Xiangying Zhang
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View article: Depressed TFAM promotes acetaminophen-induced hepatotoxicity regulated by DDX3X–PGC1α–NRF2 signaling pathway
Depressed TFAM promotes acetaminophen-induced hepatotoxicity regulated by DDX3X–PGC1α–NRF2 signaling pathway Open
View article: Enhancing ASPP2 promotes acute liver injury via an inflammatory immunoregulatory mechanism
Enhancing ASPP2 promotes acute liver injury via an inflammatory immunoregulatory mechanism Open
Background Acute liver injury (ALI), which is a type of inflammation-mediated hepatocellular injury, is a clinical syndrome that results from hepatocellular apoptosis and hemorrhagic necrosis. Apoptosis stimulating protein of p53-2 (ASPP2)…
View article: Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis
Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis Open
Background and Aims Coinfection of hepatitis delta virus (HDV) with hepatitis B virus (HBV) causes the most severe form of viral hepatitis, and the global prevalence of HDV infection is underestimated. Although serological testing of anti-…
View article: The effect of COVID-19 on patients with liver cirrhosis: A systematic review and meta-analysis of retrospective studies (Preprint)
The effect of COVID-19 on patients with liver cirrhosis: A systematic review and meta-analysis of retrospective studies (Preprint) Open
BACKGROUND Coronavirus disease 2019 (COVID-19) is long-lasting and has an adverse effect on liver function. However, the impact of COVID-19 on the outcome of patients with liver cirrhosis has not been consistently clear. OBJECTIVE We ai…
View article: Performance of Hepatitis Delta Virus (HDV) RNA Testing for the Diagnosis of Active HDV Infection: Systematic Review and Meta-analysis
Performance of Hepatitis Delta Virus (HDV) RNA Testing for the Diagnosis of Active HDV Infection: Systematic Review and Meta-analysis Open
The results show that HDV RNA assays had high diagnostic performance. However, that is limited by the number and quality of studies. Standard protocols for the development of assays by manufacturers and larger studies on the use of the ass…
View article: Inhibition of tumor immune escape by blocking PD-1/PD-L1 engagement with dual-targeting molecularly imprinted polymer layer
Inhibition of tumor immune escape by blocking PD-1/PD-L1 engagement with dual-targeting molecularly imprinted polymer layer Open
Blocking the binding of PD-1/PD-L1 has become an effective strategy in inhibition of tumor immune escape. At present, it mainly depends on the employment of macromolecular antibodies, which target PD-1/PD-L1 protein through binding one of …
View article: CRISPR/Cas13a-assisted rapid and portable HBV DNA detection for low-level viremia patients
CRISPR/Cas13a-assisted rapid and portable HBV DNA detection for low-level viremia patients Open
The WHO declared to eliminate hepatitis B virus (HBV) by 2030. However, an increasing number of patients are presenting with low-level viremia (LLV) with the widespread use of antiviral medications. The diagnostic efficiency and coverage a…
View article: Digital Droplet PCR for Detection and Quantitation of Hepatitis Delta Virus
Digital Droplet PCR for Detection and Quantitation of Hepatitis Delta Virus Open
INTRODUCTION: Hepatitis delta virus (HDV) far exceeds our expected level. There remains a lack of reliable quantitative assays for HDV RNA detection. We sought to develop a new method based on digital droplet polymerase chain reaction (ddP…
View article: The Role of Autophagy in the Mother-to-Child Transmission of Pregnant Women With a High Level of HBV DNA
The Role of Autophagy in the Mother-to-Child Transmission of Pregnant Women With a High Level of HBV DNA Open
Background Mother-to-child transmission (MTCT) is the most common propagation mode of hepatitis B virus (HBV) transmission. Exploring the mechanisms of HBV MTCT is the key to protect infant from infection. In this study, we aim to clarify …
View article: CRISPR/Cas13-assisted hepatitis B virus covalently closed circular DNA detection
CRISPR/Cas13-assisted hepatitis B virus covalently closed circular DNA detection Open
Background and aims The formation of an intranuclear pool of covalently closed circular DNA (cccDNA) in the liver is the main cause of persistent hepatitis B virus (HBV) infection. Here, we established highly sensitive and specific methods…
View article: The Qingchangligan Formula Alleviates Acute Liver Failure by Regulating Galactose Metabolism and Gut Microbiota
The Qingchangligan Formula Alleviates Acute Liver Failure by Regulating Galactose Metabolism and Gut Microbiota Open
The Qingchangligan formula (QCLGF) is a traditional Chinese medicine that has significant clinical potential for patients with acute liver failure (ALF). However, the experimental evidence of the effect of QCLGF on ALF and the associated m…
View article: Magnesium Isoglycyrrhizinate Ameliorates Concanavalin A-Induced Liver Injury by Inhibiting Autophagy
Magnesium Isoglycyrrhizinate Ameliorates Concanavalin A-Induced Liver Injury by Inhibiting Autophagy Open
Background and Aims: Acute liver failure (ALF) is a type of liver injury that is caused by multiple factors and leads to severe liver dysfunction; however, current treatments for ALF are insufficient. Magnesium isoglycyrrhizinate (MgIG), a…
View article: Effect of Comparison between Qingchangligan Granules and Qingchangligan Decoction on D-GalN/LPS-Induced Liver Injury in Mice
Effect of Comparison between Qingchangligan Granules and Qingchangligan Decoction on D-GalN/LPS-Induced Liver Injury in Mice Open
Ethnopharmacological relevance The Qingchangligan formula has two dosage forms, granules and decoction. Both of them have the same prescription; however, whether their protective effects are different remain elusive.Aim of the study To com…
View article: Digital Droplet PCR (ddPCR) for Detection and Quantitation of Hepatitis Delt Virus
Digital Droplet PCR (ddPCR) for Detection and Quantitation of Hepatitis Delt Virus Open
Background & Aims The prevalence of hepatitis delt virus (HDV) far exceeds our expected level, there remains a lack of reliable quantitative assays for HDV RNA detection. We sought to develop a new method based on digital droplet PCR (ddPC…
View article: Distinct effects of different doses of kaempferol on D‑GalN/LPS‑induced ALF depend on the autophagy pathway
Distinct effects of different doses of kaempferol on D‑GalN/LPS‑induced ALF depend on the autophagy pathway Open
Kaempferol, a flavonoid compound, has various biological functions, such as anti‑inflammatory and antitumor activities. Acute liver failure (ALF) is a lethal clinical syndrome that occurs due to severe damage of the liver function. In the …
View article: Roles of Toll-like Receptor 3 in Intrauterine Transmission of Hepatitis B Virus in Mothers with High Viral Load
Roles of Toll-like Receptor 3 in Intrauterine Transmission of Hepatitis B Virus in Mothers with High Viral Load Open
Backgrounds Despite passive and active immunization, perinatal mother-to-infant transmission (MTIT) of hepatitis B virus (HBV) still occurs in women with high levels of viremia. Thus, understanding the mechanisms of MTIT …
View article: Kaempferol Protects Mice from D-GalN/LPS-induced Acute Liver Failure by Regulating the Autophagy Pathway
Kaempferol Protects Mice from D-GalN/LPS-induced Acute Liver Failure by Regulating the Autophagy Pathway Open
Background Kaempferol, a flavonoid compound present in many edible plants, has been used in traditional medicine and has various biological functions. Acute liver failure (ALF) is a lethal clinical syndrome with severe liver function damag…
View article: GLT25D2 Is Critical for Inflammatory Immune Response to Promote Acetaminophen-Induced Hepatotoxicity by Autophagy Pathway
GLT25D2 Is Critical for Inflammatory Immune Response to Promote Acetaminophen-Induced Hepatotoxicity by Autophagy Pathway Open
Acetaminophen (APAP) overdose induces hepatocyte necrosis and causes liver hepatotoxicity. Currently, the role of galactosyltransferase in APAP-induced liver injury is still unclear. This study assessed the contribution of the GLT25D2 gene…
View article: The critical role of PPARα in the binary switch between life and death induced by endoplasmic reticulum stress
The critical role of PPARα in the binary switch between life and death induced by endoplasmic reticulum stress Open
View article: The different expression of caspase-1 in HBV-related liver disease and acts as a biomarker for acute-on-chronic liver failure
The different expression of caspase-1 in HBV-related liver disease and acts as a biomarker for acute-on-chronic liver failure Open
View article: Glycosyltransferase GLT25D2 Acts as a Negative Regulator of Autophagy to Promote Acetaminophen-Induced Hepatotoxicity
Glycosyltransferase GLT25D2 Acts as a Negative Regulator of Autophagy to Promote Acetaminophen-Induced Hepatotoxicity Open
View article: Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway
Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway Open
Kaempferol is a flavonoid compound that has gained widespread attention due to its antitumor functions. However, the underlying mechanisms are still not clear. The present study investigated the effect of kaempferol on hepatocellular carci…
View article: [Application of enhanced recovery program in laparoscopic distal pancreatectomy].
[Application of enhanced recovery program in laparoscopic distal pancreatectomy]. Open
Objective: To evaluate the feasibility and safety of applying enhanced recovery after surgery (ERAS) protocol in patients undergoing laparoscopic distal pancreatectomy. Methods: Data of 36 patients undergoing laparoscopic dis…
View article: Qingchangligan formula attenuates the inflammatory response to protect the liver from acute failure induced by d -galactosamine/lipopolysaccharide in mice
Qingchangligan formula attenuates the inflammatory response to protect the liver from acute failure induced by d -galactosamine/lipopolysaccharide in mice Open
Our findings demonstrated that the Qingchangligan formula exerts a protective effect against the pathophysiology of ALF, especially in regulating liver inflammation, and provide a rationale for using the Qingchangligan formula as a potenti…
View article: Clinical efficacy of paclitaxel in the treatment of mid-stage and advanced malignant gastric cancer, and effect of nursing interventions
Clinical efficacy of paclitaxel in the treatment of mid-stage and advanced malignant gastric cancer, and effect of nursing interventions Open
Purpose: To investigate the clinical efficacy of paclitaxel combined with additional chemotherapy for mid-stage and advanced malignant tumors, and the benefits afforded by scientific nursing.Methods: Patients with mid-stage and advanced ga…
View article: Effect of targeted nursing applied to SLE patients
Effect of targeted nursing applied to SLE patients Open
The aim of the present study was to evaluate the efficacy of targeted nursing for patients with systemic lupus erythematosus (SLE). A total of 114 patients clinically diagnosed with stable SLE were prospectively selected. The patients were…