Xiangrong Luo
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View article: Follistatin-like Protein 3 in Colorectal Cancer: Linking Immune Evasion to Treatment Resistance
Follistatin-like Protein 3 in Colorectal Cancer: Linking Immune Evasion to Treatment Resistance Open
Colorectal cancer (CRC) remains a significant global health challenge, characterized by high morbidity and mortality. Despite advances in surgical techniques, chemotherapy, targeted therapies, and immunotherapy, many CRC cases exhibit trea…
View article: Wound-care decision-making and dilemmas at different stages among patients with Wagner grade 2–3 diabetic foot ulcers: A longitudinal qualitative study
Wound-care decision-making and dilemmas at different stages among patients with Wagner grade 2–3 diabetic foot ulcers: A longitudinal qualitative study Open
Five overarching themes and eight subthemes were identified: CONCLUSIONS: Patients with Wagner grade 2-3 DFUs exhibit dynamic, stage-specific changes in wound care decision-making. These decisions are influenced by time and individual fact…
View article: PDE3B and HBB are key prognostic biomarkers driving cell proliferation and regulating immune microenvironment in breast cancer
PDE3B and HBB are key prognostic biomarkers driving cell proliferation and regulating immune microenvironment in breast cancer Open
Background Breast cancer is a heterogeneous malignancy with diverse tumor subpopulations and complex tumor-immune interactions. This study explores the prognostic and functional roles of PDE3B and HBB in breast cancer, focusing on their co…
View article: Turmeric‐Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing
Turmeric‐Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing Open
Regulation of excessive inflammation and impaired cell proliferation is crucial for healing diabetic wounds. Although plant‐to‐mammalian regulation offers effective approaches for chronic wound management, the development of a potent plant…
View article: Relationship between social isolation and glycaemic control of people previously diagnosed with diabetes: secondary analysis from the CHARLS
Relationship between social isolation and glycaemic control of people previously diagnosed with diabetes: secondary analysis from the CHARLS Open
Objectives Social isolation may affect diabetes self-management. This study aimed to explore the relations between social isolation and glycaemic control in patients with diabetes and to explore lifestyle differences among individuals with…
View article: Gram-Negative Bacteria and Lipopolysaccharides as Risk Factors for the Occurrence of Diabetic Foot
Gram-Negative Bacteria and Lipopolysaccharides as Risk Factors for the Occurrence of Diabetic Foot Open
Context Imbalance of the skin microbial community could impair skin immune homeostasis and thus trigger skin lesions. Dysbiosis of skin microbiome may be involved in the early pathogenesis of diabetic foot (DF). However, the potential mech…
View article: Seven bacterial response-related genes are biomarkers for colon cancer
Seven bacterial response-related genes are biomarkers for colon cancer Open
Background Colon cancer (CC) is a common tumor that causes significant harm to human health. Bacteria play a vital role in cancer biology, particularly the biology of CC. Genes related to bacterial response were seldom used to construct pr…
View article: Additional file 2 of Seven bacterial response-related genes are biomarkers for colon cancer
Additional file 2 of Seven bacterial response-related genes are biomarkers for colon cancer Open
Additional file 2: Table S1. 276 differentially expressed genes between normal and colon cancer samples in TCGA.
View article: Additional file 5 of Seven bacterial response-related genes are biomarkers for colon cancer
Additional file 5 of Seven bacterial response-related genes are biomarkers for colon cancer Open
Additional file 5: Table S4. Total 611 bacterial response-related genes from 3 GSEA gene sets.
View article: Additional file 7 of Seven bacterial response-related genes are biomarkers for colon cancer
Additional file 7 of Seven bacterial response-related genes are biomarkers for colon cancer Open
Additional file 7. Data or codes for figure 4–7.
View article: Additional file 3 of Seven bacterial response-related genes are biomarkers for colon cancer
Additional file 3 of Seven bacterial response-related genes are biomarkers for colon cancer Open
Additional file 3: Table S2. Differentially expressed genes in the low and high risk score groups.
View article: Additional file 4 of Seven bacterial response-related genes are biomarkers for colon cancer
Additional file 4 of Seven bacterial response-related genes are biomarkers for colon cancer Open
Additional file 4: Table S3. Differentially expressed lncRNAs of TCGA CC samples.
View article: Rapid microbiological diagnosis based on 16S rRNA gene sequencing: A comparison of bacterial composition in diabetic foot infections and contralateral intact skin
Rapid microbiological diagnosis based on 16S rRNA gene sequencing: A comparison of bacterial composition in diabetic foot infections and contralateral intact skin Open
Diabetic foot infections (DFIs) represent a frequent complication of diabetes and a major cause of amputations. This study aimed to evaluate the utility of 16S rRNA gene sequencing for the rapid microbiological diagnosis of DFIs and to con…
View article: Research progress on the mechanism by which skin macrophage dysfunction mediates chronic inflammatory injury in diabetic skin
Research progress on the mechanism by which skin macrophage dysfunction mediates chronic inflammatory injury in diabetic skin Open
Macrophages, the main immune cells in the skin, form an innate immune barrier. Under physiological conditions, skin maintains immune barrier function through macrophage phagocytosis and antigen presentation. Parenchymal and stromal cell re…
View article: Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast
Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast Open
Adenomyoepithelioma (AME) of the breast is a rare tumor that is composed of proliferating epithelial and myoepithelial cells. The pathogenesis of AME remains unclear, and no breast cancer cells have been identified in such tumor tissues. I…
View article: Analysis of the Composition and Functions of the Microbiome in Diabetic Foot Osteomyelitis Based on 16S rRNA and Metagenome Sequencing Technology
Analysis of the Composition and Functions of the Microbiome in Diabetic Foot Osteomyelitis Based on 16S rRNA and Metagenome Sequencing Technology Open
Metagenome sequencing has not been used in infected bone specimens. This prospective observational study explored the microbiome and its function in patients with diabetic foot osteomyelitis (DFO) and posttraumatic foot osteomyelitis (PFO)…
View article: DNA Nanotweezers with Hydrolytic Activity for Enzyme-Free and Sensitive Detection of Fusion Gene via Logic Operation
DNA Nanotweezers with Hydrolytic Activity for Enzyme-Free and Sensitive Detection of Fusion Gene via Logic Operation Open
Gene fusion is a molecular event occurring in cellular proliferation and differentiation, and the occurrence of irregular fusion gene results in various malignant diseases. So, sensing fusion gene with high performance is an important task…
View article: A Comparison of Tissue versus Swab Culturing of Infected Diabetic Foot Wounds
A Comparison of Tissue versus Swab Culturing of Infected Diabetic Foot Wounds Open
Objective . To compare the efficacy of swabbing versus tissue biopsy for microbiological diagnosis of diabetic foot infection. Methods . This was a prospective trial. Fifty-six patients with diabetic foot infection were divided into the fo…
View article: ERα inhibits epithelial-mesenchymal transition by suppressing Bmi1 in breast cancer
ERα inhibits epithelial-mesenchymal transition by suppressing Bmi1 in breast cancer Open
In human breast cancer, estrogen receptor-α (ERα) suppresses epithelial-mesenchymal transition (EMT) and stemness, two crucial parameters for tumor metastasis; however, the underlying mechanism by which ERα regulates these two processes re…