Xiangxiang Zhou
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View article: Recent advances in S-palmitoylation and its emerging roles in human diseases
Recent advances in S-palmitoylation and its emerging roles in human diseases Open
View article: Exosome- transported FER inhibitor suppresses progression of diffuse large B-cell lymphoma via regulating AJUBA/Hippo axis
Exosome- transported FER inhibitor suppresses progression of diffuse large B-cell lymphoma via regulating AJUBA/Hippo axis Open
FER, an intracellular tyrosine kinase, is ubiquitously expressed in malignancies. However, the regulatory mechanisms of FER in diffuse large B-cell lymphoma (DLBCL) remain elusive. Here, we found that FER was upregulated in DLBCL, leading …
View article: 754 | REAL WORLD PATIENT CHARACTERISTICS, TREATMENT PATTERNS, AND OUTCOMES FOR CHINESE PATIENTS WITH CD30‐POSITIVE PERIPHERAL T‐CELL LYMPHOMA
754 | REAL WORLD PATIENT CHARACTERISTICS, TREATMENT PATTERNS, AND OUTCOMES FOR CHINESE PATIENTS WITH CD30‐POSITIVE PERIPHERAL T‐CELL LYMPHOMA Open
View article: Expanding the Scope of Molecular Glues: TRIM21 as a Multimeric Protein Degrader
Expanding the Scope of Molecular Glues: TRIM21 as a Multimeric Protein Degrader Open
View article: CAR-NK cell therapy: latest updates from the 2024 ASH annual meeting
CAR-NK cell therapy: latest updates from the 2024 ASH annual meeting Open
Natural killer cells, integral to the innate immune response, exhibit the inherent capacity to identify and eliminate cancer cells without prior exposure, positioning them as prime candidates for immunotherapeutic strategies. Chimeric anti…
View article: Autoimmune disease and risk of lymphoma: analysis from real-world data and Mendelian randomization study
Autoimmune disease and risk of lymphoma: analysis from real-world data and Mendelian randomization study Open
Our results confirmed the causal relationships between AIDs and risks of lymphoma. Serum ALB and SA levels have demonstrated a vital influence on outcomes of AAL patients, in which the IL-17 pathway might play an active role.
View article: Targeting TTK Inhibits Tumorigenesis of T‐Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway
Targeting TTK Inhibits Tumorigenesis of T‐Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway Open
T‐cell lymphoma (TCL) is a group of non‐Hodgkin's lymphoma with high heterogeneity and unfavorable prognosis. Current standard treatments have demonstrated limited efficacy in improving the outcomes for TCL patients. Therefore, identificat…
View article: Principle Analysis and Device Development of a Novel Technology for Preventing Lockset Failure and Cable Bolt Ejection
Principle Analysis and Device Development of a Novel Technology for Preventing Lockset Failure and Cable Bolt Ejection Open
View article: Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism
Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism Open
View article: Targeted protein degradation: advances in drug discovery and clinical practice
Targeted protein degradation: advances in drug discovery and clinical practice Open
Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in disease management, providing a stark contrast to traditional therapeutic approaches like small molecule inhibitors that primarily focus on inhibiting pr…
View article: Glycosylation: mechanisms, biological functions and clinical implications
Glycosylation: mechanisms, biological functions and clinical implications Open
Protein post-translational modification (PTM) is a covalent process that occurs in proteins during or after translation through the addition or removal of one or more functional groups, and has a profound effect on protein function. Glycos…
View article: <i>N</i>‐acetyltransferase 10 facilitates tumorigenesis of diffuse large B‐cell lymphoma by regulating AMPK/mTOR signalling through N4‐acetylcytidine modification of SLC30A9
<i>N</i>‐acetyltransferase 10 facilitates tumorigenesis of diffuse large B‐cell lymphoma by regulating AMPK/mTOR signalling through N4‐acetylcytidine modification of SLC30A9 Open
Background Accumulating studies suggested that posttranscriptional modifications exert a vital role in the tumorigenesis of diffuse large B‐cell lymphoma (DLBCL). N4‐acetylcytidine (ac4C) modification, catalyzed by the N ‐acetyltransferase…
View article: Targeting regulated cell death (RCD) in hematological malignancies: Recent advances and therapeutic potential
Targeting regulated cell death (RCD) in hematological malignancies: Recent advances and therapeutic potential Open
Regulated cell death (RCD) is a form of cell death that can be regulated by numerous biomacromolecules. Accumulating evidence suggests that dysregulated expression and altered localization of related proteins in RCD promote the development…
View article: Targeted protein degradation in hematologic malignancies: latest updates from the 2023 ASH annual meeting
Targeted protein degradation in hematologic malignancies: latest updates from the 2023 ASH annual meeting Open
Protein degraders, emerging as a novel class of therapeutic agents, have gained widespread attention due to their advantages. They have several advantages over traditional small molecule inhibitors, including high target selectivity and ab…
View article: NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner
NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner Open
This study demonstrated that dysregulation of NCAPD3 could disturb chromosome compaction and segregation and regulate the transcription activity of SIRT1 in an H3K9me1-dependent manner, which provided novel insights into targeted strategy …
View article: Generation of 583 fs optical pulses at 10 GHz from a regeneratively mode-locked fiber laser combining nonlinear polarization evolution
Generation of 583 fs optical pulses at 10 GHz from a regeneratively mode-locked fiber laser combining nonlinear polarization evolution Open
A regeneratively mode-locked erbium fiber laser was numerically investigated and experimentally demonstrated, which was able to generate a 583 fs pulse train at 10 GHz via intracavity pulse compression with nonlinear polarization evolution…
View article: Serum indicators in functional high-risk multiple myeloma patients undertaking proteasome inhibitors therapy: a retrospective study
Serum indicators in functional high-risk multiple myeloma patients undertaking proteasome inhibitors therapy: a retrospective study Open
Therefore, in the PIs era, transplantations are still effective therapies for transplant-eligible MM patients.
View article: Third-Order Nonlinear Optical Properties of Phenothiazine-Based Imine Covalent Organic Framework Films
Third-Order Nonlinear Optical Properties of Phenothiazine-Based Imine Covalent Organic Framework Films Open
View article: Incidence and mortality of second primary malignancies after lymphoma: a population-based analysis
Incidence and mortality of second primary malignancies after lymphoma: a population-based analysis Open
Second primary malignancies (SPMs) account for an increasing proportion of human malignancies. We estimated the incidence, risk factors and outcomes in lymphoma survivors with SPMs. Patients diagnosed with SPMs after primary lymphoma from …
View article: Targeting YTHDF2 inhibits tumorigenesis of diffuse large B-cell lymphoma through ACER2-mediated ceramide catabolism
Targeting YTHDF2 inhibits tumorigenesis of diffuse large B-cell lymphoma through ACER2-mediated ceramide catabolism Open
This study demonstrated that YTHDF2 contributed to the progression of DLBCL by regulating ACER2-mediated ceramide metabolism in an m6A-dependent manner, providing novel insights into targeted therapies.
View article: Histone regulator KAT2A acts as a potential biomarker related to tumor microenvironment and prognosis of diffuse large B cell lymphoma
Histone regulator KAT2A acts as a potential biomarker related to tumor microenvironment and prognosis of diffuse large B cell lymphoma Open
View article: Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential
Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential Open
As highly conserved among diverse species, Hippo signaling pathway regulates various biological processes, including development, cell proliferation, stem cell function, tissue regeneration, homeostasis, and organ size. Studies in the last…
View article: Recent advances of ferroptosis in tumor: From biological function to clinical application
Recent advances of ferroptosis in tumor: From biological function to clinical application Open
Ferroptosis is a recently recognized form of cell death with distinct features in terms of morphology, biochemistry, and molecular mechanisms. Unlike other types of cell death, ferroptosis is characterized by iron dependence, reactive oxyg…
View article: P1210: TARGETING PTGDS AS A NOVEL THERAPEUTIC APPROACH IN PERIPHERAL T CELL LYMPHOMA THROUGH REGULATING IRON METABOLISM
P1210: TARGETING PTGDS AS A NOVEL THERAPEUTIC APPROACH IN PERIPHERAL T CELL LYMPHOMA THROUGH REGULATING IRON METABOLISM Open
Topic: 20. Lymphoma Biology & Translational Research Background: Ferroptosis, characterized by reactive oxygen species (ROS) accumulation and lipid peroxidation, is a kind of specialized cell death dependent on iron metabolism. Accumulatin…
View article: Identification of pyroptosis-related signature and development of a novel prognostic model in diffuse large B-cell lymphoma
Identification of pyroptosis-related signature and development of a novel prognostic model in diffuse large B-cell lymphoma Open
View article: α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis
α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis Open
View article: The epidemiological patterns of non-Hodgkin lymphoma: global estimates of disease burden, risk factors, and temporal trends
The epidemiological patterns of non-Hodgkin lymphoma: global estimates of disease burden, risk factors, and temporal trends Open
Background The incidence of non-Hodgkin’s lymphoma (NHL) has increased steadily over the past few decades. Elucidating its global burden will facilitate more effective disease management and improve patient outcomes. We explored the diseas…
View article: PROGNOSTIC SIGNIFICANCE OF KAT2A AS A HISTONE ACETYLATION REGULATOR IN DIFFUSE LARGE B‐CELL LYMPHOMA
PROGNOSTIC SIGNIFICANCE OF KAT2A AS A HISTONE ACETYLATION REGULATOR IN DIFFUSE LARGE B‐CELL LYMPHOMA Open
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm with variations in the expression of genes and genetic alterations. Histone acetylation is one of the epigenetic alterations associated with lymphoma pathoge…
View article: P-69 Efficacy and safety of surufatinib in intrahepatic cholangiocarcinoma: Preliminary results of a real-world study
P-69 Efficacy and safety of surufatinib in intrahepatic cholangiocarcinoma: Preliminary results of a real-world study Open
View article: THE RNA M6A READER YTHDF2 REGULATES ACER2‐CERAMIDE METABOLIC AXIS TO PROMOTE TUMORIGENESIS OF DIFFUSE LARGE B‐CELL LYMPHOMA
THE RNA M6A READER YTHDF2 REGULATES ACER2‐CERAMIDE METABOLIC AXIS TO PROMOTE TUMORIGENESIS OF DIFFUSE LARGE B‐CELL LYMPHOMA Open
Introduction: N6-methyladenosine (m6A) is the most abundant modification in eukaryotes and plays an important biological function in human diseases. YTHDF2 is an important m6A reading protein, which could specifically bind to m6A-modified …