Xianggui Yang
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View article: Exploring nagZ as a virulence biomarker and treatment target in Enterobacter cloacae
Exploring nagZ as a virulence biomarker and treatment target in Enterobacter cloacae Open
These findings underscore the crucial role of nagZ in E. cloacae pathogenesis and highlight its potential as a novel therapeutic target for treating infections caused by this pathogen.
View article: Approach of Dynamic Simulation and Optimization for Coevolutionary Intelligent Manufacturing Cell in Digital Twin
Approach of Dynamic Simulation and Optimization for Coevolutionary Intelligent Manufacturing Cell in Digital Twin Open
In real manufacturing industry, the timely identification of weaknesses and precise determination of optimization areas are crucial for efficient workshop production. Traditional plant simulation methods have been widely employed to suppor…
View article: NagZ modulates the virulence of <i>E. cloacae</i> by acting through the gene of unknown function, ECL_03795
NagZ modulates the virulence of <i>E. cloacae</i> by acting through the gene of unknown function, ECL_03795 Open
β-N-acetylglucosaminidase (NagZ), a cytosolic glucosaminidase, plays a pivotal role in peptidoglycan recycling. Previous research demonstrated that NagZ knockout significantly eradicated AmpC-dependent β-lactam resistance in Enterobacte…
View article: PCT, IL-6, and IL-10 facilitate early diagnosis and pathogen classifications in bloodstream infection
PCT, IL-6, and IL-10 facilitate early diagnosis and pathogen classifications in bloodstream infection Open
Background In the diagnosis of bloodstream infection (BSI), various inflammatory markers such as C-reactive protein (CRP), procalcitonin (PCT), interleukins (IL), white blood cell count (WBC), neutrophil percentage (NE%), platelet count (P…
View article: TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection
TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection Open
Background An essential fact underlying the severity of Staphylococcus aureus ( S. aureus ) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane recepto…
View article: Resistance of <i>Klebsiella pneumoniae</i> to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure
Resistance of <i>Klebsiella pneumoniae</i> to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure Open
Multidrug-resistant (MDR) Klebsiella pneumoniae strains pose a particular threat to human health. Therefore, it is very important for us to isolate phage and overcome phage resistance.
View article: Application of Single-Cell Genomics in Cardiovascular Research
Application of Single-Cell Genomics in Cardiovascular Research Open
Cardiovascular diseases (CVDs) are the leading cause of death in the global world. The emergence of single-cell technologies has greatly facilitated the research on CVDs. Currently, those single-cell technologies have been widely applied i…
View article: Blockchain-Based Process Quality Data Sharing Platform for Aviation Suppliers
Blockchain-Based Process Quality Data Sharing Platform for Aviation Suppliers Open
Given the challenge of manufacturing data silos and information credibility issues in traditional aviation suppliers’ result-oriented management approach, this paper proposes a blockchain-based aviation supplier manufacturing process quali…
View article: Cefazolin and imipenem enhance AmpC expression and resistance in NagZ-dependent manner in Enterobacter cloacae complex
Cefazolin and imipenem enhance AmpC expression and resistance in NagZ-dependent manner in Enterobacter cloacae complex Open
View article: Time to Positivity Facilitates an Early Differential Diagnosis of Candida tropicalis from Other Candida species
Time to Positivity Facilitates an Early Differential Diagnosis of Candida tropicalis from Other Candida species Open
TTP can be employed to early distinguish C. tropicalis from other Candida species in patients with candidemia, which is extremely helpful to initiate empiric antifungal treatments to improve clinical outcomes.
View article: Cefazolin and Imipenem Enhance AmpC Expression and Resistance in NagZ-Dependent Manner in Enterobacter Cloacae
Cefazolin and Imipenem Enhance AmpC Expression and Resistance in NagZ-Dependent Manner in Enterobacter Cloacae Open
Background: Enterobacter cloacae (EC) is a commonly occurring opportunistic pathogen and is responsible for causing various infections in humans. Owing to its inducible chromosomal AmpC β-lactamase (AmpC), EC is inherently resistant to the…
View article: Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene
Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene Open
Hypervirulent Klebsiella pneumoniae (hvKp), one of the major community-acquired pathogens, can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of K. pneumoniae , but the char…
View article: <i>Wzc</i>and<i>WcaJ</i>mutations in hypervirulent<i>Klebsiella pneumoniae</i>lead to phage resistance at the cost of reduced virulence
<i>Wzc</i>and<i>WcaJ</i>mutations in hypervirulent<i>Klebsiella pneumoniae</i>lead to phage resistance at the cost of reduced virulence Open
Hypervirulent Klebsiella pneumoniae (hvKp) is one of the major community-acquired pathogens, which can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of Klebsiella pneumonia…
View article: Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression
Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression Open
Background Candida tropicalis ( C. tropicalis ) is an important opportunistic pathogenic Candida species that can cause nosocomial infection. In this study, we analyzed the distribution and drug susceptibility of C. tropicalis and the rela…
View article: Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression
Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression Open
Background: Candida tropicalis ( C. tropicalis ) is an important opportunistic pathogenic Candida species that can cause nosocomial infection. In this study, we analyzed the distribution and drug susceptibility of C. tropicalis and the rel…
View article: Thymosin β10 promotes tumor-associated macrophages M2 conversion and proliferation via the PI3K/Akt pathway in lung adenocarcinoma
Thymosin β10 promotes tumor-associated macrophages M2 conversion and proliferation via the PI3K/Akt pathway in lung adenocarcinoma Open
View article: Thymosin β10 promotes tumor-associated macrophages M2 conversion and proliferation via the PI3K/Akt pathway in lung adenocarcinoma
Thymosin β10 promotes tumor-associated macrophages M2 conversion and proliferation via the PI3K/Akt pathway in lung adenocarcinoma Open
Background: Thymosin β10 (TMSB10) has been reported to play a protumorigenic role in a majority of solid cancers. However, the existence of TMSB10 in immune microenvironment may contribute to the pathogenesis of lung adenocarcinoma has not…
View article: Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression
Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression Open
Background: Candida tropicalis ( C. tropicalis ) is an important opportunistic pathogenic Candida species that can cause nosocomial infection. In this study, we analyzed the distribution and drug susceptibility of C. tropicalis and the rel…
View article: Elevating NagZ Improves Resistance to β-Lactam Antibiotics via Promoting AmpC β-Lactamase in Enterobacter cloacae
Elevating NagZ Improves Resistance to β-Lactam Antibiotics via Promoting AmpC β-Lactamase in Enterobacter cloacae Open
Enterobacter cloacae complex (ECC), one of the most common opportunistic pathogens causing multiple infections in human, is resistant to β-lactam antibiotics mainly due to its highly expressed chromosomal AmpC β-lactamase. It seems …
View article: Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression
Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression Open
Objective This study analyzed the distribution and drug susceptibility of Candida tropicalis ( C. tropicalis ) and the relationship between ERG11 and UPC2 expression and resistance to azole antifungal agents. Methods C. tropicalis was cult…
View article: Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression
Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression Open
Objective This study analyzed the distribution and drug resistance of Candida tropicalis ( C. tropicalis ) and the relationship between ERG11 and UPC2 expression and resistance to azole antifungal agents. Methods C. tropicalis was cultured…
View article: Candida tropicalis distribution and drug resistance correlated to ERG11 and UPC2 expression
Candida tropicalis distribution and drug resistance correlated to ERG11 and UPC2 expression Open
Objective: This study is to analyze the distribution characteristics and drug resistance of Candida tropicalis, and the relationship between ERG11 and UPC2 expression and the resistance to azole.Methods: The Candida tropicalis were culture…
View article: Antimicrobial susceptibility testing of Enterobacteriaceae: determination of disk content and Kirby-Bauer breakpoint for ceftazidime/avibactam
Antimicrobial susceptibility testing of Enterobacteriaceae: determination of disk content and Kirby-Bauer breakpoint for ceftazidime/avibactam Open
View article: MicroRNA-135a is involved in podocyte injury in a transient receptor potential channel 1-dependent manner
MicroRNA-135a is involved in podocyte injury in a transient receptor potential channel 1-dependent manner Open
Transient receptor potential (TRP) cation channels are essential for normal cellular physiology, and their abnormal expression may lead to a number of disorders, including podocytopathy. Therefore, it is crucial to understand the mechanism…
View article: MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9
MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9 Open
Increasing evidence revealed that miRNAs, the vital regulators of gene expression, are involved in various cellular processes, including cell growth, differentiation, apoptosis and progression. In addition, miRNAs act as oncogenes and/or t…
View article: MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFβ signaling pathway
MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFβ signaling pathway Open
Over the last few decades, the epithelial-to-mesenchymal transition (EMT) has been identified as being involved in a number of aspects of physiological processes and various pathological events, including embryonic development and renal fi…
View article: miR-135 family members mediate podocyte injury through the activation of Wnt/β-catenin signaling
miR-135 family members mediate podocyte injury through the activation of Wnt/β-catenin signaling Open
The upregulation of Wnt/β-catenin signaling occurs in virtually all types of kidney disease and is associated with podocyte injury. However, the precise mechanisms involved in the development of kidney disease remain to be elucidated. Micr…