Xavier Yerna
YOU?
Author Swipe
View article: Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X syndrome mice
Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X syndrome mice Open
View article: Aberrant generation of dentate gyrus granule cells is associated with epileptic susceptibility in p53 conditional knockout mice
Aberrant generation of dentate gyrus granule cells is associated with epileptic susceptibility in p53 conditional knockout mice Open
Neuronal apoptosis is a mechanism used to clear the cells of oxidative stress or DNA damage and refine the final number of neurons for a functional neuronal circuit. The tumor suppressor protein p53 is a key regulator of the cell cycle and…
View article: Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory
Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory Open
The postsynaptic inhibition through GABA A receptors (GABA A R) relies on two mechanisms, a shunting effect due to an increase in the postsynaptic membrane conductance and, in mature neurons, a hyperpolarization effect due to an entry of c…
View article: A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons
A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons Open
Trigeminal neuralgia (TN) is a unique pain disorder characterized by intense paroxysmal facial pain within areas innervated by the trigeminal nerve. Although most cases of TN are sporadic, familial clusters of TN suggest that genetic facto…
View article: Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission
Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission Open
View article: Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells
Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells Open
Fluid pressure in the proximal tubule activates TRPV4 to promote endocytosis and retention of albumin.
View article: Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction
Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction Open
Group I metabotropic glutamate receptors (mGluR) are involved in various forms of synaptic plasticity that are believed to underlie declarative memory. We previously showed that mGluR5 specifically activates channels containing TRPC1, an i…
View article: Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells
Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells Open
The proximal tubule (PT) mediates the endocytosis of essential substances filtered through the glomerulus, including albumin and a large variety of low molecular weight proteins that would otherwise be lost in urine. Variations in the amou…
View article: Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory
Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory Open
Group I metabotropic glutamate receptors, in particular mGluR5, have been implicated in various forms of synaptic plasticity that are believed to underlie declarative memory. We observed that mGluR5 specifically activated a channel contain…
View article: Effects of genetic deletion of soluble 5′-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles
Effects of genetic deletion of soluble 5′-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles Open
AMP-activated protein kinase (AMPK) plays a key role in energy homeostasis and is activated in response to contraction-induced ATP depletion in skeletal muscle via a rise in intracellular AMP/ADP concentrations. AMP can be deaminated by AM…
View article: TRPV4 participates in pressure‐induced inhibition of renin secretion by juxtaglomerular cells
TRPV4 participates in pressure‐induced inhibition of renin secretion by juxtaglomerular cells Open
Key points Increase in blood pressure in the renal afferent arteriole is known to induce an increase in cytosolic calcium concentration ([Ca 2+ ] i ) of juxtaglomerular (JG) cells and to result in a decreased secretion of renin. Mechanical…
View article: Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells
Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells Open