Explanipedia

Table S4 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Rebecca Dirks, Poornima Bhat‐Nakshatri, Henry Mang, Sarah Swiezy, Jacob Duane Olson , et al. · 2025

Table S4: Breast cancers with TONSL amplification selectively overexpress genes associated with E2F targets, G2/M checkpoint, mitotic spindle and mTORC1 pathways.

Table S5 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Aditi S. Khatpe, Rebecca Dirks, Poornima Bhat‐Nakshatri, Henry Mang, Katie Batic , et al. · 2025

Table S5: Description of the patients and characteristics of their tumors (n=597)

Table S3 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Aditi S. Khatpe, Poornima Bhat‐Nakshatri, Henry Mang, Katie Batic, Jacob Duane Olson , et al. · 2025

Table S3: DepMap analysis reveals gene essentiality for survival of select genes upregulated in immortalized cells compared to primary cells.

Table S1 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Aditi S. Khatpe, Rebecca Dirks, Henry Mang, Sarah Swiezy, Jacob Duane Olson , et al. · 2025

Table S1: Gene expression differences between primary and hTERT-immortalized breast epithelial cell lines.

Table S11 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Poornima Bhat‐Nakshatri, Jacob Duane Olson, Hiromi Tanaka, Sheng Liu, Jun Wan , et al. · 2025

Table S11: The effects of TONSL overexpression on proliferation signature of breast tumors.

Table S6 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Aditi S. Khatpe, Rebecca Dirks, Poornima Bhat‐Nakshatri, Henry Mang, Katie Batic , et al. · 2025

Table S6: Bivariate analysis of TONSL H-score with other tumor markers

Table S13 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Aditi S. Khatpe, Rebecca Dirks, Poornima Bhat‐Nakshatri, Katie Batic, Sarah Swiezy , et al. · 2025

Table S13: Enrichment of binding sites for NF-kB and p53 in chromatin regions that become accessible or closed, respectively, upon TONSL overexpression. Genes names and chromatin positions are indicated.

Table S2 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Rebecca Dirks, Poornima Bhat‐Nakshatri, Henry Mang, Katie Batic, Sarah Swiezy , et al. · 2025

Table S2: Gene expression differences between mature luminal and luminal progenitor cells of the breast. Data are from 15 samples, five each from women of European, African and Latina ancestry.

Table S9 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Henry Mang, Katie Batic, Sarah Swiezy, Jacob Duane Olson, Xi Rao , et al. · 2025

Table S9: Results of ATAC-seq of primary and TONSL-immortalized cells.

Table S8 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Sarah Swiezy, Jacob Duane Olson, Xi Rao, Yue Wang, Hiromi Tanaka , et al. · 2025

Table S8: Multivariable analysis for overall (N=469) and progression-free (N=453) survival NOT including HER2. Overall and Progression-Free survival data of patients with ER+ breast cancer and treated with endocrine therapy are also shown.

Table S14 from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer Open

Rebecca Dirks, Poornima Bhat‐Nakshatri, Katie Batic, Jacob Duane Olson, Xi Rao , et al. · 2025

Table S14: Genes differentially expressed in TMD-436pLKO and TMD-436shTONSL cells. Fold changes in gene expression are indicated.

Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder Open

Nick Green, Hongyu Gao, Xiaona Chu, Qiuyue Yuan, Patrick C. McGuire , et al. · 2025

Alcohol use disorder (AUD) induces complex transcriptional and regulatory changes across multiple brain regions including the caudate nucleus, which remains understudied. Using paired single-nucleus RNA-seq and ATAC-seq on caudate samples …

Genome-wide meta-analyses of cross substance use disorders in diverse populations Open

Dongbing Lai, Michael Zhang, Nick Green, Marco Abreu, Tae‐Hwi Schwantes‐An , et al. · 2025

Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges. The estimated heritability of SUDs is ~50% and many individuals experience multiple SUDs concurrently. Studie…

Response to Comment on ‘A Mendelian Randomization Study About Causal Associations Between Tofu Consumption and Stroke As Well As Related Subtypes’ Open

Yan Wang, Yunlong Liu, Mingwu Xia, Shugang Cao · 2025

Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of <i>Scn2a</i> -deficient mice Open

Ye-Eun Yoo, Purba Mandal, Zhengkuan Tang, Zaiyang Zhang, Jingliang Zhang , et al. · 2025

Truncating variants in SCN2A , which encodes the NaV1.2 sodium channel critical for action potential initiation and propagation, are associated with autism spectrum disorder (ASD) and epilepsy. To investigate SCN2A deficiency–related pheno…

ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche Open

Hua Jiang, Denggang Fu, Santhosh Kumar Pasupuleti, Baskar Ramdas, Alan Long , et al. · 2025

Single Cell Transcriptomic Analysis of Spinal Ependymoma from a Patient with NF2-related Schwannomatosis Indicates a Radial-Glia to Ependymal Cell Developmental Hierarchy Open

Noah Burket, Titto Augustine, Hongyu Gao, Robert Bell, Travis S. Johnson , et al. · 2025

i-Motif DNA molecular beacon for microRNA detection Open

T. Luo, Z.W. Guan, Yunlong Liu, Jun Zhou, Jean‐Louis Mergny , et al. · 2025

A molecular beacon (MB) is an oligonucleotide probe with a stem-loop structure designed to fluoresce upon hybridization with a specific target nucleic acid. Herein, we introduce a novel i-motif DNA-based molecular beacon (iMB) designed for…

Correction 2 for: Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury Open

Yan Sun, Shiting Dai, Jin Tao, Yunlong Li, Ziqi He , et al. · 2025

Author Correction: Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry Open

Poornima Bhat‐Nakshatri, Hongyu Gao, Aditi S. Khatpe, Adedeji K. Adebayo, Patrick McGuire , et al. · 2025

Single-nucleus analysis allows robust cell-type classification and helps to establish relationships between chromatin accessibility and cell-type-specific gene expression. Here, using samples from 92 women of several genetic ancestries, we…

Genomic and epigenomic insights into purkinje and granule neurons in Alzheimer’s disease and related dementia using single-nucleus multiome analysis Open

Feixiong Cheng, Yayan Feng, Xiaoyu Yang, Margaret E. Flanagan, Xin Chen , et al. · 2025

Protocol for labeling and manipulating “home”-activated neurons in mice Open

Xian-shi Su, J. He, Yunlong Liu, Keyu Liu, Bo Lei , et al. · 2025

Agricultural insurance improved soil nitrogen balance in China’s cities Open

Tian Li, Mengxi He, Zhenjie Tang, Pengdong Yan, Xu Duan , et al. · 2025

Summary: Nitrogen (N) balance is crucial for effective agricultural N management and plays a significant role in safeguarding environmental security and human health. Agricultural insurance (AI) has been identified as an important financia…

Multiple Myeloma Insights from Single-Cell Analysis: Clonal Evolution, the Microenvironment, Therapy Evasion, and Clinical Implications Open

Sihong Li, Jiahui Liu, Madeline Peyton, Olivia Lazaro, Sean McCabe , et al. · 2025

Multiple myeloma (MM) is a complex and heterogeneous hematologic malignancy characterized by clonal evolution, genetic instability, and interactions with a supportive tumor microenvironment. These factors contribute to treatment resistance…

Systematic functional characterization of non-coding regulatory SNPs associated with central obesity Open

Shan-Shan Dong, Yuanyuan Duan, Ren‐Jie Zhu, Yingying Jia, Jiaxin Chen , et al. · 2025

Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis Open

Ashleigh Willis, Danielle Jeong, Yunlong Liu, Marissa A. Lithopoulos, Scott A. Yuzwa , et al. · 2025

Here, we used single cell RNA sequencing and single cell spatial transcriptomics to characterize the forebrain neural stem cell (NSC) niche under homeostatic and injury conditions. We defined the dorsal and lateral ventricular-subventricul…

Alcohol Use Disorder Polygenic Score Compared With Family History and <i>ADH1B</i> Open

Dongbing Lai, Michael Zhang, Marco Abreu, Tae‐Hwi Schwantes‐An, Grace Chan , et al. · 2024

Importance Identification of individuals at high risk of alcohol use disorder (AUD) and subsequent application of prevention and intervention programs has been reported to decrease the incidence of AUD. The polygenic score (PGS), which mea…

Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open

Richard Karlsson Linnér, Travis T. Mallard, Peter B. Barr, Sandra Sanchez‐Roige, James W. Madole , et al. · 2024

Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model Open

Xindi Li, Jiayi Liu, Andrew J. Boreland, Sneha Kapadia, Siwei Zhang , et al. · 2024

Polygenic risk scores (PRSs) assess genetic susceptibility to alcohol use disorder (AUD), yet their molecular implications remain underexplored. Neuroimmune interactions, particularly in microglia, are recognized as notable contributors to…

Supplementary Table 1 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2 Open

Weini Wang, Yanchi Zhou, Ji Wang, Shu Zhang, Ali Özeş , et al. · 2024

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