Explanipedia

Low fluid shear stress stimulates the uptake of noxious endothelial extracellular vesicles via MCAM and PECAM‐1 cell adhesion molecules Open

Pierre‐Michaël Coly, Shruti Chatterjee, Fariza Mezine, Christelle El Jekmek, Cécile Devue , et al. · 2024

Atherosclerotic lesions mainly form in arterial areas exposed to low shear stress (LSS), where endothelial cells express a senescent and inflammatory phenotype. Conversely, areas exposed to high shear stress (HSS) are protected from plaque…

Splenic Marginal Zone B Lymphocytes Regulate Cardiac Remodeling After Acute Myocardial Infarction in Mice Open

Yanyi Sun, Cristina Pinto, Stéphane M. Camus, Vincent Duval, Paul Alayrac , et al. · 2022

Vésicules extracellulaires et maladies cardiovasculaires Open

Pierre‐Michaël Coly, Xavier Loyer · 2021

Les maladies cardiovasculaires constituent la principale cause de décès dans le monde. Il est donc urgent de développer de nouvelles approches pour le traitement et la détection de ces maladies. Les vésicules extracellulaires (VE) ont atti…

The power of imaging to understand extracellular vesicle biology in vivo Open

Frederik J. Verweij, Leonora Balaj, Chantal M. Boulanger, David R. F. Carter, Ewoud B. Compeer , et al. · 2021

Messages from the heart Open

Chantal M. Boulanger, Xavier Loyer, Pierre‐Michaël Coly, Nicolas Amabile · 2021

à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Restoring vascular endothelial autophagic flux reduces atherosclerotic lesions Open

Shruti Chatterjee, Marouane Kheloufi, Stephane Mazlan, Xavier Loyer, Timothy A. McKinsey , et al. · 2021

Atherosclerotic lesions preferentially develop in arterial areas exposed to low shear stress, where endothelial cells express a pro-inflammatory, apoptotic, and senescent phenotype. Endothelial cells exposed to atheroprone low shear stress…

Adipocyte‐derived extracellular vesicles in health and diseases: Nano‐packages with vast biological properties Open

Soazig Le Lay, Sophie Rome, Xavier Loyer, Laurence Nieto · 2021

As the largest human energy reservoir, adipocytes drive an intense dialog with other cells/organs throughout the body to regulate the size of adipose tissue and to communicate with other metabolic tissues and the brain to regulate energy s…

Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis Open

Franziska Kenneweg, Claudia Bang, Ke Xiao, Chantal M. Boulanger, Xavier Loyer , et al. · 2019

Differential micro-RNA expression in diabetic patients with abdominal aortic aneurysm Open

Fabien Lareyre, Marc Clément, Claudine Moratal, Xavier Loyer, Elixène Jean‐Baptiste , et al. · 2019

Neuronal NO synthase mediates plenylephrine induced cardiomyocyte hypertrophy through facilitation of NFAT-dependent transcriptional activity Open

Xavier Loyer, Caroline Dubroca, Maxime Branchereau, Graziellia Griffith, Luis Garcı́a , et al. · 2019

MiR-21 Deficiency Alters the Survival of Ly-6Clo Monocytes in ApoE -/- Mice and Reduces Early-Stage Atherosclerosis. Open

Anna Chipont, Bruno Esposito, Inès Challier, Mélanie Montabord, Alain Tedgui , et al. · 2019

Objective- To determine the role of miR-21 on the homeostasis of monocyte subsets and on atherosclerosis development in ApoE -/- mice. Approach and Results- In ApoE -/- mice, miR-21 expression was increased in circulating Ly-6Clo nonclassi…

Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction Open

Xavier Loyer, Ivana Zlatanova, Cécile Devue, Min Yin, Kiave-Yune HoWangYin , et al. · 2018

Rationale: A rapid and massive influx of inflammatory cells occurs into ischemic area after myocardial infarction (MI), resulting in local release of cytokines and growth factors. Yet, the mechanisms regulating their production are not ful…

Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis Open

Carole Hénique, Guillaume Bollée, Xavier Loyer, Florian Grahammer, Neeraj Dhaun , et al. · 2017

Endothelial autophagic flux hampers atherosclerotic lesion development Open

Marouane Kheloufi, Anne-Clémence Vion, Adel Hammoutène, Johanne Poisson, Juliette Lasselin , et al. · 2017

Blood flowing in arteries generates shear forces at the surface of the vascular endothelium that control its anti-atherogenic properties. However, due to the architecture of the vascular tree, these shear forces are heterogeneous and ather…

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow Open

Anne-Clémence Vion, Marouane Kheloufi, Adel Hammoutène, Johanne Poisson, Juliette Lasselin , et al. · 2017

Significance Atherosclerotic plaques tend to develop preferentially in areas of the vasculature exposed to low and disturbed shear stress (SS), but the mechanisms are not fully understood. In this study, we demonstrate that inefficient aut…

Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyopathy Open

Aude Carillion, Sarah Feldman, Na Na, Matthieu Biais, Wassila Carpentier , et al. · 2017

Atorvastatin restored the positive inotropic effect of the β-adrenoceptor stimulation in diabetic cardiomyopathy. This effect is mediated by multiple modifications in expression of proteins in the β-adrenergic signaling pathway, particular…

Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells Open

Padmapriya Ponnuswamy, Jérémie Joffre, Olivier Herbin, Bruno Esposito, Ludivine Laurans , et al. · 2017

The Dendritic Cell Receptor DNGR-1 Promotes the Development of Atherosclerosis in Mice Open

Yacine Haddad, Charlotte Lahoute, Marc Clément, Ludivine Laurans, Sarvenaz Metghalchi , et al. · 2017

Rationale: Necrotic core formation during the development of atherosclerosis is associated with a chronic inflammatory response and promotes accelerated plaque development and instability. However, the molecular links between necrosis and …

Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis Open

Jérémie Joffre, Stéphane Potteaux, Lynda Zeboudj, Xavier Loyer, Amir Boufenzer , et al. · 2016

Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression Open

Xavier Loyer, Valérie Paradis, Carole Hénique, Anne-Clémence Vion, Nathalie Colnot , et al. · 2015

MicroRNA-21 inhibition or suppression decreases liver injury, inflammation and fibrosis, by restoring PPARα expression. Antagomir-21 might be a future therapeutic strategy for NASH.

Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces Open

Congqing Wu, Ru‐Ting Huang, Cheng‐Hsiang Kuo, Sandeep Kumar, Chan Woo Kim , et al. · 2015

Rationale: PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery disease (CAD) by genome-wide asso…

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