Xavier Fernàndez‐Busquets
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View article: Repurposing HIV-Protease Inhibitor Precursors as Anticancer Agents: The Synthetic Molecule RDD-142 Delays Cell Cycle Progression and Induces Autophagy in HepG2 Cells with Enhanced Efficacy via Liposomal Formulation
Repurposing HIV-Protease Inhibitor Precursors as Anticancer Agents: The Synthetic Molecule RDD-142 Delays Cell Cycle Progression and Induces Autophagy in HepG2 Cells with Enhanced Efficacy via Liposomal Formulation Open
Hepatocellular carcinoma (HCC) remains a global health issue due to high incidence and mortality, complicated by limited therapeutic options and evolution of de novo resistance to conventional chemotherapy. In this study, we investigated t…
View article: Correction: The ESCRT-III machinery participates in the production of extracellular vesicles and protein export during Plasmodium falciparum infection
Correction: The ESCRT-III machinery participates in the production of extracellular vesicles and protein export during Plasmodium falciparum infection Open
[This corrects the article DOI: 10.1371/journal.ppat.1009455.].
View article: Multicomponent nasal spray delivered via penetration-enhancer containing vesicles (PEVs) for antioxidant and antibacterial protection
Multicomponent nasal spray delivered via penetration-enhancer containing vesicles (PEVs) for antioxidant and antibacterial protection Open
View article: In vitro and in vivo efficacy evaluation of new self-assembling curcumin loaded nanohyaluronan-glycerosomes on wound restoring in health and diabetic rats
In vitro and in vivo efficacy evaluation of new self-assembling curcumin loaded nanohyaluronan-glycerosomes on wound restoring in health and diabetic rats Open
In this study the wound healing efficacy of new self-assembling curcumin loaded nanohyaluronan-glycerosomes has been tested in healthy and diabetic rats. Curcumin was loaded in nanohyaluronan-liposomes and -glycerosomes, special vesicles o…
View article: Overexpression in Plasmodium falciparum of an intrinsically disordered protein segment of PfUT impairs the parasite’s proteostasis and reduces its growth rate
Overexpression in Plasmodium falciparum of an intrinsically disordered protein segment of PfUT impairs the parasite’s proteostasis and reduces its growth rate Open
The proteome of Plasmodium falciparum exhibits a marked propensity for aggregation. This characteristic results from the parasite’s AT-rich genome, which encodes numerous proteins with long asparagine-rich stretches and low structural comp…
View article: Extracellular Vesicle Abundance, but Not a High Aggregation-Prone Peptide Cargo, Is Associated with Dihydroartemisinin Exposure in Plasmodium falciparum
Extracellular Vesicle Abundance, but Not a High Aggregation-Prone Peptide Cargo, Is Associated with Dihydroartemisinin Exposure in Plasmodium falciparum Open
Our understanding of the molecular mechanisms undergirding artemisinin (ART) resistance in Plasmodium falciparum is currently based on two organizing principles: reduced hemoglobin trafficking into the digestive food vacuole, resulting in …
View article: YAT2150: Overcoming limitations of traditional amyloid dyes in aggregation studies
YAT2150: Overcoming limitations of traditional amyloid dyes in aggregation studies Open
Amyloid fibrils, which are aggregates of misfolded proteins characterized by β-sheet-rich structures, are implicated in several neurodegenerative and systemic pathologies, including Alzheimer's and Parkinson's diseases and type II diabetes…
View article: Preliminary evaluation of the in vitro and in vivo efficacy of a novel nanovesicle-doped nanoemulsion co-loading artemisinin and quercetin as a promising strategy to improve the oral malaria therapy
Preliminary evaluation of the in vitro and in vivo efficacy of a novel nanovesicle-doped nanoemulsion co-loading artemisinin and quercetin as a promising strategy to improve the oral malaria therapy Open
View article: A novel aminohydroxy sulfonamide formulated in PEGylated liposomes with potential antitumor activity
A novel aminohydroxy sulfonamide formulated in PEGylated liposomes with potential antitumor activity Open
View article: Resveratrol and grape pomace extract incorporated in modified phospholipid vesicles: A potential strategy to mitigate cigarette smoke-induced oxidative stress
Resveratrol and grape pomace extract incorporated in modified phospholipid vesicles: A potential strategy to mitigate cigarette smoke-induced oxidative stress Open
In this study, the extraction process of grape pomace from the Lebanese autochthonous cultivar Asswad Karech was enhanced through the selection of specific parameters, yielding an antioxidant extract (20 mg/mL) that was co-loaded with resv…
View article: Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women
Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women Open
View article: Sulfadoxine Drug Derivatization Through Multicomponent Reactions to Obtain New Antimalarial Drugs
Sulfadoxine Drug Derivatization Through Multicomponent Reactions to Obtain New Antimalarial Drugs Open
View article: Review 1: "A Fast-Acting Inhibitor of Blood-Stage P. falciparum with Mechanism Distinct from Artemisinin and Chloroquine"
Review 1: "A Fast-Acting Inhibitor of Blood-Stage P. falciparum with Mechanism Distinct from Artemisinin and Chloroquine" Open
View article: Reviews of "A Fast-Acting Inhibitor of Blood-Stage P. falciparum with Mechanism Distinct from Artemisinin and Chloroquine"
Reviews of "A Fast-Acting Inhibitor of Blood-Stage P. falciparum with Mechanism Distinct from Artemisinin and Chloroquine" Open
View article: A preliminary investigation on hydrogel disks imbibed with enriched transfersomes as promising tool to promote the cutaneous deposition of vaccine antigens
A preliminary investigation on hydrogel disks imbibed with enriched transfersomes as promising tool to promote the cutaneous deposition of vaccine antigens Open
View article: Beclomethasone loaded liposomes enriched with mucin: A suitable approach for the control of skin disorders
Beclomethasone loaded liposomes enriched with mucin: A suitable approach for the control of skin disorders Open
Inflammatory skin disorders are the fourth leading cause of chronic non-fatal conditions, which have a serious impact on the patient quality of life. Due to their treatment with conventional corticosteroids, which often result in poor ther…
View article: Pegylated-liposomes increase the efficacy of Idelalisib in lymphoma B-cells
Pegylated-liposomes increase the efficacy of Idelalisib in lymphoma B-cells Open
New drugs and technologies are continuously developed to improve the efficacy and minimize the critical side effects of cancer treatments. The present investigation focuses on the development of a liposomal formulation for Idelalisib, a sm…
View article: Proteomic analysis of the Aggregation Factor from the sponge<i>Clathria (Microciona) prolifera</i>suggests an ancient protein domain toolkit for allorecognition in animals
Proteomic analysis of the Aggregation Factor from the sponge<i>Clathria (Microciona) prolifera</i>suggests an ancient protein domain toolkit for allorecognition in animals Open
The discovery that sponges (Porifera) can fully regenerate from aggregates of dissociated cells launched them as one of the earliest experimental models for cell adhesion and allorecognition studies in animals. This process depends on an e…
View article: Disclosure of cinnamic acid/4,9-diaminoacridine conjugates as multi-stage antiplasmodial hits
Disclosure of cinnamic acid/4,9-diaminoacridine conjugates as multi-stage antiplasmodial hits Open
4,9-diaminoacridines with reported antiplasmodial activity were coupled to different trans-cinnamic acids, delivering a new series of conjugates inspired by the covalent bitherapy concept. The new compounds were more potent than primaquine…
View article: Effect of the aggregated protein dye YAT2150 on <i>Leishmania</i> parasite viability
Effect of the aggregated protein dye YAT2150 on <i>Leishmania</i> parasite viability Open
The problems associated with the drugs currently used to treat leishmaniasis, including resistance, toxicity, and the high cost of some formulations, call for the urgent identification of new therapeutic agents with novel modes of action. …
View article: Analysis of Complementarities Between Nanomedicine and Phytodrugs for The Treatment of Malarial Infection
Analysis of Complementarities Between Nanomedicine and Phytodrugs for The Treatment of Malarial Infection Open
The use of nanocarriers in medicine, so-called nanomedicine, is one of the most innovative strategies for targeting drugs at the action site and increasing their activity index and effectiveness. Phytomedicine is the oldest traditional met…
View article: Curcumin or quercetin loaded nutriosomes as oral adjuvants for malaria infections
Curcumin or quercetin loaded nutriosomes as oral adjuvants for malaria infections Open
View article: New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial leads
New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial leads Open
A novel family of 4-aminoacridine derivatives was obtained by linking this heteroaromatic core to different trans-cinnamic acids. The 4-(N-cinnamoylbutyl)aminoacridines obtained exhibited in vitro activity in the low- or sub-micromolar ran…
View article: Single-Chain Polymer Nanoparticles Targeting the Ookinete Stage of Malaria Parasites
Single-Chain Polymer Nanoparticles Targeting the Ookinete Stage of Malaria Parasites Open
Malaria is an infectious disease transmitted by mosquitos, whose control is hampered by drug resistance evolution in the causing agent, protist parasites of the genus Plasmodium, as well as by the resistance of the mosquito to insec…
View article: Selection of an Aptamer against the Enzyme 1-deoxy-D-xylulose-5-phosphate Reductoisomerase from Plasmodium falciparum
Selection of an Aptamer against the Enzyme 1-deoxy-D-xylulose-5-phosphate Reductoisomerase from Plasmodium falciparum Open
The methyl erythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential for malaria parasites and also for several human pathogenic bacteria, thus representing an interesting target for future antimalarials and antibiotics an…
View article: The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures
The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures Open
View article: Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide
Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide Open
Alzheimer’s disease and Type 2 diabetes are pathological processes associated to ageing. Moreover, there are evidences supporting a mechanistic link between Alzheimer’s disease and insulin resistance (one of the first hallmarks of Type 2 d…
View article: A green and cost-effective approach for the efficient conversion of grape byproducts into innovative delivery systems tailored to ensure intestinal protection and gut microbiota fortification
A green and cost-effective approach for the efficient conversion of grape byproducts into innovative delivery systems tailored to ensure intestinal protection and gut microbiota fortification Open
View article: Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway
Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway Open
The evolution of resistance by the malaria parasite to artemisinin, the key component of the combination therapy strategies that are at the core of current antimalarial treatments, calls for the urgent identification of new fast-acting ant…
View article: Liposomal Formulations to Improve Antioxidant Power of Myrtle Berry Extract for Potential Skin Application
Liposomal Formulations to Improve Antioxidant Power of Myrtle Berry Extract for Potential Skin Application Open
Many substances in plant extracts are known for their biological activities. These substances act in different ways, exerting overall protective effects against many diseases, especially skin disorders. However, plant extracts’ health bene…