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View article: Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes
Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes Open
Type 2 diabetes (T2D) is increasingly recognized as a risk factor for cognitive impairment, ranging from mild cognitive impairment (MCI) to dementia. The underlying mechanisms involve a complex interplay of hyperglycemia, insulin resistanc…
View article: Glycolytic reprogramming during microglial polarization in neurological diseases
Glycolytic reprogramming during microglial polarization in neurological diseases Open
Background Microglia, the resident immune cells of the central nervous system (CNS), play pivotal roles in the onset and progression of various neurological disorders. Owing to their remarkable plasticity, microglia can adopt diverse pheno…
View article: Chemogenetic modulation in stroke recovery: A promising stroke therapy approach
Chemogenetic modulation in stroke recovery: A promising stroke therapy approach Open
Stroke remains a leading cause of long-term disability and mortality worldwide, necessitating novel therapeutic strategies to enhance recovery. Traditional rehabilitation approaches, including physical therapy and pharmacological intervent…
View article: CD4+ T cells in ischemic stroke: effects and therapeutic targets
CD4+ T cells in ischemic stroke: effects and therapeutic targets Open
Ischemic stroke (IS) is a significant contributor to disability and death worldwide, with limited treatments beyond early intervention. The importance of CD4 + T cells in the advancement of IS has been highlighted by recent studies, provid…
View article: Cross-Species Multi-Omics Analysis Reveals Myeloid-Driven Endothelial Oxidative Stress in Ischemic Stroke
Cross-Species Multi-Omics Analysis Reveals Myeloid-Driven Endothelial Oxidative Stress in Ischemic Stroke Open
Background: Ischemic stroke is a leading cause of mortality and disability worldwide, yet the interplay between peripheral and central immune responses is still only partially understood. Emerging evidence suggests that myeloid cells, when…
View article: Interferon regulatory factor 5: a potential target for therapeutic intervention in inflammatory diseases
Interferon regulatory factor 5: a potential target for therapeutic intervention in inflammatory diseases Open
Interferon regulatory factor 5 (IRF5) is a critical transcription factor in the IRF family, playing a pivotal role in modulating immune responses, particularly within the innate immune system. IRF5 regulates the expression of type I interf…
View article: Knockdown of <scp>SESN2</scp> Exacerbates Cerebral Ischemia–Reperfusion Injury Through Enhancing Glycolysis via the <scp>mTOR</scp>/<scp>HIF</scp>‐1α Pathway
Knockdown of <span>SESN2</span> Exacerbates Cerebral Ischemia–Reperfusion Injury Through Enhancing Glycolysis via the <span>mTOR</span>/<span>HIF</span>‐1α Pathway Open
Aim Reprogramming of glycometabolism plays a crucial role in the pathogenesis of cerebral ischemia–reperfusion injury (CIRI). Sestrin2 (SESN2), a sensor upstream of the mTORC1, is closely related to glycometabolism. However, the effect and…
View article: Dapagliflozin Improves High‐Fat Diet‐Induced Cognitive Impairment in Female Mice
Dapagliflozin Improves High‐Fat Diet‐Induced Cognitive Impairment in Female Mice Open
Background High fat consumption is a known risk factor for the development of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) have been found to possess anti‐inflammatory an…
View article: Triolein alleviates ischemic stroke brain injury by regulating autophagy and inflammation through the AKT/mTOR signaling pathway
Triolein alleviates ischemic stroke brain injury by regulating autophagy and inflammation through the AKT/mTOR signaling pathway Open
Background Triolein, a symmetric triglyceride exhibiting anti-inflammatory and antioxidant properties, has demonstrated potential in mitigating cellular damage. However, its therapeutic efficacy in ischemic stroke (IS) and underlying molec…
View article: The Oral–Gut–Brain Axis: The Influence of Microbes as a Link of Periodontitis With Ischemic Stroke
The Oral–Gut–Brain Axis: The Influence of Microbes as a Link of Periodontitis With Ischemic Stroke Open
Periodontitis, a non‐communicable chronic inflammation disease resulting from dysbiosis of the oral microbiota, has been demonstrated to have a positive association with the risk of ischemic stroke (IS). The major periodontal pathogens con…
View article: Dietary Factors and Cardiovascular Diseases: Comprehensive Insights from the National Health and Nutrition Examination Survey 2017–2020 and Mendelian Randomization Analysis
Dietary Factors and Cardiovascular Diseases: Comprehensive Insights from the National Health and Nutrition Examination Survey 2017–2020 and Mendelian Randomization Analysis Open
Background: Cardiovascular diseases (CVDs) are a major public health concern. The impact of dietary components on CVD risk has been recognized, but their interactions require further investigation. This study aimed to examine the associati…
View article: Macrophage polarization and metabolic reprogramming in abdominal aortic aneurysm
Macrophage polarization and metabolic reprogramming in abdominal aortic aneurysm Open
Background Abdominal aortic aneurysm (AAA) is a macrovascular disease with high morbidity and mortality in the elderly. The limitation of the current management is that most patients can only be followed up until the AAA diameter increases…
View article: Blood‐Brain Barrier‐Penetrating Metal‐Organic Framework Antioxidant Nanozymes for Targeted Ischemic Stroke Therapy
Blood‐Brain Barrier‐Penetrating Metal‐Organic Framework Antioxidant Nanozymes for Targeted Ischemic Stroke Therapy Open
Overproduction of reactive oxygen species (ROS) during reperfusion in ischemic stroke (IS) severely impedes neuronal survival and results in high rates of morbidity and disability. The effective blood‐brain barrier (BBB) penetration and br…
View article: Multicenter integration analysis of TRP channels revealed potential mechanisms of immunosuppressive microenvironment activation and identified a machine learning‐derived signature for improving outcomes in gliomas
Multicenter integration analysis of TRP channels revealed potential mechanisms of immunosuppressive microenvironment activation and identified a machine learning‐derived signature for improving outcomes in gliomas Open
Aim This study aimed to explore the mechanisms of transient receptor potential (TRP) channels on the immune microenvironment and develop a TRP‐related signature for predicting prognosis, immunotherapy response, and drug sensitivity in glio…
View article: Exploring MAP2K3 as a prognostic biomarker and potential immunotherapy target in glioma treatment
Exploring MAP2K3 as a prognostic biomarker and potential immunotherapy target in glioma treatment Open
Glioma, the most prevalent primary brain tumor in adults, is characterized by significant invasiveness and resistance. Current glioma treatments include surgery, radiation, chemotherapy, and targeted therapy, but these methods often fail t…
View article: Anti-adhesion study of three-dimensional reconstructed carbon coatings
Anti-adhesion study of three-dimensional reconstructed carbon coatings Open
This research study focuses on the investigation of a three-dimensional reconstructed carbon coating based on stainless steel. The investigation encompasses the assessment of surface structure, elemental composition, cytotoxicity, and impa…
View article: Mitochondria‐associated endoplasmic reticulum membranes tethering protein VAPB‐PTPIP51 protects against ischemic stroke through inhibiting the activation of autophagy
Mitochondria‐associated endoplasmic reticulum membranes tethering protein VAPB‐PTPIP51 protects against ischemic stroke through inhibiting the activation of autophagy Open
Aims Mitochondria‐associated endoplasmic reticulum membranes (MAMs) serve as a crucial bridge connecting the endoplasmic reticulum (ER) and mitochondria within cells. Vesicle‐associated membrane protein‐associated protein B (VAPB) and prot…
View article: CAR-T treatment for cancer: prospects and challenges
CAR-T treatment for cancer: prospects and challenges Open
Chimeric antigen receptor (CAR-T) cell therapy has been widely used in hematological malignancies and has achieved remarkable results, but its long-term efficacy in solid tumors is greatly limited by factors such as the tumor microenvironm…
View article: Targeting Microglia/Macrophages Notch1 Protects Neurons from Pyroptosis in Ischemic Stroke
Targeting Microglia/Macrophages Notch1 Protects Neurons from Pyroptosis in Ischemic Stroke Open
Background and Aims: The immune-inflammatory cascade and pyroptosis play an important role in the pathogenesis of cerebral ischemia-reperfusion injury (CIRI). The maintenance of immune homeostasis is inextricably linked to the Notch signal…
View article: Vagus nerve stimulation in cerebral stroke: biological mechanisms, therapeutic modalities, clinical applications, and future directions
Vagus nerve stimulation in cerebral stroke: biological mechanisms, therapeutic modalities, clinical applications, and future directions Open
Stroke is a major disorder of the central nervous system that poses a serious threat to human life and quality of life. Many stroke victims are left with long-term neurological dysfunction, which adversely affects the well-being of the ind…
View article: Neutral polysaccharide from <i>Gastrodia elata</i> alleviates cerebral ischemia–reperfusion injury by inhibiting ferroptosis‐mediated neuroinflammation via the <scp>NRF2</scp>/<scp>HO</scp>‐1 signaling pathway
Neutral polysaccharide from <i>Gastrodia elata</i> alleviates cerebral ischemia–reperfusion injury by inhibiting ferroptosis‐mediated neuroinflammation via the <span>NRF2</span>/<span>HO</span>‐1 signaling pathway Open
Aims The crosstalk between ferroptosis and neuroinflammation considerably impacts the pathogenesis of cerebral ischemia–reperfusion injury (CIRI). Neutral polysaccharide from Gastrodia elata (NPGE) has shown significant effects against oxi…
View article: Cuproptosis facilitates immune activation but promotes immune escape, and a machine learning–based cuproptosis‐related signature is identified for predicting prognosis and immunotherapy response of gliomas
Cuproptosis facilitates immune activation but promotes immune escape, and a machine learning–based cuproptosis‐related signature is identified for predicting prognosis and immunotherapy response of gliomas Open
Aims Cell death, except for cuproptosis, in gliomas has been extensively studied, providing novel targets for immunotherapy by reshaping the tumor immune microenvironment through multiple mechanisms. This study aimed to explore the effect …
View article: Ferroptosis and endoplasmic reticulum stress in ischemic stroke
Ferroptosis and endoplasmic reticulum stress in ischemic stroke Open
Ferroptosis is a form of non-apoptotic programmed cell death, and its mechanisms mainly involve the accumulation of lipid peroxides, imbalance in the amino acid antioxidant system, and disordered iron metabolism. The primary organelle resp…