Xianglong Tian
YOU?
Author Swipe
View article: Prognostic implications of organ-specific metastases in advanced gastric cancer: A retrospective observational analysis of the SEER database
Prognostic implications of organ-specific metastases in advanced gastric cancer: A retrospective observational analysis of the SEER database Open
Advanced gastric cancer (GC) remains a significant global health burden with poor prognosis. Understanding organ-specific metastatic patterns and their prognostic implications is critical for optimizing patient management. This study lever…
View article: Histone-acetyl epigenome regulates TGF-β pathway-associated chemoresistance in colorectal cancer
Histone-acetyl epigenome regulates TGF-β pathway-associated chemoresistance in colorectal cancer Open
TGF-β signaling pathway has been demonstrated to be closely related to chemoresistance, which is the major cause of recurrence and poor outcome in colorectal cancer (CRC), however, the comprehensive epigenetic landscape that functionally i…
View article: Supplementary Tables 1-6 from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Supplementary Tables 1-6 from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer Open
Table S1.Expression of human ubiquitin ligase genes in 246 CRC patients of TCGAdatabase.TableS2.Clinial information of 62 cases CRC patients (fresh tissues).Table S3.Clinial information of 78 cases CRC patients (paraffin tissues).Table S4.…
View article: Data from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Data from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer Open
Objective: The E3 ubiquitin ligase RNF6 (RING-finger protein 6) plays a crucial role in carcinogenesis. However, the copy number and expression of RNF6 were rarely reported in colorectal cancer. We aimed to explore the mechanical, biologic…
View article: Supplementary Material and Methods clean from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Supplementary Material and Methods clean from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer Open
Supplementary Material and Methods clean
View article: Supplementary Figures from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Supplementary Figures from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer Open
Fig. S1. RNF6 genomic amplification is prevalent in colorectal cancer and correlated with shortened patient survival. Fig. S2. RNF6 is clinically relevant in colorectal cancer. Fig. S3. Gene Ontology (GO) and Gene Set Enrichment Analysis (…
View article: Data from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Data from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer Open
Objective: The E3 ubiquitin ligase RNF6 (RING-finger protein 6) plays a crucial role in carcinogenesis. However, the copy number and expression of RNF6 were rarely reported in colorectal cancer. We aimed to explore the mechanical, biologic…
View article: Supplementary Figure legends from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Supplementary Figure legends from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer Open
Fig. S1. RNF6 genomic amplification is prevalent in colorectal cancer and correlated with shortened patient survival. Fig. S2. RNF6 is clinically relevant in colorectal cancer. Fig. S3. Gene Ontology (GO) and Gene Set Enrichment Analysis (…
View article: Supplementary Figure legends from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Supplementary Figure legends from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer Open
Fig. S1. RNF6 genomic amplification is prevalent in colorectal cancer and correlated with shortened patient survival. Fig. S2. RNF6 is clinically relevant in colorectal cancer. Fig. S3. Gene Ontology (GO) and Gene Set Enrichment Analysis (…
View article: Supplementary Tables 1-6 from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Supplementary Tables 1-6 from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer Open
Table S1.Expression of human ubiquitin ligase genes in 246 CRC patients of TCGAdatabase.TableS2.Clinial information of 62 cases CRC patients (fresh tissues).Table S3.Clinial information of 78 cases CRC patients (paraffin tissues).Table S4.…
View article: Supplementary Figures from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Supplementary Figures from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer Open
Fig. S1. RNF6 genomic amplification is prevalent in colorectal cancer and correlated with shortened patient survival. Fig. S2. RNF6 is clinically relevant in colorectal cancer. Fig. S3. Gene Ontology (GO) and Gene Set Enrichment Analysis (…
View article: Supplementary Material and Methods clean from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Supplementary Material and Methods clean from RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer Open
Supplementary Material and Methods clean
View article: Prognostic Autophagy-Related Model Revealed by Integrating Single-Cell RNA Sequencing Data and Bulk Gene Profiles in Gastric Cancer
Prognostic Autophagy-Related Model Revealed by Integrating Single-Cell RNA Sequencing Data and Bulk Gene Profiles in Gastric Cancer Open
Autophagy has been associated with tumor progression, prognosis, and treatment response. However, an autophagy-related model and their clinical significance have not yet been fully elucidated. In the present study, through the integrative …
View article: A tumor microenvironment-specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients
A tumor microenvironment-specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients Open
Studies have shown that tumor microenvironment (TME) might affect drug sensitivity and the classification of colorectal cancer (CRC). Using TME-specific gene signature to identify CRC subtypes with distinctive clinical relevance has not ye…
View article: Metadata record for the manuscript: A tumor microenvironment specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients
Metadata record for the manuscript: A tumor microenvironment specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients Open
Summary This metadata record provides details of the data supporting the claims of the related manuscript “A tumor microenvironment specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients”. The rel…
View article: A 12-immune cell signature to predict relapse and guide chemotherapy for stage II colorectal cancer
A 12-immune cell signature to predict relapse and guide chemotherapy for stage II colorectal cancer Open
The management of stage II colorectal cancer is still difficult. We aimed to construct a new immune cell-associated signature for prognostic evaluation and guiding chemotherapy in stage II colorectal cancer. We used the "Cell Type Identifi…
View article: ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5
ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5 Open
This study illustrated that ALKBH4 may function as a novel metastasis suppressor of CRC, and inhibits H3K4me3 modification through binding WDR5 during EMT.
View article: Additional file 5 of m6A-dependent glycolysis enhances colorectal cancer progression
Additional file 5 of m6A-dependent glycolysis enhances colorectal cancer progression Open
Additional file 5 Table S3. Metabolites of glycolysis pathway measured by Liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) in HCT116 WT and METTL3-knockout cells.
View article: Additional file 7 of m6A-dependent glycolysis enhances colorectal cancer progression
Additional file 7 of m6A-dependent glycolysis enhances colorectal cancer progression Open
Additional file 7 Table S5. Clinical information of 47 cases CRC patients in Cohort 1.
View article: Additional file 10 of m6A-dependent glycolysis enhances colorectal cancer progression
Additional file 10 of m6A-dependent glycolysis enhances colorectal cancer progression Open
Additional file 10 Table S8. The sequences of siRNAs and primers used this study.
View article: Additional file 8 of m6A-dependent glycolysis enhances colorectal cancer progression
Additional file 8 of m6A-dependent glycolysis enhances colorectal cancer progression Open
Additional file 8 Table S6. Clinical information of 156 cases CRC patients in Cohort 2.
View article: Additional file 6 of m6A-dependent glycolysis enhances colorectal cancer progression
Additional file 6 of m6A-dependent glycolysis enhances colorectal cancer progression Open
Additional file 6 Table S4. m6A-seq analysis in HCT116 WT and METTL3-knockout cells.
View article: Additional file 4 of m6A-dependent glycolysis enhances colorectal cancer progression
Additional file 4 of m6A-dependent glycolysis enhances colorectal cancer progression Open
Additional file 4 Table S2. Pathways regulated by METTL3 in HCT116 cells.
View article: Additional file 2 of m6A-dependent glycolysis enhances colorectal cancer progression
Additional file 2 of m6A-dependent glycolysis enhances colorectal cancer progression Open
Additional file 2 Table S1. RNA-seq analysis in HCT116 WT and METTL3-knockout cells.
View article: Additional file 9 of m6A-dependent glycolysis enhances colorectal cancer progression
Additional file 9 of m6A-dependent glycolysis enhances colorectal cancer progression Open
Additional file 9 Table S7. Clinical information of 30 cases CRC patients in GSE110225.
View article: A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90
A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90 Open
Genome-wide association studies (GWASs) implicate 16q22.1 locus in risk for colorectal cancer (CRC). However, the underlying oncogenic mechanisms remain unknown. Here, through comprehensive filtration, we prioritized rs7198799, a common SN…
View article: Variant of SNP rs1317082 at CCSlnc362 (RP11-362K14.5) creates a binding site for miR-4658 and diminishes the susceptibility to CRC
Variant of SNP rs1317082 at CCSlnc362 (RP11-362K14.5) creates a binding site for miR-4658 and diminishes the susceptibility to CRC Open
Genome-wide association studies (GWAS) have identified several loci harboring variants that affected the risk of colorectal cancer; however, the specific mechanisms by which germline variation influenced the tumorigenesis of colorectal can…