Xavier Puéchal
YOU?
Author Swipe
View article: IRF4 haploinsufficiency in a multiplex family with Whipple’s disease
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease Open
Tropheryma whipplei is the bacterial agent responsible for Whipple’s disease (WD). However, WD occurs only very rarely in T. whipplei-infected individuals. We investigated the cause of disease in two relatives with WD. We studied a son and…
View article: Comparison of rituximab induction and maintenance regimens in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: PK/PD modelling of ANCA and gammaglobulin levels in real-world patients
Comparison of rituximab induction and maintenance regimens in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: PK/PD modelling of ANCA and gammaglobulin levels in real-world patients Open
This study received no funding.
View article: Management of Subglottic Stenosis With Tracheostomy in a Surgical Candidate Patient With Granulomatosis With Polyangiitis: A Case Report
Management of Subglottic Stenosis With Tracheostomy in a Surgical Candidate Patient With Granulomatosis With Polyangiitis: A Case Report Open
Granulomatosis with polyangiitis ( GPA ) is a rare disease of unknown aetiology with variable severity and a relapsing course. We report a case emphasizing the importance of the airway status and management of patients with a history of GP…
View article: Spondylodiscitis Caused by <i>Tropheryma whipplei</i>: Report of 2 Cases
Spondylodiscitis Caused by <i>Tropheryma whipplei</i>: Report of 2 Cases Open
View article: Trends in Patient Accrual Rates, Screening Failures, and Related Reasons in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Randomized Controlled Trials
Trends in Patient Accrual Rates, Screening Failures, and Related Reasons in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Randomized Controlled Trials Open
View article: Effect of Baseline Dialysis and Plasma Exchange on Renal Prognosis in Patients With Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis
Effect of Baseline Dialysis and Plasma Exchange on Renal Prognosis in Patients With Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis Open
View article: Isolated joint involvement in Whipple's disease: a cohort study
Isolated joint involvement in Whipple's disease: a cohort study Open
Whipple's disease can present with isolated articular forms. Joint involvement is usually inaugural and stereotypical, with little difference between the CIJI and SJI groups. The diagnosis should be considered in cases with the typical pat…
View article: Glucocorticoids versus glucocorticoids plus cyclophosphamide in eosinophilic granulomatosis with polyangiitis with poor-prognosis factors
Glucocorticoids versus glucocorticoids plus cyclophosphamide in eosinophilic granulomatosis with polyangiitis with poor-prognosis factors Open
View article: Explainability of a Deep Learning-Based Classification Model for Antineutrophil Cytoplasmic Autoantibody–Associated Glomerulonephritis
Explainability of a Deep Learning-Based Classification Model for Antineutrophil Cytoplasmic Autoantibody–Associated Glomerulonephritis Open
View article: French protocol for the diagnosis and management of giant cell arteritis
French protocol for the diagnosis and management of giant cell arteritis Open
Giant cell arteritis (GCA) is a large-vessel vasculitis that mainly affects women over fifty. GCA usually involves branches from the external carotid arteries, causing symptoms such as headaches, scalp tenderness, and jaw claudication. The…
View article: IRF4 haploinsufficiency in a multiplex family with Whipple's arthritis
IRF4 haploinsufficiency in a multiplex family with Whipple's arthritis Open
View article: French protocol for the diagnosis and management of systemic lupus erythematosus
French protocol for the diagnosis and management of systemic lupus erythematosus Open
View article: Data-driven subclassification of ANCA-associated vasculitis: model-based clustering of a federated international cohort
Data-driven subclassification of ANCA-associated vasculitis: model-based clustering of a federated international cohort Open
View article: Update on targeted treatments for ANCA-associated vasculitis
Update on targeted treatments for ANCA-associated vasculitis Open
Targeted therapy has revolutionized the management of ANCA-associated vasculitis (AAV) over the last fifteen years. Rituximab, an approved induction and maintenance agent for severe AAV, is no less effective than cyclophosphamide as induct…
View article: Large-vessel involvement in ANCA-associated vasculitis: A multicenter case-control study
Large-vessel involvement in ANCA-associated vasculitis: A multicenter case-control study Open
View article: Race, Ethnicity, Sex, Gender, Socioeconomic Status, and Representativeness of Race and Ethnicity in ANCA Vasculitis Randomized Trials
Race, Ethnicity, Sex, Gender, Socioeconomic Status, and Representativeness of Race and Ethnicity in ANCA Vasculitis Randomized Trials Open
Iudici, Michele; Rueda Sanchez, Juan Camilo; Girard-Guyonvarc'h, Charlotte; Puéchal, Xavier Author Information
View article: Diagnosis and treatment of Tropheryma whipplei infection in patients with inflammatory rheumatic disease: Data from the French Tw-IRD registry
Diagnosis and treatment of Tropheryma whipplei infection in patients with inflammatory rheumatic disease: Data from the French Tw-IRD registry Open
Tropheryma whipplei infection should be considered in inflammatory rheumatic disease patients with extra-articular manifestations, elevated C-reactive protein, and/or hypoalbuminemia before disease-modifying antirheumatic drugs initiation …
View article: Data quality and patient characteristics in European ANCA-associated vasculitis registries: data retrieval by federated querying
Data quality and patient characteristics in European ANCA-associated vasculitis registries: data retrieval by federated querying Open
In the largest reported AAV cohort-study, we federated patient registries using semantic web technologies and highlighted concerns about data quality. The comparison of patient characteristics, treatment and outcomes was hampered by hetero…
View article: Benralizumab for eosinophilic granulomatosis with polyangiitis
Benralizumab for eosinophilic granulomatosis with polyangiitis Open
View article: Intravenous versus subcutaneous tocilizumab in Takayasu arteritis: multicentre retrospective study
Intravenous versus subcutaneous tocilizumab in Takayasu arteritis: multicentre retrospective study Open
Objectives In this large multicentre study, we compared the effectiveness and safety of tocilizumab intravenous versus subcutaneous (SC) in 109 Takayasu arteritis (TAK) patients. Methods We conducted a retrospective multicentre study in re…
View article: #4466 EXPLAINABILITY OF A DEEP LEARNING BASED CLASSIFICATION MODEL FOR ANCA-ASSOCIATED GLOMERULONEPHRITIS
#4466 EXPLAINABILITY OF A DEEP LEARNING BASED CLASSIFICATION MODEL FOR ANCA-ASSOCIATED GLOMERULONEPHRITIS Open
Background and Aims The histopathological classification for ANCA-associated glomerulonephritis (ANCA-GN) is a well-established tool to reflect the variety of patterns and severity of lesions that can occur in renal biopsies of patients wi…
View article: French practical guidelines for the diagnosis and management of relapsing polychondritis
French practical guidelines for the diagnosis and management of relapsing polychondritis Open
View article: Score to assess the probability of relapse in granulomatosis with polyangiitis and microscopic polyangiitis
Score to assess the probability of relapse in granulomatosis with polyangiitis and microscopic polyangiitis Open
Objective To develop a score assessing the probability of relapse in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Methods Long-term follow-up data from GPA and MPA patients included in five consecutive randomi…
View article: Contribution of PCR to Differential Diagnosis between Patients with Whipple Disease and Tropheryma whipplei Carriers
Contribution of PCR to Differential Diagnosis between Patients with Whipple Disease and Tropheryma whipplei Carriers Open
Differentiation between Whipple disease (WD) patients and patients carrying Tropheryma whipplei but suffering from disease other than WD (“carriers”) remains complex. We aimed to evaluate T. whipplei PCR among patients with WD and carriers…
View article: Rituximab vs Cyclophosphamide Induction Therapy for Patients With Granulomatosis With Polyangiitis
Rituximab vs Cyclophosphamide Induction Therapy for Patients With Granulomatosis With Polyangiitis Open
Importance Results of randomized clinical trials have demonstrated rituximab’s noninferiority to cyclophosphamide as induction therapy for antineutrophil cytoplasm antibody (ANCA)–associated vasculitides (AAV), with neither treatment havin…
View article: Whipple’s disease: a rare cause of sacroiliitis
Whipple’s disease: a rare cause of sacroiliitis Open
View article: Differentiating tracheobronchial involvement in granulomatosis with polyangiitis and relapsing polychondritis on chest CT: a cohort study
Differentiating tracheobronchial involvement in granulomatosis with polyangiitis and relapsing polychondritis on chest CT: a cohort study Open
Background In patients with tracheobronchial involvement, the differential diagnosis between granulomatosis with polyangiitis (GPA) and relapsing polychondritis (RP) can be challenging. The aim of this study was to describe the characteris…
View article: Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT
Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT Open
Background Anti-neutrophil cytoplasm antibody-associated vasculitis is a multisystem, autoimmune disease that causes organ failure and death. Physical removal of pathogenic autoantibodies by plasma exchange is recommended for severe presen…
View article: Antineutrophil Cytoplasm Antibody–Associated Vasculitides Valvular Impairment: Multicenter Retrospective Study and Systematic Review of the Literature
Antineutrophil Cytoplasm Antibody–Associated Vasculitides Valvular Impairment: Multicenter Retrospective Study and Systematic Review of the Literature Open
Objective While myocardial impairment is a predictor of poor prognosis in antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV), little is known about valvular involvement. This study aims at describing the clinical presen…
View article: Evaluation of Rituximab for Induction and Maintenance Therapy in Patients 75 Years and Older With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Evaluation of Rituximab for Induction and Maintenance Therapy in Patients 75 Years and Older With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Open
In this cohort study, rituximab therapy was associated with achievement and maintenance of remission in most patients 75 years and older with ANCA-associated vasculitis. The incidence of serious infections and death was high when rituximab…