Jie Zhang
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View article: A Review of Wear-Resistant Coatings for Steel Substrates: Applications and Challenges
A Review of Wear-Resistant Coatings for Steel Substrates: Applications and Challenges Open
This study reviews the current research status and future trends in the field of abrasive-resistant coating preparation, focusing on steel coating technology. The types of materials, preparation methods, and application status of the abras…
View article: A New Classification of In Situ and Anvil Cirrus Clouds Uncovers Their Properties and Interhemispheric Connections
A New Classification of In Situ and Anvil Cirrus Clouds Uncovers Their Properties and Interhemispheric Connections Open
The challenge of distinguishing convective anvil cirrus from in situ cirrus has long limited the quantification of their distinct roles in regulating upper‐tropospheric moisture and modulating Earth's energy budget. In this study, we addre…
View article: FBXO2 promotes hepatocellular carcinoma progression and sorafenib resistance by targeting USP49 for proteasomal degradation
FBXO2 promotes hepatocellular carcinoma progression and sorafenib resistance by targeting USP49 for proteasomal degradation Open
Introduction Hepatocellular carcinoma (HCC) is a highly prevalent and lethal malignancy with limited treatment efficacy due to tumor heterogeneity and the development of drug resistance. Identifying novel molecular mechanisms that drive HC…
View article: Integrated confinement-chemisorption-catalysis cathode for highly stable zinc-iodine batteries
Integrated confinement-chemisorption-catalysis cathode for highly stable zinc-iodine batteries Open
View article: Emerging Understanding of Gut Microbiome in Colorectal Cancer and Food-Related Intervention Strategies
Emerging Understanding of Gut Microbiome in Colorectal Cancer and Food-Related Intervention Strategies Open
Colorectal cancer (CRC) is one of the most common cancers, accounting for approximately 10% of all new cancer cases globally. An increasing number of studies have revealed that the gut microbiome is strongly associated with the pathogenesi…
View article: Optimization of Nitrogen Injection via Top-Blown O2–N2 Mixed Gas in BOF Steelmaking for Enhanced Rebar Performance
Optimization of Nitrogen Injection via Top-Blown O2–N2 Mixed Gas in BOF Steelmaking for Enhanced Rebar Performance Open
Rebar is a critical material in concrete constructions like high-rise buildings and seismic-resistant structures. To enhance its properties, microalloying with nitrogen is employed, but traditional methods using micro alloy additives such …
View article: Structural and dynamic insights into phosphate uptake by PHT1 transporter in rice
Structural and dynamic insights into phosphate uptake by PHT1 transporter in rice Open
Summary Phosphorus is an essential macronutrient for plants, primarily absorbed from the soil as inorganic phosphate (Pi) through root-located Pi transporters. Despite decades of research into these transporters as targets for developing P…
View article: Ciprofol Alleviates Depressive-Like Behaviors in CUMS Mice Through PPARα-Associated ERK/CREB Signaling Activation
Ciprofol Alleviates Depressive-Like Behaviors in CUMS Mice Through PPARα-Associated ERK/CREB Signaling Activation Open
Ciprofol can alleviate the depressive-like behaviors in CUMS mice by inhibiting the inflammatory response and reducing synaptic loss, and the mechanism may be related to the activation of the PPARα-mediated ERK/CREB pathway.
View article: Formation of high-quality Ni/Ag contacts on p-GaN/AlGaN/GaN platform
Formation of high-quality Ni/Ag contacts on p-GaN/AlGaN/GaN platform Open
View article: Bmi1 regulates neural differentiation of mesenchymal stem cells through the Wnt3a‑RhoA signaling pathway to repair ischemic brain injury in rats
Bmi1 regulates neural differentiation of mesenchymal stem cells through the Wnt3a‑RhoA signaling pathway to repair ischemic brain injury in rats Open
Ischemic brain injury (IBI) is characterized by high morbidity, disability and mortality rates; however, it lacks effective clinical treatments. Mesenchymal stem cells (MSCs), as pluripotent stem cells with self‑renewal capacity and multil…
View article: Capnography monitoring reduces incidence of hypoxia in older patients undergoing gastrointestinal endoscopy under propofol sedation
Capnography monitoring reduces incidence of hypoxia in older patients undergoing gastrointestinal endoscopy under propofol sedation Open
Whether routine capnography monitoring during gastrointestinal endoscopy sedation can reduce occurrence of hypoxia is controversial. Older patients are more prone to hypoxia. This study aimed to determine the effect of additional capnograp…
View article: N4BP1 is a nucleocytoplasmic shuttling protein and recognizes aggregates of the ubiquitin-like protein NEDD8 to protect cells under heat shock
N4BP1 is a nucleocytoplasmic shuttling protein and recognizes aggregates of the ubiquitin-like protein NEDD8 to protect cells under heat shock Open
N4BP1 (NEDD4-binding partner 1) is a key checkpoint for proper inflammatory responses; however, its cellular localization, biologic nature, and functions in other cellular processes remain largely unknown. In this study, we demonstrate tha…
View article: DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation
DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation Open
Metastasis is a leading cause of treatment failure and high mortality in non-small cell lung cancer (NSCLC). Recently, we demonstrated that DEAD box helicase 39B (DDX39B) was upregulated and activated metabolic reprogramming in colorectal …
View article: Elevated FBXO45 promotes TFG ubiquitination and drives lung metastasis of hepatocellular carcinoma
Elevated FBXO45 promotes TFG ubiquitination and drives lung metastasis of hepatocellular carcinoma Open
View article: Extracellular vesicle-mediated transmission of circPDLIM5 promotes lymphatic metastasis in prostate cancer
Extracellular vesicle-mediated transmission of circPDLIM5 promotes lymphatic metastasis in prostate cancer Open
For patients with prostate cancer (PCa), pelvic lymph node (LN) metastasis remains a major poor prognostic factor associated with cancer-specific mortality. VEGF-C is a major lymphangiogenic ligand that plays a vital role in LN metastasis …
View article: The predictive value of total body PET/CT in high PD-L1 expression and immunotherapy in advanced non-small cell lung cancer patients
The predictive value of total body PET/CT in high PD-L1 expression and immunotherapy in advanced non-small cell lung cancer patients Open
Introduction Total-body positron emission tomography/computed tomography (PET/CT) using uEXPLORER scanners demonstrates superior imaging capabilities for assessing programmed death ligand 1 (PD-L1) expression heterogeneity between primary …
View article: From fingers to brain: virtual reality-based test capturing fine hand movements predicts cognitive function in older adults
From fingers to brain: virtual reality-based test capturing fine hand movements predicts cognitive function in older adults Open
Background and Objectives Early detection of mild cognitive impairment (MCI) is vital for managing cognitive decline in older adults. Hand movements are closely linked to cognitive function, prompting this study to develop a virtual realit…
View article: E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1
E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1 Open
Atherosclerosis arises from disrupted cholesterol metabolism, notably impaired macrophage cholesterol efflux leading to foam cell formation. Through single-cell and bulk RNA-Seq, we identified Listerin E3 ubiquitin protein ligase 1 (Lister…
View article: Anomaly Field Extraction Based on Layered-Earth Model and Equivalent Eddy Current Inversion: A Case Study of Borehole zk506 in Baishiquan, Xinjiang
Anomaly Field Extraction Based on Layered-Earth Model and Equivalent Eddy Current Inversion: A Case Study of Borehole zk506 in Baishiquan, Xinjiang Open
Based on the concept of an equivalent eddy current, anomaly field inversion provides an efficient and rapid inversion method for borehole transient electromagnetic (BHTEM) measurements. It enables the utilization of the equivalent eddy cur…
View article: Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche
Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche Open
Bone metastasis is a major cause of cancer death; however, the epigenetic determinants driving this process remain elusive. Here, we report that histone methyltransferase ASH1L is genetically amplified and is required for bone metastasis i…
View article: CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors
CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors Open
View article: Immune checkpoint inhibitor-related myocarditis in patients with lung cancer
Immune checkpoint inhibitor-related myocarditis in patients with lung cancer Open
View article: NIR-Triggered siRNA Release and Lysosomal Escape for Synergistic Photothermal Tumor Therapy
NIR-Triggered siRNA Release and Lysosomal Escape for Synergistic Photothermal Tumor Therapy Open
As a dual-function photothermal therapy agent, HSA@ICG/siRNA NPs combine targeted gene silencing with photothermal effects, demonstrating significant therapeutic promise. This integrated approach addresses tumor resistance, offering a pote…
View article: The applicability and effectiveness of the cognitive behavioral therapy for insomnia (Smart CBT-I plus) online program in patients with insomnia disorder combined with anxiety and depression: a randomized controlled trial protocol
The applicability and effectiveness of the cognitive behavioral therapy for insomnia (Smart CBT-I plus) online program in patients with insomnia disorder combined with anxiety and depression: a randomized controlled trial protocol Open
Background Insomnia is often accompanied by depression and anxiety, which can seriously affect people’s quality of life. Cognitive behavioral therapy for insomnia (CBT-I) is the first-line treatment, but the existing CBT-I ignores the inte…
View article: Icariin promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by activating PI3K-AKT-UTX/EZH2 signaling in steroid-induced femoral head osteonecrosis
Icariin promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by activating PI3K-AKT-UTX/EZH2 signaling in steroid-induced femoral head osteonecrosis Open
View article: Large‐Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain
Large‐Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain Open
While increasing peripheral mechanisms related to chronic pain, the plasma proteomics profile associated with it and its prognosis remains elusive. This study utilizes 2923 plasma proteins and chronic pain of 51 644 participants from UK Bi…
View article: Transcription factor ZbERF6-ZbbHLH2 complex enhances monoterpenoid synthesis in Zanthoxylum bungeanum by synergistically activating the expression of ZbIDI
Transcription factor ZbERF6-ZbbHLH2 complex enhances monoterpenoid synthesis in Zanthoxylum bungeanum by synergistically activating the expression of ZbIDI Open
View article: Electromagnetic pulse exposure induces neuroinflammation and blood-brain barrier disruption by activating the NLRP3 inflammasome/NF-κB signaling pathway in mice
Electromagnetic pulse exposure induces neuroinflammation and blood-brain barrier disruption by activating the NLRP3 inflammasome/NF-κB signaling pathway in mice Open
The electromagnetic pulse (EMP) is a widespread electromagnetic disturbance that can disrupt electronic systems and pose health risks to personnel in operational areas. The biological effects of EMP radiation, especially on the central ner…
View article: Patterns of lymph node metastasis and treatment outcomes of parotid gland malignancies
Patterns of lymph node metastasis and treatment outcomes of parotid gland malignancies Open
View article: Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial
Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial Open
Objective To determine whether high flow nasal cannula (HFNC) oxygenation can reduce the incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity. Design Multicentre, randomised, parallel group trial. Setting…