Xiangjian Zhang
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View article: Prompts Generalize with Low Data: Non-vacuous Generalization Bounds for Optimizing Prompts with More Informative Priors
Prompts Generalize with Low Data: Non-vacuous Generalization Bounds for Optimizing Prompts with More Informative Priors Open
Many prompt engineering techniques have been successful in practice, even when optimizing over a large prompt space with with a small amount of task-specific data. Recent work has partially explained this success by showing generalization …
View article: Neuronal activity in the cortex of mice under anesthesia depend on the type of anesthetic drug
Neuronal activity in the cortex of mice under anesthesia depend on the type of anesthetic drug Open
View article: MoE-CE: Enhancing Generalization for Deep Learning based Channel Estimation via a Mixture-of-Experts Framework
MoE-CE: Enhancing Generalization for Deep Learning based Channel Estimation via a Mixture-of-Experts Framework Open
Reliable channel estimation (CE) is fundamental for robust communication in dynamic wireless environments, where models must generalize across varying conditions such as signal-to-noise ratios (SNRs), the number of resource blocks (RBs), a…
View article: Low-intensity transcranial ultrasound stimulation promotes the extinction of fear memory through the BDNF-TrkB signaling pathway
Low-intensity transcranial ultrasound stimulation promotes the extinction of fear memory through the BDNF-TrkB signaling pathway Open
Synaptic plasticity plays a crucial role in the extinction of fearful memories. Low-intensity transcranial ultrasound stimulation (TUS) can modulate synaptic plasticity and promote the extinction of fear memories. However, the mechanism by…
View article: Poliumoside alleviates microglia-mediated inflammation and blood-brain barrier disruption via modulating the polarization of microglia after ischemic stroke in mice
Poliumoside alleviates microglia-mediated inflammation and blood-brain barrier disruption via modulating the polarization of microglia after ischemic stroke in mice Open
Pol regulates microglial polarization in ischemic stroke by down-regulating JAK/STAT3 signaling pathway, alleviating the microglia-mediated inflammatory response and the destruction of blood-brain barrier.
View article: Melatonin Promotes Cerebral Angiogenesis in Ischemic Mice via BMP6/Smad1/5/9 Pathway
Melatonin Promotes Cerebral Angiogenesis in Ischemic Mice via BMP6/Smad1/5/9 Pathway Open
View article: Silibinin protects the ischemic brain in mice by exerting anti-apoptotic effects via the EGFR/ERK pathway
Silibinin protects the ischemic brain in mice by exerting anti-apoptotic effects via the EGFR/ERK pathway Open
Apoptosis is a significant occurrence of cell death in the cerebral ischemia process, potentially revealing specific treatment points. Silibinin (SIL) has been proven to regulate a range of biological effects on inflammation, oxidative str…
View article: 70P Optimizing second-line therapy for advanced gastrointestinal stromal tumors: Real-world efficacy and safety analysis
70P Optimizing second-line therapy for advanced gastrointestinal stromal tumors: Real-world efficacy and safety analysis Open
View article: Low-Intensity Pulsed Ultrasound Promotes Oligodendrocyte Maturation and Remyelination by Down-regulating the Interleukin-17A/Notch1 Signaling Pathway in Mice with Ischemic Stroke
Low-Intensity Pulsed Ultrasound Promotes Oligodendrocyte Maturation and Remyelination by Down-regulating the Interleukin-17A/Notch1 Signaling Pathway in Mice with Ischemic Stroke Open
Increasing evidence indicates that oligodendrocyte (OL) numbers and myelin as a dynamic cellular compartment perform a key role in the maintenance of neuronal function. Inhibiting white matter (WM) demyelination or promoting remyelination …
View article: Electrophysiological Mechanism of Catestatin Antiarrhythmia: Enhancement of <i>I</i> <sub>to</sub> , <i>I</i> <sub>K,</sub> and <i>I</i> <sub>K1</sub> and Inhibition of <i>I</i> <sub>Ca</sub> <sub>‐L</sub> in Rat Ventricular Myocytes
Electrophysiological Mechanism of Catestatin Antiarrhythmia: Enhancement of <i>I</i> <sub>to</sub> , <i>I</i> <sub>K,</sub> and <i>I</i> <sub>K1</sub> and Inhibition of <i>I</i> <sub>Ca</sub> <sub>‐L</sub> in Rat Ventricular Myocytes Open
Background Cardiovascular disease remains one of the leading causes of death globally. Myocardial ischemia and infarction, in particular, frequently cause disturbances in cardiac electrical activity that can trigger ventricular arrhythmias…
View article: STZ-induced diabetes exacerbates neurons ferroptosis after ischemic stroke by upregulating LCN2 in neutrophils
STZ-induced diabetes exacerbates neurons ferroptosis after ischemic stroke by upregulating LCN2 in neutrophils Open
Diabetic is a major contributor to the unfavorable prognosis of ischemic stroke. However, intensive hypoglycemic strategies do not improve stroke outcomes, implying that diabetes may affect stroke outcomes through other ways. Ferroptosis i…
View article: Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway
Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway Open
Salidroside can restore nerve function, improve cerebral blood flow, reduce cerebral infarction volume, increase microvessel density and promote angiogenesis via the Shh signaling pathway.
View article: Comprehensive analysis of ADGRE5 gene in human tumors: Clinical relevance, prognostic implications, and potential for personalized immunotherapy
Comprehensive analysis of ADGRE5 gene in human tumors: Clinical relevance, prognostic implications, and potential for personalized immunotherapy Open
View article: Table of Contents
Table of Contents Open
View article: Anisodine hydrobromide injection promotes neural remodeling and recovery after ischemic stroke in mice
Anisodine hydrobromide injection promotes neural remodeling and recovery after ischemic stroke in mice Open
Anisodine hydrobromide injection has shown promising therapeutic effects in treating patients with cerebral infarction, improving recovery of neurological function during the post-cerebral infarction period. However, the effects of anisodi…
View article: Risk Factors for Cervical Ipsilateral Lymph Node Metastasis in Papillary Thyroid Carcinoma
Risk Factors for Cervical Ipsilateral Lymph Node Metastasis in Papillary Thyroid Carcinoma Open
View article: Risk factors for cervical ipsilateral lymph node metastasis in papillary thyroid carcinoma
Risk factors for cervical ipsilateral lymph node metastasis in papillary thyroid carcinoma Open
Background: Papillary thyroid carcinoma (PTC)is the most common type of thyroid malignancy, characterized by slow progression, long survival, and low mortality rate. However, the cervical lymph node metastasis (CLNM) rate of PTC can reach …
View article: Th17 Cells and IL-17A in Ischemic Stroke
Th17 Cells and IL-17A in Ischemic Stroke Open
The neurological injury and repair mechanisms after ischemic stroke are complex. The inflammatory response is present throughout stroke onset and functional recovery, in which CD4 + T helper(Th) cells play a non-negligible role. Th17 cells…
View article: Eriocalyxin B alleviated ischemic cerebral injury by limiting microglia-mediated excessive neuroinflammation in mice
Eriocalyxin B alleviated ischemic cerebral injury by limiting microglia-mediated excessive neuroinflammation in mice Open
Excessive neuroinflammation mediated by microglia has a detrimental effect on the progression of ischemic stroke. Eriocalyxin B (EriB) was found with a neuroprotective effect in mice with Parkinson's disease via the suppression of microgli…
View article: Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway
Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway Open
This study explored the protective effect and mechanism of hydrogen‑rich saline (HRS) on the neurological function of mice with cerebral ischemia. Effects of HRS on neurological function in mice with cerebral ischemia were evaluated by neu…
View article: Sox17 protects human brain microvascular endothelial cells from AngII-induced injury by regulating autophagy and apoptosis
Sox17 protects human brain microvascular endothelial cells from AngII-induced injury by regulating autophagy and apoptosis Open
Intracranial aneurysm (IA), is a localized dilation of the intracranial arteries, the rupture of which is catastrophic. Hypertension is major IA risk factor that mediates endothelial cell damage. Sox17 is highly expressed in intracranial v…
View article: miR-100-5p activation of the autophagy response through inhibiting the mTOR pathway and suppression of cerebral infarction progression in mice
miR-100-5p activation of the autophagy response through inhibiting the mTOR pathway and suppression of cerebral infarction progression in mice Open
In recent years, the association between microRNAs (miRNAs) and autophagy in cerebral infarction (CI) has attracted increasingly more attention. The mammalian target of the rapamycin (mTOR) pathway is a key protein regulating the autophagy…
View article: Editorial: Therapeutic relevance and mechanisms of neuro-immune communication in brain injury
Editorial: Therapeutic relevance and mechanisms of neuro-immune communication in brain injury Open
EDITORIAL article Front. Cell. Neurosci., 01 August 2023Sec. Cellular Neuropathology Volume 17 - 2023 | https://doi.org/10.3389/fncel.2023.1209083
View article: Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPAR&delta;/SGLT2/STAT3 signaling pathway
Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARδ/SGLT2/STAT3 signaling pathway Open
Mounting evidence demonstrates that hydrogen sulfide (H 2S) promotes anti-inflammatory molecules and inhibits pro-inflammatory cytokines in endothelial cells (ECs). This study aims to investigate the favorable action of H 2…
View article: Hydrogen-Rich Saline—A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro
Hydrogen-Rich Saline—A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro Open
Background: Our previous research revealed that inflammation plays an important role in the pathophysiology of cerebral ischemia. The function of the NOD-like receptor protein 3 (NLRP3) inflammasome is to activate the inflammatory process.…
View article: Indocyanine green combined with methylene blue versus methylene blue alone for sentinel lymph node biopsy in breast cancer: a retrospective study
Indocyanine green combined with methylene blue versus methylene blue alone for sentinel lymph node biopsy in breast cancer: a retrospective study Open
Background Recent studies have shown that near-infrared (NIR) fluorescence imaging using Indocyanine green (ICG) may improve the efficiency of sentinel lymph node biopsy (SLNB). This study aimed to assess the effectiveness of the combinati…
View article: Sox17 Protects Human Brain Microvascular Endothelial Cells from AngII-induced Injury by Regulating Autophagy and Apoptosis
Sox17 Protects Human Brain Microvascular Endothelial Cells from AngII-induced Injury by Regulating Autophagy and Apoptosis Open
Intracranial aneurysm (IA), is a localized dilation of the intracranial arteries, the rupture of which is catastrophic. Hypertension is major IA risk factor that mediates endothelial cell damage. Sox17 is highly expressed in intracranial v…
View article: Indocyanine green combined with methylene blue versus methylene blue alone for sentinel lymph node biopsy in breast cancer: a retrospective study
Indocyanine green combined with methylene blue versus methylene blue alone for sentinel lymph node biopsy in breast cancer: a retrospective study Open
Background: Recent studies have shown that near-infrared (NIR) fluorescence imaging using Indocyanine green (ICG) may improve the efficiency of sentinel lymph node biopsy (SLNB). This study aimed to assess the effectiveness of the combinat…
View article: Geniposide protected against cerebral ischemic injury through the anti-inflammatory effect via the NF-κB signaling pathway
Geniposide protected against cerebral ischemic injury through the anti-inflammatory effect via the NF-κB signaling pathway Open
Context Accumulated evidence indicates that geniposide exhibits neuroprotective effects in ischemic stroke. However, the potential targets of geniposide remain unclear. Objective We explore the potential targets of geniposide in ischemic s…
View article: Atorvastatin alleviates oxidative damage by activating the nuclear factor erythroid 2-related factor 2 pathway after brain ischemia in mice
Atorvastatin alleviates oxidative damage by activating the nuclear factor erythroid 2-related factor 2 pathway after brain ischemia in mice Open
Atorvastatin exhibited an antioxidant activity by activating Nrf2 signaling pathway and activating autophagy, so as to protect the brain from damage caused by dMCAO.