Xavier Roussel
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View article: A subset of pro-inflammatory CXCL10+ LILRB2+ macrophages derives from recipient monocytes and drives renal allograft rejection
A subset of pro-inflammatory CXCL10+ LILRB2+ macrophages derives from recipient monocytes and drives renal allograft rejection Open
In solid organ transplantation, monocytes and macrophages play a cross-cutting role in the rejection process, irrespective of the transplanted tissue and the type of rejection. Here, we integrated multiple single-cell assays (>150,000 cell…
View article: New leads to enhance tagraxofusp efficacy in pDC-AML
New leads to enhance tagraxofusp efficacy in pDC-AML Open
View article: Figure S3 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Figure S3 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Supplementary Figure S3: Effect of CD123 CAR-T on human Hematopoietic stem cell.
View article: Figure S1 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Figure S1 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Supplementary Figure S1: Design of five CD123 CAR-T constructs.
View article: Figure S1 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Figure S1 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Supplementary Figure S1: Design of five CD123 CAR-T constructs.
View article: Data from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Data from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Chimeric antigen receptor (CAR) T cells express an extracellular domain consisting of a single-chain fragment variable (scFv) targeting a surface tumor-associated antigen. scFv selection should involve safety profiling with evaluation of t…
View article: Data from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Data from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Chimeric antigen receptor (CAR) T cells express an extracellular domain consisting of a single-chain fragment variable (scFv) targeting a surface tumor-associated antigen. scFv selection should involve safety profiling with evaluation of t…
View article: Figure S4 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Figure S4 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Supplementary Figure S4 Effect of CD123 CAR-T on humanized mouse model, NSG-SGM3.
View article: Figure S2 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Figure S2 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Supplementary Figure S2: Characterization of CD123 CAR-T.
View article: Figure S3 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Figure S3 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Supplementary Figure S3: Effect of CD123 CAR-T on human Hematopoietic stem cell.
View article: Figure S4 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Figure S4 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Supplementary Figure S4 Effect of CD123 CAR-T on humanized mouse model, NSG-SGM3.
View article: Figure S2 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Figure S2 from Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Supplementary Figure S2: Characterization of CD123 CAR-T.
View article: Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells Open
Chimeric antigen receptor (CAR) T cells express an extracellular domain consisting of a single-chain fragment variable (scFv) targeting a surface tumor-associated antigen. scFv selection should involve safety profiling with evaluation of t…
View article: Risk factors for Nocardia infection among allogeneic hematopoietic cell transplant recipients: A case-control study of the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation
Risk factors for Nocardia infection among allogeneic hematopoietic cell transplant recipients: A case-control study of the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation Open
View article: Autologous and allogeneic stem‐cell transplantation for transformed Waldenström macroglobulinemia
Autologous and allogeneic stem‐cell transplantation for transformed Waldenström macroglobulinemia Open
Introduction: The prognosis of histological transformation (HT) in Waldenström macroglobulinemia (WM) is unfavourable despite the use of diffuse large B-cell lymphoma-directed chemo-immunotherapy. The aim of this study was to evaluate the …
View article: CAR-T cells targeting IL-1RAP produced in a closed semiautomatic system are ready for the first phase I clinical investigation in humans
CAR-T cells targeting IL-1RAP produced in a closed semiautomatic system are ready for the first phase I clinical investigation in humans Open
We demonstrated that our IL-1RAP CAR-T cell preclinical GMP-like production process meets standard regulatory requirements in terms of CAR-T cell number, subpopulation phenotype and cytotoxic functionality. Our CAR-T cell production proces…
View article: Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms
Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms Open
Plasmacytoid dendritic cells (pDC) are the main type I interferon producing cells in humans and are able to modulate innate and adaptive immune responses. Tumor infiltration by plasmacytoid dendritic cells is already well described and is …
View article: Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia
Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia Open
Background Acute myeloid leukemia (AML) remains a very difficult disease to cure due to the persistence of leukemic stem cells (LSCs), which are resistant to different lines of chemotherapy and are the basis of refractory/relapsed (R/R) di…
View article: WITHDRAWN: High-throughput preclinical screening of CD123 scFv to design 3rd generation of CAR T-cell in the treatment of BPDCN patient
WITHDRAWN: High-throughput preclinical screening of CD123 scFv to design 3rd generation of CAR T-cell in the treatment of BPDCN patient Open
Background: Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is an aggressive malignant hemopathy characterized by constant overexpression of the CD123 antigen on 100% of blasts identifying CD123 as an antigenic target for the developm…
View article: High frequency of central nervous system involvement in transformed Waldenström macroglobulinemia
High frequency of central nervous system involvement in transformed Waldenström macroglobulinemia Open
Histologicaltransformation (HT) to diffuse large B-cell lymphoma (DLBCL) is a rare event in Waldenström macroglobulinemia (WM) and is associated with a poor prognosis.1-4 It confers an inferior outcome compared with WM patients without HT.…
View article: <i>Nocardia</i> Infections in Hematopoietic Cell Transplant Recipients: A Multicenter International Retrospective Study of the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation
<i>Nocardia</i> Infections in Hematopoietic Cell Transplant Recipients: A Multicenter International Retrospective Study of the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation Open
Background Nocardiosis is rare after hematopoietic cell transplantation (HCT). Little is known regarding its presentation, management, and outcome in this population. Methods This retrospective international study reviewed nocardiosis epis…
View article: Impact of allogeneic stem cell transplantation comorbidity indexes after haplotransplant using post‐transplant cyclophosphamide
Impact of allogeneic stem cell transplantation comorbidity indexes after haplotransplant using post‐transplant cyclophosphamide Open
Background Three different scoring systems have been developed to assess pre‐transplant comorbidity in allogeneic hematopoietic stem cell transplantation (Allo‐HSCT): the Hematopoietic Cell Transplantation‐Specific Comorbidity Index, the C…
View article: Early Post-Transplantation Serum Ferritin Level Predicts Survival in Recipients of Haploidentical Stem Cell Transplantation Using Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis
Early Post-Transplantation Serum Ferritin Level Predicts Survival in Recipients of Haploidentical Stem Cell Transplantation Using Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis Open
The negative impact of high serum ferritin level (SFL) before and after allogeneic hematopoietic cell transplantation (allo-HSCT) on outcomes is well recognized. However, it is poorly documented in adults undergoing haploidentical HSCT (ha…
View article: Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients
Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients Open
View article: Overcoming target epitope masking resistance that can occur on low-antigen-expresser AML blasts after IL-1RAP chimeric antigen receptor T cell therapy using the inducible caspase 9 suicide gene safety switch
Overcoming target epitope masking resistance that can occur on low-antigen-expresser AML blasts after IL-1RAP chimeric antigen receptor T cell therapy using the inducible caspase 9 suicide gene safety switch Open
Although chimeric antigen receptor CAR) T cell immunotherapies are an undeniable and unequivocal success, knowledge obtained from the monitoring of the first clinical trials targeting the CD19 antigen in B malignancies, either refractory/r…
View article: First‐line treatment of double‐hit and triple‐hit lymphomas: Survival and tolerance data from a retrospective multicenter French study
First‐line treatment of double‐hit and triple‐hit lymphomas: Survival and tolerance data from a retrospective multicenter French study Open
Historically, double or triple hit lymphoma (DHL and THL) have poor outcomes with conventional chemotherapy, but there is currently no guideline. We report the French experience in managing DHL and THL in first line using collective data o…
View article: Acute Myeloid Leukemia: From Biology to Clinical Practices Through Development and Pre-Clinical Therapeutics
Acute Myeloid Leukemia: From Biology to Clinical Practices Through Development and Pre-Clinical Therapeutics Open
Recent studies have provided several insights into acute myeloid leukemia. Studies based on molecular biology have identified eight functional mutations involved in leukemogenesis, including driver and passenger mutations. Insight into Leu…
View article: Progressive multifocal leukoencephalopathy: MRI findings in HIV-infected patients are closer to rituximab- than natalizumab-associated PML
Progressive multifocal leukoencephalopathy: MRI findings in HIV-infected patients are closer to rituximab- than natalizumab-associated PML Open
View article: Pyogenic Granuloma During Ibrutinib Therapy for B-Cell Neoplasia
Pyogenic Granuloma During Ibrutinib Therapy for B-Cell Neoplasia Open
View article: Altered thymic CD4+ T-cell recovery after allogeneic hematopoietic stem cell transplantation is critical for nocardiosis
Altered thymic CD4+ T-cell recovery after allogeneic hematopoietic stem cell transplantation is critical for nocardiosis Open