Xinyu Zhao
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View article: Correction: Fine mapping of the dominant female sterility gene and novel model of hybrid seed production in cabbage (Brassica oleracea L. var. capitata)
Correction: Fine mapping of the dominant female sterility gene and novel model of hybrid seed production in cabbage (Brassica oleracea L. var. capitata) Open
View article: Neuropeptide Y co-opts neuronal ensembles for memory lability and stability
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability Open
Memory engrams are formed by activity-dependent recruitment of distinct subsets of excitatory principal neurons (or neuronal ensembles) whereas inhibitory neurons pivot memory lability and stability. However, the molecular logic for memory…
View article: Dynamic landscapes of gene regulatory networks in early mammalian neurogenesis: Insights into brain evolution and disorder risk
Dynamic landscapes of gene regulatory networks in early mammalian neurogenesis: Insights into brain evolution and disorder risk Open
Neurogenesis—the process of generating neurons—is governed by dynamic transcriptional programs that vary across time, brain regions, and cell types, forming regionally specialized neuronal circuits. To understand these dynamics, we constru…
View article: A Case Study on the Effects of Blended Learning on College Students' Learning Motivation and Learning Outcomes
A Case Study on the Effects of Blended Learning on College Students' Learning Motivation and Learning Outcomes Open
With the development of online education platforms, college students have widely engaged in blended teaching that combines online tools with face‑to‑face classes. Although research on online courses has surged, case studies focused on how …
View article: Fine mapping of the dominant female sterility gene and novel model of hybrid seed production in cabbage (Brassica oleracea L. var. capitata)
Fine mapping of the dominant female sterility gene and novel model of hybrid seed production in cabbage (Brassica oleracea L. var. capitata) Open
View article: Acetyl-CoA acyltransferase 2 as a metabolic modulator: Unraveling its impact on hepatic lipid dynamics in chicken embryos
Acetyl-CoA acyltransferase 2 as a metabolic modulator: Unraveling its impact on hepatic lipid dynamics in chicken embryos Open
Despite the established role of acetyl-CoA acyltransferase 2 (ACAA2) in hepatic lipid homeostasis in mammals, its function in regulating hepatic lipid metabolism during the embryonic stage of chickens remains unexplored. This study aimed t…
View article: Kidney supportive care in advanced chronic kidney disease: a qualitative meta-synthesis of healthcare professionals perspectives and attitudes
Kidney supportive care in advanced chronic kidney disease: a qualitative meta-synthesis of healthcare professionals perspectives and attitudes Open
Not applicable.
View article: Micro-sprinkling irrigation improves grain yield, dry matter accumulation and nitrogen use efficiency of purple wheat in the North China Plain
Micro-sprinkling irrigation improves grain yield, dry matter accumulation and nitrogen use efficiency of purple wheat in the North China Plain Open
Background and Aims Micro-sprinkling irrigation (MSI) has been instrumental in enhancing crop yield and water utilization efficiency. Nevertheless, there is a paucity of research on the impact of MSI on purple wheat. Methods A field experi…
View article: Shear Wave Elastography in Sjögren's Syndrome Diagnosis: A Meta-Analysis of Major Exocrine Glands
Shear Wave Elastography in Sjögren's Syndrome Diagnosis: A Meta-Analysis of Major Exocrine Glands Open
View article: Author response: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes
Author response: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes Open
View article: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes
HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes Open
The control of gluconeogenesis is critical for glucose homeostasis and the pathology of type 2 diabetes (T2D). Here, we uncover a novel function of TET2 in the regulation of gluconeogenesis. In mice, both fasting and a high-fat diet (HFD) …
View article: Correction: Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma
Correction: Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma Open
View article: Author response: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes
Author response: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes Open
View article: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes
HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes Open
The control of gluconeogenesis is critical for glucose homeostasis and the pathology of type 2 diabetes (T2D). Here, we uncover a novel function of TET2 in the regulation of gluconeogenesis. In mice, both fasting and a high-fat diet (HFD) …
View article: CGD-CD: A Contrastive Learning-Guided Graph Diffusion Model for Change Detection in Remote Sensing Images
CGD-CD: A Contrastive Learning-Guided Graph Diffusion Model for Change Detection in Remote Sensing Images Open
With the rapid development of remote sensing technology, the question of how to leverage large amounts of unlabeled remote sensing data to detect changes in multi-temporal images has become a significant challenge. Self-supervised methods …
View article: Serum metabolomic analysis in patients with Hashimoto’s thyroiditis positive for TgAb or TPOAb: a preliminary study
Serum metabolomic analysis in patients with Hashimoto’s thyroiditis positive for TgAb or TPOAb: a preliminary study Open
View article: p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer
p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer Open
Background Gastric cancer is one of the most prevalent malignant tumors within the digestive system, and ferroptosis playing a crucial role in its progression. Glutathione peroxidase 4 (GPX4), a key negative regulator of ferroptosis, is hi…
View article: SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis
SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis Open
View article: A Semi-Automated MEA Spike sorting (SAMS) method for high throughput assessment of cultured neurons
A Semi-Automated MEA Spike sorting (SAMS) method for high throughput assessment of cultured neurons Open
Neurons derived from human pluripotent stem cells (hPSCs) are valuable models for studying brain development and developing therapies for brain disorders. Evaluating human-derived neurons requires assessing their electrical activity, which…
View article: Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma
Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma Open
View article: Total Extract of Folium Rhododendri Daurici alleviate MASLD by regulating PPAR and TNF signaling pathways
Total Extract of Folium Rhododendri Daurici alleviate MASLD by regulating PPAR and TNF signaling pathways Open
View article: Fxr1 Deletion from Cortical Parvalbumin Interneurons Modifies Their Excitatory Synaptic Responses
Fxr1 Deletion from Cortical Parvalbumin Interneurons Modifies Their Excitatory Synaptic Responses Open
Fragile X autosomal homolog 1 (FXR1), a member of the fragile X messenger riboprotein 1 family, has been linked to psychiatric disorders including autism and schizophrenia. Parvalbumin (PV) interneurons play critical roles in cortical proc…
View article: Identifying Risk Factors Associated With False‐Negative Results in <scp>US</scp>‐Guided Percutaneous Transthoracic Needle Lung Biopsy of Subpleural Pulmonary Lesions
Identifying Risk Factors Associated With False‐Negative Results in <span>US</span>‐Guided Percutaneous Transthoracic Needle Lung Biopsy of Subpleural Pulmonary Lesions Open
Background This study aims to investigate the factors influencing false‐negative results in ultrasound‐guided percutaneous transthoracic needle lung biopsy results (US‐PTLB). Materials and Methods This ambispective cohort study included pa…
View article: KDM4 Regulates the Glycolysis of Hemocytes in the Immune Priming of Eriocheir sinensis
KDM4 Regulates the Glycolysis of Hemocytes in the Immune Priming of Eriocheir sinensis Open
Immune priming confers a sustained, augmented response of innate immune cells to a secondary challenge, a process that is characteristically reliant on metabolic reprogramming. Recent evidence suggests that histone demethylases play essent…
View article: Author response: TET2 contributes to gluconeogenesis and pathology of type 2 diabetes
Author response: TET2 contributes to gluconeogenesis and pathology of type 2 diabetes Open
View article: HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes
HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes Open
The control of gluconeogenesis is critical for glucose homeostasis and the pathology of type 2 diabetes (T2D). Here, we uncover a novel function of TET2 in the regulation of gluconeogenesis. In mice, both fasting and a high-fat diet (HFD) …
View article: TET2 contributes to gluconeogenesis and pathology of type 2 diabetes
TET2 contributes to gluconeogenesis and pathology of type 2 diabetes Open
The control of gluconeogenesis is critical for glucose homeostasis and the pathology of type 2 diabetes (T2D). Here, we uncover a novel function of TET2 in the regulation of gluconeogenesis. In mice, both fasting and a high-fat diet (HFD) …
View article: Phenotype Scoring of Population Scale Single-Cell Data Dissects Alzheimer’s Disease Complexity
Phenotype Scoring of Population Scale Single-Cell Data Dissects Alzheimer’s Disease Complexity Open
The complexity of Alzheimer’s disease (AD) manifests in diverse clinical phenotypes, including cognitive impairment and neuropsychiatric symptoms (NPSs). However, the etiology of these phenotypes remains elusive. To address this, the Psych…
View article: [Analysis of nerve excitability in the dentate gyrus of the hippocampus in cerebral ischaemia-reperfusion mice].
[Analysis of nerve excitability in the dentate gyrus of the hippocampus in cerebral ischaemia-reperfusion mice]. Open
Ischemic stroke often leads to cognitive dysfunction, which delays the recovery process of patients. However, its pathogenesis is not yet clear. In this study, the cerebral ischemia-reperfusion model was built as the experimental object, a…
View article: Protocol for comparative gene expression data analysis between brains and organoids using a cloud-based web app
Protocol for comparative gene expression data analysis between brains and organoids using a cloud-based web app Open
Here, we present a protocol for using Brain and Organoid Manifold Alignment (BOMA), a cloud-based web app for comparative gene expression data analysis between brains and organoids. We describe steps for performing a global alignment of de…