Xavier Berzosa
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View article: Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential
Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential Open
Current first-line antidepressants, such as selective serotonin reuptake inhibitors (SSRI), often present a delayed onset of action and fail to effectively treat a large proportion of patients, leaving a gap in the treatment of mood disord…
View article: A simple AI-driven process intensification protocol for active pharmaceutical ingredients synthesis
A simple AI-driven process intensification protocol for active pharmaceutical ingredients synthesis Open
View article: Unveiling the potential abuse liability of α-D2PV: A novel α-carbon phenyl-substituted synthetic cathinone
Unveiling the potential abuse liability of α-D2PV: A novel α-carbon phenyl-substituted synthetic cathinone Open
Synthetic cathinones are emerging psychoactive substances designed to mimic the effects of classical psychostimulants. Among them, α-D2PV, a novel pyrrolidine-containing cathinone characterized by a phenyl group on the α-carbon atom, has g…
View article: Evaluation of Polymethyl Methacrylate as a Provisional Material in a Fully Digital Workflow for Immediate-Load Complete-Arch Implant-Supported Prostheses over Three Months
Evaluation of Polymethyl Methacrylate as a Provisional Material in a Fully Digital Workflow for Immediate-Load Complete-Arch Implant-Supported Prostheses over Three Months Open
While complete-arch digital-implant-scanning protocols have been described, their clinical outcomes when using polymethyl methacrylate (PMMA) as a provisional material remain insufficiently substantiated. This clinical study aims to integr…
View article: A simple AI-Driven Process Intensification Protocol for Active Pharmaceutical Ingredients Synthesis
A simple AI-Driven Process Intensification Protocol for Active Pharmaceutical Ingredients Synthesis Open
View article: A Tribute to Ullmann’s Work: Expanding Copper Coil Reactor Applications toward the Hydroxylation of Aryl Bromides
A Tribute to Ullmann’s Work: Expanding Copper Coil Reactor Applications toward the Hydroxylation of Aryl Bromides Open
View article: Structure–Activity Relationship of Synthetic Cathinones: An Updated Review
Structure–Activity Relationship of Synthetic Cathinones: An Updated Review Open
The escalating prevalence of new psychoactive substances (NPSs) poses a significant public health challenge, evidenced by the vast chemical diversity, with over 500 substances reported annually to the United Nations Office on Drugs and Cri…
View article: Sex differences in the effects of <i>N</i>‐ethylpentylone in young CD1 mice: Insights on behaviour, thermoregulation and early gene expression
Sex differences in the effects of <i>N</i>‐ethylpentylone in young CD1 mice: Insights on behaviour, thermoregulation and early gene expression Open
Background and Purpose New psychoactive substances such as N ‐ethylpentylone (NEP) are continuously emerging in the illicit drug market, and knowledge of their effects and risks, which may vary between sexes, is scarce. Our present study c…
View article: Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties
Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties Open
Recent studies have sparked renewed interest in the therapeutic potential of psychedelics for treating depression and other mental health conditions. Simultaneously, the novel psychoactive substances (NPS) phenomenon, with a huge number of…
View article: 5-halo-substituted DMT derivatives. Hallucinogenic response and early gene expression in mice
5-halo-substituted DMT derivatives. Hallucinogenic response and early gene expression in mice Open
View article: Structure–Activity Relationship of <i>N</i>-Ethyl-Hexedrone Analogues: Role of the α-Carbon Side-Chain Length in the Mechanism of Action, Cytotoxicity, and Behavioral Effects in Mice
Structure–Activity Relationship of <i>N</i>-Ethyl-Hexedrone Analogues: Role of the α-Carbon Side-Chain Length in the Mechanism of Action, Cytotoxicity, and Behavioral Effects in Mice Open
Synthetic cathinones are β-keto amphetamine derivatives whose appearance has increased dramatically in the past decades. N-Ethyl substituted cathinones have been proven to potently inhibit dopamine (DA) uptake and induce psychostimu…
View article: 5-MeO-MET, 5-MeO-DET and 5-MeO-pyr-T strongly bind to 5-HT1A and 5-HT2A receptors and act as partial SERT substrates
5-MeO-MET, 5-MeO-DET and 5-MeO-pyr-T strongly bind to 5-HT1A and 5-HT2A receptors and act as partial SERT substrates Open
View article: The new psychoactive substance N-ethylpentylone induces locomotor sensitisation only in male mice
The new psychoactive substance N-ethylpentylone induces locomotor sensitisation only in male mice Open
View article: In vitro structure-activity relationship of 5-halo-DMT derivatives as novel psychedelics
In vitro structure-activity relationship of 5-halo-DMT derivatives as novel psychedelics Open
View article: Sex differences in the rewarding and reinforcing effects of N-ethylpentylone in mice
Sex differences in the rewarding and reinforcing effects of N-ethylpentylone in mice Open
View article: Role of the 5-HT2A and 5-HT1A receptors in the hallucinogenic effects and thermoregulation after acute administration of 5-methoxy-tryptamines in mice
Role of the 5-HT2A and 5-HT1A receptors in the hallucinogenic effects and thermoregulation after acute administration of 5-methoxy-tryptamines in mice Open
View article: Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice
Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice Open
N-ethyl-pentedrone (NEPD, 2-(ethylamino)-1-phenyl-1-pentanone) is one of the latest synthetic cathinone derivatives that emerged into the illicit drug market. This drug has psychostimulant properties and has been related with several intox…
View article: Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP (“flakka”) Derivatives
Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP (“flakka”) Derivatives Open
Changes in the molecular structure of synthetic cathinones has led to an increase in the number of novel emerging drugs in the illicit drug market at an unprecedented rate. Unfortunately, little is known about the neuropsychopharmacology o…
View article: Insights of new cytotoxic, psychoactive and addictive substances: N-ethyl-hexedrone and N-ethyl-buphedrone
Insights of new cytotoxic, psychoactive and addictive substances: N-ethyl-hexedrone and N-ethyl-buphedrone Open
View article: Behavioural and neurochemical effects after repeated administration of N‐ethylpentylone (ephylone) in mice
Behavioural and neurochemical effects after repeated administration of N‐ethylpentylone (ephylone) in mice Open
N‐ethyl‐pentylone (NEP), also known as ‘ephylone’ and N‐ethylnorpentylone, has been identified as one of the most recent novel psychostimulants to emerge into the illicit drug market and it has been associated with some intoxications and e…
View article: Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes
Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes Open
Several new synthetic cathinones, which mimic the effect of classical psychostimulants such as cocaine or MDMA, have appeared in the global illicit drug market in the last decades. In fact, the illicit drug market is continually evolving b…
View article: Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones Open
View article: Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones Open
Background and Purpose: The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related alternatives. The main goal of the present study was to cha…
View article: The Effect of Tapered Abutments on Marginal Bone Level: A Retrospective Cohort Study
The Effect of Tapered Abutments on Marginal Bone Level: A Retrospective Cohort Study Open
Background: Early peri-implant bone loss has been associated to long-term implant-prosthetic failure. Different technical, surgical, and prosthetic techniques have been introduced to enhance the clinical outcome of dental implants in terms…