Xiao Han
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View article: Surface-Enhanced Raman Spectroscopy for Detection of Bacterial Biological Warfare Agents: A Review
Surface-Enhanced Raman Spectroscopy for Detection of Bacterial Biological Warfare Agents: A Review Open
View article: Gut microbiota-derived arginine metabolism mitigates intestinal ischemia-reperfusion injury
Gut microbiota-derived arginine metabolism mitigates intestinal ischemia-reperfusion injury Open
View article: Psychometric validation of the Chinese version of the PROMIS-29 profile in community-dwelling older adults with multimorbidities
Psychometric validation of the Chinese version of the PROMIS-29 profile in community-dwelling older adults with multimorbidities Open
Background The Patient-Reported Outcomes Measurement Information System 29-item (PROMIS-29) profile is commonly used to measure patients’ self-reported health status. This study examined the psychometric properties of the Chinese version o…
View article: Differentiating post-stroke patients from healthy individuals via vision-based skeleton-optical fusion
Differentiating post-stroke patients from healthy individuals via vision-based skeleton-optical fusion Open
View article: HPV VLPs-based RNA-delivery system for synergistic BCL-2 silencing and mitochondrial apoptosis in NSCLC cells
HPV VLPs-based RNA-delivery system for synergistic BCL-2 silencing and mitochondrial apoptosis in NSCLC cells Open
Non-small cell lung cancer (NSCLC) resists apoptosis and lacks targeted therapies. We developed a tetra-functional assembly, siRNA_D-pep@VLP-SP5-2, integrating BCL-2 siRNA and a cationic mitochondrial destabilization D-peptide within the S…
View article: Structurally Flexible (Thiazol-2-ylidene)Pd(Allyl)Cl Complexes for Suzuki–Miyaura Cross-Coupling of Aryl Halides and Amides
Structurally Flexible (Thiazol-2-ylidene)Pd(Allyl)Cl Complexes for Suzuki–Miyaura Cross-Coupling of Aryl Halides and Amides Open
This study introduces a new class of (NHC)Pd(allyl)Cl complexes featuring thiazol-2-ylidene ligands, which exhibit enhanced steric and electronic properties compared to those of traditional imidazol-2-ylidenes. These air-stable Pd(II)-NHC …
View article: Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury
Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury Open
Introduction Naringenin (Nar), a common flavanone abundant in citrus fruits and tomatoes, is common in diets. Although Nar can alleviate intestinal ischemia/reperfusion injury (IRI), the exact anti-inflammatory mechanisms are unclear and r…
View article: Anesthetic efficacy with remimazolam compared with propofol: a systematic review and meta-analysis of randomized controlled trials
Anesthetic efficacy with remimazolam compared with propofol: a systematic review and meta-analysis of randomized controlled trials Open
Background: Remimazolam is a novel, ultra-short-acting benzodiazepine. This systematic review and meta-analysis compared the anesthetic efficacy and safety of remimazolam versus propofol for procedural sedation and general anesthesia. Meth…
View article: SERS nanotags for ultrasensitive and dual biomarker detection of breast cancer
SERS nanotags for ultrasensitive and dual biomarker detection of breast cancer Open
Sensitive and simultaneous detection of breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) is of significance for the early diagnosis of breast cancers, but it still challenges conventional methods. Herein, we developed a novel surface-en…
View article: Effects of concept mapping on L2 learning: a meta-analysis of studies from 2006 to 2024
Effects of concept mapping on L2 learning: a meta-analysis of studies from 2006 to 2024 Open
In recent years, there has been an increasing number of studies on the use of mind maps and learners' academic performance in second language (L2) learning. However, the results are generally divergent and have not been reasonably explaine…
View article: Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges
Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges Open
The year 2024 marks the 50th anniversary of the discovery of surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity …
View article: Topological States in One-Dimensional Phononic Crystals
Topological States in One-Dimensional Phononic Crystals Open
View article: Cationic and homoleptic copper( <scp>i</scp> )–thiazol-2-ylidenes: highly reactive thiazole N-heterocyclic carbenes as σ-Lewis acid catalysts
Cationic and homoleptic copper( <span>i</span> )–thiazol-2-ylidenes: highly reactive thiazole N-heterocyclic carbenes as σ-Lewis acid catalysts Open
Air- and moisture-stable cationic homoleptic Cu( i )–thiazol-2-ylidene complexes are developed as highly efficient σ-Lewis acid catalysts.
View article: Tuning Intermediate Adsorption and Hydrogenation Pathways on Oxide-Derived Copper via Boron-Induced Electronic Modulation for Efficient Electrocatalytic Nitrate-to-Ammonia Conversion
Tuning Intermediate Adsorption and Hydrogenation Pathways on Oxide-Derived Copper via Boron-Induced Electronic Modulation for Efficient Electrocatalytic Nitrate-to-Ammonia Conversion Open
View article: Classification and Recognition of Noncanonical DNA Structures by Surface-Enhanced Raman Spectroscopy and Principal Component Analysis
Classification and Recognition of Noncanonical DNA Structures by Surface-Enhanced Raman Spectroscopy and Principal Component Analysis Open
View article: Droplet impact dynamics on the surface of super-hydrophobic BNNTs stainless steel mesh
Droplet impact dynamics on the surface of super-hydrophobic BNNTs stainless steel mesh Open
The 'gas‒liquid‒solid' mechanism annealing method was used to create a superhydrophobic boron nitride nanotube (BNNT) stainless steel mesh in a tube furnace at 1250 °C in an NH3 environment. Fe powder was used as a catalyst, and…
View article: Achieving Color‐Tunable Solid‐State Fluorescence by Adjusting the Molecular‐State Chromophores on Carbonized Polymer Dots
Achieving Color‐Tunable Solid‐State Fluorescence by Adjusting the Molecular‐State Chromophores on Carbonized Polymer Dots Open
Carbon dots (CDs) have attracted great interest in recent years due to their excellent fluorescent properties, convenient synthetic methods, and wide availability of source materials. However, although most CDs exhibit excellent luminescen…
View article: The Formation Mechanism of Carbonized Polymer Dots: Crosslinking‐Induced Nucleation and Carbonization
The Formation Mechanism of Carbonized Polymer Dots: Crosslinking‐Induced Nucleation and Carbonization Open
Carbon dots (CDs), as a kind of zero‐dimensional nanomaterials, have been widely synthesized by bottom‐up methods from various precursors. However, the formation mechanism is still unclear and controversial, which also brings difficulty to…
View article: Evaluation of aroma characteristics in Vitis amurensis grapes across different regions by using HS-SPME-GC/MS
Evaluation of aroma characteristics in Vitis amurensis grapes across different regions by using HS-SPME-GC/MS Open
Background: Aroma compounds are important secondary metabolite in grapes and play important roles in the flavor and quality of grape berries and their wines. Vitis amurensis grape belongs to the East Asian Vitis spp., with excellent cold a…
View article: A Bayesian network for estimating hypertension risk due to occupational aluminum exposure
A Bayesian network for estimating hypertension risk due to occupational aluminum exposure Open
Background The correlation between metals and hypertension, such as sodium, zinc, potassium, and magnesium, has been confirmed, while the relationship between aluminum and hypertension is not very clear. This study aimed to evaluate the co…
View article: Association between health insurance cost-sharing and choice of hospital tier for cardiovascular diseases in China: a prospective cohort study
Association between health insurance cost-sharing and choice of hospital tier for cardiovascular diseases in China: a prospective cohort study Open
View article: Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population
Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population Open
National Natural Science Foundation of China, Kadoorie Charitable Foundation Hong Kong, UK Wellcome Trust, National Key R&D Program of China, Chinese Ministry of Science and Technology.
View article: <i>PCSK9</i> genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations
<i>PCSK9</i> genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations Open
Aims Lowering low-density lipoprotein cholesterol (LDL-C) through PCSK9 inhibition represents a new therapeutic approach to preventing and treating cardiovascular disease (CVD). Phenome-wide analyses of PCSK9 genetic variants in large biob…
View article: Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease
Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease Open
Integrated analyses of proteomic and genetic data in Chinese and European adults provided causal support for FURIN and multiple other proteins as potential novel drug targets for treatment of IHD.
View article: Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury
Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury Open
Ferroptosis is a novel way of regulating cell death, which occurs in a process that is closely linked to intracellular iron metabolism, lipid metabolism, amino acid metabolism, and multiple signaling pathways. The latest research shows tha…
View article: <i>MTHFR</i> and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults
<i>MTHFR</i> and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults Open
Background The relevance of folic acid for stroke prevention in low-folate populations such as in China is uncertain. Genetic studies of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, which increases plasma homocystein…
View article: Sleep duration and risk of stroke and coronary heart disease: a 9-year community-based prospective study of 0.5 million Chinese adults
Sleep duration and risk of stroke and coronary heart disease: a 9-year community-based prospective study of 0.5 million Chinese adults Open
View article: Unveiling the Emergence and Genetic Diversity of OXA-48-like Carbapenemase Variants in Shewanella xiamenensis
Unveiling the Emergence and Genetic Diversity of OXA-48-like Carbapenemase Variants in Shewanella xiamenensis Open
An increase in the carbapenem-hydrolyzing capacity of class D β-lactamase has been observed in strains of multiple species, posing a significant challenge to the control of antibiotic resistance. In this study, we aimed to investigate the …
View article: Expression of RNA-m6A-related genes correlates with the HIV latent reservoir level and the CD4+ and CD8+T cell profiles of patients with AIDS
Expression of RNA-m6A-related genes correlates with the HIV latent reservoir level and the CD4+ and CD8+T cell profiles of patients with AIDS Open
View article: Surface-Enhanced Raman Spectroscopic Analysis of Flavoenzyme Cofactors: Guidance for Flavin-Related Bio- and Chemo- Sensors
Surface-Enhanced Raman Spectroscopic Analysis of Flavoenzyme Cofactors: Guidance for Flavin-Related Bio- and Chemo- Sensors Open
Flavin mononucleotides (FMNs) and flavin adenine nucleotide (FAD) play vital roles in the electron-transfer processes in diverse enzymatic reactions. Owing to the isoalloxazine chromophore, flavins are easily detectable by surface-enhanced…