Xiangpeng Zhan
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View article: TRIM28 drives immune evasion via PARP1 SUMOylation and NAD <sup>+</sup> depletion in clear cell renal cell carcinoma
TRIM28 drives immune evasion via PARP1 SUMOylation and NAD <sup>+</sup> depletion in clear cell renal cell carcinoma Open
Background Immune checkpoint blockade (ICB) therapy has demonstrated significant clinical potential in a variety of cancers; however, its efficacy in clear cell renal cell carcinoma (ccRCC) remains suboptimal. In ccRCC, an increased infilt…
View article: Retraction Note: Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A
Retraction Note: Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A Open
View article: Glucose-induced STUB1-GOT2 axis promotes aspartate synthesis and mitochondrial dysfunction in bladder cancer
Glucose-induced STUB1-GOT2 axis promotes aspartate synthesis and mitochondrial dysfunction in bladder cancer Open
Aberrant glucose metabolism, a characteristic of malignant tumors, contributes to the development and progression of bladder cancer (BCa). However, the underlying mechanism by which aberrant glucose metabolism promotes BCa progression is s…
View article: Causal role of immune cells in prostate cancer: a bidirectional Mendelian-randomization analyses
Causal role of immune cells in prostate cancer: a bidirectional Mendelian-randomization analyses Open
This study provides evidence of a potential causal relationship between certain immune cell signatures and PCa. We observed that immune cell signatures involving HLA DR expression on specific cell types are associated with an increased ris…
View article: A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability promotes prostate cancer metastasis by inducing actin remodeling
A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability promotes prostate cancer metastasis by inducing actin remodeling Open
Prostate cancer bone metastasis is a predominant cause of death for prostate cancer (PCa) patients. However, the underlying mechanisms are poorly understood. Here, we report that high levels of RNF41 are associated with metastatic human pr…
View article: USP3 promotes DNA damage response and chemotherapy resistance through stabilizing and deubiquitinating SMARCA5 in prostate cancer
USP3 promotes DNA damage response and chemotherapy resistance through stabilizing and deubiquitinating SMARCA5 in prostate cancer Open
The chromatin-remodeling enzyme SMARCA5 plays a key role in DNA-templated events including transcription, DNA replication, and DNA repair. Loss of function of the SMARCA5 can cause neurodevelopmental disorder and Williams syndrome. However…
View article: Trends in suicide mortality among cancer survivors in the US, 1975-2020
Trends in suicide mortality among cancer survivors in the US, 1975-2020 Open
Our study highlights the need for targeted suicide prevention efforts for cancer survivors, particularly those diagnosed with respiratory system cancer. The trend of declining suicide mortality rates among cancer survivors is promising, bu…
View article: Predicted visceral adiposity index in relation to risk of coronary heart disease and all-cause mortality: insights from NHANES
Predicted visceral adiposity index in relation to risk of coronary heart disease and all-cause mortality: insights from NHANES Open
Background and aims The Visceral Adiposity Index (VAI) is a straightforward and gender-specific marker that combines anthropometric measurements with lipid profiles. The objective of this study was to evaluate the relationship between VAI …
View article: Trends in suicide mortality among prostate cancer survivors in the United States, 1975–2019
Trends in suicide mortality among prostate cancer survivors in the United States, 1975–2019 Open
Background Suicide was an important cause of death in prostate cancer. This study intended to investigate trends in suicide mortality among prostate cancer (PCa) survivors from 1975 to 2019 in the United States. Method We identified PCa su…
View article: The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016
The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016 Open
Background This study aimed to investigate the relationship between serum testosterone levels and the risk of congestive heart failure (CHF) in adult males. Previous research has suggested a potential link between serum testosterone and ca…
View article: Integrative bioinformatics and <i>in vitro</i> exploration of EVI2A expression: unraveling its immunological and prognostic implications in kidney renal clear cell carcinoma
Integrative bioinformatics and <i>in vitro</i> exploration of EVI2A expression: unraveling its immunological and prognostic implications in kidney renal clear cell carcinoma Open
EVI2A has emerged as a significant biomarker in various diseases; however, its biological role and mechanism in kidney renal clear cell carcinoma (KIRC) remains unexplored. We used TCGA and GEO databases to analyze EVI2A gene expression co…
View article: Urgent incontinence increases the risk of all-cause and cardiovascular mortality in people with diabetes
Urgent incontinence increases the risk of all-cause and cardiovascular mortality in people with diabetes Open
Background Studies on the association between urinary incontinence and all-cause and cardiovascular mortality in diabetic populations are limited, and further studies are needed to investigate this association. Methods Data were collected …
View article: Incidence, mortality and survival of transitional cell carcinoma in the urinary system: A population-based analysis
Incidence, mortality and survival of transitional cell carcinoma in the urinary system: A population-based analysis Open
The goal of this study is exploring the disparity of incidence, mortality and survival outcome among transitional cell carcinomas (TCCs) in the 4 parts of urinary system. This study comprehensively evaluates these disparities using the Sur…
View article: Assessing the prognostic impact of prostatic urethra involvement and developing a nomogram for T1 stage bladder cancer
Assessing the prognostic impact of prostatic urethra involvement and developing a nomogram for T1 stage bladder cancer Open
View article: Higher systemic immune-inflammation index is associated with increased risk of erectile dysfunction: Result from NHANES 2001–2004
Higher systemic immune-inflammation index is associated with increased risk of erectile dysfunction: Result from NHANES 2001–2004 Open
This study utilized data from the National Health and Nutrition Examination Survey (NHANES) to investigate the association between the systemic immune-inflammation index (SII) and erectile dysfunction (ED) in adult males. The SII is a nove…
View article: Integrative Bioinformatics and In Vitro Exploration of EVI2A Expression: Unraveling its Immunological and Prognostic Implications in Kidney Renal Clear Cell Carcinoma
Integrative Bioinformatics and In Vitro Exploration of EVI2A Expression: Unraveling its Immunological and Prognostic Implications in Kidney Renal Clear Cell Carcinoma Open
Purpose EVI2A has emerged as a meaningful marker in various diseases, but its biological role and mechanism in kidney renal clear cell carcinoma (KIRC) remain unexplored. Methods Utilizing TCGA and GEO databases, we analyzed EVI2A gene exp…
View article: Trends in cause of death among patients with renal cell carcinoma in the United States: a SEER-based study
Trends in cause of death among patients with renal cell carcinoma in the United States: a SEER-based study Open
View article: For small (1-3cm) nonfunctional adrenal incidentaloma (NFAI), which option is more appropriate for conservative treatment or surgery?
For small (1-3cm) nonfunctional adrenal incidentaloma (NFAI), which option is more appropriate for conservative treatment or surgery? Open
Objective To compare the efficacy and safety between conservative treatment and surgery for the patients with small (1-3cm) nonfunctional adrenal incidentaloma (NFAI). Methods The patients with small (1-3cm) NFAI who received conservative …
View article: Predictive nomograms for early death in metastatic bladder cancer
Predictive nomograms for early death in metastatic bladder cancer Open
Background Metastatic bladder cancer (MBC) is an incurable malignancy, which is prone to early death. We aimed to establish models to evaluating the risk of early death in patients with metastatic bladder cancer Methods The data of 1,264 p…
View article: Increased Burden of Second Bladder Cancer and Rectal Cancer in Prostate Cancer Treated With Radiotherapy: Results From Surveillance, Epidemiology, and End Results
Increased Burden of Second Bladder Cancer and Rectal Cancer in Prostate Cancer Treated With Radiotherapy: Results From Surveillance, Epidemiology, and End Results Open
Background Previous studies have confirmed the higher risk of bladder cancer (BC) and rectal cancer (RC) development among prostate cancer (PCa) patients receiving radiotherapy. In this study, we intend to explore the long-term trend in se…
View article: Risk and prognosis of secondary malignant neoplasms after radiation therapy for bladder cancer: A large population-based cohort study
Risk and prognosis of secondary malignant neoplasms after radiation therapy for bladder cancer: A large population-based cohort study Open
Objective To investigate the association between radiotherapy and the risk of second malignant neoplasm (SMN) development among patients with bladder cancer (BC). Overall survival (OS) is compared among patients developing SMN and without.…
View article: Survival Outcome of Partial Cystectomy versus Transurethral Bladder Tumor Resection in T1 High-Grade Bladder Cancer Patients: A Propensity Score Matching Study
Survival Outcome of Partial Cystectomy versus Transurethral Bladder Tumor Resection in T1 High-Grade Bladder Cancer Patients: A Propensity Score Matching Study Open
Purpose. Partial cystectomy was investigated as a method of bladder preservation with better disease outcomes than transurethral bladder tumor resection in T1 high-grade bladder cancer patients. Method and materials. The national Surveilla…
View article: High cardiovascular disease mortality after penile squamous cell carcinomas diagnosis: Results from the United States SEER population, 2005-2016
High cardiovascular disease mortality after penile squamous cell carcinomas diagnosis: Results from the United States SEER population, 2005-2016 Open
Background Cancer survivorship care is an emerging and necessary component of oncology management. To explore cardiovascular disease (CVD)-specific mortality and prognostic factors among patients with penile squamous cell carcinomas (PSCC)…
View article: Predictive Value of the Log Odds of Negative Lymph Nodes/T Stage as a Novel Prognostic Factor in Bladder Cancer Patients After Radical Cystectomy
Predictive Value of the Log Odds of Negative Lymph Nodes/T Stage as a Novel Prognostic Factor in Bladder Cancer Patients After Radical Cystectomy Open
Background The effect of lymph node resection on the prognosis of bladder cancer (BLCA) patients receiving radical cystectomy should not be ignored. Our aim was to explore the prognostic value of the log odds of negative lymph nodes/T stag…
View article: Trends in Incidence, Mortality, and Survival of Penile Cancer in the United States: A Population-Based Study
Trends in Incidence, Mortality, and Survival of Penile Cancer in the United States: A Population-Based Study Open
Purpose The aim of this study is to investigate the trends in incidence and mortality, and explore any change in survival of penile cancer in the United States. Methods We obtained data from the Surveillance, Epidemiology, and End Results …
View article: A Simple-To-Use Nomogram for Predicting Early Death in Metastatic Renal Cell Carcinoma: A Population-Based Study
A Simple-To-Use Nomogram for Predicting Early Death in Metastatic Renal Cell Carcinoma: A Population-Based Study Open
Background Metastatic renal cell carcinoma (mRCC) is usually considered to have a poor prognosis, which has a high risk of early death (≤3 months). Our aim was to developed a predictive nomogram for early death of mRCC. Methods The SEER da…
View article: Get insight into the cause of death distribution and epidemiology of penile squamous cell carcinoma: A population‐based study
Get insight into the cause of death distribution and epidemiology of penile squamous cell carcinoma: A population‐based study Open
Background Penile squamous cell carcinoma (PSCC) survival had no significant improvement since 1990 in the United States. This study aims to get insight into the changing trend and distribution of death causes of PSCC. The epidemiology of …
View article: A Novel Nomogram and Risk Classification System Predicting the Cancer-Specific Survival of Muscle-Invasive Bladder Cancer Patients after Partial Cystectomy
A Novel Nomogram and Risk Classification System Predicting the Cancer-Specific Survival of Muscle-Invasive Bladder Cancer Patients after Partial Cystectomy Open
Purpose. To establish a prognostic model that estimates cancer-specific survival (CSS) probability for muscle-invasive bladder cancer patients undergoing partial cystectomy. Patients and Methods. 866 patients from the Surveillance, Epidemi…
View article: Development and Validation of a Prognostic Nomogram for Predicting Cancer-Specific Survival in Patients With Lymph Node Positive Bladder Cancer: A Study Based on SEER Database
Development and Validation of a Prognostic Nomogram for Predicting Cancer-Specific Survival in Patients With Lymph Node Positive Bladder Cancer: A Study Based on SEER Database Open
Purpose To construct a prognostic model to predict the cancer-specific survival (CSS) for bladder cancer patients with lymph node-positive. Patients and Methods We enrolled 2,050 patients diagnosed with lymph node-positive bladder cancer f…
View article: Partial Cystectomy Could Be a Better Option of Bladder Preservation in T1 High-Grade Bladder Cancer Patients: A Propensity Score Matching Study
Partial Cystectomy Could Be a Better Option of Bladder Preservation in T1 High-Grade Bladder Cancer Patients: A Propensity Score Matching Study Open
Purpose: Partial cystectomy was investigated as a method of bladder preservation with better disease outcomes than transurethral bladder tumor resection in T1 high-grade bladder cancer patients.Method and materials: The national Surveillan…