Xiali Zhang
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View article: Identification of diagnostic genes for acute appendicitis and appendiceal cancer based on bioinformatics and machine learning
Identification of diagnostic genes for acute appendicitis and appendiceal cancer based on bioinformatics and machine learning Open
Background Appendiceal cancer is a rare malignancy that is often discovered incidentally in acute appendicitis patients. The diagnosis and treatment of this disease are challenging due to its low incidence and nonspecific symptoms. In this…
View article: A necroptosis gene signature predicts prostate cancer recurrence, and is linked to somatic mutation, therapeutic landscape, and immune infiltration.
A necroptosis gene signature predicts prostate cancer recurrence, and is linked to somatic mutation, therapeutic landscape, and immune infiltration. Open
Altogether, the necroptosis gene signature may effectively predict prostatic carcinoma recurrence and therapeutic responses, but its clinical feasibility must be verified.
View article: Nonclassical Growth of Atomically Flat Two‐Dimensional Organic Single Crystals on a Liquid Surface through Fusion
Nonclassical Growth of Atomically Flat Two‐Dimensional Organic Single Crystals on a Liquid Surface through Fusion Open
Organic single crystals with low defect density are key functional materials for next‐generation electronics. Classical crystallization commonly results in a high density of molecular steps, which are defects that can trap charge carriers …
View article: The Role of Linc00467/TRAF5 in Promoting the Malignant Progression of Prostate Cancer and its Mechanism
The Role of Linc00467/TRAF5 in Promoting the Malignant Progression of Prostate Cancer and its Mechanism Open
Background Prostate cancer (PCa) is a commonly occurring cancer in the prostate. However, its pathogenesis is complex and remains largely unknown. This study aims to uncover the biological role of Linc00467/TRAF5 in influencing the progres…
View article: Inflammasome Inhibition Prevents Motor Deficit and Cerebellar Degeneration Induced by Chronic Methamphetamine Administration
Inflammasome Inhibition Prevents Motor Deficit and Cerebellar Degeneration Induced by Chronic Methamphetamine Administration Open
Methamphetamine (METH), a psychostimulant, has the potential to cause neurodegeneration by targeting the cerebrum and cerebellum. It has been suggested that the NLRP3 inflammasome may be responsible for the neurotoxicity caused by METH. Ho…
View article: An Exploration on the Effective Way to Solve the Bottleneck in Improving the Overall Grain Production Capacity
An Exploration on the Effective Way to Solve the Bottleneck in Improving the Overall Grain Production Capacity Open
There are four constraints and bottlenecks in improving the overall grain production capacity in China. Among them, poor infrastructure and weak disaster resistance is the basic factor. And high cost and risk in grain production is another…
View article: Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells
Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells Open
Advanced and recurrent ovarian cancer has a poor prognosis and is frequently resistant to numerous therapeutics; thus, safe and effective drugs are needed to combat this disease. Previous studies have demonstrated that triptolide (TPL) exh…
View article: Inside Back Cover: Layer‐Defining Strategy to Grow Two‐Dimensional Molecular Crystals on a Liquid Surface down to the Monolayer Limit (Angew. Chem. Int. Ed. 45/2019)
Inside Back Cover: Layer‐Defining Strategy to Grow Two‐Dimensional Molecular Crystals on a Liquid Surface down to the Monolayer Limit (Angew. Chem. Int. Ed. 45/2019) Open
Two-dimensional molecular crystals with a defined number of molecular layers were produced by a layer-defining strategy of crystal growth on a liquid substrate, reported by R. Li, W. Hu, et. al in their Communication on page 16082 ff. By c…
View article: Roles of the MST1-JNK signaling pathway in apoptosis of colorectal cancer cells induced by Taurine
Roles of the MST1-JNK signaling pathway in apoptosis of colorectal cancer cells induced by Taurine Open
The aim of this study was to observe the impact of the mammalian sterile 20-like kinase 1-c-Jun N-terminal kinase (MST1-JNK) signaling pathway on apoptosis in colorectal cancer (CRC) cells induced by Taurine (Tau). Caco-2 and SW620 cells t…
View article: Effect of taurine on the proliferation and apoptosis of human hepatocellular carcinoma HepG2 cells
Effect of taurine on the proliferation and apoptosis of human hepatocellular carcinoma HepG2 cells Open
The aim of the present study was to observe the effect and molecular mechanism of taurine (Tau) on the cell proliferation and apoptosis of human hepatocellular carcinoma (HHCC) HepG2 cells. HHCC HepG2 cells were used as target cells, and t…
View article: γ-secretase inhibitor inhibits bladder cancer cell drug resistance and invasion by reducing epithelial-mesenchymal transition
γ-secretase inhibitor inhibits bladder cancer cell drug resistance and invasion by reducing epithelial-mesenchymal transition Open
A previous study by our group demonstrated that the expression levels of Notch 1 and Jagged 1 in bladder cancer cells was significantly lower compared with those in normal bladder mucosa, while the expression levels of Notch 1 and Jagged 1…
View article: miR-221-induced PUMA silencing mediates immune evasion of bladder cancer cells
miR-221-induced PUMA silencing mediates immune evasion of bladder cancer cells Open
Immune evasion of cancer cells is mainly due to the impaired transduction of apoptotic signals from immune cells to cancer cells, as well as inhibition of subsequent apoptosis signal cascades within the cancer cells. Over the past few deca…