Xavier Verhelst
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View article: Complex Management of High-Flow Gastrointestinal Arteriovenous Malformation With Chronic Portomesenteric Thrombosis in PTEN Hamartoma Tumor Syndrome
Complex Management of High-Flow Gastrointestinal Arteriovenous Malformation With Chronic Portomesenteric Thrombosis in PTEN Hamartoma Tumor Syndrome Open
We present a rare case of life-threatening gastrointestinal bleeding from a high-flow terminal ileal arteriovenous malformation (AVM) in a 19-year-old woman, complicated by chronic portomesenteric thrombosis. Management included sequential…
View article: The double-edged sword of metabolic and bariatric surgery: extending the biliary limb can trigger bacterial translocation, sepsis, and liver inflammation – an experimental study
The double-edged sword of metabolic and bariatric surgery: extending the biliary limb can trigger bacterial translocation, sepsis, and liver inflammation – an experimental study Open
Background: Metabolic and bariatric surgery (MBS) procedures with extended biliary limb length are gaining popularity to expedite weight loss but can induce liver failure. We aimed to investigate the underlying pathophysiology for this pot…
View article: Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults
Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults Open
Background. Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the ser…
View article: Mitochondrial dysfunction characterises the multigenerational effects of maternal obesity on MASLD
Mitochondrial dysfunction characterises the multigenerational effects of maternal obesity on MASLD Open
The underlying mechanisms of maternal obesity contributing to metabolic dysfunction-associated steatotic liver disease (MASLD) severity in the offspring are not completely understood. Our study characterises the impact of multigenerational…
View article: Early plasmapheresis in type 2 benign recurrent intrahepatic cholestasis: A case report and review of literature
Early plasmapheresis in type 2 benign recurrent intrahepatic cholestasis: A case report and review of literature Open
BACKGROUND Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive liver disease, causing episodic cholestasis with intense pruritus. This case report highlights the effectiveness of early plasmapheresis as a therape…
View article: The pan-PPAR agonist lanifibranor reduces portal pressure independent of fibrosis reduction through the splanchnic vasculature
The pan-PPAR agonist lanifibranor reduces portal pressure independent of fibrosis reduction through the splanchnic vasculature Open
Portal hypertension (PH) can cause severe complications in patients with advanced chronic liver disease (aCLD). The pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist lanifibranor reduces portal pressure in preclinical model…
View article: Prior metabolic and bariatric surgery is an independent determinant of severity of decompensation in alcohol‐associated liver disease
Prior metabolic and bariatric surgery is an independent determinant of severity of decompensation in alcohol‐associated liver disease Open
Background Patients with a history of metabolic and bariatric surgery (MBS) are susceptible to developing alcohol use disorder, potentially resulting in end‐stage liver disease, with a paucity of data on the evolution of cirrhosis. Aims Ou…
View article: Unravelling the coagulation paradox in liver cirrhosis: challenges and insights
Unravelling the coagulation paradox in liver cirrhosis: challenges and insights Open
Patients with liver disease experience complex haemostatic changes leading to a state of 'rebalanced haemostasis' that may shift towards bleeding or thrombosis due to complications like kidney dysfunction, bacterial infection, or acute-on-…
View article: Glycomics as prognostic biomarkers of hepatocellular carcinoma: A systematic review
Glycomics as prognostic biomarkers of hepatocellular carcinoma: A systematic review Open
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, which is associated with a low 5-year survival rate. The importance of effective disease monitoring and prognostic evaluation is undeniable. For the present study, a sy…
View article: The association of ultra‐processed food intake with adolescent <scp>metabolic dysfunction‐associated steatotic liver disease</scp> in the NHANES
The association of ultra‐processed food intake with adolescent <span>metabolic dysfunction‐associated steatotic liver disease</span> in the NHANES Open
Summary Introduction Metabolic dysfunction‐associated steatotic liver disease (MASLD) has become a major public health concern. A thorough analysis of the link between ultra‐processed food (UPF) intake and MASLD in the adolescent populatio…
View article: Editorial: Recompensation in <scp>PBC</scp> is good. But is it good enough?
Editorial: Recompensation in <span>PBC</span> is good. But is it good enough? Open
LINKED CONTENT This article is linked to Hofer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17908 and https://doi.org/10.1111/apt.17966
View article: Validation of a glycomics-based test associated with risk of HCC development in cirrhosis
Validation of a glycomics-based test associated with risk of HCC development in cirrhosis Open
Background Cirrhosis is the main risk factor for the development of Hepatocellular carcinoma (HCC). Six-monthly screening with ultrasound is advocated for the surveillance of cirrhotic patients. We recently showed that a glycomics-based te…
View article: Determinants of clinical response to empirical antibiotic treatment in patients with cirrhosis and bacterial and fungal infections—Results from the ICA “Global Study” (EABCIR-Global Study)
Determinants of clinical response to empirical antibiotic treatment in patients with cirrhosis and bacterial and fungal infections—Results from the ICA “Global Study” (EABCIR-Global Study) Open
Background: The administration of an appropriate empirical antibiotic treatment is essential in cirrhosis and severe bacterial infections. We aimed to investigate the predictors of clinical response of empirical antibiotic treatment in a p…
View article: Serological response and breakthrough infection after COVID-19 vaccination in patients with cirrhosis and post-liver transplant
Serological response and breakthrough infection after COVID-19 vaccination in patients with cirrhosis and post-liver transplant Open
Background: Vaccine hesitancy and lack of access remain major issues in disseminating COVID-19 vaccination to liver patients globally. Factors predicting poor response to vaccination and risk of breakthrough infection are important data to…
View article: Patients hospitalized with alcohol‐related liver disease and prior bariatric surgery are more prone to develop acute‐on‐chronic liver failure
Patients hospitalized with alcohol‐related liver disease and prior bariatric surgery are more prone to develop acute‐on‐chronic liver failure Open
Background & Aims Patients with a history of bariatric surgery (BS) are susceptible to developing alcohol use disorder. We and others have previously shown that these patients can develop severe alcohol‐related liver disease (ARLD). Our ai…
View article: A remarkable presentation of a massive Budd-Chiari syndrome
A remarkable presentation of a massive Budd-Chiari syndrome Open
A 59-year-old female presented to the emergency department with malaise, significant weight loss, abdominal discomfort, dyspnoea and severely swollen peripheral extremities. She had a past medical history of sickle cell anaemia, a latent t…
View article: An unusual cause of portal hypertension
An unusual cause of portal hypertension Open
A 66-year-old male with a medical history of coronary artery disease presented with nonspecific symptoms of anorexia, lethargy and an increase in abdominal girth. He was diagnosed 3 months ago with chronic liver disease of undetermined aet…