Xiahe Chen
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View article: Engineering Non-haem Enzymes for Nickel-Catalyzed C(sp2)‒S Coupling via Ligand-to-Metal Charge Transfer Photocatalysis
Engineering Non-haem Enzymes for Nickel-Catalyzed C(sp2)‒S Coupling via Ligand-to-Metal Charge Transfer Photocatalysis Open
Integrating new metal-catalysed transformations into enzymes is a key objective in biocatalysis. This study introduces photoinduced ligand-to-metal charge transfer (LMCT) as a new strategy for enabling abiotic cross-coupling reactions in m…
View article: Enantioconvergent benzylic C(sp <sup>3</sup> )‒N coupling with a copper-substituted nonheme enzyme
Enantioconvergent benzylic C(sp <sup>3</sup> )‒N coupling with a copper-substituted nonheme enzyme Open
Copper-catalyzed radical C(sp 3 )‒N coupling has become a major focus in synthetic catalysis over the past decade. However, achieving this reaction manifold by using enzymes has remained elusive. In this study, we introduce a photobiocatal…
View article: An Enzymatic Platform for Asymmetric Synthesis of <i>Si</i> ‐Stereogenic Silanols
An Enzymatic Platform for Asymmetric Synthesis of <i>Si</i> ‐Stereogenic Silanols Open
Chiral silanols are important synthetic targets and have garnered increasing attention in the materials and pharmaceutical industries over recent decades. A promising approach for their efficient synthesis is asymmetric silane oxidation. W…
View article: Cluster model study of the mechanism and origins of enantio- and chemoselectivity in non-heme iron enzyme-catalyzed C–H azidation
Cluster model study of the mechanism and origins of enantio- and chemoselectivity in non-heme iron enzyme-catalyzed C–H azidation Open
Computational insights reveal the origin of enantio- and chemoselectivity in non-heme iron enzyme-catalyzed C–H azidation.
View article: Mechanistic Investigation of Ni-Catalyzed Reductive Cross-Coupling of Alkenyl and Benzyl Electrophiles
Mechanistic Investigation of Ni-Catalyzed Reductive Cross-Coupling of Alkenyl and Benzyl Electrophiles Open
Mechanistic investigations of the Ni-catalyzed asymmetric reductive alkenylation of N-hydroxyphthalimide (NHP) esters and benzylic chlorides are reported. Investigations of the redox properties of the Ni-bis(oxazoline) catalyst, the reacti…