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View article: Endothelial Dysfunction Contributes to Chondrocyte Senescence Associated With Insulin‐Like Growth Factor‐Binding Protein‐6 in a Spontaneously Hypertensive Rat Model
Endothelial Dysfunction Contributes to Chondrocyte Senescence Associated With Insulin‐Like Growth Factor‐Binding Protein‐6 in a Spontaneously Hypertensive Rat Model Open
Background Given an epidemiological association between hypertension and osteoarthritis, we aim to elucidate how vascular pathology triggers avascular articular cartilage loss by comparing vascular and joint phenotypes between spontaneousl…
View article: Mesenchymal stem cell–derived small extracellular vesicles (sEVs) as a therapy for sepsis-related liver injury: evidence from a systematic review and meta-analysis
Mesenchymal stem cell–derived small extracellular vesicles (sEVs) as a therapy for sepsis-related liver injury: evidence from a systematic review and meta-analysis Open
Background Sepsis-induced liver injury (SILI) is critical in the progression of high morbidity and mortality associated with sepsis which ends in hepatic dysfunction and multi-organ failure. Mesenchymal stem cell–derived small extracellula…
View article: KnockRBP: an integrated multi-omics database of functional perturbation profiles for RNA-binding proteins
KnockRBP: an integrated multi-omics database of functional perturbation profiles for RNA-binding proteins Open
RNA-binding proteins (RBPs) regulate diverse post-transcriptional processes, yet their functional impacts across multiple molecular layers remain incompletely characterized. KnockRBP (https://knockrbp.xu-bioinfo.com) is presented as a comp…
View article: P3-GemOx as a novel immunochemotherapy candidate in NK/T-cell lymphoma management
P3-GemOx as a novel immunochemotherapy candidate in NK/T-cell lymphoma management Open
Introduction Natural killer/T-cell lymphoma (NKTL) is a rare disease that shows suboptimal responses to existing therapies. This study reports the efficacy of the P3-GemOx regimen compared to the traditional PP-GemOx regimen in advanced NK…
View article: Calcium signaling is required for anterior patterning in the mouse embryo
Calcium signaling is required for anterior patterning in the mouse embryo Open
Anterior–posterior axis formation in the mouse embryo requires the active migration of the DVE cell population at E5.5. While intracellular Ca 2+ signaling has been shown to control cell migration in multiple cell contexts, it is unknown w…
View article: Metal-decorated ceria-based reducible oxide catalysts for CO2 transformation
Metal-decorated ceria-based reducible oxide catalysts for CO2 transformation Open
(English) Noble metal clusters and single atoms have been considered as effective co-catalysts for the enhancement of carbon dioxide hydrogenation due to their singular geometric structures, electronic properties and unique reactivity. Nev…
View article: Incidence and predictive factors of urinary catheter reinsertion in cardiac surgery patients: A cross-sectional study in Nanning, China
Incidence and predictive factors of urinary catheter reinsertion in cardiac surgery patients: A cross-sectional study in Nanning, China Open
This study investigates the incidence and risk factors associated with the reinsertion of urinary catheters in post-cardiac surgery patients. Conducted at the Cardiac Surgery Ward of a university-affiliated hospital in Nanning, China, from…
View article: Comparative Analysis of 3D Culture Methodologies in Prostate Cancer Cells
Comparative Analysis of 3D Culture Methodologies in Prostate Cancer Cells Open
Three-dimensional (3D) cell culture models are increasingly utilized in cancer research to better replicate in vivo tumor microenvironments. This study examines the effects of different 3D scaffolding materials, including Matrigel, GelTrex…
View article: Adipogenic dedifferentiation enhances survival of human umbilical cord-derived mesenchymal stem cells under oxidative stress
Adipogenic dedifferentiation enhances survival of human umbilical cord-derived mesenchymal stem cells under oxidative stress Open
Mesenchymal stem cells (MSCs) serve as ideal candidates for a broad range of cell-based therapies. However, cell ageing caused by long-term in vitro expansion and poor survival after in vivo delivery greatly limits their success in preclin…
View article: Bibliometric analysis of global research status and trends of circadian rhythms in cancer from 2004 to 2024
Bibliometric analysis of global research status and trends of circadian rhythms in cancer from 2004 to 2024 Open
Research linking circadian dysregulation to cancer development has received increasing attention recently. However, a comprehensive understanding of research hotspots and trends in this area remains limited. International studies on the ci…
View article: Long Noncoding RNA–Messenger RNA (lncRNA–mRNA) Network in Resistance to Gummy Stem Blight (Stagonosporopsis cucurbitacearum) of Melon Plant Introduction (PI) 420145
Long Noncoding RNA–Messenger RNA (lncRNA–mRNA) Network in Resistance to Gummy Stem Blight (Stagonosporopsis cucurbitacearum) of Melon Plant Introduction (PI) 420145 Open
Gummy stem blight (GSB), caused by Stagonosporopsis cucurbitacearum (Didymella bryoniae), poses a growing threat to greenhouse melon production. Despite this, the defense mechanism of melon against S. cucurbitacearum remains poorly underst…
View article: Cardiocutaneous syndrome is caused by aggregation of iASPP mutants
Cardiocutaneous syndrome is caused by aggregation of iASPP mutants Open
The ASPP (apoptosis-stimulating protein of p53) family of proteins is involved in many cellular interactions and is starting to emerge as a major scaffolding hub for numerous proteins involved in cancer biology, inflammation and cellular i…
View article: Calcium signalling is required for anterior patterning in the mouse embryo
Calcium signalling is required for anterior patterning in the mouse embryo Open
Anterior-Posterior axis formation in the mouse embryo requires the active migration of the DVE cell population at E5.5. While intracellular Ca 2+ signalling has been shown to control cell migration in multiple cell contexts, it is unknown …
View article: Dormancy-inducing 3D engineered matrix uncovers mechanosensitive and drug-protective FHL2-p21 signaling axis
Dormancy-inducing 3D engineered matrix uncovers mechanosensitive and drug-protective FHL2-p21 signaling axis Open
Solid cancers frequently relapse with distant metastasis, despite local and systemic treatment. Cellular dormancy has been identified as an important mechanism underlying drug resistance enabling late relapse. Therefore, relapse from invis…
View article: FOXO1-mediated nuclear sequestration of STAT3 and AKT1 triggers FOXO3-dependent autophagic death in hypoxic granulosa cells
FOXO1-mediated nuclear sequestration of STAT3 and AKT1 triggers FOXO3-dependent autophagic death in hypoxic granulosa cells Open
FOXO proteins, especially FOXO1 and FOXO3, are recognized for their roles in controlling apoptosis and autophagy. Both apoptosis and autophagy have been induced in granulosa cells (GCs) by hypoxic conditions in ovarian follicles; however, …
View article: Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients
Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients Open
While cell‐free liquid biopsy (cfLB) approaches provide simple and inexpensive disease monitoring, cell‐based liquid biopsy (cLB) may enable additional molecular genetic assessment of systemic disease heterogeneity and preclinical model de…
View article: Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome
Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome Open
Pseudouridine (Ψ) is one of the most abundant modifications in cellular RNA. However, its function remains elusive, mainly due to the lack of highly sensitive and accurate detection methods. Here, we introduced 2-bromoacrylamide-assisted c…
View article: Independent and joint associations between urinary polycyclic aromatic hydrocarbon metabolites and cognitive function in older adults in the United States
Independent and joint associations between urinary polycyclic aromatic hydrocarbon metabolites and cognitive function in older adults in the United States Open
Background Polycyclic aromatic hydrocarbons (PAHs), as organic pollutants widely present in daily environments, have been shown by existing epidemiological studies to be significantly associated with deficits in learning and memory functio…
View article: Detecting Temporal shape changes with the Euler Characteristic Transform
Detecting Temporal shape changes with the Euler Characteristic Transform Open
Organoids are multi-cellular structures that are cultured in vitro from stem cells to resemble specific organs (e.g., brain, liver) in their three-dimensional composition. Dynamic changes in the shape and composition of these model systems…
View article: Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment
Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment Open
Hypoxia signaling influences tumor development through both cell-intrinsic and -extrinsic pathways. Inhibiting hypoxia-inducible factor (HIF) function has recently been approved as a cancer treatment strategy. Hence, it is important to und…
View article: Diagnostic strategy of metagenomic next-generation sequencing for gram negative bacteria in respiratory infections
Diagnostic strategy of metagenomic next-generation sequencing for gram negative bacteria in respiratory infections Open
Objective This study aims to identify the most effective diagnostic method for distinguishing pathogenic and non-pathogenic Gram-negative bacteria (GNB) in suspected pneumonia cases using metagenomic next-generation sequencing (mNGS) on br…
View article: Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome
Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome Open
Pseudouridine (Ψ) is one of the most abundant modifications in cellular RNA. However, its function remains elusive, mainly due to the lack of highly sensitive and accurate detection methods. To address this challenge, we introduced 2-bromo…
View article: OGC O06 Long term outcomes of immune checkpoint inhibition in oesophageal cancer
OGC O06 Long term outcomes of immune checkpoint inhibition in oesophageal cancer Open
Background Phase III studies have shown a survival benefit for the addition of immune checkpoint inhibitors (ICIs) to conventional chemotherapy for patients with gastro-oesophageal cancer. Large scale studies of chemo-immunotherapy prior t…
View article: ASPP2 binds to hepatitis C virus NS5A protein via an SH3 domain/PxxP motif-mediated interaction and potentiates infection
ASPP2 binds to hepatitis C virus NS5A protein via an SH3 domain/PxxP motif-mediated interaction and potentiates infection Open
Hepatitis C virus (HCV) infects millions of people worldwide and is a leading cause of liver disease. Despite recent advances in antiviral therapies, viral resistance can limit drug efficacy and understanding the mechanisms that confer vir…
View article: Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution
Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution Open
Somatic driver mutations, in genes such as FBXW7, have been discovered in phenotypically normal colonic tissue, however their role in cancer initiation remains elusive. Using normal and gene-edited patient-derived human colon organoids as …