Xavier Sabaté-Cadenas
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View article: The long non-coding RNA CRNDE stabilises SIRT1 protein and influences Hedgehog signalling in multiple myeloma
The long non-coding RNA CRNDE stabilises SIRT1 protein and influences Hedgehog signalling in multiple myeloma Open
Multiple myeloma (MM) is a malignancy of immunoglobulin-secreting plasma cells that represents 10% of all hematological cancers and remains essentially incurable, despite recent advances. Long non-coding RNAs (lncRNAs) are an important cla…
View article: Conserved RNA-binding protein interactions mediate syntologous lncRNA functions
Conserved RNA-binding protein interactions mediate syntologous lncRNA functions Open
Syntologous long noncoding RNAs (lncRNAs) are loci with conserved genomic positions that often show little or no sequence similarity. Despite diverging primary sequences, lncRNA syntologs from distant species can carry out similar function…
View article: The lincRNA JUNI regulates the stress-dependent induction of c-Jun, cellular migration and survival through the modulation of the DUSP14-JNK axis
The lincRNA JUNI regulates the stress-dependent induction of c-Jun, cellular migration and survival through the modulation of the DUSP14-JNK axis Open
View article: The stress-induced lincRNA<i>JUNI</i>is a critical factor for cancer cell survival whose interactome is a prognostic signature in clear cell renal cell carcinoma
The stress-induced lincRNA<i>JUNI</i>is a critical factor for cancer cell survival whose interactome is a prognostic signature in clear cell renal cell carcinoma Open
Cancer cells rely on adaptive mechanisms to survive the multiple stressors they encounter, including replication stress, toxic metabolic products and exposure to genotoxic drugs. Understanding the factors involved in these stress responses…
View article: Cancer cells survival is dependent on the lincRNA JUNI
Cancer cells survival is dependent on the lincRNA JUNI Open
Summary Identification of key factors for cellular survival is a basis for therapy. We identified JUNI (linc01135) as a stress-regulated lncRNA, essential for cell survival and implicated in cancer. Besides regulating c-Jun expression we d…
View article: In-Cell Discovery of RNA–Protein Interactions
In-Cell Discovery of RNA–Protein Interactions Open