Xiangsheng Fu
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View article: Preliminary Efficacy Analysis of Early Combination Therapy with Intravitreal Aflibercept and Dexamethasone Implant for Diabetic Macular Edema
Preliminary Efficacy Analysis of Early Combination Therapy with Intravitreal Aflibercept and Dexamethasone Implant for Diabetic Macular Edema Open
Purpose To evaluate the differences in preliminary clinical efficacy and safety between intravitreal aflibercept monotherapy and early combination therapy with aflibercept and dexamethasone implant (DEX-I) for diabetic macular edema (DME).…
View article: Inverted Colonic Diverticulum: Diagnostic Features on Conventional Colonoscopy and Endoscopic Ultrasound
Inverted Colonic Diverticulum: Diagnostic Features on Conventional Colonoscopy and Endoscopic Ultrasound Open
View article: The relationship between the intraocular position of dexamethasone intravitreal implant and post-injection intraocular pressure elevation
The relationship between the intraocular position of dexamethasone intravitreal implant and post-injection intraocular pressure elevation Open
Objective To investigate the relationship between the implantation position of dexamethasone intravitreal implant (DEX-I) and post-injection intraocular pressure (IOP) elevation. Methods This retrospective study included 324 patients (332 …
View article: Gastric microbiota transplantation enhanced the eradication of refractory <i>Helicobacter pylori</i> infection by modulating the gastric microbiota: a pilot study
Gastric microbiota transplantation enhanced the eradication of refractory <i>Helicobacter pylori</i> infection by modulating the gastric microbiota: a pilot study Open
Dysbiosis of the gastric microecology is implicated in various gastric diseases, with Helicobacter pylori ( H. pylori ) infection serving as a pivotal factor influencing the gastric microecological balance and vice versa. In this study, we…
View article: Microbial characteristics of gut microbiome dysbiosis in patients with chronic liver disease
Microbial characteristics of gut microbiome dysbiosis in patients with chronic liver disease Open
BACKGROUND In this study, we are committed to exploring the characteristics of the gut microbiome in three different stages of chronic liver disease (CLD): Chronic hepatitis B, liver cirrhosis, and hepatocellular carcinoma (HCC). AIM To de…
View article: LncRNA SNHG4 Regulates Lipid Metabolism and Inflammation in Non-Alcoholic Fatty Liver Disease by Targeting miR-34b-5p/XIAP Axis
LncRNA SNHG4 Regulates Lipid Metabolism and Inflammation in Non-Alcoholic Fatty Liver Disease by Targeting miR-34b-5p/XIAP Axis Open
Background/Aims: This research aimed at probing the mechanism of long non-coding RNA small nucleolar RNA host gene 4 (SNHG4) in regulating lipid metabolism and inflammation in non-alcoholic fatty liver disease (NAFLD). Materials and Method…
View article: Interkingdom signaling between gastrointestinal hormones and the gut microbiome
Interkingdom signaling between gastrointestinal hormones and the gut microbiome Open
The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in the health of the host and the development of diseases. As a vital component of the intestinal microecosystem, the gut microbiota influences the…
View article: Fedtc: An Effective Federated Learning Approach to Alleviate Model Forgetting and Model Drifting for Gastritis Detection
Fedtc: An Effective Federated Learning Approach to Alleviate Model Forgetting and Model Drifting for Gastritis Detection Open
View article: Development and validation of biomarkers related to anoikis in liver cirrhosis based on bioinformatics analysis
Development and validation of biomarkers related to anoikis in liver cirrhosis based on bioinformatics analysis Open
BACKGROUND According to study, anoikis-related genes (ARGs) have been demonstrated to play a significant impact in cirrhosis, a major disease threatening human health worldwide. AIM To investigate the relationship between ARGs and cirrhosi…
View article: Norepinephrine may promote the progression of <i>Fusobacterium nucleatum</i> related colorectal cancer via quorum sensing signalling
Norepinephrine may promote the progression of <i>Fusobacterium nucleatum</i> related colorectal cancer via quorum sensing signalling Open
Fusobacterium nucleatum (F. nucleatum) is closely correlated with tumorigenesis in colorectal cancer (CRC). We aimed to investigate the effects of host norepinephrine on the carcinogenicity of F. nucleatum in CRC and reveal t…
View article: Editorial: Gastric microbiota dysbiosis and gastric diseases
Editorial: Gastric microbiota dysbiosis and gastric diseases Open
Keywords: gastric microecology, gastric diseases, H.pylori, microbial dysbiosis, gastric microbiota transplantation
View article: Current insights into the hepatic microenvironment and advances in immunotherapy for hepatocellular carcinoma
Current insights into the hepatic microenvironment and advances in immunotherapy for hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and shows high global incidence and mortality rates. The liver is an immune-tolerated organ with a specific immune microenvironment that causes traditional ther…
View article: Gastric microbiota dysbiosis and Helicobacter pylori infection
Gastric microbiota dysbiosis and Helicobacter pylori infection Open
Helicobacter pylori ( H. pylori ) infection is one of the most common causes of gastric disease. The persistent increase in antibiotic resistance worldwide has made H. pylori eradication challenging for clinicians. The stomach is unsterile…
View article: Successful ultrasound-assisted endoscopic removal of a fishbone penetrating the full thickness of the antrum wall
Successful ultrasound-assisted endoscopic removal of a fishbone penetrating the full thickness of the antrum wall Open
A 57-year-old man presented with upper quadrant abdominal pain after had accidental ingestion of a sharp fishbone a few days earlier. Abdominal computed tomography scan demonstrated a hyperdense needle-shaped structure penetrating the stom…
View article: Stress Promoted the Progression of <i>Fusobacterium nucleatum</i> Related Colorectal Cancer Through Catecholamine/Autoinducer-2 Signaling
Stress Promoted the Progression of <i>Fusobacterium nucleatum</i> Related Colorectal Cancer Through Catecholamine/Autoinducer-2 Signaling Open
View article: Alterations of the Gut Microbiome and Fecal Metabolome in Colorectal Cancer: Implication of Intestinal Metabolism for Tumorigenesis
Alterations of the Gut Microbiome and Fecal Metabolome in Colorectal Cancer: Implication of Intestinal Metabolism for Tumorigenesis Open
Objective: The gut microbiota and its metabolites are important for host physiological homeostasis, while dysbiosis is related to diseases including the development of cancers such as colorectal cancer (CRC). In this study, we characterize…
View article: Sequestration of Intestinal Acidic Toxins by Cationic Resin Attenuates Pancreatic Cancer Progression through Promoting Autophagic Flux for YAP Degradation
Sequestration of Intestinal Acidic Toxins by Cationic Resin Attenuates Pancreatic Cancer Progression through Promoting Autophagic Flux for YAP Degradation Open
Pancreatic cancer is driven by risk factors such as diabetes and chronic pancreatic injury, which are further associated with gut dysbiosis. Intestinal toxins such as bile acids and bacterial endotoxin (LPS), in excess and persistence, can…
View article: ZNF32 promotes the self-renewal of colorectal cancer cells by regulating the LEPR-STAT3 signaling pathway
ZNF32 promotes the self-renewal of colorectal cancer cells by regulating the LEPR-STAT3 signaling pathway Open
Due to the self-renewal characteristics and tumorigenic abilities of cancer stem cells (CSCs), CSCs have been demonstrated to play vital roles in carcinogenesis and antitumor therapy. Our previous report found that Krüppel-like family memb…
View article: <i>Fusobacterium nucleatum</i> Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression: Erratum
<i>Fusobacterium nucleatum</i> Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression: Erratum Open
[This corrects the article DOI: 10.7150/thno.38870.].
View article: Supplementary Material for: How to Reduce the Risk of Arteriovenous Fistula Dysfunction by Observing Prepump Arterial Pressure during Hemodialysis: A Multicenter Retrospective Study
Supplementary Material for: How to Reduce the Risk of Arteriovenous Fistula Dysfunction by Observing Prepump Arterial Pressure during Hemodialysis: A Multicenter Retrospective Study Open
Objective: Prepump arterial (Pa) pressure indicates the ease or difficulty with which the blood pump can draw blood from the vascular access (VA) during hemodialysis. Some studies have suggested that the absolute value of the…
View article: Succession of the Gut Microbiome in the Tibetan Population of Minjiang River Basin
Succession of the Gut Microbiome in the Tibetan Population of Minjiang River Basin Open
Background: Tibetans are one of the oldest ethnic groups in China and South Asia. Tibetan has a unique lifestyle and a long history, which leads to the particularity of their gut microflora in composition and function. Different from the T…
View article: Intervention on gut microbiota may change the strategy for management of colorectal cancer
Intervention on gut microbiota may change the strategy for management of colorectal cancer Open
Dysbiosis in the gut microbiota composition due to environmental or genetic variations can disrupt the immune system and may promote several diseases such as colorectal cancer (CRC). Gut microbiota can alter the toxicity and efficiency of …
View article: Twenty years of research on HPV vaccines based on genetically modified lactic acid bacteria: an overview on the gut-vagina axis
Twenty years of research on HPV vaccines based on genetically modified lactic acid bacteria: an overview on the gut-vagina axis Open
View article: Efficacy and Safety of Peroral Endoscopic Myotomy in Achalasia Patients with Failed Previous Intervention: A Systematic Review and Meta-Analysis
Efficacy and Safety of Peroral Endoscopic Myotomy in Achalasia Patients with Failed Previous Intervention: A Systematic Review and Meta-Analysis Open
Peroral endoscopic myotomy (POEM) has emerged as a rescue treatment for recurrent or persistent achalasia after failed initial management. Therefore, we aimed to investigate the efficacy and safety of POEM in achalasia patients with failed…
View article: Body fluids may contribute to human-to-human transmission of severe acute respiratory syndrome coronavirus 2: evidence and practical experience
Body fluids may contribute to human-to-human transmission of severe acute respiratory syndrome coronavirus 2: evidence and practical experience Open
Background In December 2019, an unbelievable outbreak of pneumonia associated with coronavirus was reported in the city of Wuhan, Hubei Province. This virus was called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although …
View article: Sa2056 NOVEL TECHNIQUE OF NEAR-FOCUS MODE FOR ACCURATE OPERATION DURING ENDOSCOPIC SUBMUCOSAL TUNNELING PROCEDURE: A TWO-CENTER COMPARATIVE STUDY (WITH VIDEO)
Sa2056 NOVEL TECHNIQUE OF NEAR-FOCUS MODE FOR ACCURATE OPERATION DURING ENDOSCOPIC SUBMUCOSAL TUNNELING PROCEDURE: A TWO-CENTER COMPARATIVE STUDY (WITH VIDEO) Open
The working space in the submucosal tunnel of endoscopic submucosal tunnel technique (ESTT) is limited, and the visual field is obscure during close inspection or hemostasis. This retrospective study aimed to evaluate the efficacy and safe…
View article: Are Lumen-Apposing Metal Stents More Effective Than Plastic Stents for the Management of Pancreatic Fluid Collections: An Updated Systematic Review and Meta-analysis
Are Lumen-Apposing Metal Stents More Effective Than Plastic Stents for the Management of Pancreatic Fluid Collections: An Updated Systematic Review and Meta-analysis Open
Background and Aims . Recently, a new type of metal stent, named lumen-apposing metal stents (LAMS), has been designed to manage pancreatic fluid collections (PFC), and a few studies have reported its efficacy and safety. Therefore, we con…
View article: Efficacy and safety of endoscopic submucosal tunnel dissection for superficial esophageal neoplastic lesions: a systematic review and meta-analysis
Efficacy and safety of endoscopic submucosal tunnel dissection for superficial esophageal neoplastic lesions: a systematic review and meta-analysis Open
View article: Quality of Life Following Peroral Endoscopic Myotomy for Esophageal Achalasia: A Systematic Review and Meta-Analysis
Quality of Life Following Peroral Endoscopic Myotomy for Esophageal Achalasia: A Systematic Review and Meta-Analysis Open
Our current evidence suggests there is significant improvement in QoL after POEM procedure.
View article: Supplementary tables
Supplementary tables Open
Supplementary tables