‐Line Endovascular Therapy Technique for Primary Medium and Distal Intracranial Occlusions: A Propensity‐Score Matched Multicenter Analysis
Aspiration Versus Stent‐Retriever as First‐Line Endovascular Therapy Technique for Primary Medium and Distal Intracranial Occlusions: A Propensity‐Score Matched Multicenter Analysis Open
Background For acute proximal intracranial artery occlusions, contact aspiration may be more effective than stent‐retriever for first‐line reperfusion therapy. Due to the lack of data regarding medium vessel occlusion thrombectomy, we eval…
View article: O-056 Coating study (the first RCT evaluating a surface-modified flow diverter/P64-MW-HPC): current status
O-056 Coating study (the first RCT evaluating a surface-modified flow diverter/P64-MW-HPC): current status Open
Introduction/Purpose The most recent development in the field of devices dedicated to aneurysm treatment is surface-modified flow diverters (FD). Surface modification has different roles including facilitating navigation, increasing endoth…
View article: 24-Hour Carotid Stent Patency and Outcomes After Endovascular Therapy: A Multicenter Study
24-Hour Carotid Stent Patency and Outcomes After Endovascular Therapy: A Multicenter Study Open
Background: Management of extracranial internal carotid artery steno-occlusive lesion during endovascular therapy remains debated. Stent occlusion within 24 hours of endovascular therapy is a frequent event after acute carotid artery stent…
View article: Etiologic and prognostic value of external carotid artery thrombus detection during endovascular therapy for anterior circulation proximal occlusions
Etiologic and prognostic value of external carotid artery thrombus detection during endovascular therapy for anterior circulation proximal occlusions Open
Background and purpose An early understanding of stroke mechanism may improve treatment and outcome in patients presenting with large vessel occlusion stroke (LVOS) treated with mechanical thrombectomy (MT). We aimed to investigate whether…
View article: CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): 12-month angiographic results of a multicenter study
CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): 12-month angiographic results of a multicenter study Open
Background The CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS) study has shown that the endovascular treatment of ruptured bifurcation aneurysms with the Woven EndoBridge (WEB) is safe and effective and provides protection…
View article: Aneurysm treatment with the Woven EndoBridge (WEB) device in the combined population of two prospective, multicenter series: 5-year follow-up
Aneurysm treatment with the Woven EndoBridge (WEB) device in the combined population of two prospective, multicenter series: 5-year follow-up Open
Background Evaluating a new endovascular treatment for intracranial aneurysms must not only demonstrate short-term safety and efficacy, but also evaluate longer-term outcomes (eg, delayed complications, anatomical results, retreatment). Th…
View article: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial
Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial Open
View article: Coating (Coating to Optimize Aneurysm Treatment in the New Flow Diverter Generation) study. The first randomized controlled trial evaluating a coated flow diverter (p64 MW HPC): study design
Coating (Coating to Optimize Aneurysm Treatment in the New Flow Diverter Generation) study. The first randomized controlled trial evaluating a coated flow diverter (p64 MW HPC): study design Open
Background Due to its high efficacy, flow diversion is increasingly used in the management of unruptured and recanalized aneurysms. Because of the need for perioperative dual antiplatelet treatment (DAPT), flow diversion is not indicated f…
View article: Benefit of mechanical thrombectomy in acute ischemic stroke related to calcified cerebral embolus
Benefit of mechanical thrombectomy in acute ischemic stroke related to calcified cerebral embolus Open
View article: Aneurysm Treatment With Woven EndoBridge in the Cumulative Population of 3 Prospective, Multicenter Series: 2-Year Follow-Up
Aneurysm Treatment With Woven EndoBridge in the Cumulative Population of 3 Prospective, Multicenter Series: 2-Year Follow-Up Open
Pierot, Laurent MD, PhD; Moret, Jacques MD, PhD; Barreau, Xavier MD; Szikora, Istvan MD, PhD; Herbreteau, Denis MD, PhD; Turjman, Francis MD, PhD; Holtmannspötter, Markus MD; Januel, Anne-Christine MD; Costalat, Vincent MD, PhD; Fiehler, J…
View article: Diversion-p64: results from an international, prospective, multicenter, single-arm post-market study to assess the safety and effectiveness of the p64 flow modulation device
Diversion-p64: results from an international, prospective, multicenter, single-arm post-market study to assess the safety and effectiveness of the p64 flow modulation device Open
Background The use of flow diversion to treat intracranial aneurysms has increased in recent years. Objective To assess the safety and angiographic efficacy of the p64 flow modulation device. Methods Diversion-p64 is an international, pros…
View article: Relevance of Brain Regions' Eloquence Assessment in Patients With a Large Ischemic Core Treated With Mechanical Thrombectomy
Relevance of Brain Regions' Eloquence Assessment in Patients With a Large Ischemic Core Treated With Mechanical Thrombectomy Open
This study provides Class II evidence that, in patients with AIS and LIC, considering the functional eloquence of the infarct location improves prediction of disability status at 3 months.
View article: Functional Outcome, Recanalization, and Hemorrhage Rates After Large Vessel Occlusion Stroke Treated With Tenecteplase Before Thrombectomy
Functional Outcome, Recanalization, and Hemorrhage Rates After Large Vessel Occlusion Stroke Treated With Tenecteplase Before Thrombectomy Open
This study provides Class IV evidence that tenecteplase within 270 minutes of LVO-AIS increases the probability of functional independence.
View article: CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): results of 1-month and 1-year assessment of rebleeding protection and clinical safety in a multicenter study
CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): results of 1-month and 1-year assessment of rebleeding protection and clinical safety in a multicenter study Open
Background The primary goal of the CLARYS study is to assess the protection against rebleeding when treating ruptured bifurcation aneurysms with the Woven EndoBridge (WEB) device. Methods The CLARYS study is a prospective, multicenter stud…
View article: Multi-centric European post-market follow-up study of the Neuroform Atlas Stent System: primary results
Multi-centric European post-market follow-up study of the Neuroform Atlas Stent System: primary results Open
Background Few prospective series have described the safety and effectiveness of the Neuroform Atlas Stent System. We aimed to investigate the efficacy and safety of the device in patients treated for unruptured aneurysm. Methods ATLAS EU …
View article: Influence of operator experience on the technical and clinical results of Woven EndoBridge endovascular treatment for intracranial aneurysms
Influence of operator experience on the technical and clinical results of Woven EndoBridge endovascular treatment for intracranial aneurysms Open
View article: Association of Hypotension During Thrombectomy and Outcomes Differs With the Posterior Communicating Artery Patency
Association of Hypotension During Thrombectomy and Outcomes Differs With the Posterior Communicating Artery Patency Open
Background and Purpose: Hypotension during endovascular therapy for acute ischemic stroke is associated with worse functional outcomes (FO). Given its important role in intracranial hemodynamics, we investigated whether hypotension during …
View article: Safety and Outcome of Carotid Dissection Stenting During the Treatment of Tandem Occlusions
Safety and Outcome of Carotid Dissection Stenting During the Treatment of Tandem Occlusions Open
Background and Purpose: The efficacy of endovascular therapy in patients with acute ischemic stroke due to tandem occlusion is comparable to that for isolated intracranial occlusion in the anterior circulation. However, the optimal managem…