Xiangting Wang
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View article: Insights into organelle forming <scp>RNAs</scp> : Diversity, functions and future perspectives
Insights into organelle forming <span>RNAs</span> : Diversity, functions and future perspectives Open
RNA molecules play diverse and essential roles in cellular processes beyond their well‐known functions in gene expression and regulation. While ribosomal RNAs (rRNAs) have long been recognized as structural components of ribosomes, recent …
View article: Characterizing and decoding ultraconserved regions uncovers their regulatory significance in human brain development and disorders
Characterizing and decoding ultraconserved regions uncovers their regulatory significance in human brain development and disorders Open
Ultraconserved regions (UCRs) represent genomic elements with perfect sequence conservation across humans, rats, and mice. Though evolutionarily significant, most UCRs' functions remain elusive. Here, by leveraging current reference genome…
View article: Alternative splicing in stem cells and development: research progress and emerging technologies
Alternative splicing in stem cells and development: research progress and emerging technologies Open
View article: Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis
Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis Open
View article: DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells
DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells Open
Ribosome biogenesis plays a pivotal role in maintaining stem cell homeostasis, yet the precise regulatory mechanisms governing this process in mouse embryonic stem cells (mESCs) remain largely unknown. In this investigation, we ascertain t…
View article: LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination
LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination Open
A long-standing hypothesis proposes that certain RNA(s) must exhibit structural roles in microtubule assembly. Here, we identify a long noncoding RNA ( TubAR ) that is highly expressed in cerebellum and forms RNA–protein complex with TUBB4…
View article: Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats
Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats Open
Inflammation and fibrosis often occur in the kidney after acute injury, resulting in chronic kidney disease and consequent renal failure. Recent studies have indicated that lymphangiogenesis can drive renal inflammation and fibrosis in inj…
View article: Losartan ameliorates renal fibrosis by inhibiting tumor necrosis factor signal pathway
Losartan ameliorates renal fibrosis by inhibiting tumor necrosis factor signal pathway Open
Losartan is widely used in the treatment of chronic kidney disease (CKD) and has achieved good clinical efficacy, but its exact mechanism is not clear. We performed high-throughput sequencing (HTS) technology to screen the potential target…
View article: Synthesis and Electrochemical Properties of Two Cobalt(Ii) and Nickel(Ii) Metal-Organic Frameworks for Excellent Performance Supercapacitors
Synthesis and Electrochemical Properties of Two Cobalt(Ii) and Nickel(Ii) Metal-Organic Frameworks for Excellent Performance Supercapacitors Open
View article: NEK2 promotes TP53 ubiquitination to enhance the proliferation and migration of TP53 wild-type glioblastoma cells
NEK2 promotes TP53 ubiquitination to enhance the proliferation and migration of TP53 wild-type glioblastoma cells Open
The most common primary malignant tumor in the adult brain is glioblastoma multiforme (GBM); however, its underlying pathogenic mechanism remains elusive. The never in mitosis (NIMA)-related kinase 2 (NEK2) has been closely associated with…
View article: <scp>LncRNAs</scp>: Current understanding, future directions, and challenges
<span>LncRNAs</span>: Current understanding, future directions, and challenges Open
Long non-coding RNAs (lncRNAs) are a class of regulatory RNA molecules that have captured the attention of researchers in recent years due to their diverse roles in development, physiological and pathological processes.1-6 Unlike the conve…
View article: The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis
The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis Open
The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle …
View article: Mesenchymal stem cell-derived extracellular vesicles for treatment of chronic kidney disease in preclinical animal models: a meta-analysis
Mesenchymal stem cell-derived extracellular vesicles for treatment of chronic kidney disease in preclinical animal models: a meta-analysis Open
Objective. Evaluate the effectiveness of extracellular vesicles derived from mesenchymal stem cells (MSCs) in the treatment of chronic kidney disease based on meta-analysis. Methods. We searched CNKI, Wanfang, VIP, SinoMed, PubMed, Cochran…
View article: 6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification
6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification Open
6-Gingerol (6G) is the main phenolic active component of ginger, which has a certain protective effect against liver injury induced by drugs, and chemical pollutants. However, the mechanism of protection of 6G against arsenic trioxide (ATO…
View article: Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway
Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway Open
LQ protected against myocardial fibrosis following MI by improving cardiac function, and attenuating oxidative damage and inflammatory response, which may be associated with inhibition of CCL5 expression and the NF-κB pathway.
View article: Yiqi Huoxue Tongluo recipe regulates NR4A1 to improve renal mitochondrial function in unilateral ureteral obstruction (UUO) rats
Yiqi Huoxue Tongluo recipe regulates NR4A1 to improve renal mitochondrial function in unilateral ureteral obstruction (UUO) rats Open
YHTR significantly improved the development of CKD; this study may provide new ideas for the pathogenesis of CKD and new strategies for the development of new drugs against CKD.
View article: The nuclear receptor subfamily 4 group A1 in human disease
The nuclear receptor subfamily 4 group A1 in human disease Open
Nuclear receptor 4A1 (NR4A1), a member of the NR4A subfamily, acts as a gene regulator in a wide range of signaling pathways and responses to human diseases. Here, we provided a brief overview of the current functions of NR4A1 in human dis…
View article: Characterizing the molecular heterogeneity of clear cell renal cell carcinoma subgroups classified by miRNA expression profile
Characterizing the molecular heterogeneity of clear cell renal cell carcinoma subgroups classified by miRNA expression profile Open
Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease that is associated with poor prognosis. Recent works have revealed the significant roles of miRNA in ccRCC initiation and progression. Comprehensive characterization of ccR…
View article: The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension Open
Background: Renal T cells contribute importantly to hypertension, but the underlying mechanism is incompletely understood. We reported that CD8Ts directly stimulate distal convoluted tubule cells (DCTs) to increase NCC (sodium chloride co-…
View article: Eplerenone Prevents Cardiac Fibrosis by Inhibiting Angiogenesis in Unilateral Urinary Obstruction Rats
Eplerenone Prevents Cardiac Fibrosis by Inhibiting Angiogenesis in Unilateral Urinary Obstruction Rats Open
Introduction. Cardiovascular disease constitutes the leading cause of mortality in patients with chronic kidney disease (CKD), which is termed cardiorenal syndrome type 4 (CRS-4). Here, we report the development of pathological cardiac rem…
View article: Characterization of Alzheimer’s Disease-Associated Excitatory Neurons via Single-Cell RNA Sequencing Analysis
Characterization of Alzheimer’s Disease-Associated Excitatory Neurons via Single-Cell RNA Sequencing Analysis Open
The detailed characteristics of neuronal cell populations in Alzheimer’s disease (AD) using single-cell RNA sequencing have not been fully elucidated. To explore the characterization of neuronal cell populations in AD, this study utilized …
View article: A pair of long intergenic non-coding RNA LINC00887 variants act antagonistically to control Carbonic Anhydrase IX transcription upon hypoxia in tongue squamous carcinoma progression
A pair of long intergenic non-coding RNA LINC00887 variants act antagonistically to control Carbonic Anhydrase IX transcription upon hypoxia in tongue squamous carcinoma progression Open
Background Long noncoding RNAs (lncRNAs) are important regulators in tumor progression. However, their biological functions and underlying mechanisms in hypoxia adaptation remain largely unclear. Results Here, we established a correlation …
View article: Identification of Autophagy- and Ferroptosis-Related lncRNAs Functioned through Immune-Related Pathways in Head and Neck Squamous Carcinoma
Identification of Autophagy- and Ferroptosis-Related lncRNAs Functioned through Immune-Related Pathways in Head and Neck Squamous Carcinoma Open
The interplay between autophagy and ferroptosis has been highlighted as an important event to decide cancer cell fate. However, the underlying mechanisms remain largely unclear. In this study, we systematically explored the expression, pro…
View article: Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1β Pathway
Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1β Pathway Open
Objectives. To study the protective effects and mechanisms of Huoxue Jiedu Huayu formula on cell pyroptosis through the NLRP3/caspase-1/IL-1β pathway in contralateral kidneys in 6-month-old unilateral ureteral obstruction (UUO) rats. Metho…
View article: Long noncoding RNA PM maintains cerebellar synaptic integrity and Cbln1 activation via Pax6/Mll1-mediated H3K4me3
Long noncoding RNA PM maintains cerebellar synaptic integrity and Cbln1 activation via Pax6/Mll1-mediated H3K4me3 Open
Recent studies have shown that long noncoding RNAs (lncRNAs) are critical regulators in the central nervous system (CNS). However, their roles in the cerebellum are currently unclear. In this work, we identified the isoform 204 of lncRNA G…
View article: RNA and liquid-liquid phase separation
RNA and liquid-liquid phase separation Open
View article: Comparative Analyses Reveal Peroxidases Play Important Roles in Soybean Tolerance to Aluminum Toxicity
Comparative Analyses Reveal Peroxidases Play Important Roles in Soybean Tolerance to Aluminum Toxicity Open
Aluminum (Al) toxicity is an important barrier to soybean (Glycine max (L.) Merr.) production in acid soils. However, little is known about the genes underlying Al tolerance in soybean. We aim to find the key candidate genes and investigat…
View article: 7SK Acts as an Anti-tumor Factor in Tongue Squamous Cell Carcinoma
7SK Acts as an Anti-tumor Factor in Tongue Squamous Cell Carcinoma Open
Increasing evidence has shown the mechanistic insights about non-coding RNA 7SK in controlling the transcription. However, the biological function and mechanism of 7SK in cancer are largely unclear. Here, we show that 7SK is down-regulated…
View article: Astragaloside IV Inhibits Mitochondrial-Dependent Apoptosis of the Dorsal Root Ganglion in Diabetic Peripheral Neuropathy Rats Through Modulation of the SIRT1/p53 Signaling Pathway
Astragaloside IV Inhibits Mitochondrial-Dependent Apoptosis of the Dorsal Root Ganglion in Diabetic Peripheral Neuropathy Rats Through Modulation of the SIRT1/p53 Signaling Pathway Open
AS-IV can reduce the occurrence of mitochondrial-dependent apoptosis by regulating the SIRT1/p53 pathway. It has a similar therapeutic effect as ALA and is therefore a promising drug for the potential treatment of DPN.
View article: Characterization of the complete chloroplast genome of <i>Homalomena occulta</i> (Lour.) Schott
Characterization of the complete chloroplast genome of <i>Homalomena occulta</i> (Lour.) Schott Open
Homalomena occulta (Lour.) Schott (H. occulta) is a traditional Chinese medicine. However, the chloroplast genome has not been reported. Here, we assembled and analyzed the complete chloroplast (CP) genome of H. occulta.