Yongxiang Luo
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View article: Antiepileptic Drug Combinations for Epilepsy: Mechanisms, Clinical Strategies, and Future Prospects
Antiepileptic Drug Combinations for Epilepsy: Mechanisms, Clinical Strategies, and Future Prospects Open
Epilepsy is a chronic neurological disorder characterized by abnormal neuronal discharge, leading to recurrent and unpredictable disruptions in brain function. Despite over 30 antiepileptic drugs (AEDs), 30% of patients develop drug-resist…
View article: Unraveling abiotic organic synthesis pathways in the mafic crust of mid-ocean ridges
Unraveling abiotic organic synthesis pathways in the mafic crust of mid-ocean ridges Open
The aqueous alteration of the oceanic lithosphere provides significant energy that impacts the synthesis and diversity of organic compounds, which are crucial for the deep carbon cycle and may have provided the first building blocks for li…
View article: Factors influencing recurrence and model development for recurrence of minimally invasive percutaneous transhepatic lithotripsy: a single-center retrospective study
Factors influencing recurrence and model development for recurrence of minimally invasive percutaneous transhepatic lithotripsy: a single-center retrospective study Open
Biliary stricture, stone diameter, diabetes, stone number, age, and total bilirubin significantly influence stone recurrence after PTCSL. The GBM model, based on these factors, demonstrates robust accuracy and discrimination. Both GBM and …
View article: 3D-Printed Composite Bioceramic Scaffolds for Bone and Cartilage Integrated Regeneration
3D-Printed Composite Bioceramic Scaffolds for Bone and Cartilage Integrated Regeneration Open
Osteoarthritis may result in both cartilage and subchondral bone damage. It is a significant challenge to simultaneously repair cartilage due to the distinct biological properties between cartilage and bone. Here, strontium copper tetrasil…
View article: 3D-printed scaffold harboring copper ions combined with near-infrared irradiation for local therapy of cancer
3D-printed scaffold harboring copper ions combined with near-infrared irradiation for local therapy of cancer Open
Cancer is a major health threat and a leading cause of human death worldwide. Surgical resection is the primary treatment for most cancers; however, some patients develop locoregional recurrence. Here, we developed an in situ cancer therap…
View article: Three-Dimensional Printing Multi-Drug Delivery Core/Shell Fiber Systems with Designed Release Capability
Three-Dimensional Printing Multi-Drug Delivery Core/Shell Fiber Systems with Designed Release Capability Open
A hydrogel system with the ability to control the delivery of multiple drugs has gained increasing interest for localized disease treatment and tissue engineering applications. In this study, a triple-drug-loaded model based on a core/shel…
View article: 3D printed hollow channeled hydrogel scaffolds with antibacterial and wound healing activities
3D printed hollow channeled hydrogel scaffolds with antibacterial and wound healing activities Open
The development of hydrogel based scaffold with the capability of enhanced antibacterial effects and wound healing is the promising strategy for the treatment of wound tissues with bacterial infection. Herein, we fabricated a hollow channe…
View article: Single-Cell Transcriptome Comparison of Bladder Cancer Reveals Its Ecosystem
Single-Cell Transcriptome Comparison of Bladder Cancer Reveals Its Ecosystem Open
Bladder carcinoma (BLCA) is a highly heterogeneous disease, and the underlying biological behavior is still poorly understood. Here, single-cell RNA sequencing was performed on four clinical samples of different grades from three patients,…
View article: 3D Printed Wesselsite Nanosheets Functionalized Scaffold Facilitates NIR‐II Photothermal Therapy and Vascularized Bone Regeneration
3D Printed Wesselsite Nanosheets Functionalized Scaffold Facilitates NIR‐II Photothermal Therapy and Vascularized Bone Regeneration Open
Various bifunctional scaffolds have recently been developed to address the reconstruction of tumor‐initiated bone defects. Such scaffolds are usually composed of a near‐infrared (NIR) photothermal conversion agent and a conventional bone s…
View article: The Effects of Antioxidant Supplements on the Inflammatory Gene Expression of Osteoarthritis-Like Chondrocytes
The Effects of Antioxidant Supplements on the Inflammatory Gene Expression of Osteoarthritis-Like Chondrocytes Open
Osteoarthritis patients often experience pain and inflammation in joints. To understand whether antioxidant supplements could reduce inflammation and could potentially be applied for osteoarthritis treatment, vitamin E and resveratrol were…
View article: PhotoactivatedH2 Nanogenerator for EnhancedChemotherapy of Bladder Cancer
PhotoactivatedH2 Nanogenerator for EnhancedChemotherapy of Bladder Cancer Open
Hydrogen
gas can mitigate oxidative stress in many diseases and
is regarded to be safe and free of side effects. Inspired by a metalloenzyme
in a variety of microorganisms, here, we propose a photoactivated
H2 nanogenerator that comprises …
View article: Identification of Microenvironment-Related Prognostic Genes in Bladder Cancer Based on Gene Expression Profile
Identification of Microenvironment-Related Prognostic Genes in Bladder Cancer Based on Gene Expression Profile Open
Background and Objective: Bladder cancer is the most common tumor in the urinary system, with a higher incidence in men than in women and a high recurrence rate. However, the mechanism of recurrence is still unclear, and it is urgent to cl…