Xavier Estivil
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View article: The serotonin receptor 3E variant is a risk factor for female IBS-D
The serotonin receptor 3E variant is a risk factor for female IBS-D Open
Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT 3 receptor family. 5-HT 3 Rs are encoded by HTR3 genes and control GI function, an…
View article: Genome-wide association study identifies new locus associated with OCD
Genome-wide association study identifies new locus associated with OCD Open
Obsessive-compulsive disorder (OCD) is a heritable disorder, but no definitive, replicated OCD susceptibility loci have yet been identified by any genome-wide association study (GWAS). Here, we report results from a GWAS in the largest OCD…
View article: The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome
The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome Open
Irritable bowel syndrome (IBS) is a gut‐brain disorder in which symptoms are shaped by serotonin acting centrally and peripherally. The serotonin transporter gene SLC6A4 has been implicated in IBS pathophysiology, but the underlying geneti…