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View article: Boosting the cellulolytic oxidative and hydrolytic enzyme systems in Myceliophthora thermophila for the efficient enzymatic saccharification of lignocellulosic biomass
Boosting the cellulolytic oxidative and hydrolytic enzyme systems in Myceliophthora thermophila for the efficient enzymatic saccharification of lignocellulosic biomass Open
The thermophilic fungus Myceliophthora thermophila serves as a vital platform for producing cellulolytic complex enzymes. However, their efficiency still requires enhancement to meet the cost-effective demands of lignocellulosic biomass co…
View article: Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal
Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal Open
By integrating spatial multi-omics with rational nanocarrier design, we designed a glutamine-functionalized liposomal system that exploits ASCT2 overexpression for tumor-selective accumulation of LND. Our findings revealed that this nanoag…
View article: Engineered sulfur and iron nanoparticles enhance cotton tolerance to lead stress via distinct molecular and physiological strategies
Engineered sulfur and iron nanoparticles enhance cotton tolerance to lead stress via distinct molecular and physiological strategies Open
View article: Mechanical responses of triply periodic minimal surface gyroid lattice structures fabricated by binder jetting additive manufacturing
Mechanical responses of triply periodic minimal surface gyroid lattice structures fabricated by binder jetting additive manufacturing Open
Lattice structures with triply periodic minimal surface (TPMS) are promising in many applications, such as bone implantation and aerospace field. The binder jetting (BJ) additive manufacturing technique offers advantages such as low cost a…
View article: Central nervous system infection with Hantavirus in a solid organ transplant patient
Central nervous system infection with Hantavirus in a solid organ transplant patient Open
View article: Engineering a non-oxidative glycolysis pathway in escherichia coli for high-level citramalate production
Engineering a non-oxidative glycolysis pathway in escherichia coli for high-level citramalate production Open
View article: Nuclear miR-451a activates KDM7A and leads to cetuximab resistance in head and neck squamous cell carcinoma
Nuclear miR-451a activates KDM7A and leads to cetuximab resistance in head and neck squamous cell carcinoma Open
View article: Mechanical Responses of Triply Periodic Minimal Surface Gyroid Lattice Structures Fabricated by Binder Jetting Additive Manufacturing
Mechanical Responses of Triply Periodic Minimal Surface Gyroid Lattice Structures Fabricated by Binder Jetting Additive Manufacturing Open
View article: Cancer‐targeting carbon quantum dots synthesized by plasma electrochemical method for red‐light‐activated photodynamic therapy
Cancer‐targeting carbon quantum dots synthesized by plasma electrochemical method for red‐light‐activated photodynamic therapy Open
Cancer‐targeting carbon quantum dots (CQDs) with red‐light absorption/emission featuring inherent biological functionality and deep biological penetration depth are promising for biomedical applications. However, traditional high‐temperatu…
View article: Development of an efficient protein expression system in the thermophilic fungus Myceliophthora thermophila
Development of an efficient protein expression system in the thermophilic fungus Myceliophthora thermophila Open
View article: FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner
FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner Open
Taken together, our data favored that FUNDC1 promoted hepatocyte injury through GPx4 binding to facilitate its mitochondrial translocation through TOM/TIM complex, where GPx4 was degraded by mitophagy to trigger ferroptosis. Targeting FUND…
View article: Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF‐1α
Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF‐1α Open
Tumour cells under hypoxia tend to modulate the number and contents of extracellular vesicles (EVs) to regulate the tumour microenvironment (TME) and thus promote tumour progression. However, the mechanism of how hypoxia influences the sec…
View article: Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages Open
Background Osteoarthritis (OA) is a common joint disorder worldwide which causes great health and economic burden. However, there remains an unmet goal to develop an effective therapeutic method to prevent or delay OA. Chondrocytes, as the…
View article: Clinical evaluation of fenestration decompression combined with secondary curettage for ameloblastoma of the jaw: retrospective radiographic analysis
Clinical evaluation of fenestration decompression combined with secondary curettage for ameloblastoma of the jaw: retrospective radiographic analysis Open
View article: The genome of homosporous maidenhair fern sheds light on the euphyllophyte evolution and defences
The genome of homosporous maidenhair fern sheds light on the euphyllophyte evolution and defences Open
View article: A novel CREB5/TOP1MT axis confers cisplatin resistance through inhibiting mitochondrial apoptosis in head and neck squamous cell carcinoma
A novel CREB5/TOP1MT axis confers cisplatin resistance through inhibiting mitochondrial apoptosis in head and neck squamous cell carcinoma Open
View article: Additional file 2 of A novel CREB5/TOP1MT axis confers cisplatin resistance through inhibiting mitochondrial apoptosis in head and neck squamous cell carcinoma
Additional file 2 of A novel CREB5/TOP1MT axis confers cisplatin resistance through inhibiting mitochondrial apoptosis in head and neck squamous cell carcinoma Open
Additional file 2. The images of the original, uncropped gels/blots.
View article: Cancer-associated Fibroblast-derived IL-6 Promotes Head and Neck Cancer Progression via the Osteopontin-NF-kappa B Signaling Pathway: Erratum
Cancer-associated Fibroblast-derived IL-6 Promotes Head and Neck Cancer Progression via the Osteopontin-NF-kappa B Signaling Pathway: Erratum Open
[This corrects the article DOI: 10.7150/thno.22182.].
View article: MAL suppresses OSCC tumorigenesis by maintaining epithelial cell differentiation
MAL suppresses OSCC tumorigenesis by maintaining epithelial cell differentiation Open
Oral squamous cell carcinoma (OSCC) is widely recognized as an optimal model for precise medicine guided molecular biomarkers of cancer, however, few clinical practices were applied till now. Based on the data from our own studies and publ…
View article: Two-level Bayesian interaction analysis for survival data incorporating pathway information
Two-level Bayesian interaction analysis for survival data incorporating pathway information Open
Genetic interactions play an important role in the progression of complex diseases, providing explanation of variations in disease phenotype missed by main genetic effects. Comparatively, there are fewer investigations on prognostic surviv…
View article: Identification and Confirmation of the miR-30 Family as a Potential Central Player in Tobacco-Related Head and Neck Squamous Cell Carcinoma
Identification and Confirmation of the miR-30 Family as a Potential Central Player in Tobacco-Related Head and Neck Squamous Cell Carcinoma Open
Constituents of tobacco that can cause DNA adduct formation and oxidative stress are implicated in the development of head and neck squamous cell carcinoma (HNSCC). However, there are few studies on the mechanism(s) that underlie tobacco-a…
View article: Sugars promote graft union development in the heterograft of cucumber onto pumpkin
Sugars promote graft union development in the heterograft of cucumber onto pumpkin Open
The use of heterografts is widely applied for the production of several important commercial crops, but the molecular mechanism of graft union formation remains poorly understood. Here, cucumber grafted onto pumpkin was used to study graft…
View article: lncRNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5
lncRNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5 Open
View article: Synthesis of Yellow-Fluorescent Carbon Nano-dots by Microplasma for Imaging and Photocatalytic Inactivation of Cancer Cells
Synthesis of Yellow-Fluorescent Carbon Nano-dots by Microplasma for Imaging and Photocatalytic Inactivation of Cancer Cells Open
View article: Oral cancer cell‑derived exosomes modulate natural killer cell activity by regulating the receptors on these cells
Oral cancer cell‑derived exosomes modulate natural killer cell activity by regulating the receptors on these cells Open
Oral cancer (OC) is the most common type of head and neck malignant tumor. Tumor‑derived exosomes induce a complex extracellular environment that affects tumor immunity. In the present study, exosomes were isolated from OC cell lines (WSU‑…
View article: Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner
Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner Open
Our finding suggested that Cur rescued against DOX-induced cardiac injury probably through regulation of autophagy and pyroptosis in a mTOR-dependent manner.
View article: Identification of key genes in head and neck squamous cell carcinoma microenvironment based on gene expression profile
Identification of key genes in head and neck squamous cell carcinoma microenvironment based on gene expression profile Open
Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent malignancy worldwide with high incidence and mortality. Recently, it has been well established that tumor microenvironment (TME) is intimately associate…
View article: A genome-wide survey of copy number variations reveals an asymmetric evolution of duplicated genes in rice
A genome-wide survey of copy number variations reveals an asymmetric evolution of duplicated genes in rice Open
Background Copy number variations (CNVs) are an important type of structural variations in the genome that usually affect gene expression levels by gene dosage effect. Understanding CNVs as part of genome evolution may provide insights int…
View article: <p>A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma</p>
A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma Open
Our results demonstrate that SPINK5/LEKTI might be a tumor suppressor in HNSCCs and serve as an independent prognostic predictor for HNSCC patients.
View article: Comprehensive analysis of transcriptome data for identifying biomarkers and therapeutic targets in head and neck squamous cell carcinoma
Comprehensive analysis of transcriptome data for identifying biomarkers and therapeutic targets in head and neck squamous cell carcinoma Open
We performed an integrated and comprehensive bioinformatics analysis of miRNAs and mRNAs in HNSCC, contributing to explore the underlying regulatory mechanisms and to identify genetic biomarkers and therapeutic targets for HNSCC.