Xiang‐mei Wen
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View article: FOXP1 is associated with oncogenesis and clinical outcomes in hematologic malignancies
FOXP1 is associated with oncogenesis and clinical outcomes in hematologic malignancies Open
Depending on the cellular context and cancer type, FOXP1 functions as an oncogene or a tumor suppressor. However, the clinical role of FOXP1 in hematologic malignancies has not been studied comprehensively. This study systematically analyz…
View article: Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity
Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity Open
Introduction Stimulator of interferon response cGAMP interactor (STING) is essential for both innate and adaptive immunity. However, a comprehensive molecular characterization of STING expression across hematological malignancies is lackin…
View article: ALOX5AP is a new prognostic indicator in acute myeloid leukemia
ALOX5AP is a new prognostic indicator in acute myeloid leukemia Open
View article: Identification and validation of necroptosis-related gene signatures to predict clinical outcomes and therapeutic responses in acute myeloid leukemia
Identification and validation of necroptosis-related gene signatures to predict clinical outcomes and therapeutic responses in acute myeloid leukemia Open
Consequently, our findings may contribute to deeper understanding of NRGs in AML, and facilitate assessment of the prognosis and treatment strategies.
View article: Abnormal regulation of miR-29b-ID1 signaling is involved in the process of decitabine resistance in leukemia cells
Abnormal regulation of miR-29b-ID1 signaling is involved in the process of decitabine resistance in leukemia cells Open
Decitabine (DAC) is an inhibitor of DNA methyltransferase used to treat leukemia, but primary or secondary resistance to DAC may develop during therapy. The mechanisms related to DAC resistance remain poorly understood. In this study, we f…
View article: ALOX5AP is a new prognostic indicator in acute myeloid leukemia
ALOX5AP is a new prognostic indicator in acute myeloid leukemia Open
Background To identify the expression and methylation patterns of ALOX5AP in bone marrow (BM) samples of acute myeloid leukemia (AML) patients, and further explore its clinical significance. Methods Eighty-two de novo AML patients and 20 h…
View article: Identification and Validation of Necroptosis-Related Gene Signatures to Predict Clinical Outcomes and Therapeutic Responses in Acute Myeloid Leukemia
Identification and Validation of Necroptosis-Related Gene Signatures to Predict Clinical Outcomes and Therapeutic Responses in Acute Myeloid Leukemia Open
Necroptosis is a tightly regulated form of necrotic cell death that promotes inflammation and contributes to disease development. However, the potential roles of necroptosis-related genes (NRGs) in acute myeloid leukemia (AML) have not bee…
View article: SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemia
SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemia Open
Background We screened out several hypermethylated solute carrier (SLC) family genes in acute myeloid leukemia by reduced representation bisulfite sequencing. SLC22A3 encodes an organic cation transport protein, which is critical for drug …
View article: Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemia
Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemia Open
View article: SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemia
SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemia Open
Background: We screened out several hypermethylated solute carrier (SLC) family genes in acute myeloid leukemia (AML) by reduced representation bisulfite sequencing (RRBS). SLC22A3 encodes an organic cation transport protein, which is crit…
View article: Pan‐cancer analysis identifies <scp><i>CD300</i></scp> molecules as potential immune regulators and promising therapeutic targets in acute myeloid leukemia
Pan‐cancer analysis identifies <span><i>CD300</i></span> molecules as potential immune regulators and promising therapeutic targets in acute myeloid leukemia Open
Background CD300s are a group of proteins playing vital roles in immune responses. However, much is yet to be elucidated regarding the expression patterns and clinical significances of CD300s in cancers. Methods In this study, we comprehen…
View article: Additional file 10 of DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis
Additional file 10 of DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis Open
Additional file 10: Table S10. Identification miR-181d-5p as a downstream target of SGMS1-AS1 by Venn analysis of publicly available online tools (LncBase Predicted v.2 and starBase) together with RNA sequencing (miRNA).
View article: Additional file 9 of DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis
Additional file 9 of DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis Open
Additional file 9: Table S9. PEAKs and PEAK-annotated genes associated with DLX7 analyzed by ATAC-seq in K562 cell (original data).
View article: Association Analyses of TP53 Mutation With Prognosis, Tumor Mutational Burden, and Immunological Features in Acute Myeloid Leukemia
Association Analyses of TP53 Mutation With Prognosis, Tumor Mutational Burden, and Immunological Features in Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) is a heterogeneous disease related to a broad spectrum of molecular alterations. The successes of immunotherapies treating solid tumors and a deeper understanding of the immune systems of patients with hematolo…
View article: Integrated Pan-Cancer Analysis Reveals Distinct Clinical, Genomic and Immunological Features of the LILRB Immune Checkpoint Family in Acute Myeloid Leukemia
Integrated Pan-Cancer Analysis Reveals Distinct Clinical, Genomic and Immunological Features of the LILRB Immune Checkpoint Family in Acute Myeloid Leukemia Open
Background Leukocyte immunoglobulin (Ig)-like receptor Bs (LILRBs), a family of type I transmembrane glycoproteins, are known to inhibit immune activation. Methods We comprehensively evaluated the transcriptional levels and prognostic sign…
View article: Clinical and prognostic relevance of <i>CXCL12</i> expression in acute myeloid leukemia
Clinical and prognostic relevance of <i>CXCL12</i> expression in acute myeloid leukemia Open
Background Accumulating studies have been made to understand the association between CXC chemokine ligand-12 ( CXCL12 )/ CXC chemokine receptor 4 ( CXCR4 ) and acute myeloid leukemia (AML). However, large-scale data analysis of potential r…
View article: Genome-wide methylation sequencing identifies progression-related epigenetic drivers in myelodysplastic syndromes
Genome-wide methylation sequencing identifies progression-related epigenetic drivers in myelodysplastic syndromes Open
View article: Genome-Wide Methylation Sequencing Identifies Progression-Related Epigenetic Drivers in Myelodysplastic Syndromes
Genome-Wide Methylation Sequencing Identifies Progression-Related Epigenetic Drivers in Myelodysplastic Syndromes Open
Background: The mechanism underlying disease progression of myelodysplastic syndromes (MDS) to acute myeloid leukemia (AML) remains poorly elucidated. Epigenetic alterations are increasingly implicated in the pathogenesis of cancer progres…
View article: Identification and validation of prognosis‐related <i>DLX5</i> methylation as an epigenetic driver in myeloid neoplasms
Identification and validation of prognosis‐related <i>DLX5</i> methylation as an epigenetic driver in myeloid neoplasms Open
The deregulated DLX gene family members DLX1/2/3/4/5/6 ( DLXs ) caused by DNA methylation has been demonstrated in various cancers with therapeutic target value. However, the potential role of DLXs methylation in myeloid neoplasms such as …
View article: Hypomethylation of <i>MIR‐378</i> 5’‐flanking region predicts poor survival in young patients with myelodysplastic syndrome
Hypomethylation of <i>MIR‐378</i> 5’‐flanking region predicts poor survival in young patients with myelodysplastic syndrome Open
Background Previous studies have disclosed up‐regulation of MIR‐378 in acute myeloid leukemia (AML), and might consequently affect the outcome of the patients. Correspondingly, hypomethylation of MIR‐378 was also identified in AML, particu…
View article: <i>EZH2</i> dysregulation: Potential biomarkers predicting prognosis and guiding treatment choice in acute myeloid leukaemia
<i>EZH2</i> dysregulation: Potential biomarkers predicting prognosis and guiding treatment choice in acute myeloid leukaemia Open
Accumulating studies have proved EZH2 dysregulation mediated by mutation and expression in diverse human cancers including AML. However, the expression pattern of EZH2 remains controversial in acute myeloid leukaemia (AML). EZH1/2 expressi…
View article: The M2 macrophage marker <i>CD206</i> : a novel prognostic indicator for acute myeloid leukemia
The M2 macrophage marker <i>CD206</i> : a novel prognostic indicator for acute myeloid leukemia Open
Hematological malignancies possess a distinctive immunologic microenvironment compared with solid tumors. Here, using an established computational algorithm (CIBERSORT), we systematically analyzed the overall distribution of 22 tumor-infil…
View article: BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia
BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia Open
View article: <p><em>SOX30</em> methylation correlates with disease progression in patients with chronic myeloid leukemia</p>
<em>SOX30</em> methylation correlates with disease progression in patients with chronic myeloid leukemia Open
Our study revealed that SOX30 methylation correlated with disease progression in chronic myeloid leukemia.
View article: MicroRNA-335/ID4 dysregulation predicts clinical outcome and facilitates leukemogenesis by activating PI3K/Akt signaling pathway in acute myeloid leukemia
MicroRNA-335/ID4 dysregulation predicts clinical outcome and facilitates leukemogenesis by activating PI3K/Akt signaling pathway in acute myeloid leukemia Open
MircoRNA-335 (miR-335) has been reported as a significant cancer-associated microRNA, which was often epigenetically silenced and acted as a tumor suppressor gene in diverse human solid tumors. Conversely, recent studies show…
View article: <p>Increased <em>MCL-1</em> expression predicts poor prognosis and disease recurrence in acute myeloid leukemia</p>
Increased <em>MCL-1</em> expression predicts poor prognosis and disease recurrence in acute myeloid leukemia Open
Background: Altered expression of the BCL-2 family member MCL-1 has been linked to the progression and outcome of various malignancies. Recently, MCL-1 inhibitor S63845 was reported to kill MCL-1-dependen…
View article: Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia
Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia Open
View article: MOESM2 of Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia
MOESM2 of Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia Open
Additional file 2. List of 443 down-regulated probes/genes in LSCs versus normal HSCs.
View article: Additional file 3: of BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia
Additional file 3: of BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia Open
Different expressed genes of RNA for BCL2high and BCL2low. (XLSX 1682 kb)
View article: Promoter methylation of the candidate tumor suppressor gene TCF21 in myelodysplastic syndrome and acute myeloid leukemia.
Promoter methylation of the candidate tumor suppressor gene TCF21 in myelodysplastic syndrome and acute myeloid leukemia. Open
Transcription factor 21 (TCF21) has been identified as a candidate tumor suppressor gene which was epigenetically inactivated in a variety of human cancers. However, TCF21 methylation pattern remains unknown in hematologic ma…