Xiangling Feng
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View article: Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains
Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains Open
View article: LGR4 promotes proliferation and homing via activation of the NF‑κB signaling pathway in multiple myeloma
LGR4 promotes proliferation and homing via activation of the NF‑κB signaling pathway in multiple myeloma Open
Multiple myeloma (MM) is a plasma cell malignancy characterized by clonal proliferation in the bone marrow (BM). Previously, it was reported that G‑protein‑coupled receptor 4 (LGR4) contributed to early hematopoiesis and was associated wit…
View article: Targeting <i>Enterobacter cloacae</i> attenuates osteolysis by reducing ammonium in multiple myeloma
Targeting <i>Enterobacter cloacae</i> attenuates osteolysis by reducing ammonium in multiple myeloma Open
Multiple myeloma (MM)-induced bone disease affects not only patients’ quality of life but also their overall survival. Our previous work demonstrated that the gut microbiome plays a crucial role in MM progression and drug resistance. Howev…
View article: The landscape of immune cell infiltration and potential biomarkers in intervertebral disc degeneration
The landscape of immune cell infiltration and potential biomarkers in intervertebral disc degeneration Open
Background Immune cell infiltration has been found to be strongly associated with the occurrence and progression of intervertebral disc degeneration (IDD), and intervertebral discs (IVDs) are immune-privileged organs. This research aimed t…
View article: Cultivated <i>Enterococcus faecium</i> B6 from children with obesity promotes nonalcoholic fatty liver disease by the bioactive metabolite tyramine
Cultivated <i>Enterococcus faecium</i> B6 from children with obesity promotes nonalcoholic fatty liver disease by the bioactive metabolite tyramine Open
Gut microbiota plays an essential role in nonalcoholic fatty liver disease (NAFLD). However, the contribution of individual bacterial strains and their metabolites to childhood NAFLD pathogenesis remains poorly understood. Herein, the crit…
View article: Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains
Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains Open
Cortical interneurons generated from ganglionic eminence via a long-distance journey of tangential migration display evident cellular and molecular differences across brain regions, which seeds the heterogeneous cortical circuitry in prima…
View article: Mechanisms of the role of proto-oncogene activation in promoting malignant transformation of mature B cells.
Mechanisms of the role of proto-oncogene activation in promoting malignant transformation of mature B cells. Open
Malignant tumors continue to pose a significant threat to human life and safety and their development is primarily due to the activation of proto-oncogenes and the inactivation of suppressor genes. Among these, the activation of proto-onco…
View article: Landscape of enhancer disruption and functional screen in melanoma cells
Landscape of enhancer disruption and functional screen in melanoma cells Open
View article: Lactobacillus fermentum Alleviates the Colorectal Inflammation Induced by Low-Dose Sub-Chronic Microcystin-LR Exposure
Lactobacillus fermentum Alleviates the Colorectal Inflammation Induced by Low-Dose Sub-Chronic Microcystin-LR Exposure Open
Microcystin-LR (MC-LR) contamination is a worldwide environmental problem that poses a grave threat to the water ecosystem and public health. Exposure to MC-LR has been associated with the development of intestinal injury, but there are no…
View article: Author Correction: Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways
Author Correction: Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways Open
As a result of an error during figure assembly, in Figure 2A the image for the loading control for HONE1/HK1/ C666-1 is a duplication of the image for the loading control for HNE1/HNE2/HNE3.The correct Figure 2 is shown below, as Figure 1.
View article: High expression of VARS promotes the growth of multiple myeloma cells by causing imbalance in valine metabolism.
High expression of VARS promotes the growth of multiple myeloma cells by causing imbalance in valine metabolism. Open
MM patients with abnormal high expression of VARS have a poor prognosis. VARS promotes the malignant growth of MM cells by affecting the regulation of valine metabolism.
View article: Multimetallic nanoparticles decorated metal-organic framework for boosting peroxidase-like catalytic activity and its application in point-of-care testing
Multimetallic nanoparticles decorated metal-organic framework for boosting peroxidase-like catalytic activity and its application in point-of-care testing Open
View article: Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma Open
View article: Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells
Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells Open
Inflammatory cascade and extracellular matrix remodeling have been identified as pivotal pathological factors in the progression of intervertebral disc degeneration (IDD), but the mechanisms underlying the aberrant activation of transcript…
View article: An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping
An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping Open
View article: Proline promotes proliferation and drug resistance of multiple myeloma by downregulation of proline dehydrogenase
Proline promotes proliferation and drug resistance of multiple myeloma by downregulation of proline dehydrogenase Open
Summary Amino acids in the bone marrow microenvironment (BMME) are a critical factor for multiple myeloma (MM) progression. Here, we have determined that proline is elevated in BMME of MM patients and links to poor prognosis in MM. Moreove…
View article: MC-LR Aggravates Liver Lipid Metabolism Disorders in Obese Mice Fed a High-Fat Diet via PI3K/AKT/mTOR/SREBP1 Signaling Pathway
MC-LR Aggravates Liver Lipid Metabolism Disorders in Obese Mice Fed a High-Fat Diet via PI3K/AKT/mTOR/SREBP1 Signaling Pathway Open
Obesity, a metabolic disease caused by excessive fat accumulation in the body, has attracted worldwide attention. Microcystin-LR (MC-LR) is a hepatotoxic cyanotoxin which has been reportedly to cause lipid metabolism disorder. In this stud…
View article: QTLbase2: an enhanced catalog of human quantitative trait loci on extensive molecular phenotypes
QTLbase2: an enhanced catalog of human quantitative trait loci on extensive molecular phenotypes Open
Deciphering the fine-scale molecular mechanisms that shape the genetic effects at disease-associated loci from genome-wide association studies (GWAS) remains challenging. The key avenue is to identify the essential molecular phenotypes tha…
View article: Intestinal Klebsiella pneumoniae Contributes to Pneumonia by Synthesizing Glutamine in Multiple Myeloma
Intestinal Klebsiella pneumoniae Contributes to Pneumonia by Synthesizing Glutamine in Multiple Myeloma Open
Pneumonia accounts for a significant cause of morbidity and mortality in multiple myeloma (MM) patients. It has been previously shown that intestinal Klebsiella pneumonia (K. pneumonia) enriches in MM and promotes MM progression. However, …
View article: Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance
Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance Open
View article: <scp>PGE<sub>2</sub>‐EP3</scp> axis promotes brown adipose tissue formation through stabilization of <scp>WTAP RNA</scp> methyltransferase
<span>PGE<sub>2</sub>‐EP3</span> axis promotes brown adipose tissue formation through stabilization of <span>WTAP RNA</span> methyltransferase Open
Brown adipose tissue (BAT) functions as a thermogenic organ and is negatively associated with cardiometabolic diseases. N 6 ‐methyladenosine (m 6 A) modulation regulates the fate of stem cells. Here, we show that the prostaglandin E 2 (PGE…
View article: Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder
Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder Open
Microcystin-LR (MC-LR), a potent hepatotoxin can cause liver damages. However, research on hepatic lipid metabolism caused by long-term exposure to environmental concentrations MC-LR is limited. In the current study, mice were exposed to v…
View article: Development of a Risk Score Model for Osteosarcoma Based on DNA Methylation-Driven Differentially Expressed Genes
Development of a Risk Score Model for Osteosarcoma Based on DNA Methylation-Driven Differentially Expressed Genes Open
Osteosarcoma (OS) is the commonest malignant bone tumor in adolescent patients, and patients face amputation, tumor metastasis, chemotherapy resistance, and even death. We investigated the potential connection between abnormal methylation …
View article: 3DCoop: An approach for computational inference of cell-type-specific transcriptional regulators cooperation in 3D chromatin
3DCoop: An approach for computational inference of cell-type-specific transcriptional regulators cooperation in 3D chromatin Open
View article: Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma Open
Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show that thrombocytopenia is linked to poor prognosis in the …
View article: NEK2 promotes the progression of liver cancer by resisting the cellular senescence.
NEK2 promotes the progression of liver cancer by resisting the cellular senescence. Open
NEK2 may mediate the anti-aging effect of hepatoma cells through p16/Rb and PTEN/Akt signal transduction pathways, which provides a new theoretical basis for NEK2 to promote the progress of liver cancer and a new idea for the targeting tre…
View article: Genetic Aberrations and Interaction of <i>NEK2</i> and <i>TP53</i> Accelerate Aggressiveness of Multiple Myeloma
Genetic Aberrations and Interaction of <i>NEK2</i> and <i>TP53</i> Accelerate Aggressiveness of Multiple Myeloma Open
It has been previously shown that (never in mitosis gene A)‐related kinase 2 ( NEK2 ) is upregulated in multiple myeloma (MM) and contributes to drug resistance. However, the mechanisms behind this upregulation remain poorly understood. In…
View article: Long-Term Environmental Levels of Microcystin-LR Exposure Induces Colorectal Chronic Inflammation, Fibrosis and Barrier Disruption via CSF1R/Rap1b Signaling Pathway
Long-Term Environmental Levels of Microcystin-LR Exposure Induces Colorectal Chronic Inflammation, Fibrosis and Barrier Disruption via CSF1R/Rap1b Signaling Pathway Open
View article: A Validated Uhplc-Ms/Ms Assay for Rapid and Sensitive Determination of Crisaborale in Human Plasma and its Clinico-Pharmacokinetic Application
A Validated Uhplc-Ms/Ms Assay for Rapid and Sensitive Determination of Crisaborale in Human Plasma and its Clinico-Pharmacokinetic Application Open
View article: Long-Term Environmental Levels of Microcystin-Lr Exposure Induces Colorectal Chronic Inflammation, Fibrosis and Barrier Disruption Via Csf1r/Rap1b Signaling Pathway
Long-Term Environmental Levels of Microcystin-Lr Exposure Induces Colorectal Chronic Inflammation, Fibrosis and Barrier Disruption Via Csf1r/Rap1b Signaling Pathway Open