Xianfeng Hou
YOU?
Author Swipe
View article: Different DNA Binding and Damage Mode between Anticancer Antibiotics Trioxacarcin A and LL-D49194α1
Different DNA Binding and Damage Mode between Anticancer Antibiotics Trioxacarcin A and LL-D49194α1 Open
Trioxacarcin A (TXN) is a highly potent cytotoxic antibiotic with remarkable structural complexity. The crystal structure of TXN bound to double-stranded DNA (dsDNA) suggested that the TXN interaction might depend on positions of two sugar…
View article: Efficacy and Functional Mechanisms of a Two-Stage Pretreatment Approach Based on Alkali and Ionic Liquid for Bioconversion of Waste Medium-Density Fiberboard
Efficacy and Functional Mechanisms of a Two-Stage Pretreatment Approach Based on Alkali and Ionic Liquid for Bioconversion of Waste Medium-Density Fiberboard Open
A novel pretreatment strategy utilizing a combination of NaOH and 1-Butyl-3-methylimidazolium chloride ([Bmim]Cl) was proposed to enhance the enzymatic hydrolysis of abandoned Medium-density fiberboard (MDF). The synergistic effect of NaOH…
View article: Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity
Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity Open
A 61-kb biosynthetic gene cluster (BGC), which is accountable for the biosynthesis of hibarimicin (HBM) B from Microbispora rosea subsp. hibaria TP-A0121, was heterologously expressed in Streptomyces coelicolor M1154, which generated a tra…
View article: A Novel Fluorescent Probe for the Detection of Oxalyl Chloride in Air
A Novel Fluorescent Probe for the Detection of Oxalyl Chloride in Air Open
View article: Strategy for Understanding Cuticle-Cutinase Interaction and In-Situ Signaling the Infection of Plant Pathogenic Fungi by Fluorescent Molecules
Strategy for Understanding Cuticle-Cutinase Interaction and In-Situ Signaling the Infection of Plant Pathogenic Fungi by Fluorescent Molecules Open
View article: Water Solvable Fluorescent Molecule for Dual Detection of Hydrazine and Sulfur Dioxide Derivates and its Applications in Total Environmental Conditions
Water Solvable Fluorescent Molecule for Dual Detection of Hydrazine and Sulfur Dioxide Derivates and its Applications in Total Environmental Conditions Open
View article: A Novel Fluorescent Probe for the Detection of Oxalyl Chloride in Air
A Novel Fluorescent Probe for the Detection of Oxalyl Chloride in Air Open
View article: A Turn-On Fluorescent Probe Based on Pyrene for Hydrazine Detection
A Turn-On Fluorescent Probe Based on Pyrene for Hydrazine Detection Open
View article: A Fluorescent Probe for Facile Detection of Gaseous Styrene Quantitatively
A Fluorescent Probe for Facile Detection of Gaseous Styrene Quantitatively Open
View article: A Turn-On Fluorescent Probe Based on Pyrene for Hydrazine Detection
A Turn-On Fluorescent Probe Based on Pyrene for Hydrazine Detection Open
View article: A Fluorescent Probe for Facile Detection of Gaseous Styrene Quantitatively
A Fluorescent Probe for Facile Detection of Gaseous Styrene Quantitatively Open
View article: A Fluorescent Probe for Facile Detection of Gaseous Styrene Quantitatively
A Fluorescent Probe for Facile Detection of Gaseous Styrene Quantitatively Open
View article: <i>In vivo</i> Studies on the Biosynthetic Pathway of Aureonuclemycin and Identification of Key Metabolites
<i>In vivo</i> Studies on the Biosynthetic Pathway of Aureonuclemycin and Identification of Key Metabolites Open
On the basis of aureonuclemycin biosynthetic gene cluster obtained in the previous work, in-frame markerless deletion mutants of all genes were constructed, and the key genes that play a role in the biosynthesis of aureonuclemycin were ide…
View article: Biosynthesis of DNA-Alkylating Antitumor Natural Products
Biosynthesis of DNA-Alkylating Antitumor Natural Products Open
DNA-alkylating natural products play an important role in drug development due to their significant antitumor activities. They usually show high affinity with DNA through different mechanisms with the aid of their unique scaffold and highl…
View article: Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance
Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance Open
Two families of DNA glycosylases (YtkR2/AlkD, AlkZ/YcaQ) have been found to remove bulky and crosslinking DNA adducts produced by bacterial natural products. Whether DNA glycosylases eliminate other types of damage formed by structurally d…
View article: Biosynthesis of trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase
Biosynthesis of trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase Open
Different starter unit and complex tailoring steps for type II polyketide synthase in trioxacarcin biosynthesis.