Xiangning Fu
YOU?
Author Swipe
View article: Protein Induced by Vitamin K Absence or Antagonist‐ <scp>II</scp> : Significantly Elevated in Obstructive Jaundice and Sepsis Patients Without Hepatocellular Carcinoma
Protein Induced by Vitamin K Absence or Antagonist‐ <span>II</span> : Significantly Elevated in Obstructive Jaundice and Sepsis Patients Without Hepatocellular Carcinoma Open
Background PIVKA‐II is a promising diagnostic and prognostic biomarker for HCC. However, a particular PIVKA‐II variant can be abnormally elevated in patients with obstructive jaundice or sepsis, complicating its interpretation in HCC condi…
View article: Neoadjuvant immunochemotherapy versus chemotherapy alone for locally advanced esophageal squamous cell carcinoma: a real-world retrospective study
Neoadjuvant immunochemotherapy versus chemotherapy alone for locally advanced esophageal squamous cell carcinoma: a real-world retrospective study Open
NICT is a safe and effective approach for locally advanced ESCC, offering improved pathological response and DFS compared to chemotherapy alone. These findings support the integration of immunotherapy into neoadjuvant regimens for ESCC.
View article: The correlation between EGFR mutation status and clinicopathological characteristics, Ki67 expression and immune cell infiltration in lung adenocarcinoma with different radiological subtypes
The correlation between EGFR mutation status and clinicopathological characteristics, Ki67 expression and immune cell infiltration in lung adenocarcinoma with different radiological subtypes Open
EGFR mutation rates vary by clinicopathological characteristics and EGFR mutation status significantly influence tumor proliferation and immune cell infiltration in LUAD across radiological subtypes. These findings not only indicate that E…
View article: Pulmonary Subsolid Nodules
Pulmonary Subsolid Nodules Open
View article: Learning curve for electromagnetic navigation bronchoscopy-guided microwave ablation: a cumulative sum analysis
Learning curve for electromagnetic navigation bronchoscopy-guided microwave ablation: a cumulative sum analysis Open
ENB-guided MWA for treating pulmonary nodules is a safe and relatively easy-to-learn technique, indicating the potential for popularization in clinical practice. Though limits exists and further multi-center studies with more operators are…
View article: Analysis of tumor cell proliferation (Ki-67) and cell cycle regulator proteins in lung adenocarcinoma with different radiological subtypes
Analysis of tumor cell proliferation (Ki-67) and cell cycle regulator proteins in lung adenocarcinoma with different radiological subtypes Open
View article: Targeting PD-1 and CD85j can restore intratumoral CD4<sup>+</sup> GzmB<sup>+</sup> T-cell functions to combat MHC-II-expressing tumors
Targeting PD-1 and CD85j can restore intratumoral CD4<sup>+</sup> GzmB<sup>+</sup> T-cell functions to combat MHC-II-expressing tumors Open
Background A subset of CD4 + T cells with cytotoxic activity has been identified, and these cells exert their effects by expressing perforin and granzymes. Despite the progress made in characterizing cytotoxic CD4 + T cells in various dise…
View article: Improving outcomes in electromagnetic navigation bronchoscopy-guided transbronchial microwave ablation for pulmonary nodules: the role of cone-beam computed tomography
Improving outcomes in electromagnetic navigation bronchoscopy-guided transbronchial microwave ablation for pulmonary nodules: the role of cone-beam computed tomography Open
Background: Studies have shown the potential of electromagnetic navigation bronchoscopy (ENB)-guided transbronchial microwave ablation (MWA) for treating pulmonary nodules. The role of cone-beam computed tomography (CBCT) in the procedure …
View article: Resection and reconstruction of the left atrium with cardiopulmonary bypass for T4 non–small cell lung cancer
Resection and reconstruction of the left atrium with cardiopulmonary bypass for T4 non–small cell lung cancer Open
View article: Differences in tumor angiogenesis and related factors between lung adenocarcinomas manifesting as pure ground glass opacity and solid nodules
Differences in tumor angiogenesis and related factors between lung adenocarcinomas manifesting as pure ground glass opacity and solid nodules Open
View article: Glutamine deprivation confers immunotherapy resistance by inhibiting IFN-γ signaling in cancer cells
Glutamine deprivation confers immunotherapy resistance by inhibiting IFN-γ signaling in cancer cells Open
Glutamine metabolism is emerging as a target for improving immunotherapy efficacy. However, the outcomes remain inconclusive. Given that the tumor-intrinsic response to interferon-γ (IFN-γ) is a key determinant of immunotherapy efficacy, w…
View article: Three-field vs two-field lymphadenectomy in thoracic ESCC patients: a multicenter randomized study (NST 1503)
Three-field vs two-field lymphadenectomy in thoracic ESCC patients: a multicenter randomized study (NST 1503) Open
Additional cervical lymphadenectomy can be avoided in the patients with middle or lower thoracic ESCC and negative RRLN-LNs by frozen section treated by upfront surgery.Trial Registration: ClinicalTrials.gov Identifier NCT02448953.
View article: Exploration and validation of biomarkers related to bile acid metabolism in obese patients
Exploration and validation of biomarkers related to bile acid metabolism in obese patients Open
Background Studies have shown that bile acids can effectively improve metabolism and play an anti-obesity role. However, the mechanism of bile acid-related genes in obesity has not been fully elucidated. Methods Differential analysis was i…
View article: Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis
Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis Open
Our study implies that albendazole can act as a potent agonist of LRRN3 during fibroblast to myofibroblast differentiation and its oral administration shows potential as a viable therapeutic approach for managing IPF.
View article: A disproportionality analysis of sunitinib in the FDA adverse event reporting system (FAERS)
A disproportionality analysis of sunitinib in the FDA adverse event reporting system (FAERS) Open
In the clinical utilization of sunitinib, vigilant monitoring of potential adverse reactions is imperative during the initial phase of drug administration. In addition to the documented adverse reactions outlined in the drug specification,…
View article: Bazedoxifene Inhibits Cell Viability, Colony‐Forming Activity, and Cell Migration in Human Non<b>–</b>Small Cell Lung Cancer Cells and Improves the Treatment Efficacy of Paclitaxel and Gemcitabine
Bazedoxifene Inhibits Cell Viability, Colony‐Forming Activity, and Cell Migration in Human Non<b>–</b>Small Cell Lung Cancer Cells and Improves the Treatment Efficacy of Paclitaxel and Gemcitabine Open
Background Bazedoxifene is a third‐generation selective estrogen receptor modulator that inhibits the IL6/IL6R/GP130 signaling pathway by inhibiting IL6‐induced homodimerization of GP130. Considering that the IL6/IL6R/GP130 signaling pathw…
View article: An individualized strategy for a large tracheal neurogenic tumor resection and carina reconstruction
An individualized strategy for a large tracheal neurogenic tumor resection and carina reconstruction Open
View article: Lung cancer cell-intrinsic IL-15 promotes cell migration and sensitizes murine lung tumors to anti-PD-L1 therapy
Lung cancer cell-intrinsic IL-15 promotes cell migration and sensitizes murine lung tumors to anti-PD-L1 therapy Open
Background IL-15 plays a vital role in enhancing NK cell- and T-cell-mediated antitumor immune responses; however, the direct effect of IL-15 on tumor cells has not been fully elucidated. Herein, we investigated the effect of IL-15 on lung…
View article: Localized Administration of Bcar3 siRNA via Nano-Self-Assembly to Treat Idiopathic Pulmonary Fibrosis by Disrupting Macrophage-Fibroblast Crosstalk
Localized Administration of Bcar3 siRNA via Nano-Self-Assembly to Treat Idiopathic Pulmonary Fibrosis by Disrupting Macrophage-Fibroblast Crosstalk Open
Our study underscores the pivotal role of Bcar3 in orchestrating the macrophage-fibroblast crosstalk during pulmonary fibrosis progression. Targeting Bcar3 emerges as a novel therapeutic avenue to halt IPF progression and enhance patient p…
View article: Wnt5a Functions as a Novel Ferroptosis Inhibitor to Alleviate Aortic Dissection by Enhancing DHODH mRNA Stability
Wnt5a Functions as a Novel Ferroptosis Inhibitor to Alleviate Aortic Dissection by Enhancing DHODH mRNA Stability Open
View article: “Low-age, low-frequency” lung cancer screening strategies maybe adaptable to the situation in China
“Low-age, low-frequency” lung cancer screening strategies maybe adaptable to the situation in China Open
Background The object was to compare changes in patients undergoing lung surgery before and after COVID-19 outbreak, and to explore the impact of COVID-19 on lung surgery and its coping strategies. Method A retrospective review of patients…
View article: Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis
Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis Open
Background Idiopathic pulmonary fibrosis (IPF) is a chronic and lethal lung disorder for which effective treatments remain limited. Recent investigations revealed a potential link between altered glucose metabolism and the activation of fi…
View article: Accurate and non-invasive localization of multi-focal ground-glass opacities via electromagnetic navigation bronchoscopy assisting video-assisted thoracoscopic surgery: a single-center study
Accurate and non-invasive localization of multi-focal ground-glass opacities via electromagnetic navigation bronchoscopy assisting video-assisted thoracoscopic surgery: a single-center study Open
Background Accurate localization of multi-focal ground-glass opacities (GGOs) is crucial for successful video-assisted thoracoscopic surgery (VATS). Electromagnetic navigation bronchoscopy (ENB) provides a minimally invasive and dependable…
View article: CACA guidelines for holistic integrative management of esophageal carcinoma
CACA guidelines for holistic integrative management of esophageal carcinoma Open
Esophageal carcinoma (EC) is a common malignant tumor of the upper digestive tract worldwide. An analysis of the latest data from cancer centers in China showed that the incidence of EC and the number of deaths due to EC in China in 2015 w…
View article: Composition of patients undergoing pulmonary surgery before and after pandemic of COVID-19
Composition of patients undergoing pulmonary surgery before and after pandemic of COVID-19 Open
Background: The object was to compare changes in patients undergoing lung surgery before and after COVID-19 outbreak, and to explore the impact of COVID-19 on lung surgery and its coping strategies. Method: A single-institution, retrospect…
View article: Local Delivery of Bcar3 siRNA by Nano-Self-Assembly for Treating Pulmonary Fibrosis via Blocking the Interaction of Macrophages and Fibroblasts
Local Delivery of Bcar3 siRNA by Nano-Self-Assembly for Treating Pulmonary Fibrosis via Blocking the Interaction of Macrophages and Fibroblasts Open
Background Idiopathic pulmonary fibrosis (IPF) is a life-threatening progressive interstitial lung disease with limited therapeutic options, characterized by macrophage infiltration and fibroblast activation in response to chronic lung inj…
View article: Treatment and survival analysis for 40-year SEER data on upper esophageal cancer
Treatment and survival analysis for 40-year SEER data on upper esophageal cancer Open
Background Upper esophageal cancer (UEC) is rare in both Eastern and Western countries. The epidemiological characteristics and long-term survival of UEC patients are less known. In addition, the choice of optimal treatment for UEC has bee…
View article: Real-world surgical treatment patterns and clinical outcomes in patients with stages IA–IIIA non-small cell lung cancer: a retrospective multicentric observational study involving 11,958 patients
Real-world surgical treatment patterns and clinical outcomes in patients with stages IA–IIIA non-small cell lung cancer: a retrospective multicentric observational study involving 11,958 patients Open
View article: Figure S2 from An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma
Figure S2 from An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma Open
S2. Differentially expressed genes in A549 and HCC827 cells in response to IFN-� stimulation.
View article: Figure S1 from An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma
Figure S1 from An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma Open
S1. Detection of ZEB1 protein expression in tumors.