Xueting Deng
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View article: A prognostic nomogram for predicting overall survival in gastric signet ring cell carcinoma patients: a SEER database and Chinese registry analysis
A prognostic nomogram for predicting overall survival in gastric signet ring cell carcinoma patients: a SEER database and Chinese registry analysis Open
Purpose Gastric signet ring cell carcinoma (GSRC) is a distinct gastric cancer (GC) subtype. This study aimed to develop and validate a nomogram to predict overall survival (OS) and guide clinical decision-making. Methods This study includ…
View article: A Mechanistic Study of the Feasibility of Ursodeoxycholic Acid in the Treatment of Colon Adenocarcinoma
A Mechanistic Study of the Feasibility of Ursodeoxycholic Acid in the Treatment of Colon Adenocarcinoma Open
The antitumor activity of ursodeoxycholic acid may be related to cell apoptosis, proliferation, migration and vascular neogenesis.
View article: Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator Open
Objective Pancreatic cancer is distinguished by its high likelihood of metastasis and drug resistance, while the fundamental mechanisms are inadequately elucidated. This study aimed to identify pivotal hub genes associated with pancreatic …
View article: Systematic pan-cancer analysis identifies ZBTB11 as a potential pan-cancer biomarker and immunotherapy target in multiple tumor types
Systematic pan-cancer analysis identifies ZBTB11 as a potential pan-cancer biomarker and immunotherapy target in multiple tumor types Open
These findings demonstrate that ZBTB11 is associated with multiple tumor types and disease prognosis. ZBTB11 may represent a potential key biomarker and therapeutic target in cancers.
View article: Endoscopic retrograde cholangiopancreatography using a pediatric colonoscope in patients with Roux‑en‑Y gastrectomy and an intact major duodenal papilla
Endoscopic retrograde cholangiopancreatography using a pediatric colonoscope in patients with Roux‑en‑Y gastrectomy and an intact major duodenal papilla Open
Endoscopic retrograde cholangiopancreatography (ERCP) in patients with Roux-en-Y gastrectomy and an intact major duodenal papilla is challenging and difficult, with unsatisfactory outcomes using various endoscopes. Limited data are availab…
View article: Systematic pan-cancer analysis identifies ZBTB11 as a potential pan-cancer biomarker and immunotherapy target in multiple tumor types
Systematic pan-cancer analysis identifies ZBTB11 as a potential pan-cancer biomarker and immunotherapy target in multiple tumor types Open
Background ZBTB11 is a putative transcription factor with an N-terminal BTB domain and tandem C-terminal zinc finger motifs. Recent studies have suggested a potential role for ZBTB11 in tumorigenesis. However, the biological significance o…
View article: Focusing on the Immune Cells: Recent Advances in Immunotherapy for Biliary Tract Cancer
Focusing on the Immune Cells: Recent Advances in Immunotherapy for Biliary Tract Cancer Open
Biliary tract cancer (BTC) represents a challenging malignancy characterized by aggressive behavior, high relapse rates, and poor prognosis. In recent years, immunotherapy has revolutionized the treatment landscape for various cancers, but…
View article: Construction of prediction model for fetal growth restriction during first trimester in an Asian population
Construction of prediction model for fetal growth restriction during first trimester in an Asian population Open
Objective To construct a prediction model for fetal growth restriction (FGR) during the first trimester of pregnancy and evaluate its screening performance. Methods This was a prospective cohort study of singleton pregnancies that underwen…
View article: A nomogram for the prediction of overall survival and Prognostic significance of different treatment modalities for elderly Hepatocellular carcinoma
A nomogram for the prediction of overall survival and Prognostic significance of different treatment modalities for elderly Hepatocellular carcinoma Open
Background：Hepatocellular carcinoma (HCC) has a poor prognosis, especially in elderly HCC patients. A growing number of studies have confirmed that nomogram based on demographic information, pathologic information, and treatment modalities…
View article: Neurokinin-1 receptor antagonist aprepitant regulates autophagy and apoptosis through ROS/JNK pathway in intrahepatic cholangiocarcinoma
Neurokinin-1 receptor antagonist aprepitant regulates autophagy and apoptosis through ROS/JNK pathway in intrahepatic cholangiocarcinoma Open
Intrahepatic cholangiocarcinoma (iCCA) has a poor prognosis and limited treatment options. Aprepitant, a selective NK-1R antagonist, is capable of inhibiting the growth of various tumors in vitro and in vivo. To investigate the cytotoxic e…
View article: Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation
Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation Open
Background: Aprepitant, as a neurokinin-1 receptor (NK-1R) antagonist, originally applied for curing chemotherapy-induced nausea and vomiting, has been reported to have significant antitumor effect on several malignant tumors. However, the…
View article: Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain
Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain Open
Substance P contributes to the pathogenesis of pain by acting on NK-1R, specialized sensory neurons that detect noxious stimuli. Aprepitant, an antagonist of NK-1R, is widely used to treat chemotherapy-induced nausea and vomiting. In this …
View article: Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation in Microglia and Suppresses Inflammatory Pain
Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation in Microglia and Suppresses Inflammatory Pain Open
Background: Substance P (SP) contributes to the pathogenesis of pain by acting on neurokinin‐1 receptor (NK-1R), specialized sensory neurons that detect noxious stimuli. Aprepitant, an antagonist of NK-1R widely used to treat chemotherapy-…
View article: Role of Matrix Metalloproteinases in Myelin Abnormalities and Mechanical Allodynia in Rodents with Diabetic Neuropathy
Role of Matrix Metalloproteinases in Myelin Abnormalities and Mechanical Allodynia in Rodents with Diabetic Neuropathy Open
The treatment of diabetic neuropathic pain (DNP) is a major clinical challenge. The underlying mechanisms of diabetic neuropathy remain unclear, and treatment approaches are limited. Here, we report that the gelatinases MMP-9 and MMP-2 pla…
View article: Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges
Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges Open
Cholangiocarcinoma (CCA), a cancer with a relatively low incidence rate, is usually associated with poor prognosis. Current modalities for the diagnosis and treatment of CCA patients are still far from satisfactory. In recent years, numero…
View article: CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target
CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target Open
The components of the tumor microenvironment (TME) in solid tumors, especially chemokines, are currently attracting much attention from scientists. C‐X‐C motif chemokine ligand 5 (CXCL5) is one of the important chemokines in TME. Overexpre…
View article: P04.07: A novel screening protocol in prenatally identifying the variants and malformations of fetal hepatic circulation: a multicentre study
P04.07: A novel screening protocol in prenatally identifying the variants and malformations of fetal hepatic circulation: a multicentre study Open
To evaluate the efficiency of a newly proposed screening protocol for the anomalies of fetal hepatic circulation system (FHCS) and to describe the the possible variants and malformations of FHCS and their postnatal outcomes. This was a pro…
View article: SP/NK‐1R promotes gallbladder cancer cell proliferation and migration
SP/NK‐1R promotes gallbladder cancer cell proliferation and migration Open
Aberrant substance P/neurokinin‐1 receptor (SP/NK‐1R) system activation plays a critical role in various disorders, however, little is known about the expression and the detailed molecular mechanism of the SP and NK‐1R in gallbladder cance…
View article: Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery
Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery Open
Henry M Smilowitz,1 Alexandria Meyers,1 Khalil Rahman,1 Nathaniel A Dyment,2 Dan Sasso,1 Crystal Xue,3 Douglas L Oliver,4 Alexander Lichtler,5 Xiaomeng Deng,6 Sharif M Ridwan,1 Lauren J Tarmu,7,8 Qian Wu,9 Andrew L Salner,10 Ketan R Bulsar…
View article: Biodistribution of gold nanoparticles in BBN-induced muscle-invasive bladder cancer in mice
Biodistribution of gold nanoparticles in BBN-induced muscle-invasive bladder cancer in mice Open
Henry M Smilowitz,1 Lauren J Tarmu,1–3 Mary Melinda Sanders,4 John A Taylor III,5 Dharamainder Choudhary,6 Crystal Xue,7 Nathaniel A Dyment,8 Dan Sasso,1 Xiaomeng Deng,9 James F Hainfeld10 1Department of Cell Biology, University of Connect…
View article: The diagnostic/prognostic potential and molecular functions of long non-coding RNAs in the exosomes derived from the bile of human cholangiocarcinoma
The diagnostic/prognostic potential and molecular functions of long non-coding RNAs in the exosomes derived from the bile of human cholangiocarcinoma Open
Cholangiocarcinoma (CCA) is an aggressive malignancy associated with unfavorable prognosis, and it's difficult to diagnose and no effective treatments are available. Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis and …