Xianding Wang
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View article: Comprehensive dietary patterns explain acquired cystic kidney disease risk through genetic and metabolomic mechanisms
Comprehensive dietary patterns explain acquired cystic kidney disease risk through genetic and metabolomic mechanisms Open
Background Acquired renal cysts (ARC) are associated with kidney function decline, necessitating novel dietary pattern (DP) analyses in large cohorts. Methods This UK Biobank prospective cohort study (2006–2010) included participants with …
View article: Allostatic load and kidney cancer incidence and mortality: a genetic susceptibility and proteomic mediation analysis
Allostatic load and kidney cancer incidence and mortality: a genetic susceptibility and proteomic mediation analysis Open
AL is associated with increased KC incidence and mortality, mediated through inflammatory and metabolic proteins. These findings underscore chronic physiological stress as a significant factor in KC pathogenesis, providing potential biomar…
View article: Evaluation of early donor renal function recovery after living-donor nephrectomy as a predictor of allograft failure after kidney transplantation: a longitudinal cohort and machine learning study
Evaluation of early donor renal function recovery after living-donor nephrectomy as a predictor of allograft failure after kidney transplantation: a longitudinal cohort and machine learning study Open
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View article: ERMAP attenuates DSS-induced colitis in mice by regulating macrophage and T cell functions
ERMAP attenuates DSS-induced colitis in mice by regulating macrophage and T cell functions Open
In summary, our results suggest that administration of ERMAP can protect DSS-induced colitis in mice by regulating T cell and macrophage functions. This study adds to the evidence for various mechanistic pathways associated to the pathogen…
View article: Which subtypes of degenerative lumbar spondylolisthesis are suitable for oblique lumbar interbody fusion? A retrospective study in China based on the clinical and radiographic degenerative spondylolisthesis classification
Which subtypes of degenerative lumbar spondylolisthesis are suitable for oblique lumbar interbody fusion? A retrospective study in China based on the clinical and radiographic degenerative spondylolisthesis classification Open
Study Design: Retrospective study.Purpose: To evaluate the radiological characteristics of degenerative lumbar spondylolisthesis (DS) and analyze the suitability of oblique lumbar interbody fusion (OLIF) for different DS subtypes. Overview…
View article: Engineering Smart Light-Triggered Bone-Targeting Nanocarriers for Promoting Bone Repair
Engineering Smart Light-Triggered Bone-Targeting Nanocarriers for Promoting Bone Repair Open
View article: Helicobacter pylori and hypertension-a cross-sectional study based on a healthy population
Helicobacter pylori and hypertension-a cross-sectional study based on a healthy population Open
Objective: In this study, we aimed to elucidate the potential association between H. pylori infection and the prevalence of hypertension in the Inner Mongolia population, while also exploring the impact of sex and age on the relationship b…
View article: Circulating levels of blood biomarkers and risk of benign prostatic hyperplasia: Results from two large cohorts in Europe and East Asia
Circulating levels of blood biomarkers and risk of benign prostatic hyperplasia: Results from two large cohorts in Europe and East Asia Open
This large prospective biomarker-based study highlights that high-density lipoprotein (HDL) cholesterol and apolipoprotein A are significant protective factors against the development of BPH, with L-shaped associations suggesting an optima…
View article: Risk for Donor-Derived Syphilis after Kidney Transplantation, China, 2007–2022
Risk for Donor-Derived Syphilis after Kidney Transplantation, China, 2007–2022 Open
To evaluate the risk of acquiring syphilis from a donated kidney, we evaluated kidney transplantation pairs from West China Hospital, Sichuan, China, during 2007-2022. Donor-derived syphilis was rare. Risk may be higher if donors have acti…
View article: Clinicopathologic characteristics and outcomes of prostate cancer incidentally discovered at the time of radical cystoprostatectomy: a population-based cohort study
Clinicopathologic characteristics and outcomes of prostate cancer incidentally discovered at the time of radical cystoprostatectomy: a population-based cohort study Open
Objective: This study aimed to comprehensively analyze the clinical characteristics and prognosis of patients with concomitant bladder cancer (BCa) and prostate cancer (PCa) using a large population-based database. Methods: Within the Surv…
View article: Discovery of a glucocorticoid receptor (GR) activity signature correlates with immune cell infiltration in adrenocortical carcinoma
Discovery of a glucocorticoid receptor (GR) activity signature correlates with immune cell infiltration in adrenocortical carcinoma Open
Background Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine malignancy, of which >40% present with glucocorticoid excess. Glucocorticoids and glucocorticoid receptor (GR) signaling have long been thought to suppress…
View article: 1018O Phase I study of GCC CAR-T therapy IM96 in patients with advanced colorectal cancer
1018O Phase I study of GCC CAR-T therapy IM96 in patients with advanced colorectal cancer Open
View article: Expanding the donor pool: Kidney transplantation from serum <scp>HBV DNA</scp> or <scp>HBeAg</scp>‐positive donors to <scp>HBsAg</scp>‐negative recipients
Expanding the donor pool: Kidney transplantation from serum <span>HBV DNA</span> or <span>HBeAg</span>‐positive donors to <span>HBsAg</span>‐negative recipients Open
Background & Aims HBsAg‐positive (HBsAg[+]) donors are rarely accepted for kidney transplantation (KT), especially when the donor is also HBV DNA‐positive (HBV DNA[+]) or HBeAg‐positive (HBeAg[+]) serologically. This study aimed to report …
View article: Psoriasis and risk of chronic kidney diseases: A population‐based cross‐sectional study and Mendelian randomization analysis
Psoriasis and risk of chronic kidney diseases: A population‐based cross‐sectional study and Mendelian randomization analysis Open
Background Conflicting results have been reported regarding the association between psoriasis and risk of chronic kidney diseases (CKD). Furthermore, the causal nature of the possible association remains unexplored. Methods We conducted a …
View article: A POPULATION‐BASED STUDY REVEALS THE UNIQUE CLINICAL CHARACTERISTICS AND LONG‐TERM SURVIVAL OF PATIENTS WITH GRAY ZONE LYMPHOMA
A POPULATION‐BASED STUDY REVEALS THE UNIQUE CLINICAL CHARACTERISTICS AND LONG‐TERM SURVIVAL OF PATIENTS WITH GRAY ZONE LYMPHOMA Open
Background: Gray zone lymphoma (GZL) is a rare disease entity with pathological features intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (HL). Given its rarity, a relative paucity of clinical data …
View article: A REAL‐WORLD STUDY OF CHIDAMIDE FOR PATIENTS WITH PERIPHERAL T‐CELL LYMPHOMA IN CHINA
A REAL‐WORLD STUDY OF CHIDAMIDE FOR PATIENTS WITH PERIPHERAL T‐CELL LYMPHOMA IN CHINA Open
Background: Peripheral T-cell lymphoma (PTCL) is featured with a poor survival outcome. Targeting histone deacetylases (HDACs) has become a novel treatment option for PTCL. Chidamide is the first oral selective HDAC inhibitor. Objective: T…
View article: Incidence, risk factors, and clinical outcomes of HBV reactivation in non-liver solid organ transplant recipients with resolved HBV infection: A systematic review and meta-analysis
Incidence, risk factors, and clinical outcomes of HBV reactivation in non-liver solid organ transplant recipients with resolved HBV infection: A systematic review and meta-analysis Open
Background Current guidelines do not recommend routine antiviral prophylaxis to prevent hepatitis B virus (HBV) reactivation in non-liver solid organ transplant (SOT) recipients with resolved HBV infection, even in anti-hepatitis B surface…
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View article: Supplementary Material for: Cognitive impairment is associated with new-onset stroke: evidence from a nationwide prospective cohort study
Supplementary Material for: Cognitive impairment is associated with new-onset stroke: evidence from a nationwide prospective cohort study Open
• Background and purpose: Stroke is closely related to cognitive function, and many patients experience cognitive impairment after stroke; however, whether cognitive impairment is associated with an increased risk of stroke remains inconcl…
View article: Supplementary Material for: Development and validation of a nomogram for predicting all-cause mortality in patients with hemodialysis having pulmonary hypertension
Supplementary Material for: Development and validation of a nomogram for predicting all-cause mortality in patients with hemodialysis having pulmonary hypertension Open
Introduction: Patients with end-stage renal disease receiving hemodialysis (HD) have a high morbidity and mortality rate associated with pulmonary hypertension (PH). A nomogram was developed to predict all-cause mortality in HD patients wi…
View article: Supplementary Material for: Development and validation of a nomogram for predicting all-cause mortality in patients with hemodialysis having pulmonary hypertension
Supplementary Material for: Development and validation of a nomogram for predicting all-cause mortality in patients with hemodialysis having pulmonary hypertension Open
Introduction: Patients with end-stage renal disease receiving hemodialysis (HD) have a high morbidity and mortality rate associated with pulmonary hypertension (PH). A nomogram was developed to predict all-cause mortality in HD patients wi…
View article: Supplementary Material for: Development and validation of a nomogram for predicting all-cause mortality in patients with hemodialysis having pulmonary hypertension
Supplementary Material for: Development and validation of a nomogram for predicting all-cause mortality in patients with hemodialysis having pulmonary hypertension Open
Introduction: Patients with end-stage renal disease receiving hemodialysis (HD) have a high morbidity and mortality rate associated with pulmonary hypertension (PH). A nomogram was developed to predict all-cause mortality in HD patients wi…
View article: Supplementary Material for: Development and validation of a nomogram for predicting all-cause mortality in patients with hemodialysis having pulmonary hypertension
Supplementary Material for: Development and validation of a nomogram for predicting all-cause mortality in patients with hemodialysis having pulmonary hypertension Open
Introduction: Patients with end-stage renal disease receiving hemodialysis (HD) have a high morbidity and mortality rate associated with pulmonary hypertension (PH). A nomogram was developed to predict all-cause mortality in HD patients wi…
View article: Serum uric acid as a risk factor for rejection after deceased donor kidney transplantation: A mono-institutional analysis of paired kidneys
Serum uric acid as a risk factor for rejection after deceased donor kidney transplantation: A mono-institutional analysis of paired kidneys Open
Background Deceased donor kidney transplantation (DDKT) is a major therapeutic option for patients with end-stage renal diseases. Although medical techniques improved in recent years, acute or chronic rejection after DDKT is not uncommon a…
View article: Macrophage-Specific Cathepsin as a Marker Correlated with Prognosis and Tumor Microenvironmental Characteristics of Clear Cell Renal Cell Carcinoma
Macrophage-Specific Cathepsin as a Marker Correlated with Prognosis and Tumor Microenvironmental Characteristics of Clear Cell Renal Cell Carcinoma Open
Macrophage-specific CTSZ was associated with activation of epithelial-to-mesenchymal transition, cell cycle signatures, and a higher infiltration level of B cells, macrophages, neutrophils, and dendritic cells in the tumor microenvironment…
View article: Clinicopathological characteristics and outcomes of synchronous renal cell carcinoma and urothelial carcinoma: A population-based analysis
Clinicopathological characteristics and outcomes of synchronous renal cell carcinoma and urothelial carcinoma: A population-based analysis Open
Background To better understand the characteristics, and survival outcomes of synchronous renal cell carcinoma (RCC) and urothelial carcinoma (UC), we described and analyzed the clinical features, factors, and prognosis of patients with sy…
View article: Cuprotosis-related signature predicts overall survival in clear cell renal cell carcinoma
Cuprotosis-related signature predicts overall survival in clear cell renal cell carcinoma Open
Background: Cuprotosis is a new form of programmed cell death induced by copper. We explored the correlation of cuprotosis with clear cell renal cell carcinoma (ccRCC) and constructed a cuprotosis-related signature to predict the prognosis…
View article: Transplant outcomes of 100 cases of living-donor ABO-incompatible kidney transplantation
Transplant outcomes of 100 cases of living-donor ABO-incompatible kidney transplantation Open
Background: Although ABO-incompatible (ABOi) kidney transplantation (KT) has been performed successfully, a standard preconditioning regimen has not been established. Based on the initial antidonor ABO antibody titers, an individualized pr…
View article: Identification of an amino acid metabolism-associated gene signature predicting the prognosis and immune therapy response of clear cell renal cell carcinoma
Identification of an amino acid metabolism-associated gene signature predicting the prognosis and immune therapy response of clear cell renal cell carcinoma Open
Background The upregulation of amino acid metabolism is an essential form of metabolic reprogramming in cancer. Here, we developed an amino acid metabolism signature to predict prognosis and anti-PD-1 therapy response in clear cell renal c…
View article: Cholecalciferol supplementation effectively improved tertiary hyperparathyroidism, FGF23 resistance and lowered coronary calcification score: a prospective study
Cholecalciferol supplementation effectively improved tertiary hyperparathyroidism, FGF23 resistance and lowered coronary calcification score: a prospective study Open
Introduction Tertiary hyperparathyroidism (THPT) and vitamin D deficiency are commonly seen in kidney transplant recipients, which may result in persistently elevated fibroblast growth factor 23 (FGF23) level after transplantation and decr…