Xiajie Huang
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View article: Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications
Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications Open
Distraction osteogenesis, or the Illizarov technique, induces bone regeneration using distractive mechanical forces. Nevertheless, Wolff's law holds that bone adapts to reverse compressive mechanical loads, growing denser in areas of high …
View article: Programmed enhancement of endogenous iron-mediated lysosomal membrane permeabilization for tumor ferroptosis/pyroptosis dual-induction
Programmed enhancement of endogenous iron-mediated lysosomal membrane permeabilization for tumor ferroptosis/pyroptosis dual-induction Open
Ferroptosis and pyroptosis, as emerging regulated forms of cell death capable of overcoming apoptotic resistance, demonstrate promising potential in tumor therapy. Given that iron manipulation and reactive oxygen species elevation serve as…
View article: A Discontinuous Galerkin Method for H(curl)-Elliptic Hemivariational Inequalities
A Discontinuous Galerkin Method for H(curl)-Elliptic Hemivariational Inequalities Open
In this paper, we develop a Discontinuous Galerkin (DG) method for solving H(curl)-elliptic hemivariational inequalities. By selecting an appropriate numerical flux, we construct an Interior Penalty Discontinuous Galerkin (IPDG) scheme. A …
View article: Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway
Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway Open
The findings showed that TTT enhanced the production of growth factors that in turn activated EPC proliferation and migration through the Ras/Raf/MEK/ERK pathway, ultimately contributing to angiogenesis and DFU healing. Based on these find…
View article: Multiple misdiagnoses of paraspinal synovial sarcoma as tuberculosis: A case report and literature review
Multiple misdiagnoses of paraspinal synovial sarcoma as tuberculosis: A case report and literature review Open
Background Synovial sarcoma (SS) is a rare but aggressive soft tissue sarcoma that can be challenging to diagnose accurately, especially when it mimics more common conditions such as tuberculosis. This case report aims to highlight the dia…
View article: Efficient explicit gate construction of block-encoding for Hamiltonians needed for simulating partial differential equations
Efficient explicit gate construction of block-encoding for Hamiltonians needed for simulating partial differential equations Open
One of the most promising applications of quantum computers is solving partial differential equations (PDEs). By using the Schrodingerisation technique - which converts non-conservative PDEs into Schrodinger equations - the problem can be …
View article: Tibial Cortex Transverse Transport Facilitates Severe Diabetic Foot Wound Healing via HIF-1α-Induced Angiogenesis
Tibial Cortex Transverse Transport Facilitates Severe Diabetic Foot Wound Healing via HIF-1α-Induced Angiogenesis Open
TTT enhanced neovascularization and perfusion at the hindlimb and accelerated healing of the severe DFUs. The underlying mechanism is related to HIF-1α-induced angiogenesis.
View article: Pyroptosis in Osteoarthritis: Molecular Mechanisms and Therapeutic Implications
Pyroptosis in Osteoarthritis: Molecular Mechanisms and Therapeutic Implications Open
Osteoarthritis (OA) is a chronic disease that causes pain and functional impairment by affecting joint tissue. Its global impact is noteworthy, causing significant economic losses and property damage. Despite extensive research, the underl…
View article: Complete resorption of the humerus in metastatic follicular thyroid carcinoma: A case report and literature review
Complete resorption of the humerus in metastatic follicular thyroid carcinoma: A case report and literature review Open
Background Thyroid carcinoma is the commonest endocrinological malignancy. Bone metastasis of thyroid carcinoma is rare. Particularly, bone metastases leading to complete resorption of the humerus are extremely uncommon. Case presentation …
View article: Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy
Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy Open
View article: Cartilage organoids and osteoarthritis research: a narrative review
Cartilage organoids and osteoarthritis research: a narrative review Open
Osteoarthritis (OA) is one of the most common degenerative joint diseases, significantly impacting individuals and society. With the acceleration of global aging, the incidence of OA is increasing. The pathogenesis of osteoarthritis is not…
View article: Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy
Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy Open
Poor renal distribution of antibody-based drugs is the key factor contributing to low treatment efficiency for renal diseases and side effects. Here, we prepared F(ab′)2 fragmented vascular endothelial growth factor receptor 2 a…