Xiaofan Guo
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View article: Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection
Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection Open
Importance Fibromuscular dysplasia (FMD) is found in 6 to 14% of patients with spontaneous cervical artery dissection (SCEAD) and may be associated with recurrent SCEAD. Objective To evaluate the correlates of FMD in patients with SCEAD an…
View article: DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights
DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights Open
Background DNA G-quadruplexes (G4s) are non-canonical secondary structures formed in guanine-rich DNA sequences and play important roles in modulating biological processes through a variety of gene regulatory mechanisms. Emerging G4 profil…
View article: Health literacy model integrating health education, health behaviors, self-rated health, and socioeconomic status in the Chinese population
Health literacy model integrating health education, health behaviors, self-rated health, and socioeconomic status in the Chinese population Open
View article: Intensive Systolic Blood Pressure Reduction and Kidney and Cardiovascular Outcomes
Intensive Systolic Blood Pressure Reduction and Kidney and Cardiovascular Outcomes Open
Importance Intensive blood pressure (BP) control is effective in reducing major cardiovascular events. However, whether the reduction of systolic BP may lead to kidney injury remains controversial. Objective To elucidate the association of…
View article: Recent research advances in interleukin, microRNA and neuroendocrine tumor biomarkers (Review)
Recent research advances in interleukin, microRNA and neuroendocrine tumor biomarkers (Review) Open
The incidence of neuroendocrine tumors (NETs) has been increasing in recent years and most cases are not easily detected in the early stages. The diagnostic modalities used for NETs are currently limited due to the small number of individu…
View article: Correction: Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomalmitochondrial axis
Correction: Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomalmitochondrial axis Open
View article: Impact of health intervention coverage on reducing maternal mortality in 126 low- and middle-income countries: a Lives Saved Tool modelling study
Impact of health intervention coverage on reducing maternal mortality in 126 low- and middle-income countries: a Lives Saved Tool modelling study Open
View article: Correlation between mild cognitive impairment and flourishing among Chinese residents: a cross-sectional study
Correlation between mild cognitive impairment and flourishing among Chinese residents: a cross-sectional study Open
Objective This study aimed to investigate the correlation between mild cognitive impairment and flourishing among Chinese residents. Methods A total of 527 community residents aged ≥18 years were recruited from December 2023 to April 2024.…
View article: Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages
Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages Open
Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to d…
View article: Intravenous Thrombolysis in Cervical Artery Dissection–Related Stroke: A Nationwide Study
Intravenous Thrombolysis in Cervical Artery Dissection–Related Stroke: A Nationwide Study Open
Background Although intravenous thrombolysis (IVT) is safe and effective in populations with general stroke, its impact on cervical artery dissection–related acute ischemic stroke (CeAD‐AIS) remains unclear. This retrospective study used t…
View article: Revolutionising Dual Therapy: Biodegradable Polymers for Sustained Metformin and Alendronate Delivery in Chronic Illness Management
Revolutionising Dual Therapy: Biodegradable Polymers for Sustained Metformin and Alendronate Delivery in Chronic Illness Management Open
View article: Cost-Effectiveness of Intensive Blood Pressure Management Led by Non-physician Community Healthcare Providers in Rural China: Findings from China Rural Hypertension Control Project
Cost-Effectiveness of Intensive Blood Pressure Management Led by Non-physician Community Healthcare Providers in Rural China: Findings from China Rural Hypertension Control Project Open
View article: Impact of scaling up health intervention coverage on reducing maternal mortality in 26 low- and middle-income countries: A modelling study
Impact of scaling up health intervention coverage on reducing maternal mortality in 26 low- and middle-income countries: A modelling study Open
Scaling up the coverage of health interventions is critical for reducing MMRs. If a substantial scale-up or scaling up to universal coverage of continuous maternity interventions from preconception to postpartum period can be achieved, LMI…
View article: The relationship between leisure activity participation and cognitive function among older Chinese adults: the differences across gender and age
The relationship between leisure activity participation and cognitive function among older Chinese adults: the differences across gender and age Open
View article: Abstract 458: Utilizing Transcranial Doppler in the Diagnosis of Cervical Artery Dissection: Insights from a Multicenter Survey within the STOP‐CAD Study
Abstract 458: Utilizing Transcranial Doppler in the Diagnosis of Cervical Artery Dissection: Insights from a Multicenter Survey within the STOP‐CAD Study Open
Background Cervical artery dissection (CAD) is a common cause of ischemic stroke in young adults. Local blood clot formation and distal emboli are the key mechanisms for the development of stroke in patients with CAD. Microemboli distal to…
View article: HDAC7 drives glioblastoma to a mesenchymal-like state via LGALS3-mediated crosstalk between cancer cells and macrophages
HDAC7 drives glioblastoma to a mesenchymal-like state via LGALS3-mediated crosstalk between cancer cells and macrophages Open
Background: Glioblastoma multiforme (GBM) is an aggressive brain tumour for which current traditional treatment approaches have been unsuccessful, owing to the high genetic heterogeneity and immunosuppressive tumour microenvironment…
View article: Assessing the value of liver fibrosis scores in hypertension: findings from a cross-sectional study
Assessing the value of liver fibrosis scores in hypertension: findings from a cross-sectional study Open
Background and purpose: Hypertension is the most significant modifiable risk factor for all-cause morbidity worldwide and is associated with an increased risk of cardiovascular disease. To alleviate the public health burden of hypertension…
View article: Effects of different doses of tirofiban combined with dual antiplatelet drugs on platelet indices, vascular endothelial function, and major adverse cardiovascular events in patients with acute ST-segment elevated myocardial infarction undergoing percutaneous coronary intervention
Effects of different doses of tirofiban combined with dual antiplatelet drugs on platelet indices, vascular endothelial function, and major adverse cardiovascular events in patients with acute ST-segment elevated myocardial infarction undergoing percutaneous coronary intervention Open
This trial targeted to analyze the effects of different doses of tirofiban combined with dual antiplatelet drugs on platelet indices, vascular endothelial function, and major adverse cardiovascular events (MACE) in patients with acute ST-s…
View article: Predictors of Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection
Predictors of Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection Open
Objective Patients with cervical artery dissection (CAD) are at increased ischemic stroke risk. We aimed to identify characteristics that are associated with increased risk of ischemic stroke following initial presentation of CAD and to ev…
View article: Local pH variability scenario: Prebiotic synthesis of cyclic dipeptides via prolinamide on the Hadean Earth
Local pH variability scenario: Prebiotic synthesis of cyclic dipeptides via prolinamide on the Hadean Earth Open
Small pools near early volcanoes are recognized as optimal field for the origin of life. However, the significance of pH variability in the polymerization of biomolecules has been undervalued. Within a simulated "warm little pond," our stu…
View article: Clinical outcomes of second-line chemotherapy in patients with advanced pancreatic adenocarcinoma: a real-world study
Clinical outcomes of second-line chemotherapy in patients with advanced pancreatic adenocarcinoma: a real-world study Open
Objective: Little progress has been made in recent years using first-line chemotherapy, including gemcitabine combined with nab-paclitaxel, FOLFIRINOX, and NALIRIFOX, for advanced pancreatic adenocarcinoma (APC). In addition, the optimal s…
View article: Cerium Vanadate Nanozyme with pH-Dependent Dual Enzymatic Activity for Glioblastoma Targeted Therapy and Postradiotherapy Damage Protection
Cerium Vanadate Nanozyme with pH-Dependent Dual Enzymatic Activity for Glioblastoma Targeted Therapy and Postradiotherapy Damage Protection Open
Nanocatalytic therapy is an emerging technology that uses synthetic nanoscale enzyme mimics for biomedical treatment. However, in the field of neuroscience, achieving neurological protection while simultaneously killing tumor cells is a te…
View article: Independent and Joint Associations of Socioeconomic Status and Lifestyle behaviors with Cognitive Impairment among Elderly Chinese Population
Independent and Joint Associations of Socioeconomic Status and Lifestyle behaviors with Cognitive Impairment among Elderly Chinese Population Open
Cognitive impairment has socioeconomic disparities among the elderly Chinese population. A healthy lifestyle may attenuate the impact of socioeconomic inequality on cognitive impairment, emphasizing the important role of LBs modification i…
View article: Triglyceride-glucose index predicts all-cause mortality, but not cardiovascular mortality, in rural Northeast Chinese patients with metabolic syndrome: a community-based retrospective cohort study
Triglyceride-glucose index predicts all-cause mortality, but not cardiovascular mortality, in rural Northeast Chinese patients with metabolic syndrome: a community-based retrospective cohort study Open
View article: Figure S3 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation
Figure S3 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation Open
Figure S3. Activated neuron promote microglial M2 polarization.
View article: Table S2 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation
Table S2 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation Open
Table S2. siRNA, miRNA mimics and antagomir used.
View article: Figure S8 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation
Figure S8 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation Open
Figure S8. miR-200c-3p promotes the M2 polarization of microglia in vitro.
View article: Table S1 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation
Table S1 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation Open
Table S1. The sequence information of lentivirus and AAV.
View article: Figure S1 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation
Figure S1 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation Open
Figure S1. Hypoxia drives glioma stem cells to activate neurons via glutamate.
View article: Table S4 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation
Table S4 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m<sup>6</sup>A Demethylation Open
Table S4. Antibodies used.