Xiangfu Zhong
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View article: Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia
Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia Open
View article: Targeting Dysregulated Epigenetic and Transcription Factor Networks in KMT2A-Rearranged AML Using iPSC Models
Targeting Dysregulated Epigenetic and Transcription Factor Networks in KMT2A-Rearranged AML Using iPSC Models Open
View article: MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response
MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response Open
View article: Diphtheria Toxoid-Derived T-Helper Epitope and α-galactosylceramide Synergistically Enhance the Immunogenicity of Glycopeptide Antigen
Diphtheria Toxoid-Derived T-Helper Epitope and α-galactosylceramide Synergistically Enhance the Immunogenicity of Glycopeptide Antigen Open
The tumor-associated antigen MUC1 is an attractive target for immunotherapy, however, its weak immunogenicity limits the induction of antitumor immune responses. To overcome this limitation, in this study, MUC1 glycopeptide was covalently …
View article: New antibiotic against multi-drug resistant bacteria
New antibiotic against multi-drug resistant bacteria Open
View article: The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia Open
View article: The limits of human microRNA annotation have been met
The limits of human microRNA annotation have been met Open
Over the last few years, the number of microRNAs in the human genome has become a controversially debated issue. Several publications reported thousands of putative novel microRNAs not included in the curated microRNA gene database MirGene…
View article: MirGeneDB 2.1: toward a complete sampling of all major animal phyla
MirGeneDB 2.1: toward a complete sampling of all major animal phyla Open
We describe an update of MirGeneDB, the manually curated microRNA gene database. Adhering to uniform and consistent criteria for microRNA annotation and nomenclature, we substantially expanded MirGeneDB with 30 additional species represent…
View article: MicroRNA Expression Differences in Blood-Derived CD19+ B Cells of Methotrexate Treated Rheumatoid Arthritis Patients
MicroRNA Expression Differences in Blood-Derived CD19+ B Cells of Methotrexate Treated Rheumatoid Arthritis Patients Open
Rheumatoid arthritis (RA) is a complex disease with a wide range of underlying susceptibility factors. Recently, dysregulation of microRNAs (miRNAs) in RA have been reported in several immune cell types from blood. However, B cells have no…
View article: An extension to: Systematic assessment of commercially available low-input miRNA library preparation kits
An extension to: Systematic assessment of commercially available low-input miRNA library preparation kits Open
High-throughput sequencing has emerged as the favoured method to study microRNA (miRNA) expression, but biases introduced during library preparation have been reported. We recently compared the performance (sensitivity, reliability, titrat…
View article: An extension to: Systematic assessment of commercially available low-input miRNA library preparation kits
An extension to: Systematic assessment of commercially available low-input miRNA library preparation kits Open
High-throughput sequencing has emerged as the favoured method to study microRNA (miRNA) expression, but biases introduced during library preparation have been reported. To assist researchers choose the most appropriate library preparation …
View article: An extension to: Systematic assessment of commercially available low-input miRNA library preparation kits
An extension to: Systematic assessment of commercially available low-input miRNA library preparation kits Open
High-throughput sequencing has emerged as the favoured method to study microRNA (miRNA) expression, but biases introduced during library preparation have been reported. We recently compared the performance (sensitivity, reliability, titrat…
View article: Improving the understanding of mammalian microRNAs: from annotation, isomiR and function
Improving the understanding of mammalian microRNAs: from annotation, isomiR and function Open
MicroRNAs (miRNAs) are a class of small non-coding RNAs, ~22nt. They have extensive roles in gene expression regulation, fine-tuning a wide range of biological processes. Next-generation sequencing is currently a widely used approach to st…
View article: Jasmine: a Java pipeline for isomiR characterization in miRNA-Seq data
Jasmine: a Java pipeline for isomiR characterization in miRNA-Seq data Open
Motivation The existence of complex subpopulations of miRNA isoforms, or isomiRs, is well established. While many tools exist for investigating isomiR populations, they differ in how they characterize an isomiR, making it difficult to comp…
View article: Accurate Adapter Information Is Crucial for Reproducibility and Reusability in Small RNA Seq Studies
Accurate Adapter Information Is Crucial for Reproducibility and Reusability in Small RNA Seq Studies Open
A necessary pre-processing data analysis step is the removal of adapter sequences from the raw reads. While most adapter trimming tools require adapter sequence as an essential input, adapter information is often incomplete or missing. Thi…
View article: Systematic assessment of commercially available low-input miRNA library preparation kits
Systematic assessment of commercially available low-input miRNA library preparation kits Open
High-throughput sequencing is increasingly favoured to assay the presence and abundance of microRNAs (miRNAs) in biological samples, even from low RNA amounts, and a number of commercial vendors now offer kits that allow miRNA sequencing f…
View article: Systematic assessment of commercially available low-input miRNA library preparation kits
Systematic assessment of commercially available low-input miRNA library preparation kits Open
High-throughput sequencing is increasingly favoured to assay the presence and abundance of micro RNAs (miRNAs) in biological samples, even from low RNA amounts, and a number of commercial vendors now offer kits that allow miRNA sequencing …
View article: miRBaseMiner, a tool for investigating miRBase content
miRBaseMiner, a tool for investigating miRBase content Open
microRNAs are small non-coding RNA molecules playing a central role in gene regulation. miRBase is the standard reference source for analysis and interpretation of experimental studies. However, the richness and complexity of the annotatio…
View article: Systematic assessment of commercially available low-input miRNA library preparation kits
Systematic assessment of commercially available low-input miRNA library preparation kits Open
High-throughput sequencing is increasingly favoured to assay the presence and abundance of microRNAs (miRNAs) in biological samples, even from low RNA amounts, and a number of commercial vendors now offer kits that allow miRNA sequencing f…
View article: miRAW: A deep learning-based approach to predict microRNA targets by analyzing whole microRNA transcripts
miRAW: A deep learning-based approach to predict microRNA targets by analyzing whole microRNA transcripts Open
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to partially complementary regions within the 3'UTR of their target genes. Computational methods play an important role in target prediction and assume t…
View article: Research on Ultrasonic Vibration Rolling of Aluminum Alloy
Research on Ultrasonic Vibration Rolling of Aluminum Alloy Open
View article: miRAW: A deep learning approach to predict miRNA targets by analyzing whole miRNA transcripts
miRAW: A deep learning approach to predict miRNA targets by analyzing whole miRNA transcripts Open
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to partially complementary regions within the ’UTR of their target genes. Computational methods play an important role in target prediction and assume th…