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View article: Serum TSP-1 is a useful biomarker in severity assessment and the diagnosis of osteoarthritis
Serum TSP-1 is a useful biomarker in severity assessment and the diagnosis of osteoarthritis Open
Serum TSP-1 concentration is associated with OA severity in both mice and humans and may serve as a useful diagnostic biomarker for OA.
View article: Predicting Postoperative Blood Transfusion in Elderly Patients Undergoing Total Hip and Knee Arthroplasty Using Machine Learning Models
Predicting Postoperative Blood Transfusion in Elderly Patients Undergoing Total Hip and Knee Arthroplasty Using Machine Learning Models Open
The developed models and online tool support personalized transfusion risk assessment, optimizing perioperative management, optimizing blood utilization, and enhancing patient outcomes.
View article: <scp>HDAC4</scp> regulates apoptosis in Acan‐ <scp> Cre <sup>ERT2</sup> </scp> ; <scp> HDAC4 <sup>d</sup> </scp> <sup>/d</sup> mice with osteoarthritis by downregulating <scp>ATF4</scp>
<span>HDAC4</span> regulates apoptosis in Acan‐ <span> Cre <sup>ERT2</sup> </span> ; <span> HDAC4 <sup>d</sup> </span> <sup>/d</sup> mice with osteoarthritis by downregulating <span>ATF4</span> Open
Several studies have previously shown that histone deacetylase 4 (HDAC4) can regulate endoplasmic reticulum stress‐induced apoptosis through the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signa…
View article: HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model
HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model Open
Background The present study evaluated whether the lack of histone deacetylase 4 (HDAC4) increases endoplasmic reticulum stress-induced chondrocyte apoptosis by releasing activating transcription factor 4 (ATF4) in human osteoarthritis (OA…
View article: A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence
A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence Open
Osteoarthritis (OA) is a kind of arthritis that impairs movement and causes joint discomfort. Recent research has demonstrated a connection between cellular senescence and the degenerative processes of OA chondrocytes. In yeast and human c…
View article: Bibliometric study and visualization of cellular senescence associated with osteoarthritis from 2009 to 2023
Bibliometric study and visualization of cellular senescence associated with osteoarthritis from 2009 to 2023 Open
Background: Osteoarthritis is a common degenerative joint disease that is highly prevalent in the elderly population. Along with the occurrence of sports injuries, osteoarthritis is gradually showing a younger trend. Osteoarthritis has man…
View article: TSP-1 increases autophagy level in cartilage by upregulating HSP27 which delays progression of osteoarthritis
TSP-1 increases autophagy level in cartilage by upregulating HSP27 which delays progression of osteoarthritis Open
This study aimed to determine whether Thrombospondin-1 (TSP-1) can be used as a biomarker to diagnose early osteoarthritis (OA) and whether it has a chondroprotective effect against OA. We examined TSP-1 expression in cartilage, synovial f…
View article: MiR-1 is a critical regulator of chondrocyte proliferation and hypertrophy by inhibiting Indian hedgehog pathway during postnatal endochondral ossification in miR-1 overexpression transgenic mice
MiR-1 is a critical regulator of chondrocyte proliferation and hypertrophy by inhibiting Indian hedgehog pathway during postnatal endochondral ossification in miR-1 overexpression transgenic mice Open
Endochondral bone formation from the growth plate plays a critical role in vertebrate limb development and skeletal homeostasis. Although miR-1 is mainly expressed in the hypertrophic region of the growth plate during this process, its rol…
View article: MicroRNA-1 small nucleic acid drugs attenuate the progression of osteoarthritis by downregulating Indian hedgehog
MicroRNA-1 small nucleic acid drugs attenuate the progression of osteoarthritis by downregulating Indian hedgehog Open
Objective To verify whether MicroRNA-1 (miR-1) small nucleic acid drugs can delay the progression of osteoarthritis (OA) by downregulating Indian hedgehog (Ihh). Methods Costal chondrocytes were isolated from male Sprague-Dawley rats aged …
View article: WITHDRAWN: Comparison of the accuracy between imageless navigation and manual freehand approaches for total hip arthroplasty: a systematic review and meta-analysis
WITHDRAWN: Comparison of the accuracy between imageless navigation and manual freehand approaches for total hip arthroplasty: a systematic review and meta-analysis Open
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our…
View article: MicroRNA-1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post-transcriptional suppression of Ihh expression
MicroRNA-1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post-transcriptional suppression of Ihh expression Open
Indian hedgehog signaling molecule (Ihh) is known to play critical roles in chondrogenesis and cartilage development. However, it remains largely unknown how Ihh is regulated during the process. Previous studies suggest that Ihh plays an i…
View article: MicroRNA‑1 regulates the development of osteoarthritis in a Col2a1‑Cre‑ERT2/GFPfl/fl‑RFP‑miR‑1 mouse model of osteoarthritis through the downregulation of Indian hedgehog expression
MicroRNA‑1 regulates the development of osteoarthritis in a Col2a1‑Cre‑ERT2/GFPfl/fl‑RFP‑miR‑1 mouse model of osteoarthritis through the downregulation of Indian hedgehog expression Open
The present study assessed the effects of microRNA‑1 (miR‑1) on the development of osteoarthritis using human tissues and a Col2a1‑Cre‑ERT2/GFPfl/fl‑RFP‑miR‑1 mouse model of osteoarthritis. Human cartilage tissues (n=20) were collected for…
View article: Proteomics and Bioinformatics Analysis of Cartilage in Post-Traumatic Osteoarthritis in a Mini-Pig Model of Anterior Cruciate Ligament Repair
Proteomics and Bioinformatics Analysis of Cartilage in Post-Traumatic Osteoarthritis in a Mini-Pig Model of Anterior Cruciate Ligament Repair Open
BACKGROUND Although osteoarthritis (OA) is a degenerative disease that is increasingly common with age, the pathogenesis of post-traumatic OA (PTOA) is poorly understood. This study aimed to undertake proteomics and bioinformatics analysis…