Xiaokui Mo
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View article: Supplementary Table S1 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Supplementary Table S1 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
LIST OF DIFFERENTIALLY METHYLATED SITES IN EOCRC VS AOCRC FROM TCGA
View article: Supplementary Table S3 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Supplementary Table S3 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
LIST OF DIFFERERNTIALLY METHYLATED GENES GROUPED INTO CANNONICAL PATHWAYS IN EOCRC BY USING IPA
View article: Figure 2 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Figure 2 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
Methylation signature validation through GE profiles in EOCRC. A, Integration of the differentially methylated sites with paired RNA-seq showed genes that vary in methylation and transcription. The threshold for the FDR-adjusted …
View article: Figure 1 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Figure 1 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
Accelerated aging with epigenetic signatures in EOCRC. A, Heatmap was drawn with samples (patients) in the row and CpG sites (probes) in the column. The DNAm values range from 0.0 (completely unmethylated, blue) to 1.0 (completely m…
View article: Supplementary Table S9 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Supplementary Table S9 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
CORRELATION BETWEEN IMMUNE CELLS AND MICROBES IN TCGA
View article: Supplementary Figure S2 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Supplementary Figure S2 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
Supplementary Figure S2 showed microbial composition by tumor location.
View article: Supplementary Table S4 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Supplementary Table S4 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
LIST OF GENES GROUPED INTO CANNONICAL PATHWAYS IN EOCRC FROM TCGA BY USING IPA
View article: Supplementary Table S6 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Supplementary Table S6 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
LIST OF MICROBES IN TCGA AND ORIEN BY RNA-SEQ
View article: Supplementary Figure S1 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Supplementary Figure S1 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
Supplementary Figure S1 showed Fusobacterium abundance by age status across the TCGA and ORIEN datasets.
View article: Table 2 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Table 2 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
Patient characteristics with colorectal cancer tumors in ORIEN, stratified by the age of onset.
View article: Figure 4 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Figure 4 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
Relationship between microbes and immune cell composition. A, All microbe-genus level abundances (columns) correlated to the deconvolved immune cell abundances (rows), with the strength of the association and its direction indicated…
View article: Supplementary Table S7 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Supplementary Table S7 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
LIST OF MICROBES BY 16S
View article: Supplementary Table S5 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Supplementary Table S5 from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
LIST OF GENES GROUPED INTO CANNONICAL PATHWAYS IN EOCRC FROM ORIEN BY USING IPA
View article: Data from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Data from Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
The incidence of colorectal cancer in young adults (age of diagnosis Significance:We investigated whether environmentally driven factors contribute to EOCRC. We observed accelerated epigenetic aging in EOCRC and epigenetic changes associat…
View article: TMET-15. SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity
TMET-15. SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity Open
Rapidly growing tumors require a continuous supply of cholesterol, which is sustained by upregulating sterol regulatory element-binding protein 1 (SREBP-1), a master transcription factor that drives cholesterol uptake and biosynthesis. Une…
View article: Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
The incidence of colorectal cancer in young adults (age of diagnosis <50 years) has been rapidly increasing. Although ∼20% of early-onset colorectal cancer (EOCRC) cases are due to germline mutations, the etiology of the majority of EOC…
View article: Nanoparticle vaccine based on the pre-fusion F glycoprotein of respiratory syncytial virus elicits robust protective immune responses
Nanoparticle vaccine based on the pre-fusion F glycoprotein of respiratory syncytial virus elicits robust protective immune responses Open
Respiratory syncytial virus (RSV) is a global public health concern. Currently, RSV vaccines are approved only for use in older adults, while preventing the disease in infants and children, as well as ensuring vaccine durability, remains a…
View article: Kaempferol Alleviates Acrolein‐Induced Lung Injury In Vitro and In Vivo by Binding to Peli2 and Disrupting the Peli2‐NLRP3 Interaction
Kaempferol Alleviates Acrolein‐Induced Lung Injury In Vitro and In Vivo by Binding to Peli2 and Disrupting the Peli2‐NLRP3 Interaction Open
Acrolein (ACR) is a highly toxic agent that induces lung inflammation and causes acute lung injury (ALI). However, effective treatments for ACR‐induced ALI are currently lacking. We investigated the protective effects of kaempferol (Kae) a…
View article: Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysis
Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysis Open
Objective To evaluate the diagnostic value of 3.0T high-resolution magnetic resonance imaging (3.0T HR-MRI), ultrasound imaging, and GATA3 protein expression in breast cancer (BC) and their prognostic implications. Methods A retrospective …
View article: Dose-finding and in vivo safety study of an adipose targeted leptin gene therapy for congenital leptin deficiency
Dose-finding and in vivo safety study of an adipose targeted leptin gene therapy for congenital leptin deficiency Open
Congenital leptin deficiency is a monogenic disease originated from adipose tissue, causing hyperphagia, severe obesity, and hyperinsulinemia. Moreover, most forms of lipodystrophy syndromes exhibit leptin deficiency. Leptin replacement th…
View article: Extracellular Vesicular Delta‐Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer Diagnosis
Extracellular Vesicular Delta‐Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer Diagnosis Open
Small cell lung cancer (SCLC) is associated with high mortality and limited therapeutic options. There is increasing recognition that SCLC harbors molecular heterogeneity. Using a new liquid biopsy assay, it is demonstrated that SCLC subty…
View article: Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth
Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth Open
Elevated hexosamine biosynthesis fuels tumor growth by facilitating protein and lipid glycosylation. But which enzyme in this pathway is better to serve as an antitumor target remains unclear. Here, we revealed that targeting GFAT1, the ra…
View article: Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer
Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer Open
Background: The incidence of colorectal cancer (CRC) in young adults (age of diagnosis < 50 years old) has been rapidly increasing. Although ~20% of early-onset (EO) CRC cases are due to germline mutations, the etiology of the majority of …
View article: Engineering a novel HSV-1 strain for oncolytic therapy of solid tumors
Engineering a novel HSV-1 strain for oncolytic therapy of solid tumors Open
Oncolytic herpes simplex virus (HSV)-1-derived viruses are being developed for cancer treatment. Here, we describe the isolation of a novel strain of HSV-1 and its engineering to safely harness it as an oncolytic therapeutic. This strain (…
View article: sdRNA-D43 derived from small nucleolar RNA snoRD43 improves chondrocyte senescence and osteoarthritis progression by negatively regulating PINK1/Parkin-mediated mitophagy pathway via dual-targeting NRF1 and WIPI2
sdRNA-D43 derived from small nucleolar RNA snoRD43 improves chondrocyte senescence and osteoarthritis progression by negatively regulating PINK1/Parkin-mediated mitophagy pathway via dual-targeting NRF1 and WIPI2 Open
View article: Design of Photoactivatable Methylene Blue-Bufalin Conjugate for Gpx4-Targeted Degradation to Induce Ferroptosis-Like Death in Breast Cancer Therapy
Design of Photoactivatable Methylene Blue-Bufalin Conjugate for Gpx4-Targeted Degradation to Induce Ferroptosis-Like Death in Breast Cancer Therapy Open
View article: 999 Oncolytic virotherapy-mediated intratumoral IL-12 and its impact on immune cell function: insights from spectral flow cytometry
999 Oncolytic virotherapy-mediated intratumoral IL-12 and its impact on immune cell function: insights from spectral flow cytometry Open
View article: IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2 Open
Osteoarthritis (OA) is an age-related cartilage-degenerating joint disease. Mitochondrial dysfunction has been reported to promote the development of OA. Poly (ADP-ribose) polymerase family member 12 (PARP12) is a key regulator of mitochon…
View article: Combinatorial immunotherapy of anti-MCAM CAR-modified expanded natural killer cells and NKTR-255 against neuroblastoma
Combinatorial immunotherapy of anti-MCAM CAR-modified expanded natural killer cells and NKTR-255 against neuroblastoma Open
View article: CD37 in acute myeloid leukemia: a novel surface target for drug delivery
CD37 in acute myeloid leukemia: a novel surface target for drug delivery Open
Acute myeloid leukemia (AML) is the most common and lethal leukemia in adults. AML consists of many genetic subtypes, which limits broad applicability of targeted therapy. We discovered that the hematopoiesis-restricted tetraspanin CD37 is…