Xiangquan Mi
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View article: Nigericin Induces Paraptosis‐Like Cell Death Instead of Pyroptosis in Corneal Keratocytes
Nigericin Induces Paraptosis‐Like Cell Death Instead of Pyroptosis in Corneal Keratocytes Open
The purpose of this study was to examine the nature of the underlying molecular mechanisms of cell death in human keratocytes treated with nigericin, a known pyroptosis inducer. Human keratocytes were exposed to nigericin, and cell death w…
View article: Xanthohumol Suppresses Endometrial Cancer Cell Proliferation via Promotion of Smurf1-mediated ACLY Ubiquitination and Degradation
Xanthohumol Suppresses Endometrial Cancer Cell Proliferation via Promotion of Smurf1-mediated ACLY Ubiquitination and Degradation Open
ATP citrate lyase (ACLY) is pivotal in de novo fatty acid synthesis. It emerges as a core metabolic enzyme implicated in malignant tumor progression, especially in Endometrial Cancer (EC). The present investigation revealed that Xanthohumo…
View article: Xanthohumol inhibits proliferation via increasing reactive oxygen species and inducing G1/S phase cell cycle arrest in NG108-15 cells
Xanthohumol inhibits proliferation via increasing reactive oxygen species and inducing G1/S phase cell cycle arrest in NG108-15 cells Open
Xanthohomul (XN), a naturally prenylated flavonoid, is extracted from hops (Humulus lupulus L.; Cannabaceae). XN treated NG108-15 cells significantly decreased cell viability through increased ROS and arrested the cell cycle at G1/S phase.…
View article: Xanthohumol Induces ROS through NADPH Oxidase, Causes Cell Cycle Arrest and Apoptosis
Xanthohumol Induces ROS through NADPH Oxidase, Causes Cell Cycle Arrest and Apoptosis Open
Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely related to the site of generation. Xanthohumol (XN) is an important natural product of hops ( Humulus l…
View article: An acute lytic cell death induced by xanthohumol obstructed ROS detecting in HL-60 cells
An acute lytic cell death induced by xanthohumol obstructed ROS detecting in HL-60 cells Open
Serum is an important component in cell culture medium. It also possesses potent antioxidant properties. Therefore, the conventional protocols for detecting reactive oxygen species (ROS) in cultured cells with fluorescent probes include wa…
View article: Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway
Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway Open
Xanthohumol as a natural polyphenol demonstrates an anticancer activity, but its underlying mechanism remains unclear. In this study, we showed that xanthohumol (XN) induces paraptosis of leukemia cells. The paraptosis is one cell death wh…
View article: MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential
MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential Open
During the process of oxidative phosphorylation, protons are pumped into the mitochondrial intermembrane space to establish a mitochondrial membrane potential (MMP). The electrochemical gradient generated allows protons to return to the ma…
View article: Rosmarinic Acid Alleviates the Endothelial Dysfunction Induced by Hydrogen Peroxide in Rat Aortic Rings via Activation of AMPK
Rosmarinic Acid Alleviates the Endothelial Dysfunction Induced by Hydrogen Peroxide in Rat Aortic Rings via Activation of AMPK Open
Endothelial dysfunction is the key player in the development and progression of vascular events. Oxidative stress is involved in endothelial injury. Rosmarinic acid (RA) is a natural polyphenol with antioxidative, antiapoptotic, and anti‐i…