Ming Zhan
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View article: Fibroblasts promote the progression of benign prostatic hyperplasia through colony-stimulating factor 1 receptor-mediated RTK signaling in prostatic epithelial cells
Fibroblasts promote the progression of benign prostatic hyperplasia through colony-stimulating factor 1 receptor-mediated RTK signaling in prostatic epithelial cells Open
Benign prostatic hyperplasia (BPH) is a prevalent condition characterized by nonmalignant proliferation of epithelial and stromal components in the prostate, frequently resulting in lower urinary tract symptoms in aging men. While receptor…
View article: Multidisciplinary collaborative multi-component intervention for patients with postoperative constipation following mixed hemorrhoidectomy
Multidisciplinary collaborative multi-component intervention for patients with postoperative constipation following mixed hemorrhoidectomy Open
View article: BLVRA promotes glioblastoma progression by regulating fatty acid metabolism
BLVRA promotes glioblastoma progression by regulating fatty acid metabolism Open
View article: Gene discovery and expression analysis of the B cell receptor repertoire in the domestic ferret model
Gene discovery and expression analysis of the B cell receptor repertoire in the domestic ferret model Open
The domestic ferret is the preferred model organism for the study of influenza A infection and responses to vaccination, because its respiratory tract architecture and sialic acid receptor type and distribution are similar to those in huma…
View article: Genome survey and evolutionary analysis of 8 <i>Lamprotula</i> species: SSR profiling, mitochondrial characterization, and population dynamics inference
Genome survey and evolutionary analysis of 8 <i>Lamprotula</i> species: SSR profiling, mitochondrial characterization, and population dynamics inference Open
Freshwater bivalves are vital to aquatic ecosystems but face severe global threats. Understanding their genomic traits and evolution is crucial for effective conservation. This study conducted whole-genome sequencing on 8 Lamprotula specie…
View article: The function and mechanisms of action of non-coding RNAs in prostatic diseases
The function and mechanisms of action of non-coding RNAs in prostatic diseases Open
View article: Targeting RBP4–STRA6 retinol signaling disrupts adipose–prostate crosstalk: A novel strategy to suppress basal cell plasticity in androgen deprivation
Targeting RBP4–STRA6 retinol signaling disrupts adipose–prostate crosstalk: A novel strategy to suppress basal cell plasticity in androgen deprivation Open
View article: Bridging Science and Hope: integrating and Communicating Lived experience in Accelerating Medicines Partnership® Schizophrenia Program
Bridging Science and Hope: integrating and Communicating Lived experience in Accelerating Medicines Partnership® Schizophrenia Program Open
The Accelerating Medicines Partnership Schizophrenia (AMP® SCZ) program integrates lived experience into psychosis research, leveraging over three decades of foundational studies to improve research quality, promote community engagement, a…
View article: Predicting the pathological subdiagnosis of benign prostatic hyperplasia with MRI radiomics: A noninvasive approach
Predicting the pathological subdiagnosis of benign prostatic hyperplasia with MRI radiomics: A noninvasive approach Open
To predict the pathological subdiagnosis of benign prostatic hyperplasia (BPH‐PS) with the overarching aim of mitigating finasteride overtreatment, we conducted a study integrating clinical, pathological, and radiomic data from BPH patient…
View article: Small nucleolar RNA host gene 1 (SNHG1) facilitates gemcitabine chemosensitivity in gallbladder cancer by regulating the miR-23b-3p/phosphatase and tensin homolog (PTEN) pathway
Small nucleolar RNA host gene 1 (SNHG1) facilitates gemcitabine chemosensitivity in gallbladder cancer by regulating the miR-23b-3p/phosphatase and tensin homolog (PTEN) pathway Open
Background: Growing evidence suggests that long non-coding RNAs (lncRNAs) exert pivotal roles in fostering chemoresistance across diverse tumors. Nevertheless, the precise involvement of lncRNAs in modulating chemoresistance within the con…
View article: Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer
Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer Open
View article: Metabolic Syndrome and Socioeconomic Status in Association with Chronic Kidney Disease: A Cross-Sectional Study in Ningbo, China
Metabolic Syndrome and Socioeconomic Status in Association with Chronic Kidney Disease: A Cross-Sectional Study in Ningbo, China Open
The prevalence of metabolic syndrome and chronic kidney disease is high among adults in Ningbo. Metabolic syndrome and low socioeconomic status are associated with the high risk of developing chronic kidney disease.
View article: Screening of tumor antigens and immunogenic cell death landscapes of prostate adenocarcinoma for exploration of mRNA vaccine
Screening of tumor antigens and immunogenic cell death landscapes of prostate adenocarcinoma for exploration of mRNA vaccine Open
In summary, the research may provide a theoretical foundation for developing mRNA vaccine against PRAD as well as determining appropriate vaccine recipients.
View article: Androgen receptor deficiency-induced TUG1 in suppressing ferroptosis to promote benign prostatic hyperplasia through the miR-188-3p/GPX4 signal pathway
Androgen receptor deficiency-induced TUG1 in suppressing ferroptosis to promote benign prostatic hyperplasia through the miR-188-3p/GPX4 signal pathway Open
View article: VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats Open
Activated VDR could contribute to restore mitophagy through Mfn2-MAMs-Fundc1 pathway in renal tubular cell. VDR could recover mitochondrial ATP, complex V activity and MAMs integrity, inhibit mitochondrial fission and mitochondrial ROS. It…
View article: Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB
Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB Open
View article: MRI apparent diffusion coefficient as potential biomarkers in the diagnosis of osteosarcoma
MRI apparent diffusion coefficient as potential biomarkers in the diagnosis of osteosarcoma Open
Objective: To assess MRI apparent diffusion coefficient as potential biomarkers in the diagnosis of osteosarcoma. Methods: 94 patients with osteosarcoma confirmed by surgical pathology in our hospital from September 2019 to September 2021 …
View article: Exposure to parabens and semen quality in reproductive-aged men
Exposure to parabens and semen quality in reproductive-aged men Open
Our results suggest negative associations between paraben mixture and sperm concentration, total sperm count, and sperm motility among reproductive-aged men.
View article: Screening of tumor antigens and immunogenic cell death landscapes of prostate cancer for exploration of mRNA vaccine
Screening of tumor antigens and immunogenic cell death landscapes of prostate cancer for exploration of mRNA vaccine Open
Background Although the mRNA vaccine is effective against many kinds of cancers, its efficacy against prostate adenocarcinoma (PRAD) is still unclear. In this study, effective antigens of mRNA vaccine were excavated from the perspective of…
View article: Value of ultrasound imaging-omics features in the diagnosis of primary nephrotic syndrome
Value of ultrasound imaging-omics features in the diagnosis of primary nephrotic syndrome Open
Primary nephrotic syndrome (PNS) is a common autoimmune systemic suppressive disease that, if left untreated, can develop into end-stage renal disease in severe cases, seriously threatening the health of patients. This disease is gradually…
View article: Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS
Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS Open
Aim To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR-P): the Structured Interview for Psychosis-risk Syndromes (SIPS) and the Comprehensive Assessment of At…
View article: Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3
Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3 Open
View article: Molecular Mechanisms of Noncoding RNA in the Occurrence of Castration-Resistant Prostate Cancer
Molecular Mechanisms of Noncoding RNA in the Occurrence of Castration-Resistant Prostate Cancer Open
Although several therapeutic options have been shown to improve survival of most patients with prostate cancer, progression to castration-refractory state continues to present challenges in clinics and scientific research. As a highly hete…
View article: Exploration of diagnostic biomarkers, microenvironment characteristics, and ursolic acid's therapeutic effect for benign prostate hyperplasia
Exploration of diagnostic biomarkers, microenvironment characteristics, and ursolic acid's therapeutic effect for benign prostate hyperplasia Open
Benign prostatic hyperplasia (BPH) and early-stage prostate cancer (PC) have similar symptoms, making it challenging to differentially diagnose these two conditions. The study used Weighted Gene Co-Expression Network Analysis, as well as t…
View article: The Association between Symptoms of Depression and Anxiety, Quality of Life, and Diabetic Kidney Disease among Chinese Adults: A Cross-Sectional Study
The Association between Symptoms of Depression and Anxiety, Quality of Life, and Diabetic Kidney Disease among Chinese Adults: A Cross-Sectional Study Open
Depression and anxiety are common comorbid symptoms among patients with diabetic kidney disease (DKD). Little is known about the influence of poor psychological conditions on the disease progression and quality of life (QOL) in DKD patient…
View article: Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis
Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis Open
The extracellular matrix (ECM) is made up of noncellular components that have special properties for influencing cell behavior and tissue structure. Small leucine-rich proteoglycans (SLRPs) are nonfibrillar ECM components that serve as str…
View article: Integrative Analysis of Transcriptome and Metabolome Reveals Molecular Responses in Eriocheir sinensis with Hepatopancreatic Necrosis Disease
Integrative Analysis of Transcriptome and Metabolome Reveals Molecular Responses in Eriocheir sinensis with Hepatopancreatic Necrosis Disease Open
Hepatopancreatic necrosis disease (HPND) is a highly lethal disease that first emerged in 2015 in Jiangsu Province, China. So far, most researchers believe that this disease is caused by abiotic factors. However, its true pathogenic mechan…
View article: MAFG-AS1 is a prognostic biomarker and facilitates prostate cancer progression
MAFG-AS1 is a prognostic biomarker and facilitates prostate cancer progression Open
Long Noncoding RNAs (LncRNAs) have recently been identified as key regulator in tumor progression. The LncRNA MAFG-AS1 has been reported to facilitate the progression of multiple cancers, however, its role in prostate cancer is still unkno…
View article: Identification of Metabolism-Related Gene-Based Subgroup in Prostate Cancer
Identification of Metabolism-Related Gene-Based Subgroup in Prostate Cancer Open
Prostate cancer is still the main male health problem in the world. The role of metabolism in the occurrence and development of prostate cancer is becoming more and more obvious, but it is not clear. Here we firstly identified a metabolism…
View article: Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer
Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer Open
Background 5-Methylcytidine (m5C) methylation is an emerging epigenetic modification in recent years, which is associated with the development and progression of various cancers. However, the prognostic value of m5C regulatory genes and th…